Postural Instability Is Associated with Brain Atrophy and Cognitive Impairment in the Elderly: The J-SHIPP Study

Dementia and Geriatric Cognitive Disorders - Tập 29 Số 5 - Trang 379-387 - 2010
Tomoko Kido1, Yasuharu Tabara2,3,4, Michiya Igase2,1, Namiko Ochi1, Eri Uetani1, Takayuki Nagai1, Miyuki Yamamoto1, Keiko Taguchi1, Tetsuro Miki2,1,4, Katsuhiko Kohara2,1,4
1Departments of Geriatric Medicine and
2Antiaging Center, Ehime University Hospital, Ton City, Japan
3Basic Medical Research and Education, Ehime University Graduate School of Medicine,
4Ehime Proteo Medicine Research Center, and

Tóm tắt

<i>Background/Aims:</i> Mobility impairment in older adults has been suggested to be a marker of subclinical structural and functional brain abnormalities. We investigated a possible association between static postural instability and brain abnormalities and cognitive decline. <i>Methods:</i> The study subjects were 390 community residents without definitive dementia (67 ± 7 years old) and 21 patients with Alzheimer’s disease (AD). Brain atrophy was measured by MRI. <i>Results:</i> The mobility of the posturography-measured center of gravity (COG) was positively associated with the temporal horn area (THA; r = 0.260; p < 0.001). Subjects who could not stand on one leg for >40 s (n = 102) showed a significantly larger THA (22 ± 18 vs. 14 ± 11 × 10<sup>–2</sup> cm<sup>2</sup>; p < 0.001). Multiple regression analysis identified COG path length (β = 0.118; p = 0.032) and one-leg standing time (β = 0.176; p = 0.001) as independent determinants of THA. Mild cognitive impairment (MCI) subjects (n = 61) had a significantly enlarged THA compared to that of normal cognitive subjects (22 ± 16 vs. 16 ± 13 × 10<sup>–2</sup> cm<sup>2</sup>; p = 0.002). AD patients showed a more enlarged THA (78 ± 55 × 10<sup>–2</sup> cm<sup>2</sup>). Subjects with cognitive decline showed a significantly shorter one-leg standing time (normal: 50 ± 17 s; MCI: 42 ± 21 s; AD: 18 ± 20s; p < 0.001). <i>Conclusion:</i> Reduced postural stability was an independent marker of brain atrophy and pathological cognitive decline in the elderly.

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Thông tin xuất bản

Dementia and Geriatric Cognitive Disorders

Tập 29 Số 5

379-387

Thông tin tác giả