170 Targeting RIG-I-like receptor signaling and innate immunity for adjuvant activityCytokine - Tập 63 - Trang 283 - 2013
Wilkins Courtney, Fowler Kerry, Wang Myra, Dong Ran, Pattabhi Sowmya, Munoz Ernesto J., Iadonato Shawn P., Grigg John, Ireton Renee C., Bedard Kristin M., Gale Michael, Loo Yueh-Ming
RIG-I-like receptors (RLR) are cytoplasmic pathogen recognition receptors that
detect pathogen-associated molecular patterns (PAMP) within viral RNA and
initiate the innate antiviral immune response that is essential for controlling
many RNA virus infections. Viral PAMP engagement of RLR initiates a signaling
cascade and transcriptional program that culminates in the expression of
antiviral genes ... hiện toàn bộ