Cytogenetic and Genome Research
SCOPUS (1962-1972,2002-2025)SCIE-ISI
1424-8581
1424-859X
Thụy Sĩ
Cơ quản chủ quản: KARGER , S. Karger AG
Lĩnh vực:
Genetics (clinical)GeneticsMolecular Biology
Các bài báo tiêu biểu
An Air-Drying Method for Chromosome Preparations from Mouse Eggs
Tập 5 Số 6 - Trang 394-400 - 1966
The eggs, after being washed out from the genital tract, are put into hypotonic
(1%) sodium citrate and left to stand at room temperature for 5–15 minutes. The
duration of treatment is not very critical, but later stages, especially
blastocysts, need longer treatment. A microdrop of this solution together with
the eggs is placed on a grease-free slide. A few drops of acetic alcohol (3
parts of abs...
An Air-Drying Method for Meiotic Preparations from Mammalian Testes
Tập 3 Số 5 - Trang 289-294 - 1964
A suspension is made in isotonic (2.2%) sodium citrate solution from the
contents of the tubules from a whole testis or a testicular biopsy specimen. The
germinal cells are sedimented by centrifuging, leaving most of the sperm in the
supernatant fluid, which is discarded. The cells are resuspended in hypo-tonic
(1%) sodium citrate solution and left to stand at room temperature for 12
minutes, afte...
Yeast stimulation of bone marrow mitosis for cytogenetic investigations
Tập 26 Số 1 - Trang 36-40 - 1980
We report a simple, dependable method for stimulating bone marrow mitosis in
small mammals. Subcutaneous injections of a suspension of active baker’s yeast
may elevate the mitotic index as much as six times or more. Additionally, the
metaphases obtained are easily spread when air dried, and the chromosomes are
readily banded. This method should prove useful to investigators who wish to use
bone ma...
Stress activation and genomic impact of Tnt1 retrotransposons in Solanaceae
Tập 110 Số 1-4 - Trang 229-241 - 2005
Tnt1 elements are a superfamily of LTR-retrotransposons distributed in the
Solanaceae plant family and represent good model systems for studying regulatory
and evolutionary controls established between hosts and transposable elements.
Tnt1 retrotransposons tightly control their activation, by restricting
expression to specific conditions. The Tnt1A element, originally discovered in
tobacco, is exp...
Digitized and differentially shaded human chromosome ideograms for genomic applications
Tập 65 Số 3 - Trang 206-219 - 1994
Human chromosome ideograms that depict 850 bands, numbered in agreement with
ISCN (1981) nomenclature but based on actual measurements of band sizes and
differentiated by five shades of staining intensity, have been digitized using
commercially available graphics software. They provide for more accurate
estimates of distances within chromosome arms, DNA content of chromosome bands
and correlation ...
Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes
Tập 90 Số 3-4 - Trang 291-297 - 2000
PRG4 (proteoglycan 4) has been identified as megakaryocyte stimulating factor
and articular superficial zone protein. PRG4 has characteristic motifs including
somatomedin B and hemopexin domains, a chondroitin sulfate-attachment site and
mucin-like repeats. During a screen of genes implicated in ectopic ossification,
we found a novel mouse gene highly homologous to human and bovine PRG4 genes.
Her...
A simplified technique for in vivo analysis of sister-chromatid exchanges using 5-bromodeoxyuridine tablets
Tập 18 Số 4 - Trang 231-237 - 1977
A small tablet of 5-bromodeoxyuridine (BrdU), implanted subcutaneously in a
mouse, provides sustained release of base analog sufficient to effect
substitution of DNA throughout an entire replication period. As illustrated by
studies of mouse bone-marrow and spleen cells in the presence or absence of
cyclophosphamide, this depot method of BrdU administration greatly simplifies in
vivo analysis of s...
Report of the committee on chromosome and gene loss in human neoplasia
Tập 58 Số 3-4 - Trang 1080-1096 - 1991
Meningioma: a cytogenetic model of a complex benign human tumor, including data on 394 karyotyped cases
Tập 93 Số 3-4 - Trang 207-220 - 2001
Meningioma is the most frequent tumor of neuroectodermal origin in humans. It is
usually benign. Only a minority of cases shows progression to an anaplastic
tumor (WHO grade II and III). Meningioma is generally a sporadic tumor. Multiple
and familial cases are rare and mostly associated with (hereditary)
neurofibromatosis 2 (NF2). Meningiomas show an unexpectedly high recurrence
rate. Also, comple...