Current Pharmacology Reports

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Stilbenes: Chemistry and Molecular Mechanisms of Anti-obesity
Current Pharmacology Reports - - 2018
Ya-Chun Chou, Chi-Tang Ho, Min-Hsiung Pan
Stilbenoids, a class of plant polyphenols abundant in berries, have been found to have many biological actions. Resveratrol, the most well-known of the stilbenes, is used for disease prevention, particularly for anti-obesity. Due to the low bioavailability of resveratrol, other stilbenes and their metabolites are also considered as candidates for anti-obesity. Obesity has numerous known causes, in...... hiện toàn bộ
Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery
Current Pharmacology Reports - Tập 2 - Trang 1-10 - 2016
Yan Wang, Ying Xie, David Oupický
This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies. Overview of drug delivery systems targeted to cancers that overexpress CXCR4 is provided, together with the main types...... hiện toàn bộ
Link between Homocysteine and Cardiovascular Diseases
Current Pharmacology Reports - Tập 4 Số 1 - Trang 1-9 - 2018
Obradovic, Milan, Zaric, Bozidarka L, Haidara, Mohamed A, Isenovic, Esma R.
Numerous studies have shown a positive correlation between serum Hcy level and various pathological conditions such as coronary, carotid, and peripheral vascular disease. Increased plasma Hcy levels are associated not only with an increased risk of arteriosclerosis but also with atherosclerosis and thrombosis. The aim of this review is to review biochemical mechanisms responsible for development a...... hiện toàn bộ
A Molecular Aspect in the Regulation of Drug Metabolism: Does PXR-Induced Enzyme Expression Always Lead to Functional Changes in Drug Metabolism?
Current Pharmacology Reports - Tập 2 - Trang 187-192 - 2016
Yuan Wei, Chenxiao Tang, Vinayak Sant, Song Li, Samuel M. Poloyac, Wen Xie
Pregnane X receptor (PXR, NR112) is a xenobiotic receptor whose primary function is to regulate the expression of drug-metabolizing enzymes (DMEs) and drug transporters. Drug-induced PXR activation and subsequent enzyme and transporter induction has been proposed to be an important mechanism for the drug-drug interactions. In addition to activating PXR, many pharmaceutical chemicals can also funct...... hiện toàn bộ
An Update on Advancements in Treatment Options for Managing Klebsiella pneumoniae Infections
Current Pharmacology Reports - Tập 8 Số 6 - Trang 439-449
Sunil Kumar, Razique Anwer, Mukesh Yadav, Gourav Vats, Shivali Thakur, Nirmala Sehrawat, Vikas Kumar, Manoj Kumar Singh
Ayurveda and Allopathic Therapeutic Strategies in Coronavirus Pandemic Treatment 2020
Current Pharmacology Reports - Tập 6 - Trang 354-363 - 2020
Shivangi Talwar, Shivani Sood, Jayant Kumar, Ritu Chauhan, Mamta Sharma, Hardeep Singh Tuli
In the last month of 2019, i.e., December, COVID-19 hit Wuhan city in China. Since then, it has infected more than 210 countries and nearly about 33.4 million people with one million deaths globally. It is a viral disease with flu-like symptoms; hence, prevention and management is the best option to be adopted for its cure. Many healthcare systems, scientists, and researchers are fighting for the ...... hiện toàn bộ
The Emergence of Mpox: Epidemiology and Current Therapeutic Options
Current Pharmacology Reports - Tập 9 - Trang 144-153 - 2023
Samriddhi Ranjan, Kanupriya Vashishth, Katrin Sak, Hardeep Singh Tuli
The world recently witnessed the emergence of new epidemic outbreaks like COVID-19 and mpox. The 2022 outbreak of mpox amid COVID-19 presents an intricate situation and requires strategies to combat the status quo. Some of the challenges to controlling an epidemic include present knowledge of the disease, available treatment options, appropriate health infrastructures facilities, current scientifi...... hiện toàn bộ
Anti-Disialoganglioside-2 Monoclonal Antibodies as an Emerging Therapeutic Approach in Treatment of High-Risk Neuroblastoma
Current Pharmacology Reports - - 2022
Hemant Kumar, Rachna Gupta
Neutrophil-Derived S100A8/A9 in Cardiovascular Disease and Beyond
Current Pharmacology Reports - Tập 9 - Trang 353-363 - 2023
Ronisha Shankar Rao, Suvetha Panbhukarasu, Muhammad Waleed, Cassandra Rifflin Charles Raichel, Kidher Rahman, Kameshwaran Sivakumar, Baskaran Athmanathan
Increase in neutrophil counts that are associated with cardiovascular risk factors including myocardial infarction (MI) and early development of heart attack is a major concern among all age groups in recent years. Neutrophil production in response to heart failure is mediated by various ways including recruitment of immune cells at the site of injury, release inflammatory molecules, and continuou...... hiện toàn bộ
Traditional Siddha Approach to Treatment of Cognitive Impairment in Menopause
Current Pharmacology Reports - Tập 8 - Trang 312-320 - 2022
S. Mary Princess Sulekha
Menopause is a multifaceted biological and psychosomatic health disorder induced by the reduction and cessation of ovarian physiology and reproductive hormones such as estrogen, progesterone, follicular stimulating hormone (FSH), and luteinizing hormone (LH). This literature review aimed to synthesize the results of published studies on factors associated with symptoms in women during the transiti...... hiện toàn bộ
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