Current Pharmacology Reports

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Stilbenes: Chemistry and Molecular Mechanisms of Anti-obesity
Current Pharmacology Reports - - 2018
Ya-Chun Chou, Chi-Tang Ho, Min-Hsiung Pan
Stilbenoids, a class of plant polyphenols abundant in berries, have been found to have many biological actions. Resveratrol, the most well-known of the stilbenes, is used for disease prevention, particularly for anti-obesity. Due to the low bioavailability of resveratrol, other stilbenes and their metabolites are also considered as candidates for anti-obesity. Obesity has numerous known causes, in... hiện toàn bộ
Role of Lateral Hypothalamic Orexin (Hypocretin) Neurons in Alcohol Use and Abuse: Recent Advances
Current Pharmacology Reports - Tập 2 - Trang 241-252 - 2016
Leigh C. Walker, Sarah Sulaiman Ch’ng, Andrew J. Lawrence
Alcohol use disorders (AUDs) are chronic relapsing disorders with the modest efficacy of current medications. The US Food and Drug Administration (FDA) and Japanese Pharmaceuticals and Medical Devices Agency (PMDA) approval of the dual orexin (OX) receptor antagonist, suvorexant for the treatment of insomnia, may enable repurposing of this drug for the treatment of other diseases. Here, we summari... hiện toàn bộ
67-kDa Laminin Receptor Mediates the Beneficial Effects of Green Tea Polyphenol EGCG
Current Pharmacology Reports - Tập 6 - Trang 280-285 - 2020
Motofumi Kumazoe, Yoshinori Fujimura, Hirofumi Tachibana
Green tea is one of the most consumed beverages in the world. Through in vivo models and clinical trials, several studies have shown the beneficial effects of green tea. Epidemiological studies have revealed that green tea consumption is negatively correlated with the risk of cardiovascular diseases, stroke and cancer; however, little is known about the underlying molecular mechanisms. (−)-Epigall... hiện toàn bộ
Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery
Current Pharmacology Reports - Tập 2 - Trang 1-10 - 2016
Yan Wang, Ying Xie, David Oupický
This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies. Overview of drug delivery systems targeted to cancers that overexpress CXCR4 is provided, together with the main types... hiện toàn bộ
Mechanistic Role of MicroRNA in Cancer Chemoprevention by Nonsteroidal Anti-inflammatory Drugs
Current Pharmacology Reports - Tập 1 - Trang 154-160 - 2015
Ruixia Ma, Bin Yi, Gary A. Piazza, Yaguang Xi
Over the past several decades, studies have documented the cancer chemopreventive activity of nonsteroidal anti-inflammatory drugs (NSAIDs) by lowering incidence and slowing down progression of malignant disease, which consequently lead to decline of cancer-related mortality and improvement of disease progression-free survival (PFS). Inhibition of cyclooxygenase (COX) has been primarily believed t... hiện toàn bộ
Link between Homocysteine and Cardiovascular Diseases
Current Pharmacology Reports - Tập 4 Số 1 - Trang 1-9 - 2018
Obradovic, Milan, Zaric, Bozidarka L, Haidara, Mohamed A, Isenovic, Esma R.
Numerous studies have shown a positive correlation between serum Hcy level and various pathological conditions such as coronary, carotid, and peripheral vascular disease. Increased plasma Hcy levels are associated not only with an increased risk of arteriosclerosis but also with atherosclerosis and thrombosis. The aim of this review is to review biochemical mechanisms responsible for development a... hiện toàn bộ
Bitter Melon as a Therapy for Diabetes, Inflammation, and Cancer: a Panacea?
Current Pharmacology Reports - Tập 2 - Trang 34-44 - 2016
Deep Kwatra, Prasad Dandawate, Subhash Padhye, Shrikant Anant
Natural products have been used for centuries for cures prevention, treatment, and cure of multiple diseases. Some dietary agents are present in multiple systems of medicines as proposed treatments for chronic and difficult to treat diseases. Once such natural product is Momordica charantia or bitter melon. Bitter melon is cultivated in multiple regions across the world, and various parts of the p... hiện toàn bộ
Disease Progression Modeling: Key Concepts and Recent Developments
Current Pharmacology Reports - - 2016
Sarah F. Cook, Robert R. Bies
A Molecular Aspect in the Regulation of Drug Metabolism: Does PXR-Induced Enzyme Expression Always Lead to Functional Changes in Drug Metabolism?
Current Pharmacology Reports - Tập 2 - Trang 187-192 - 2016
Yuan Wei, Chenxiao Tang, Vinayak Sant, Song Li, Samuel M. Poloyac, Wen Xie
Pregnane X receptor (PXR, NR112) is a xenobiotic receptor whose primary function is to regulate the expression of drug-metabolizing enzymes (DMEs) and drug transporters. Drug-induced PXR activation and subsequent enzyme and transporter induction has been proposed to be an important mechanism for the drug-drug interactions. In addition to activating PXR, many pharmaceutical chemicals can also funct... hiện toàn bộ
Natural Agents Used in Chemoprevention of Aerodigestive and GI Cancers
Current Pharmacology Reports - Tập 2 - Trang 11-20 - 2016
Jay Morris, Yuan Fang, Keya De Mukhopdhyay, Michael J. Wargovich
Aerodigestive cancers are on an increasing level in both occurrence and mortality. A major cause in many of these cancers is disruption of the inflammatory pathway, leading to increased cell proliferation and epigenetic silencing of normal regulatory genes. Here, we review the research on several natural products: silibinin, silymarin, quercetin, neem and nimbolide, gingerol, epigallatecatechin-3-... hiện toàn bộ
Tổng số: 226   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10