Current Hepatitis Reports
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Chronic hepatitis C and steatosis
Current Hepatitis Reports - Tập 3 - Trang 123-128 - 2004
Steatosis is a common finding in chronic hepatitis C infection. It is associated
with increased fibrogenesis and, in nongenotype 3 infection, with a reduced
response to antiviral therapy. The steatosis is multifactorial; host factors,
particularly excess body mass and insulin resistance, and viral cytopathic
effects each play a variable role in different genotypes. How steatosis or the
accompanyin...
Treatment of Hepatitis C in HIV Patients in the New Era of Direct-Acting Antivirals
Current Hepatitis Reports - Tập 12 - Trang 269-275 - 2013
Chronic hepatitis C virus (HCV) infection occurs globally in 20 % of
HIV-seropositive patients. In coinfected individuals, HCV-related liver disease
is a leading cause of morbidity and mortality. The advent of new direct-acting
antivirals (DAA) has been particularly awaited for this population, in whom
treatment with peginterferon plus ribavirin depicts limited efficacy and poor
tolerability. Howe...
Acute hepatitis C infection: Can immunology teach us the right way to treat?
Current Hepatitis Reports - Tập 3 - Trang 148-156 - 2004
Management of acute hepatitis C has been discussed controversially in recent
years. Early administration of interferon alpha prevents chronicity in almost
all cases. However, interferon treatment is associated with significant side
effects and costs; thus, alternative treatment strategies were also
investigated. These data also suggested that a delayed therapy may cure the
infection in 80% to 90% ...
Hepatitis C in patients with psychiatric disease and substance abuse: Screening strategies and comanagement models of care
Current Hepatitis Reports - Tập 2 - Trang 93-100 - 2003
Increasingly, hepatologists and other health care providers have recognized the
need for a systematic approach to hepatitis C that addresses the common
comorbidities of psychiatric and substance use disorders, and one that demands
active participation from mental health care providers. The majority of new and
existing cases of hepatitis C are related to injection drug use, and in this
population t...
Liver transplantation for HBV and management of reinfection
Current Hepatitis Reports - Tập 4 - Trang 39-44 - 2005
Despite the application of vaccination and the growing list of agents effective
in chronic hepatitis B, this disease remains an important indication for
transplantation. Early experience was marked by viral recurrence and dismal
outcomes; current protocols using hepatitis B immunoglobulin and nucleoside
analogues now make recurrence uncommon and outcomes excellent. Nevertheless,
allograft infectio...
Hepatitis D in the Middle East and North Africa (MENA): Update and Challenges Ahead
Current Hepatitis Reports - Tập 11 Số 4 - Trang 272-278 - 2012
Role of Resistance Testing During Oral Antiviral Therapy of Chronic Hepatitis B
Current Hepatitis Reports - Tập 11 - Trang 55-64 - 2012
Hepatitis B virus (HBV) DNA replication is an error prone mechanism and coupled
with selection pressure from antiviral agents, emergence of resistance can be
frequent. Antiviral drug resistance has been associated with treatment failure,
and the widespread use of readily available antiviral agents with limited
potency and low genetic barrier, the risk of emergence of multidrug resistant
HBV makes ...
Treatment of chronic hepatitis B virus infection in children
Current Hepatitis Reports - Tập 8 - Trang 96-102 - 2009
Hepatitis B virus (HBV) remains an important global pathogen. In countries of
high endemicity, virus is typically acquired either vertically or during the
preschool years, contributing to a large burden of pediatric infection.
Seroconversion and progression to the inactive carrier phase of infection is
associated with improved outcome and decreased rates of cirrhosis and
hepatocellular carcinoma. ...
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