Current Diabetes Reports
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Rationale Use of GLP-1 Receptor Agonists in Patients with Type 1 Diabetes
Current Diabetes Reports - Tập 13 Số 5 - Trang 663-668 - 2013
Global Updates on Cardiovascular Disease Mortality Trends and Attribution of Traditional Risk Factors
Current Diabetes Reports - Tập 19 - Trang 1-12 - 2019
The last 2–3 decades have witnessed a decline in age-standardized cardiovascular mortality rates in high-income regions, whereas this has only slightly decreased or even increased in most of the low- and middle-income countries. A systematic comparison of global CVD mortality by regions attributable to various modifiable risk factors such as diabetes, obesity, hypertension, poor diet, and physical......
Gastrointestinal Peptides as Therapeutic Targets to Mitigate Obesity and Metabolic Syndrome
Current Diabetes Reports - Tập 20 - Trang 1-7 - 2020
Obesity affects over than 600 million adults worldwide resulting in multi-organ complications and major socioeconomic impact. The purpose of this review is to summarise the physiological effects as well as the therapeutic implications of the gut hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin, peptide YY (PYY), and glucose-dependent insulinotropic peptide (GIP) in the treatment of obesity ......
β-cell failure in type 2 diabetes mellitus
Current Diabetes Reports - Tập 8 - Trang 179-184 - 2008
Diabetes mellitus has been defined as a “group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both” and encompasses a wide range of heterogeneous conditions. Common type 2 diabetes mellitus (T2DM) results from a combination of genetic and acquired factors. However, lifestyle factors, particularly overeating and physical inactivi......
Candidate Genes Expressed in Human Islets and Their Role in the Pathogenesis of Type 1 Diabetes
Current Diabetes Reports - Tập 13 - Trang 633-641 - 2013
In type 1 diabetes (T1D), the insulin-producing β cells are destroyed by an immune-mediated process leading to complete insulin deficiency. There is a strong genetic component in T1D. Genes located in the human leukocyte antigen (HLA) region are the most important genetic determinants of disease, but more than 40 additional loci are known to significantly affect T1D risk. Since most of the current......
Developmental Origins of Obesity: Programmed Adipogenesis
Current Diabetes Reports - Tập 13 - Trang 27-33 - 2012
The metabolic syndrome epidemic, including a marked increase in the prevalence of obesity and gestational diabetes mellitus (GDM) among pregnant women, represents a significant public health problem. There is increasing recognition that the risk of adult obesity is clearly influenced by prenatal and infant environmental exposures, particularly nutrition. This tenet is the fundamental basis of deve......
MicroRNAs in Type 1 Diabetes: Complex Interregulation of the Immune System, β Cell Function and Viral Infections
Current Diabetes Reports - Tập 16 - Trang 1-12 - 2016
Since the discovery of the first mammalian microRNA (miRNA) more than two decades ago, a plethora of miRNAs has been identified in humans, now amounting to more than 2500. Essential for post-transcriptional regulation of gene networks integral for developmental pathways and immune response, it is not surprising that dysregulation of miRNAs is often associated with the aetiology of complex diseases......
Preconception Counseling for Adolescents and Young Adults with Diabetes: a Literature Review of the Past 10 Years
Current Diabetes Reports - Tập 18 - Trang 1-9 - 2018
Women with diabetes who have unplanned pregnancies and uncontrolled blood sugars are at a higher risk for maternal and fetal morbidities and mortalities. Preconception counseling (PC) has been shown to decrease the risks and improve health outcomes. From 2009 to 2017, the American Diabetes Association has recommended that preconception counseling be given at each clinic visit for all women with di......
Lactation, diabetes, and nutrition recommendations
Current Diabetes Reports - Tập 4 - Trang 370-376 - 2004
Human milk is recommended for infants throughout at least the first year of life. Breastfeeding is also recommended for infants of women with preexisting diabetes or gestational diabetes. Dietary Reference Intakes (DRIs) 2002 provides recommendations for energy and macronutrients for all ages and for pregnancy and lactation. During the first 6 months, infants receive an average of 500 kcal/d from ......
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