Current Diabetes Reports
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Rationale Use of GLP-1 Receptor Agonists in Patients with Type 1 Diabetes
Current Diabetes Reports - Tập 13 Số 5 - Trang 663-668 - 2013
Global Updates on Cardiovascular Disease Mortality Trends and Attribution of Traditional Risk Factors
Current Diabetes Reports - Tập 19 - Trang 1-12 - 2019
The last 2–3 decades have witnessed a decline in age-standardized cardiovascular mortality rates in high-income regions, whereas this has only slightly decreased or even increased in most of the low- and middle-income countries. A systematic comparison of global CVD mortality by regions attributable to various modifiable risk factors such as diabetes, obesity, hypertension, poor diet, and physical......
Gastrointestinal Peptides as Therapeutic Targets to Mitigate Obesity and Metabolic Syndrome
Current Diabetes Reports - Tập 20 - Trang 1-7 - 2020
Obesity affects over than 600 million adults worldwide resulting in multi-organ complications and major socioeconomic impact. The purpose of this review is to summarise the physiological effects as well as the therapeutic implications of the gut hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin, peptide YY (PYY), and glucose-dependent insulinotropic peptide (GIP) in the treatment of obesity ......
β-cell failure in type 2 diabetes mellitus
Current Diabetes Reports - Tập 8 - Trang 179-184 - 2008
Diabetes mellitus has been defined as a “group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both” and encompasses a wide range of heterogeneous conditions. Common type 2 diabetes mellitus (T2DM) results from a combination of genetic and acquired factors. However, lifestyle factors, particularly overeating and physical inactivi......
Candidate Genes Expressed in Human Islets and Their Role in the Pathogenesis of Type 1 Diabetes
Current Diabetes Reports - Tập 13 - Trang 633-641 - 2013
In type 1 diabetes (T1D), the insulin-producing β cells are destroyed by an immune-mediated process leading to complete insulin deficiency. There is a strong genetic component in T1D. Genes located in the human leukocyte antigen (HLA) region are the most important genetic determinants of disease, but more than 40 additional loci are known to significantly affect T1D risk. Since most of the current......
Developmental Origins of Obesity: Programmed Adipogenesis
Current Diabetes Reports - Tập 13 - Trang 27-33 - 2012
The metabolic syndrome epidemic, including a marked increase in the prevalence of obesity and gestational diabetes mellitus (GDM) among pregnant women, represents a significant public health problem. There is increasing recognition that the risk of adult obesity is clearly influenced by prenatal and infant environmental exposures, particularly nutrition. This tenet is the fundamental basis of deve......
MicroRNAs in Type 1 Diabetes: Complex Interregulation of the Immune System, β Cell Function and Viral Infections
Current Diabetes Reports - Tập 16 - Trang 1-12 - 2016
Since the discovery of the first mammalian microRNA (miRNA) more than two decades ago, a plethora of miRNAs has been identified in humans, now amounting to more than 2500. Essential for post-transcriptional regulation of gene networks integral for developmental pathways and immune response, it is not surprising that dysregulation of miRNAs is often associated with the aetiology of complex diseases......
Material Need Support Interventions for Diabetes Prevention and Control: a Systematic Review
Current Diabetes Reports - Tập 15 - Trang 1-8 - 2015
Unmet material needs, such as food insecurity and housing instability, are associated with increased risk of diabetes and worse outcomes among diabetes patients. Healthcare delivery organizations are increasingly held accountable for health outcomes that may be related to these “social determinants,” which are outside the scope of traditional medical intervention. This review summarizes the curren......
Impact of surgical and nonsurgical weight loss on diabetes resolution and cardiovascular risk reduction
Current Diabetes Reports - Tập 9 - Trang 223-228 - 2009
Weight loss favorably modifies most cardiovascular risk factors, in particular the diagnostic criteria for metabolic syndrome, type 2 diabetes mellitus, and hypertension. Treating the spectrum of diabetes by promoting disease control or resolution invariably improves cardiovascular outcomes. However, in clinical trials and routine medical practice, long-term weight loss has been difficult to achie......
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