β-cell failure in type 2 diabetes mellitus

Current Diabetes Reports - Tập 8 - Trang 179-184 - 2008
Cristina Lencioni, Roberto Lupi, Stefano Del Prato1
1Department of Endocrinology and Metabolism, Section of Diabetes and Metabolic Diseases, University of Pisa, Ospedale Cisanello, Pisa, Italy

Tóm tắt

Diabetes mellitus has been defined as a “group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both” and encompasses a wide range of heterogeneous conditions. Common type 2 diabetes mellitus (T2DM) results from a combination of genetic and acquired factors. However, lifestyle factors, particularly overeating and physical inactivity, are the major clinical determinants of T2DM. Insulin resistance is a common feature of T2DM, but it is unlikely to cause T2DM unless progressive loss of β-cell function develops. Significant reduction in β-cell function is already present at the time of T2DM diagnosis, and it continuously declines irrespective of treatment. As such, the progressive loss of β-cell function dictates the rate of worsened glycemic control. Development of progressive deterioration accelerates via gluco-and lipotoxicity, loss of β-cell function, and shrinkage of β-cell mass. Understanding the causes for β-cell failure is therefore of capital importance to develop new and more effective therapeutic strategies.

Tài liệu tham khảo

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