Alternatives to unmodified human islets for transplantation

Alberto Hayek1, Gillian M. Beattie1
1UCSD Department of Pediatrics, The Whittier Institute, 0831, 9500 Gilman Drive, 92093-0831, La Jolla, CA, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Eriksson PS, Perfilieve P, Bjork-Eriksson T, et al.: Neurogensis in the adult human hippocampus. Nat Med 1998, 4:1313–1337.

Otonkoski T, Beattie GM, Rubin JS, et al.: Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes 1994, 43:947–953.

Otonkoski T, Cirulli V, Beattie GM, et al.: A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology 1996, 137:3131–3139.

Hayek A, Beattie GM, Cirulli V, et al.: Growth factor/matrixinduced proliferation of human adult beta-cells. Diabetes 1995, 44:1458–1460.

Beattie GM, Itkin-Ansari P, Cirulli V, et al.: Sustained proliferation of PDX- 1+ cells derived from human islets. Diabetes 1999, 48:1013–1019. Reports on the ability to proliferate β-cell lineage cells from human adult islets.

Beattie GM, Leibowitz G, Lopez AD, et al.: Protection from cell death in cultured human fetal pancreatic cells. Cell Transplant 2000, 9:431–438.

Lefebvre VH, Otonkoski T, Ustinov J, et al.: Culture of adult islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for beta-cells. Diabetes 1998, 47:134–137.

Garcia-Ocana A, Vasavada RC, Cebrian A, et al.: Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes 2001, 50:2752–2762.

Leibowitz G, Beattie GM, Kafri T, et al.: Gene transfer to human pancreatic endocrine cells using viral vectors. Diabetes 1999, 48:745–753. Discusses the efficient transfer of genes to human islet cells using viral vectors.

Beattie GM, Levine F, Mally MI, et al.: Acid beta-galactosidase: a developmentally regulated marker of endocrine cell precursors in the human fetal pancreas. J Clin Endocrinol Metab 1994, 78:1232–1240.

Castaing M, Peault B, Basmaciogullari A, et al.: Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice. Diabetologia 2001, 44:2066–2076.

Beattie GM, Otonkoski T, Lopez AD, et al.: Functional beta-cell mass after transplantation of human fetal pancreatic cells: differentiation or proliferation. Diabetes 1997, 46:244–248.

Lundqvist M, Oberg K: In vitro culture of neuroendocrine tumors of the pancreas and gut. Acta Oncol 1989, 28:335–339.

Wang S, Beattie GM, Hayek A, et al.: Development of a VSV-G protein pseudotyped retroviral vector system expressing dominant oncogenes from a lacO-modified inducible LTR promoter. Gene 1996, 182:145–150.

Wang S, Beattie GM, Mally MI, et al.: Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas. Cell Transplant 1997, 6:59–67.

Halvorsen TL, Beattie GM, Lopez AD, et al.: Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. J Endocrinol 2000, 166:103–109.

Itkin-Ansari P, Demeterco C, Bossie S, et al.: PDX-1 and cell-cell contact act in synergy to promote delta-cell development in a human pancreatic endocrine precursor cell line. Mol Endocrinol 2000, 14:814–822.

Dufayet de la Tour D, Halvorsen T, Demeterco C, et al.: beta-cell differentiation from a human pancreatic cell line in vitro and in vivo. Mol Endocrinol 2001, 15:476–483.

Shaw JW, Latimer EO: Regeneration of pancreatic tissue from the transplanted pancreatic duct in the dog. Am Physiol Soc 1926, 76:49–53.

Bonner-Weir S, Trent DF, Weir GC: Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 1983, 71:1544–1553.

Ramiya VK, Maraist M, Arfors KE, et al.: Reversal of insulindependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 2000, 6:278–282.

Kerr-Conte J, Pattou F, Lecomte-Houcke M, et al.: Ductal cyst formation in collagen-embedded adult human islet preparations. A means to the reproduction of nesidioblastosis in vitro. Diabetes 1996, 45:1108–1114.

Gmyr V, Kerr-Conte J, Belaich S, et al.: Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: further evidence for pluripotent pancreatic stem cells in humans. Diabetes 2000, 49:1671–1680.

Gmyr V, Kerr-Conte J, Vandewalle B, et al.: Human pancreatic ductal cells: large-scale isolation and expansion. Cell Transplant 2001, 10:109–121.

Bonner-Weir S, Taneja M, Weir GC, et al.: In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A 2000, 97:7999–8004. In vitro production of human islets from ductal tissue is discussed.

Gu D, Sarvetnik N: Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development 1993, 118:33–46.

Kritzik MR, Krahl T, Good A, et al.: Transcription factor expression during pancreatic islet regeneration. Mol Cell Endocrinol 2000, 164:99–107.

Wang TC, Bonner-Weir S, Oates PS, et al.: Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest 1993, 92:1349–1356.

Xu G, Stoffers DA, Habener JF, et al.: Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increase beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999, 48:2270–2276.

Stoffers DA, Kieffer TJ, Hussain MA, et al.: Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000, 49:741–748.

Rafaeloff R, Pittenger GL, Barlow SW, et al.: Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest 1997, 99:2100–2109.

Hui H, Wright C, Perfetti R: Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 2001, 50:785–796.

Zulewski H, Abraham EJ, Gerlach MJ, et al.: Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 2001, 50:521–533.

Beattie GM, Rubin JS, Mally MI, et al.: Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor and cell-cell contact. Diabetes 1996, 45:1223–1228.

Hayek A, Beattie G: Processing, storage and experimental transplantation of human fetal pancreatic cells. Ann Transplant 1999, 2:46–54.

Beattie GM, Lopez AD, Otonkoski T, et al.: Transplantation of human fetal pancreas: fresh vs. cultured fetal islets or ICCS. J Mol Med 1999, 77:70–73.

Hayek A, Beattie GM: Experimental transplantation of human fetal and adult pancreatic islets. J Clin Endocrinol Metab 1997, 82:2471–2475.

Ferber S, Halkin A, Cohen H, et al.: Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000, 6:568–572.

Lee HC, Kim SJ, Kim KS, et al.: Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature 2000, 408:483–488.

Cheung AT, Dayanandan B, Lewis JT, et al.: Glucose-dependent insulin release from genetically engineered K cells. Science 2000, 290:1959–1962.

Soria B: In-vitro differentiation of pancreatic beta-cells. Differentiation 2001, 68:205–219. The first report of differentiation of embryonic mouse stem cells into β cells.

Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al.: Embryonic stem cell lines derived from human blastocysts. Science 1998, 282:1145–1147.

Shamblott MJ, Axelman J, Wang S, et al.: Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci U S A 1998, 95:13726–13731.

Soria B, Roche E, Berna G, et al.: Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000, 49:157–162.

Lumelsky N, Blondel O, Laeng P, et al.: Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001, 292:1389–1394.

Assady S, Maor G, Amit M, et al.: Insulin production by human embryonic stem cells. Diabetes 2001, 50:1691–1697. The first report of insulin production by human embryonic stem cells.

van derLaan LJ, Lockey C, Griffeth BC, et al.: Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice. Nature 2000, 407:90–94.

Cabot RA, Kuhholzer B, Chan AW, et al.: Transgenic pigs produced using in vitro matured oocytes infected with a retroviral vector. Anim Biotechnol 2001, 12:205–214.

Lai L, Kolber-Simonds D, Park KW, et al.: Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002, 295:1089–1092.

Heneine W, Tibell A, Switzer WM, et al.: No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts. Lancet 1998, 352:695–699.

Efrat S: Genetically engineered pancreatic beta-cell lines for cell therapy of diabetes. Ann N Y Acad Sci 1999, 875:286–293. Genetic engineering of β cells by transfection of the human insulin gene into rodent cells is reviewed.

Efrat S: Prospects for gene therapy of insulin-dependent diabetes mellitus. Diabetologia 1998, 41:1401–1409.