Communications Biology
SCOPUS (2018-2023)SCIE-ISI
2399-3642
Mỹ
Cơ quản chủ quản: Springer Nature , NATURE PORTFOLIO
Lĩnh vực:
Biochemistry, Genetics and Molecular Biology (miscellaneous)Agricultural and Biological Sciences (miscellaneous)Medicine (miscellaneous)
Các bài báo tiêu biểu
pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeuticsAbstract The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems is often hampered by issues such as poor circulation stability and targeting inefficiency. Here, we have utilized a simple approach to prepare biocompatible and biodegradable pH-responsive hybrid NPs that overcome these issues. The NPs consist of a drug-loaded polylac... ...
Tập 3 Số 1
Z-DNA and Z-RNA in human diseaseAbstract Left-handed Z-DNA/Z-RNA is bound with high affinity by the Zα domain protein family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1 and viral orthologs regulating innate immunity. Loss-of-function mutations in ADAR p150 allow persistent activation of the interferon system by Alu dsRNAs and are causal for Aicardi-Goutières Syndrome. Heterodim... ...
Tập 2 Số 1
Regulation of RNA editing by RNA-binding proteins in human cellsAbstract Adenosine-to-inosine (A-to-I) editing, mediated by the ADAR enzymes, diversifies the transcriptome by altering RNA sequences. Recent studies reported global changes in RNA editing in disease and development. Such widespread editing variations necessitate an improved understanding of the regulatory mechanisms of RNA editing. Here, we study the roles of >2... ...
Tập 2 Số 1
Evolutionary history of plant hosts and fungal symbionts predicts the strength of mycorrhizal mutualismAbstract Most plants engage in symbioses with mycorrhizal fungi in soils and net consequences for plants vary widely from mutualism to parasitism. However, we lack a synthetic understanding of the evolutionary and ecological forces driving such variation for this or any other nutritional symbiosis. We used meta-analysis across 646 combinations of plants and fungi to... ...
Tập 1 Số 1
The feather degradation mechanisms of a new Streptomyces sp. isolate SCUT-3Abstract Feather waste is the highest protein-containing resource in nature and is poorly reused. Bioconversion is widely accepted as a low-cost and environmentally benign process, but limited by the availability of safe and highly efficient feather degrading bacteria (FDB) for its industrial-scale fermentation. Excessive focuses on keratinase and limited knowledge ... ...
Tập 3 Số 1
Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferaseAbstract Although palmitoylation regulates numerous cellular processes, as yet efforts to manipulate this post-translational modification for therapeutic gain have proved unsuccessful. The Na-pump accessory sub-unit phospholemman (PLM) is palmitoylated by zDHHC5. Here, we show that PLM palmitoylation is facilitated by recruitment of the Na-pump α sub-unit to a speci... ...
Tập 3 Số 1
Rab5-mediated endosome formation is regulated at the trans-Golgi networkAbstract Early endosomes, also called sorting endosomes, are known to mature into late endosomes via the Rab5-mediated endolysosomal trafficking pathway. Thus, early endosome existence is thought to be maintained by the continual fusion of transport vesicles from the plasma membrane and the trans -Golgi network (TGN). Here we show instead t... ...
Tập 2 Số 1
Genome editing in plants using CRISPR type I-D nucleaseAbstract Genome editing in plants has advanced greatly by applying the clustered regularly interspaced short palindromic repeats (CRISPRs)-Cas system, especially CRISPR-Cas9. However, CRISPR type I—the most abundant CRISPR system in bacteria—has not been exploited for plant genome modification. In type I CRISPR-Cas systems, e.g., type I-E, Cas3 nucleases degrade the... ...
Tập 3 Số 1
The repurposing of type I-E CRISPR-Cascade for gene activation in plantsAbstract CRISPR-Cas systems are robust and facile tools for manipulating the genome, epigenome and transcriptome of eukaryotic organisms. Most groups use class 2 effectors, such as Cas9 and Cas12a, however, other CRISPR-Cas systems may provide unique opportunities for genome engineering. Indeed, the multi-subunit composition of class 1 systems offers to expand the n... ...
Tập 2 Số 1
Initial hydraulic failure followed by late-stage carbon starvation leads to drought-induced death in the tree Trema orientalisAbstract Drought-induced tree death has become a serious problem in global forest ecosystems. Two nonexclusive hypotheses, hydraulic failure and carbon starvation, have been proposed to explain tree die-offs. To clarify the mechanisms, we investigated the physiological processes of drought-induced tree death in saplings with contrasting Huber values (sapwood area/to... ...
Tập 2 Số 1