Communications Biology
SCOPUS (2018-2025)SCIE-ISI
2399-3642
Mỹ
Cơ quản chủ quản: Springer Nature , NATURE PORTFOLIO
Lĩnh vực:
Biochemistry, Genetics and Molecular Biology (miscellaneous)Agricultural and Biological Sciences (miscellaneous)Medicine (miscellaneous)
Các bài báo tiêu biểu
pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics
Tập 3 Số 1
AbstractThe practical application of nanoparticles (NPs) as chemotherapeutic
drug delivery systems is often hampered by issues such as poor circulation
stability and targeting inefficiency. Here, we have utilized a simple approach
to prepare biocompatible and biodegradable pH-responsive hybrid NPs that
overcome these issues. The NPs consist of a drug-loaded polylactic-co-glycolic
acid (PLGA) core ...
Z-DNA and Z-RNA in human disease
Tập 2 Số 1
AbstractLeft-handed Z-DNA/Z-RNA is bound with high affinity by the Zα domain
protein family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1
and viral orthologs regulating innate immunity. Loss-of-function mutations in
ADAR p150 allow persistent activation of the interferon system by Alu dsRNAs and
are causal for Aicardi-Goutières Syndrome. Heterodimers of ADAR and DICER1
regulate t...
Regulation of RNA editing by RNA-binding proteins in human cells
Tập 2 Số 1
AbstractAdenosine-to-inosine (A-to-I) editing, mediated by the ADAR enzymes,
diversifies the transcriptome by altering RNA sequences. Recent studies reported
global changes in RNA editing in disease and development. Such widespread
editing variations necessitate an improved understanding of the regulatory
mechanisms of RNA editing. Here, we study the roles of >200 RNA-binding proteins
(RBPs) in me...
Evolutionary history of plant hosts and fungal symbionts predicts the strength of mycorrhizal mutualism
Tập 1 Số 1
AbstractMost plants engage in symbioses with mycorrhizal fungi in soils and net
consequences for plants vary widely from mutualism to parasitism. However, we
lack a synthetic understanding of the evolutionary and ecological forces driving
such variation for this or any other nutritional symbiosis. We used
meta-analysis across 646 combinations of plants and fungi to show that
evolutionary history e...
The feather degradation mechanisms of a new Streptomyces sp. isolate SCUT-3
Tập 3 Số 1
AbstractFeather waste is the highest protein-containing resource in nature and
is poorly reused. Bioconversion is widely accepted as a low-cost and
environmentally benign process, but limited by the availability of safe and
highly efficient feather degrading bacteria (FDB) for its industrial-scale
fermentation. Excessive focuses on keratinase and limited knowledge of other
factors have hindered co...
Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase
Tập 3 Số 1
AbstractAlthough palmitoylation regulates numerous cellular processes, as yet
efforts to manipulate this post-translational modification for therapeutic gain
have proved unsuccessful. The Na-pump accessory sub-unit phospholemman (PLM) is
palmitoylated by zDHHC5. Here, we show that PLM palmitoylation is facilitated by
recruitment of the Na-pump α sub-unit to a specific site on zDHHC5 that contains
...
Genome editing in plants using CRISPR type I-D nuclease
Tập 3 Số 1
AbstractGenome editing in plants has advanced greatly by applying the clustered
regularly interspaced short palindromic repeats (CRISPRs)-Cas system, especially
CRISPR-Cas9. However, CRISPR type I—the most abundant CRISPR system in
bacteria—has not been exploited for plant genome modification. In type I
CRISPR-Cas systems, e.g., type I-E, Cas3 nucleases degrade the target DNA in
mammals. Here, we ...
Rab5-mediated endosome formation is regulated at the trans-Golgi network
Tập 2 Số 1
AbstractEarly endosomes, also called sorting endosomes, are known to mature into
late endosomes via the Rab5-mediated endolysosomal trafficking pathway. Thus,
early endosome existence is thought to be maintained by the continual fusion of
transport vesicles from the plasma membrane and the trans-Golgi network (TGN).
Here we show instead that endocytosis is dispensable and post-Golgi vesicle
transp...
The repurposing of type I-E CRISPR-Cascade for gene activation in plants
Tập 2 Số 1
AbstractCRISPR-Cas systems are robust and facile tools for manipulating the
genome, epigenome and transcriptome of eukaryotic organisms. Most groups use
class 2 effectors, such as Cas9 and Cas12a, however, other CRISPR-Cas systems
may provide unique opportunities for genome engineering. Indeed, the
multi-subunit composition of class 1 systems offers to expand the number of
domains and functionalit...
Initial hydraulic failure followed by late-stage carbon starvation leads to drought-induced death in the tree Trema orientalis
Tập 2 Số 1
AbstractDrought-induced tree death has become a serious problem in global forest
ecosystems. Two nonexclusive hypotheses, hydraulic failure and carbon
starvation, have been proposed to explain tree die-offs. To clarify the
mechanisms, we investigated the physiological processes of drought-induced tree
death in saplings with contrasting Huber values (sapwood area/total leaf area).
First, hydraulic ...