Communications Biology

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Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function
Communications Biology - Tập 5 Số 1
E. Sandra Chocrón, Kennedy S. Mdaki, Nisi Jiang, Jodie Cropper, Andrew M. Pickering
AbstractMitochondrial dysfunction is a key driver of diabetes and other metabolic diseases. Mitochondrial redox state is highly impactful to metabolic function but the mechanism driving this is unclear. We generated a transgenic mouse which overexpressed the redox enzyme Thioredoxin Reductase 2 (TrxR2), the rate limiting enzyme in the mitochondrial thioredoxin syst...... hiện toàn bộ
Rab5-mediated endosome formation is regulated at the trans-Golgi network
Communications Biology - Tập 2 Số 1
Makoto Nagano, Junko Y. Toshima, Daria E. Siekhaus, Jiro Toshima
AbstractEarly endosomes, also called sorting endosomes, are known to mature into late endosomes via the Rab5-mediated endolysosomal trafficking pathway. Thus, early endosome existence is thought to be maintained by the continual fusion of transport vesicles from the plasma membrane and the trans-Golgi network (TGN). Here we show instead t...... hiện toàn bộ
Downregulation of pectin biosynthesis gene GAUT4 leads to reduced ferulate and lignin-carbohydrate cross-linking in switchgrass
Communications Biology - Tập 2 Số 1
Mi Li, Chang Geun Yoo, Yunqiao Pu, Ajaya K. Biswal, Allison K. Tolbert, Debra Mohnen, Arthur J. Ragauskas
AbstractKnockdown (KD) expression of GAlactUronosylTransferase 4 (GAUT4) in switchgrass improves sugar yield and ethanol production from the biomass. The reduced recalcitrance of GAUT4-KD transgenic biomass is associated with reduced cell wall pectic homogalacturonan and rhamnogalactur...... hiện toàn bộ
The feather degradation mechanisms of a new Streptomyces sp. isolate SCUT-3
Communications Biology - Tập 3 Số 1
Zhiwei Li, Shuang Liang, Ke Ye, Jun‐Jin Deng, Ming-Shu Zhang, De‐Lin Lu, Jiansheng Zhang, Xiao‐Chun Luo
AbstractFeather waste is the highest protein-containing resource in nature and is poorly reused. Bioconversion is widely accepted as a low-cost and environmentally benign process, but limited by the availability of safe and highly efficient feather degrading bacteria (FDB) for its industrial-scale fermentation. Excessive focuses on keratinase and limited knowledge ...... hiện toàn bộ
Cell-type specific pallial circuits shape categorical tuning responses in the crow telencephalon
Communications Biology - Tập 5 Số 1
Helen M. Ditz, Julia Fechner, Andreas Nieder
AbstractThe nidopallium caudolaterale (NCL), an integration centre in the telencephalon of birds, plays a crucial role in representing and maintaining abstract categories and concepts. However, the computational principles allowing pallial microcircuits consisting of excitatory and inhibitory neurons to shape the tuning to abstract categories remain elusive. Here w...... hiện toàn bộ
Compatibility between snails and schistosomes: insights from new genetic resources, comparative genomics, and genetic mapping
Communications Biology - Tập 5 Số 1
Lijing Bu, Daibin Zhong, Lijun Lu, Eric S. Loker, Guiyun Yan, Si‐Ming Zhang
AbstractThe freshwater snailBiomphalaria glabratais an important intermediate host of the parasiteSchistosoma mansonithat causes human intestinal schistosomiasis. To better understand vector snail biology and help advance innovative snail control strategies, we have developed a new snail model consisting of two ...... hiện toàn bộ
Regulation of RNA editing by RNA-binding proteins in human cells
Communications Biology - Tập 2 Số 1
Giovanni Quinones-Valdez, Stephen Tran, Hyun-Ik Jun, Jae Hoon Bahn, Ei-Wen Yang, Lijun Zhan, Anneke Brümmer, Xintao Wei, Eric L. Van Nostrand, Gabriel A. Pratt, G Yeo, Jacques Ravel, Xinshu Xiao
AbstractAdenosine-to-inosine (A-to-I) editing, mediated by the ADAR enzymes, diversifies the transcriptome by altering RNA sequences. Recent studies reported global changes in RNA editing in disease and development. Such widespread editing variations necessitate an improved understanding of the regulatory mechanisms of RNA editing. Here, we study the roles of >2...... hiện toàn bộ
Structural determinants of dynamic fluctuations between segregation and integration on the human connectome
Communications Biology - Tập 3 Số 1
Makoto Fukushima, Olaf Sporns
AbstractWhile segregation and integration of neural information in the neocortex are thought to be important for human behavior and cognition, the neural substrates enabling their dynamic fluctuations remain elusive. To tackle this problem, we aim to identify specific network features of the connectome that are responsible for the emergence of dynamic fluctuations ...... hiện toàn bộ
Transferrin receptor 1 is a cellular receptor for human heme-albumin
Communications Biology - Tập 3 Số 1
Jennifer Brell, Verena Berg, Madhura Modak, Alexander Puck, Maria Seyerl‐Jiresch, Sarojinidevi Künig, Gerhard J. Zlabinger, Peter Steinberger, Janet Chou, Raif S. Geha, Leopold Öhler, Akihiro Yachie, Hyeryun Choe, Markus Kraller, Hannes Stockinger, Johannes Stöckl
AbstractIron is essential for living cells. Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed. Here, we demonstrate that CD71 utilizes heme-albumin as cargo to transport iron into human cells. Binding and endocytosis of heme-albumin via ...... hiện toàn bộ
Two-tone distortion in reticular lamina vibration of the living cochlea
Communications Biology - Tập 3 Số 1
Tianying Ren, Wenxuan He
AbstractIt has been demonstrated that isolated auditory sensory cells, outer hair cells, can generate distortion products at low frequencies. It remains unknown, however, whether or not motile outer hair cells are able to generate two-tone distortion at high frequencies in living cochleae under the mechanical loads caused by surounding tissues and fluids. By measur...... hiện toàn bộ
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