Communications Biology

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GardeninA confers neuroprotection against environmental toxin in a Drosophila model of Parkinson’s disease
Communications Biology - Tập 4 Số 1
Urmila Maitra, Thomas C. Harding, Qiaoli Liang, Łukasz Cieśla
AbstractParkinson’s disease is an age-associated neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons from the midbrain. Epidemiological studies have implicated exposures to environmental toxins like the herbicide paraquat as major contributors to Parkinson’s disease etiology in both mammalian and invertebrate models. We have emp...... hiện toàn bộ
Characterization of nanoparticles combining polyamine detection with photodynamic therapy
Communications Biology - Tập 4 Số 1
Wenting Li, Lingyun Wang, Tianlei Sun, Hao Tang, Brian Bui, Derong Cao, Ruibing Wang, Wei Chen
AbstractPolyamine detection and depletion have been extensively investigated for cancer prevention and treatment. However, the therapeutic efficacy is far from satisfactory, mainly due to a polyamine compensation mechanism from the systemic circulation in the tumor environment. Herein, we explore a new solution for improving polyamine detection as well as a possibl...... hiện toàn bộ
Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function
Communications Biology - Tập 5 Số 1
E. Sandra Chocrón, Kennedy S. Mdaki, Nisi Jiang, Jodie Cropper, Andrew M. Pickering
AbstractMitochondrial dysfunction is a key driver of diabetes and other metabolic diseases. Mitochondrial redox state is highly impactful to metabolic function but the mechanism driving this is unclear. We generated a transgenic mouse which overexpressed the redox enzyme Thioredoxin Reductase 2 (TrxR2), the rate limiting enzyme in the mitochondrial thioredoxin syst...... hiện toàn bộ
Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos
Communications Biology - Tập 3 Số 1
Hye‐Kyung Lee, Harold E. Smith, Chengyu Liu, Michaela Willi, Lothar Hennighausen
AbstractDeaminase base editing has emerged as a tool to install or correct point mutations in the genomes of living cells in a wide range of organisms. However, the genome-wide off-target effects introduced by base editors in the mammalian genome have been examined in only one study. Here, we have investigated the fidelity of cytosine base editor 4 (BE4) and adenin...... hiện toàn bộ
Genome editing in plants using CRISPR type I-D nuclease
Communications Biology - Tập 3 Số 1
Keishi Osakabe, Naoki Wada, Tomoko Miyaji, Emi Murakami, Kazuya Marui, Risa Ueta, Ryosuke Hashimoto, Chihiro Abe-Hara, Bihe Kong, Kentaro Yano, Yuriko Osakabe
AbstractGenome editing in plants has advanced greatly by applying the clustered regularly interspaced short palindromic repeats (CRISPRs)-Cas system, especially CRISPR-Cas9. However, CRISPR type I—the most abundant CRISPR system in bacteria—has not been exploited for plant genome modification. In type I CRISPR-Cas systems, e.g., type I-E, Cas3 nucleases degrade the...... hiện toàn bộ
The repurposing of type I-E CRISPR-Cascade for gene activation in plants
Communications Biology - Tập 2 Số 1
Joshua K. Young, Stephen L. Gasior, Spencer Jones, Lijuan Wang, Pedro Navarro, Becca Vickroy, Rodolphe Barrangou
AbstractCRISPR-Cas systems are robust and facile tools for manipulating the genome, epigenome and transcriptome of eukaryotic organisms. Most groups use class 2 effectors, such as Cas9 and Cas12a, however, other CRISPR-Cas systems may provide unique opportunities for genome engineering. Indeed, the multi-subunit composition of class 1 systems offers to expand the n...... hiện toàn bộ
Identification of genes required for eye development by high-throughput screening of mouse knockouts
Communications Biology - Tập 1 Số 1
Bret A. Moore, Brian C. Leonard, Lionel Sebbag, Sydney Edwards, Ann Cooper, Denise M. Imai, Ewan Straiton, Luís Santos, Christopher M. Reilly, Stephen M. Griffey, Lynette Bower, Dave Clary, Jeremy Mason, Michelle Simon, Hamid Méziane, Yann Hérault, Anna Swan, Ruairidh King, Piia Keskivali-Bond, Lois Kelsey, Igor Vukobradovic, Dawei Qu, Ruolin Guo, Elisa Tran, Lily Morikawa, Milan Ganguly, Napoleon Law, Xueyuan Shang, Patricia Feugas, Yanchun Wang, Yingchun Zhu, Kyle Duffin, Ayexa Ramirez, Patricia Penton, Valerie Laurin, Shannon Clarke, Qing Lan, Gillian Sleep, Amie Creighton, Elsa Jacob, Heather Cater, Joanna Joeng, Marina Gertsenstein, Monica Pereira, Sue MacMaster, Sandra Tondat, Thomas J. Carroll, Jorge Cabezas, Je Kyung Seong, Jane Hunter, Gregory B. Clark, Mohammed Bubshait, D. Craig Miller, Khondoker Sohel, Alexandr Bezginov, Matthew McKay, Kevin Peterson, Leslie Goodwin, Rachel Urban, Susan Kales, Robin Hallett, Dong Nguyen-Bresinsky, Timothy Leach, Audrie Seluke, Sara Perkins, Ann‐Marie Mallon, Rick Bedigian, Leah Rae Donahue, Robert A. Taft, James M. Denegre, Zachery Seavey, Amelia Willett, Lindsay Bates, Leslie Haynes, Julie Creed, Catherine Witmeyer, Willson Roper, James Clark, Pamela Stanley, Samantha Burrill, Jennifer Ryan, Yuichi Obata, Masaru Tamura, Hideki Kaneda, Tamio Furuse, Kimio Kobayashi, Ikuo Miura, Ikuko Yamada, Hiroshi Masuya, Nobuhiko Tanaka, Shin‐ichi Ayabe, Atsushi Yoshiki, Valerie E. Vancollie, Francesco Chiani, Paul Dent, Gianfranco Di Segni, Olga Ermakova, Fabrizio Ferrara, Paolo Fruscoloni, Alessia Gambadoro, Serena Gastaldi, Elisabetta Golini, Gina La Sala, Silvia Mandillo, Daniela Marazziti, Marzia Massimi, Rafaele Matteoni, Tiziana Orsini, Miriam Pasquini, Marcello Raspa, Aline Rauch, G. F. Rossi, Nicoletta Rossi, Sabrina Putti, Ferdinando Scavizzi, Glauco P. Tocchini‐Valentini, Colin McKerlie, Ann M. Flenniken, Goo Taeg Oh, Zorana Berberovic, Celeste Owen, Hibret A. Adissu, Mohammed Eskandarian, Chih‐Wei Hsu, Sowmya Kalaga, Uchechukwu Udensi, Chinwe Asomugha, Ritu Bohat, Juan Gallegos, John R. Seavitt, Jason D. Heaney, Arthur L. Beaudet, Mary E. Dickinson, Vivek M. Philip, Vivek Kumar, Karen L. Svenson, Robert E. Braun, Sara Wells, Michelle Stewart, Russell Joynson, Xiang Gao, Tomohiro Suzuki, Shigeharu Wakana, Damian Smedley, Mark W. Moore, Colin Fletcher, Natasha A. Karp, Ramiro Ramírez‐Solis, Jacqueline K. White, Martin Hrabě de Angelis, Wolfgang Wurst, Sara M. Thomasy, Paul Flicek, Helen Parkinson, S.D.M. Brown, Terrence F. Meehan, Patsy M. Nishina, Stephen A. Murray, Mark P. Krebs, K. C. Kent Lloyd, Christopher J. Murphy, Ala Moshiri
AbstractDespite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the Inter...... hiện toàn bộ
Rab5-mediated endosome formation is regulated at the trans-Golgi network
Communications Biology - Tập 2 Số 1
Makoto Nagano, Junko Y. Toshima, Daria E. Siekhaus, Jiro Toshima
AbstractEarly endosomes, also called sorting endosomes, are known to mature into late endosomes via the Rab5-mediated endolysosomal trafficking pathway. Thus, early endosome existence is thought to be maintained by the continual fusion of transport vesicles from the plasma membrane and the trans-Golgi network (TGN). Here we show instead t...... hiện toàn bộ
Evolutionary history of plant hosts and fungal symbionts predicts the strength of mycorrhizal mutualism
Communications Biology - Tập 1 Số 1
Jason D. Hoeksema, James D. Bever, Sounak Chakraborty, V. Bala Chaudhary, Monique Gardes, Catherine A. Gehring, Miranda M. Hart, Elizabeth A. Housworth, Wittaya Kaonongbua, John N. Klironomos, Marc J. Lajeunesse, James Meadow, Brook G. Milligan, Bridget J. Piculell, Anne Pringle, Megan A. Rúa, James Umbanhowar, Wolfgang Viechtbauer, Yen‐Wen Wang, Gail W. T. Wilson, Peter C. Zee
AbstractMost plants engage in symbioses with mycorrhizal fungi in soils and net consequences for plants vary widely from mutualism to parasitism. However, we lack a synthetic understanding of the evolutionary and ecological forces driving such variation for this or any other nutritional symbiosis. We used meta-analysis across 646 combinations of plants and fungi to...... hiện toàn bộ
Effects of energy metabolism on the mechanical properties of breast cancer cells
Communications Biology - Tập 3 Số 1
Marina L. Yubero, Priscila M. Kosaka, Álvaro San Paulo, Marcos Malumbres, Montserrat Calleja, Javier Tamayo
AbstractTumorigenesis induces actin cortex remodeling, which makes cancerous cells softer. Cell deformability is largely determined by myosin-driven cortical tension and actin fiber architecture at the cell cortex. However, it is still unclear what the weight of each contribution is, and how these contributions change during cancer development. Moreover, little att...... hiện toàn bộ
Tổng số: 34   
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