Communications Biology

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function
Communications Biology - Tập 5 Số 1
E. Sandra Chocrón, Kennedy S. Mdaki, Nisi Jiang, Jodie Cropper, Andrew M. Pickering
AbstractMitochondrial dysfunction is a key driver of diabetes and other metabolic diseases. Mitochondrial redox state is highly impactful to metabolic function but the mechanism driving this is unclear. We generated a transgenic mouse which overexpressed the redox enzyme Thioredoxin Reductase 2 (TrxR2), the rate limiting enzyme in the mitochondrial thioredoxin syst...... hiện toàn bộ
Identification of genes required for eye development by high-throughput screening of mouse knockouts
Communications Biology - Tập 1 Số 1
Bret A. Moore, Brian C. Leonard, Lionel Sebbag, Sydney Edwards, Ann Cooper, Denise M. Imai, Ewan Straiton, Luís Santos, Christopher M. Reilly, Stephen M. Griffey, Lynette Bower, Dave Clary, Jeremy Mason, Michelle Simon, Hamid Méziane, Yann Hérault, Anna Swan, Ruairidh King, Piia Keskivali-Bond, Lois Kelsey, Igor Vukobradovic, Dawei Qu, Ruolin Guo, Elisa Tran, Lily Morikawa, Milan Ganguly, Napoleon Law, Xueyuan Shang, Patricia Feugas, Yanchun Wang, Yingchun Zhu, Kyle Duffin, Ayexa Ramirez, Patricia Penton, Valerie Laurin, Shannon Clarke, Qing Lan, Gillian Sleep, Amie Creighton, Elsa Jacob, Heather Cater, Joanna Joeng, Marina Gertsenstein, Monica Pereira, Sue MacMaster, Sandra Tondat, Thomas J. Carroll, Jorge Cabezas, Je Kyung Seong, Jane Hunter, Gregory B. Clark, Mohammed Bubshait, D. Craig Miller, Khondoker Sohel, Alexandr Bezginov, Matthew McKay, Kevin Peterson, Leslie Goodwin, Rachel Urban, Susan Kales, Robin Hallett, Dong Nguyen-Bresinsky, Timothy Leach, Audrie Seluke, Sara Perkins, Ann‐Marie Mallon, Rick Bedigian, Leah Rae Donahue, Robert A. Taft, James M. Denegre, Zachery Seavey, Amelia Willett, Lindsay Bates, Leslie Haynes, Julie Creed, Catherine Witmeyer, Willson Roper, James Clark, Pamela Stanley, Samantha Burrill, Jennifer Ryan, Yuichi Obata, Masaru Tamura, Hideki Kaneda, Tamio Furuse, Kimio Kobayashi, Ikuo Miura, Ikuko Yamada, Hiroshi Masuya, Nobuhiko Tanaka, Shin‐ichi Ayabe, Atsushi Yoshiki, Valerie E. Vancollie, Francesco Chiani, Paul Dent, Gianfranco Di Segni, Olga Ermakova, Fabrizio Ferrara, Paolo Fruscoloni, Alessia Gambadoro, Serena Gastaldi, Elisabetta Golini, Gina La Sala, Silvia Mandillo, Daniela Marazziti, Marzia Massimi, Rafaele Matteoni, Tiziana Orsini, Miriam Pasquini, Marcello Raspa, Aline Rauch, G. F. Rossi, Nicoletta Rossi, Sabrina Putti, Ferdinando Scavizzi, Glauco P. Tocchini‐Valentini, Colin McKerlie, Ann M. Flenniken, Goo Taeg Oh, Zorana Berberovic, Celeste Owen, Hibret A. Adissu, Mohammed Eskandarian, Chih‐Wei Hsu, Sowmya Kalaga, Uchechukwu Udensi, Chinwe Asomugha, Ritu Bohat, Juan Gallegos, John R. Seavitt, Jason D. Heaney, Arthur L. Beaudet, Mary E. Dickinson, Vivek M. Philip, Vivek Kumar, Karen L. Svenson, Robert E. Braun, Sara Wells, Michelle Stewart, Russell Joynson, Xiang Gao, Tomohiro Suzuki, Shigeharu Wakana, Damian Smedley, Mark W. Moore, Colin Fletcher, Natasha A. Karp, Ramiro Ramírez‐Solis, Jacqueline K. White, Martin Hrabě de Angelis, Wolfgang Wurst, Sara M. Thomasy, Paul Flicek, Helen Parkinson, S.D.M. Brown, Terrence F. Meehan, Patsy M. Nishina, Stephen A. Murray, Mark P. Krebs, K. C. Kent Lloyd, Christopher J. Murphy, Ala Moshiri
AbstractDespite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the Inter...... hiện toàn bộ
Rab5-mediated endosome formation is regulated at the trans-Golgi network
Communications Biology - Tập 2 Số 1
Makoto Nagano, Junko Y. Toshima, Daria E. Siekhaus, Jiro Toshima
AbstractEarly endosomes, also called sorting endosomes, are known to mature into late endosomes via the Rab5-mediated endolysosomal trafficking pathway. Thus, early endosome existence is thought to be maintained by the continual fusion of transport vesicles from the plasma membrane and the trans-Golgi network (TGN). Here we show instead t...... hiện toàn bộ
Downregulation of pectin biosynthesis gene GAUT4 leads to reduced ferulate and lignin-carbohydrate cross-linking in switchgrass
Communications Biology - Tập 2 Số 1
Mi Li, Chang Geun Yoo, Yunqiao Pu, Ajaya K. Biswal, Allison K. Tolbert, Debra Mohnen, Arthur J. Ragauskas
AbstractKnockdown (KD) expression of GAlactUronosylTransferase 4 (GAUT4) in switchgrass improves sugar yield and ethanol production from the biomass. The reduced recalcitrance of GAUT4-KD transgenic biomass is associated with reduced cell wall pectic homogalacturonan and rhamnogalactur...... hiện toàn bộ
The feather degradation mechanisms of a new Streptomyces sp. isolate SCUT-3
Communications Biology - Tập 3 Số 1
Zhiwei Li, Shuang Liang, Ke Ye, Jun‐Jin Deng, Ming-Shu Zhang, De‐Lin Lu, Jiansheng Zhang, Xiao‐Chun Luo
AbstractFeather waste is the highest protein-containing resource in nature and is poorly reused. Bioconversion is widely accepted as a low-cost and environmentally benign process, but limited by the availability of safe and highly efficient feather degrading bacteria (FDB) for its industrial-scale fermentation. Excessive focuses on keratinase and limited knowledge ...... hiện toàn bộ
Cell-type specific pallial circuits shape categorical tuning responses in the crow telencephalon
Communications Biology - Tập 5 Số 1
Helen M. Ditz, Julia Fechner, Andreas Nieder
AbstractThe nidopallium caudolaterale (NCL), an integration centre in the telencephalon of birds, plays a crucial role in representing and maintaining abstract categories and concepts. However, the computational principles allowing pallial microcircuits consisting of excitatory and inhibitory neurons to shape the tuning to abstract categories remain elusive. Here w...... hiện toàn bộ
A reference-grade genome identifies salt-tolerance genes from the salt-secreting mangrove species Avicennia marina
Communications Biology - Tập 4 Số 1
Purushothaman Natarajan, Ashok Kumar Murugesan, Ganesan Govindan, A Gopalakrishnan, Kumar Ravichandiran, Purushothaman Duraisamy, Raju Balaji, Tanuja Tanuja, P. Sushree Shyamli, Ajay Parida, Madasamy Parani
AbstractWater scarcity and salinity are major challenges facing agriculture today, which can be addressed by engineering plants to grow in the boundless seawater. Understanding the mangrove plants at the molecular level will be necessary for developing such highly salt-tolerant agricultural crops. With this objective, we sequenced the genome of a salt-secreting and...... hiện toàn bộ
Compatibility between snails and schistosomes: insights from new genetic resources, comparative genomics, and genetic mapping
Communications Biology - Tập 5 Số 1
Lijing Bu, Daibin Zhong, Lijun Lu, Eric S. Loker, Guiyun Yan, Si‐Ming Zhang
AbstractThe freshwater snailBiomphalaria glabratais an important intermediate host of the parasiteSchistosoma mansonithat causes human intestinal schistosomiasis. To better understand vector snail biology and help advance innovative snail control strategies, we have developed a new snail model consisting of two ...... hiện toàn bộ
Regulation of RNA editing by RNA-binding proteins in human cells
Communications Biology - Tập 2 Số 1
Giovanni Quinones-Valdez, Stephen Tran, Hyun-Ik Jun, Jae Hoon Bahn, Ei-Wen Yang, Lijun Zhan, Anneke Brümmer, Xintao Wei, Eric L. Van Nostrand, Gabriel A. Pratt, G Yeo, Jacques Ravel, Xinshu Xiao
AbstractAdenosine-to-inosine (A-to-I) editing, mediated by the ADAR enzymes, diversifies the transcriptome by altering RNA sequences. Recent studies reported global changes in RNA editing in disease and development. Such widespread editing variations necessitate an improved understanding of the regulatory mechanisms of RNA editing. Here, we study the roles of >2...... hiện toàn bộ
Structural determinants of dynamic fluctuations between segregation and integration on the human connectome
Communications Biology - Tập 3 Số 1
Makoto Fukushima, Olaf Sporns
AbstractWhile segregation and integration of neural information in the neocortex are thought to be important for human behavior and cognition, the neural substrates enabling their dynamic fluctuations remain elusive. To tackle this problem, we aim to identify specific network features of the connectome that are responsible for the emergence of dynamic fluctuations ...... hiện toàn bộ
Tổng số: 34   
  • 1
  • 2
  • 3
  • 4