Communications Biology

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Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function
Communications Biology - Tập 5 Số 1
E. Sandra Chocrón, Kennedy S. Mdaki, Nisi Jiang, Jodie Cropper, Andrew M. Pickering
AbstractMitochondrial dysfunction is a key driver of diabetes and other metabolic diseases. Mitochondrial redox state is highly impactful to metabolic function but the mechanism driving this is unclear. We generated a transgenic mouse which overexpressed the redox enzyme Thioredoxin Reductase 2 (TrxR2), the rate limiting enzyme in the mitochondrial thioredoxin syst...... hiện toàn bộ
The feather degradation mechanisms of a new Streptomyces sp. isolate SCUT-3
Communications Biology - Tập 3 Số 1
Zhiwei Li, Shuang Liang, Ke Ye, Jun‐Jin Deng, Ming-Shu Zhang, De‐Lin Lu, Jiansheng Zhang, Xiao‐Chun Luo
AbstractFeather waste is the highest protein-containing resource in nature and is poorly reused. Bioconversion is widely accepted as a low-cost and environmentally benign process, but limited by the availability of safe and highly efficient feather degrading bacteria (FDB) for its industrial-scale fermentation. Excessive focuses on keratinase and limited knowledge ...... hiện toàn bộ
Cell-type specific pallial circuits shape categorical tuning responses in the crow telencephalon
Communications Biology - Tập 5 Số 1
Helen M. Ditz, Julia Fechner, Andreas Nieder
AbstractThe nidopallium caudolaterale (NCL), an integration centre in the telencephalon of birds, plays a crucial role in representing and maintaining abstract categories and concepts. However, the computational principles allowing pallial microcircuits consisting of excitatory and inhibitory neurons to shape the tuning to abstract categories remain elusive. Here w...... hiện toàn bộ
Regulation of RNA editing by RNA-binding proteins in human cells
Communications Biology - Tập 2 Số 1
Giovanni Quinones-Valdez, Stephen Tran, Hyun-Ik Jun, Jae Hoon Bahn, Ei-Wen Yang, Lijun Zhan, Anneke Brümmer, Xintao Wei, Eric L. Van Nostrand, Gabriel A. Pratt, G Yeo, Jacques Ravel, Xinshu Xiao
AbstractAdenosine-to-inosine (A-to-I) editing, mediated by the ADAR enzymes, diversifies the transcriptome by altering RNA sequences. Recent studies reported global changes in RNA editing in disease and development. Such widespread editing variations necessitate an improved understanding of the regulatory mechanisms of RNA editing. Here, we study the roles of >2...... hiện toàn bộ
Transferrin receptor 1 is a cellular receptor for human heme-albumin
Communications Biology - Tập 3 Số 1
Jennifer Brell, Verena Berg, Madhura Modak, Alexander Puck, Maria Seyerl‐Jiresch, Sarojinidevi Künig, Gerhard J. Zlabinger, Peter Steinberger, Janet Chou, Raif S. Geha, Leopold Öhler, Akihiro Yachie, Hyeryun Choe, Markus Kraller, Hannes Stockinger, Johannes Stöckl
AbstractIron is essential for living cells. Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed. Here, we demonstrate that CD71 utilizes heme-albumin as cargo to transport iron into human cells. Binding and endocytosis of heme-albumin via ...... hiện toàn bộ
Two-tone distortion in reticular lamina vibration of the living cochlea
Communications Biology - Tập 3 Số 1
Tianying Ren, Wenxuan He
AbstractIt has been demonstrated that isolated auditory sensory cells, outer hair cells, can generate distortion products at low frequencies. It remains unknown, however, whether or not motile outer hair cells are able to generate two-tone distortion at high frequencies in living cochleae under the mechanical loads caused by surounding tissues and fluids. By measur...... hiện toàn bộ
GardeninA confers neuroprotection against environmental toxin in a Drosophila model of Parkinson’s disease
Communications Biology - Tập 4 Số 1
Urmila Maitra, Thomas C. Harding, Qiaoli Liang, Łukasz Cieśla
AbstractParkinson’s disease is an age-associated neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons from the midbrain. Epidemiological studies have implicated exposures to environmental toxins like the herbicide paraquat as major contributors to Parkinson’s disease etiology in both mammalian and invertebrate models. We have emp...... hiện toàn bộ
Characterization of nanoparticles combining polyamine detection with photodynamic therapy
Communications Biology - Tập 4 Số 1
Wenting Li, Lingyun Wang, Tianlei Sun, Hao Tang, Brian Bui, Derong Cao, Ruibing Wang, Wei Chen
AbstractPolyamine detection and depletion have been extensively investigated for cancer prevention and treatment. However, the therapeutic efficacy is far from satisfactory, mainly due to a polyamine compensation mechanism from the systemic circulation in the tumor environment. Herein, we explore a new solution for improving polyamine detection as well as a possibl...... hiện toàn bộ
Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos
Communications Biology - Tập 3 Số 1
Hye‐Kyung Lee, Harold E. Smith, Chengyu Liu, Michaela Willi, Lothar Hennighausen
AbstractDeaminase base editing has emerged as a tool to install or correct point mutations in the genomes of living cells in a wide range of organisms. However, the genome-wide off-target effects introduced by base editors in the mammalian genome have been examined in only one study. Here, we have investigated the fidelity of cytosine base editor 4 (BE4) and adenin...... hiện toàn bộ
Genome editing in plants using CRISPR type I-D nuclease
Communications Biology - Tập 3 Số 1
Keishi Osakabe, Naoki Wada, Tomoko Miyaji, Emi Murakami, Kazuya Marui, Risa Ueta, Ryosuke Hashimoto, Chihiro Abe-Hara, Bihe Kong, Kentaro Yano, Yuriko Osakabe
AbstractGenome editing in plants has advanced greatly by applying the clustered regularly interspaced short palindromic repeats (CRISPRs)-Cas system, especially CRISPR-Cas9. However, CRISPR type I—the most abundant CRISPR system in bacteria—has not been exploited for plant genome modification. In type I CRISPR-Cas systems, e.g., type I-E, Cas3 nucleases degrade the...... hiện toàn bộ
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