Clinical and Experimental Allergy
SCOPUS (1971-2025)SCIE-ISI
0954-7894
1365-2222
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
Immunology and AllergyImmunology
Các bài báo tiêu biểu
The International Study of Asthma and Allergies in Childhood (ISAAC)
Tập 28 Số s5 - Trang 52-66 - 1998
Despite considerable research, the aetiology of asthma and allergic disease
remains poorly understood. The International Study of Asthma and Allergies In
Childhood (ISAAC), was founded to maximize the value of epidemiological research
into asthma and allergic disease by establishing a standardized methodology and
facilitating international collaboration. It has achieved its specific aims
which are...
Lessons for management of anaphylaxis from a study of fatal reactions
Tập 30 Số 8 - Trang 1144-1150 - 2000
BackgroundThe unpredictability of anaphylactic reactions and the need for
immediate, often improvised treatment will make controlled trials impracticable;
other means must therefore be used to determine optimal
management.ObjectivesThis study aimed to investigate the circumstances leading
to fatal anaphylaxis.MethodsA register was established including all fatal
anaphylactic reactions in the UK si...
Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria
Tập 43 Số 8 - Trang 850-873 - 2013
SummaryAllergic bronchopulmonary aspergillosis (ABPA) is an immunological
pulmonary disorder caused by hypersensitivity to Aspergillus fumigatus,
manifesting with poorly controlled asthma, recurrent pulmonary infiltrates and
bronchiectasis. There are estimated to be in excess of four million patients
affected world‐wide. The importance of recognizing ABPA relates to the
improvement of patient symp...
Immunoglobulin G4: an odd antibody
Tập 39 Số 4 - Trang 469-477 - 2009
SummaryDespite its well‐known association with IgE‐mediated allergy, IgG4
antibodies still have several poorly understood characteristics. IgG4 is a very
dynamic antibody: the antibody is involved in a continuous process of
half‐molecules (i.e. a heavy and attached light‐chain) exchange. This process,
also referred to as ‘Fab‐arm exchange’, results usually in asymmetric antibodies
with two differe...
Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community
Tập 29 Số 1 - Trang 28-34 - 1999
IntroductionLower prevalence rates of allergic diseases in rural as compared
with urban populations have been interpreted as indicating an effect of air
pollution. However, little is known about other factors of the rural environment
which may determine the development of atopic sensitization and related
diseases.ObjectiveThe authors tested the hypothesis that children growing up on
a farm were le...
Low gut microbiota diversity in early infancy precedes asthma at school age
Tập 44 Số 6 - Trang 842-850 - 2014
SummaryBackgroundLow total diversity of the gut microbiota during the first year
of life is associated with allergic diseases in infancy, but little is known how
early microbial diversity is related to allergic disease later in school
age.ObjectiveTo assess microbial diversity and characterize the dominant
bacteria in stool during the first year of life in relation to the prevalence of
different a...
Exposure to endotoxin or other bacterial components might protect against the development of atopy
Tập 30 Số 9 - Trang 1230-1234 - 2000
BackgroundSeveral recent studies have shown that growing up on a farm confers
significant protection against the development of atopy. These findings point
particularly towards the importance of exposure to stable dust and farm animals.
It has furthermore been reported that endotoxin, an intrinsic part of the outer
membrane of gram negative bacteria, is abundant in environments where livestock
and...
Does early exposure to cat or dog protect against later allergy development?
Tập 29 Số 5 - Trang 611-617 - 1999
BackgroundIt is unknown which factors in modern western society that have caused
the current increase in prevalence of allergic diseases. Improved hygiene,
smaller families, altered exposure to allergens have been suggested.ObjectivesTo
assess the relationship between exposure to pets in early life, family size,
allergic manifestations and allergic sensitization at 7–9 and 12–13 years of
age.Metho...
Efficacy and safety of a recombinant anti‐immunoglobulin E antibody (omalizumab) in severe allergic asthma
Tập 34 Số 4 - Trang 632-638 - 2004
SummaryBackground Patients with severe asthma are often inadequately controlled
on existing anti‐asthma therapy, constituting an unmet clinical need.Objective
This randomized, double‐blind, placebo‐controlled trial evaluated the ability of
omalizumab, a humanized monoclonal anti‐IgE antibody, to improve disease control
sufficiently to enable inhaled corticosteroid reduction in patients with severe...
Increase of asthma, allergic rhinitis and eczema in Swedish schoolchildren between 1979 and 1991
Tập 25 Số 9 - Trang 815-819 - 1995
SummaryBackground: A previous study has shown a twofold increase in prevalence
of asthma and allergic rhinitis (AR) in Swedish recruits during the 1970s. The
increase was higher in more northerly colder regions. Objectives To follow up
the previously found trend to increasing prevalences with time as well as the
climatic variations within the country.Methods: The prevalences of asthma,
allergic rh...