The International Study of Asthma and Allergies in Childhood (ISAAC) Tập 28 Số s5 - Trang 52-66 - 1998
Asher, Weiland
Despite considerable research, the aetiology of asthma and allergic disease remains poorly understood. The International Study of Asthma and Allergies In Childhood (ISAAC), was founded to maximize the value of epidemiological research into asthma and allergic disease by establishing a standardized methodology and facilitating international collaboration. It has achieved its specific aims w...... hiện toàn bộ Lessons for management of anaphylaxis from a study of fatal reactions Tập 30 Số 8 - Trang 1144-1150 - 2000
Pumphrey
BackgroundThe unpredictability of anaphylactic reactions and the need for immediate, often improvised treatment will make controlled trials impracticable; other means must therefore be used to determine optimal management.ObjectivesThis study aimed to investigate the circumstances leading to f...... hiện toàn bộ Immunoglobulin G4: an odd antibody Tập 39 Số 4 - Trang 469-477 - 2009
Rob C. Aalberse, Steven O. Stapel, Janine Schuurman, Theo Rispens
SummaryDespite its well‐known association with IgE‐mediated allergy, IgG4 antibodies still have several poorly understood characteristics. IgG4 is a very dynamic antibody: the antibody is involved in a continuous process of half‐molecules (i.e. a heavy and attached light‐chain) exchange. This process, also referred to as ‘Fab‐arm exchange’, results usually in asymm...... hiện toàn bộ Low gut microbiota diversity in early infancy precedes asthma at school age Tập 44 Số 6 - Trang 842-850 - 2014
Thomas Abrahamsson, Hedvig E. Jakobsson, Anders F. Andersson, Bengt Björkstén, Lars Engstrand, Maria C. Jenmalm
SummaryBackgroundLow total diversity of the gut microbiota during the first year of life is associated with allergic diseases in infancy, but little is known how early microbial diversity is related to allergic disease later in school age.ObjectiveTo assess microbial d...... hiện toàn bộ Exposure to endotoxin or other bacterial components might protect against the development of atopy Tập 30 Số 9 - Trang 1230-1234 - 2000
Von Mutius, Braun‐Fahrländer, Schierl, Riedler, Ehlermann, Maisch, Waser, Nowak
BackgroundSeveral recent studies have shown that growing up on a farm confers significant protection against the development of atopy. These findings point particularly towards the importance of exposure to stable dust and farm animals. It has furthermore been reported that endotoxin, an intrinsic part of the outer membrane of gram negative bacteria, is a...... hiện toàn bộ Does early exposure to cat or dog protect against later allergy development? Tập 29 Số 5 - Trang 611-617 - 1999
HESSELMAR, Åberg, �. Eriksson, Björkstén
BackgroundIt is unknown which factors in modern western society that have caused the current increase in prevalence of allergic diseases. Improved hygiene, smaller families, altered exposure to allergens have been suggested.ObjectivesTo assess the relationship between exposure to pets in early...... hiện toàn bộ Efficacy and safety of a recombinant anti‐immunoglobulin E antibody (omalizumab) in severe allergic asthma Tập 34 Số 4 - Trang 632-638 - 2004
Stephen T. Holgate, Chuchalin Ag, Jean‐Louis Hébert, Jan Lötvall, G. Persson, Kian Fan Chung, Jean Bousquet, Huib A.M. Kerstjens, Helen Fox, J. Thirlwell, Giovanni Della Cioppa
SummaryBackground
Patients with severe asthma are often inadequately controlled on existing anti‐asthma therapy, constituting an unmet clinical need.Objective
This randomized, double‐blind, placebo‐controlled trial evaluated the ability of omalizumab, a humanized monoclonal anti‐IgE antibody...... hiện toàn bộ