Clinical Pharmacology and Therapeutics

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Sắp xếp:  
Pharmacokinetic-pharmacodynamic relationships of morphine in neonates
Clinical Pharmacology and Therapeutics - Tập 51 Số 3 - Trang 334-342 - 1992
Paul Chay, B. J. Duffy, Judith S. Walker
Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver
Clinical Pharmacology and Therapeutics - Tập 94 Số 1 - Trang 126-141 - 2013
Xiaoyan Chu, Ken Korzekwa, Robert Elsby, Katherine S. Fenner, Aleksandra Galetin, Yurong Lai, Pär Matsson, Aaron M. Moss, Swati Nagar, Gus R. Rosania, Jingwen Bai, Joseph W. Polli, Yuichi Sugiyama, Kim L. R. Brouwer
Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches
Clinical Pharmacology and Therapeutics - Tập 104 Số 5 - Trang 865-889 - 2018
Yingying Guo, Xiaoyan Chu, Neil Parrott, Kim L. R. Brouwer, Vicky Hsu, Swati Nagar, Pär Matsson, Pradeep Sharma, Jan Snoeys, Yuichi Sugiyama, Daniel Tatosian, Jashvant D. Unadkat, Shiew‐Mei Huang, Aleksandra Galetin
This white paper examines recent progress, applications, and challenges in predicting unbound and total tissue and intra/subcellular drug concentrations using in vitro and preclinical models, imaging techniques, and physiologically based pharmacokinetic (PBPK) modeling. Published examples, regulatory s...... hiện toàn bộ
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny
Clinical Pharmacology and Therapeutics - Tập 74 Số 4 - Trang 312-325 - 2003
Gregory L. Kearns
The hypoalgesic effect of tramadol in relation to CYP2D6*
Clinical Pharmacology and Therapeutics - Tập 60 Số 6 - Trang 636-644 - 1996
Lars K. Poulsen, Lars Arendt‐Nielsen, Kim Brøsen, Søren H. Sindrup
Ibuprofen pharmacokinetics in preterm infants with patent ductus arteriosus
Clinical Pharmacology and Therapeutics - Tập 70 Số 4 - Trang 336-343 - 2001
Bart Van Overmeire
Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms*1
Clinical Pharmacology and Therapeutics - Tập 76 Số 2 - Trang 119-127 - 2004
Elena García‐Martín
Isoniazid acetylation metabolic ratio during maturation in children
Clinical Pharmacology and Therapeutics - Tập 62 Số 4 - Trang 377-383 - 1997
Ann Pariente‐Khayat, Elisabeth Rey, D Gendrel, F Vauzelle-Kervroëdan, Odile Crémier, Philippe d’Athis, J Badoual, Georges Olive, Gérard Pons
Quantitative comparisons of the electroencephalographic stimulant effects of deanol, choline, and amphetamine
Clinical Pharmacology and Therapeutics - Tập 4 Số 4 - Trang 461-466 - 1963
Carl C. Pfeiffer, Leonide Goldstein, Carlos Muiioz, Henry B. Murphree, Elizabeth H. Jenney
Quantitative electroencephalography is a sensitive method for assaying stimulant and depressant effects of drugs. This method was utilized to study the stimulant effect of deanol in rabbits and human subjects as compared with the efJect of amphetamine. Choline and placebo controls were applied. In both species, both deanol and amphetamine had statistically significant stimulant effects. In...... hiện toàn bộ
Advances in the Treatment of Breast Cancer
Clinical Pharmacology and Therapeutics - Tập 83 Số 1 - Trang 26-36 - 2008
Stacey Moulder, Gabriel N. Hortobágyi
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