Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the LiverClinical Pharmacology and Therapeutics - Tập 94 Số 1 - Trang 126-141 - 2013
Xiaoyan Chu, Ken Korzekwa, Robert Elsby, Katherine S. Fenner, Aleksandra Galetin, Yurong Lai, Pär Matsson, Aaron M. Moss, Swati Nagar, Gus R. Rosania, Jingwen Bai, Joseph W. Polli, Yuichi Sugiyama, Kim L. R. Brouwer
Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling ApproachesClinical Pharmacology and Therapeutics - Tập 104 Số 5 - Trang 865-889 - 2018
Yingying Guo, Xiaoyan Chu, Neil Parrott, Kim L. R. Brouwer, Vicky Hsu, Swati Nagar, Pär Matsson, Pradeep Sharma, Jan Snoeys, Yuichi Sugiyama, Daniel Tatosian, Jashvant D. Unadkat, Shiew‐Mei Huang, Aleksandra Galetin
This white paper examines recent progress, applications, and challenges in predicting unbound and total tissue and intra/subcellular drug concentrations using in vitro and preclinical models, imaging techniques, and physiologically based pharmacokinetic (PBPK) modeling. Published examples, regulatory s...... hiện toàn bộ
Quantitative comparisons of the electroencephalographic stimulant effects of deanol, choline, and amphetamineClinical Pharmacology and Therapeutics - Tập 4 Số 4 - Trang 461-466 - 1963
Carl C. Pfeiffer, Leonide Goldstein, Carlos Muiioz, Henry B. Murphree, Elizabeth H. Jenney
Quantitative electroencephalography is a sensitive method for assaying stimulant and depressant effects of drugs. This method was utilized to study the stimulant effect of deanol in rabbits and human subjects as compared with the efJect of amphetamine. Choline and placebo controls were applied. In both species, both deanol and amphetamine had statistically significant stimulant effects. In...... hiện toàn bộ