Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>CYP2D6</i> and <i>CYP2C19</i> Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

Clinical Pharmacology and Therapeutics - Tập 98 Số 2 - Trang 127-134 - 2015
J. Kevin Hicks1,2,3, JR Bishop4, Katrin Sangkuhl5, Daniel J. Müller6,7, Yuan Ji8, SG Leckband9, JS Leeder10, Ronald L. Graham11, DL Chiulli12, Adrián LLerena13, TC Skaar14, Stuart A. Scott15, Julia Kirchheiner16, Teri E. Klein5, KE Caudle17, Andrea Gaedigk10
1Department of Pharmacy Cleveland Clinic, Cleveland, Ohio, USA; Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA; and Department of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Ohio USA
2Department of PharmacyCleveland Clinic, Cleveland, Ohio, USA
3Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA
4University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology Minneapolis Minnesota USA
5Department of Genetics, Stanford University, Stanford, California, USA
6Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto Toronto Ontario Canada
7Department of Psychiatry, University of TorontoToronto Ontario Canada
8Department of Laboratory Medicine and Pathology Division of Laboratory Genetics Mayo Clinic Rochester Minnesota USA
9Veterans Affairs San Diego Healthcare System, Mental Health Care Line, University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Psychiatry San Diego California USA
10Division of Clinical Pharmacology Toxicology &amp; Innovative Therapeutics, Children's Mercy Hospital, Kansas City, Missouri and Department of Pediatrics, University of Missouri‐Kansas City Kansas City Missouri USA
11Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
12Veterans Affairs Palo Alto Health Care System, San Jose Division San Jose California USA
13CICAB Clinical Research Center Extremadura University Hospital and Medical School Badajoz Spain
14Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA;
15Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
16Federal Institute of Drugs and Medical Devices, Bonn, Germany
17Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

Tóm tắt

Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major depressive and anxiety disorders. CYP2D6 and CYP2C19 polymorphisms can influence the metabolism of SSRIs, thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide dosing recommendations for fluvoxamine, paroxetine, citalopram, escitalopram, and sertraline based on CYP2D6 and/or CYP2C19 genotype (updates at www.pharmgkb.org).

Từ khóa


Tài liệu tham khảo

10.1038/mp.2012.42

10.1038/clpt.2013.254

10.1038/sj.clpt.6100406

10.1016/j.clpt.2005.10.002

10.1038/clpt.2013.105

10.1177/1060028013501994

10.2174/092986712800099749

10.1517/14656566.9.5.787

10.1038/clpt.2012.96

10.1177/0269881111414451

10.1016/j.pnpbp.2011.06.007

10.1001/jamapsychiatry.2014.436

10.3109/09540261.2013.825579

10.1177/070674371405900203

10.3109/09540261.2013.838944

10.1097/00007691-200312000-00014

10.1097/FTD.0b013e31817d6f5d

10.1097/01.jcp.0000203225.79364.85

10.1592/phco.22.12.1001.33603

10.1055/s-0031-1286287

10.1016/S0009-9236(96)90134-4

10.1007/s00228-004-0792-6

10.1007/s002280050261

10.1177/0269881113512041

10.1038/sj.clpt.6100291

10.1111/jcpt.12029

10.1016/j.ejphar.2009.10.007

10.1007/s00228-009-0657-0

10.1007/s00228-008-0533-3

10.1067/mcp.2001.116513

10.1007/s00228-004-0766-8

10.1038/sj.clpt.6100101

10.1124/dmd.31.3.289

10.2174/138161212803523617

10.1097/00007691-200112000-00004

10.1161/CIRCULATIONAHA.109.885194