Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

Clinical Pharmacology and Therapeutics - Tập 94 Số 1 - Trang 126-141 - 2013
Xiaoyan Chu1, Ken Korzekwa2, Robert Elsby3, Katherine S. Fenner3, Aleksandra Galetin4, Yurong Lai5,6, Pär Matsson7, Aaron M. Moss8, Swati Nagar2, Gus R. Rosania9, Jingwen Bai10, Joseph W. Polli11, Yuichi Sugiyama12, Kim L. R. Brouwer13
1Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey, USA
2Department of Pharmaceutical Sciences; Temple University School of Pharmacy; Philadelphia Pennsylvania, USA
3Global DMPK, AstraZeneca R&D Alderley Park, Macclesfield, Cheshire, United Kingdom
4School of Pharmacy & Pharmaceutical Sciences, University of Manchester, Manchester, UK
5Pharmaceutical Candidate Optimization, Bristol‐Myers Squibb Princeton New Jersey USA
6Pharmacokinetics, Dynamics, and Metabolism, Pfizer Groton Connecticut USA
7Department of Pharmacy, Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Uppsala University, Uppsala, Sweden
8Clinical Pharmacology, Seattle Genetics, Inc. Bothell Washington USA
9Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.
10Office of Clinical Pharmacology Office of Translational Sciences Center for Drug Evaluation & Research US Food and Drug Administration Silver Spring Maryland USA
11Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, USA
12Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, Yokohama, Japan
13Division of Pharmacotherapy and Experimental Therapeutics UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.1038/nrd3287

10.1124/jpet.108.146647

10.1146/annurev-pharmtox-010611-134529

10.1124/dmd.111.040758

10.1146/annurev-pharmtox-011112-140309

10.1007/BF01059688

10.3109/03602530903491824

10.3109/03602532.2011.560607

10.1002/bdd.1823

10.1124/dmd.111.040477

10.1124/dmd.110.035998

10.1124/dmd.107.015131

10.1371/journal.pone.0037471

10.1021/mp200093z

10.1124/dmd.110.032862

10.1097/RCT.0b013e31821a02aa

10.1124/mol.63.4.844

10.1124/dmd.112.044875

10.1172/JCI30558

10.1124/dmd.108.023648

10.1007/s11095-008-9597-0

Bar-Meir S., 1982, Radiology, 142, 743, 10.1148/radiology.142.3.7063695

10.1161/CIRCGENETICS.109.898502

10.1038/clpt.2009.79

10.1158/1078-0432.CCR-08-1609

Ward E.S., 2001, J. Pharmacol. Exp. Ther, 297, 141

10.1124/dmd.111.041012

10.1093/toxsci/kfp094

10.1152/ajpgi.90672.2008

Lipman B.J., 1990, J. Biol. Chem, 265, 2142, 10.1016/S0021-9258(19)39952-1

10.1073/pnas.84.22.8160

10.1124/pr.110.002857

10.1016/j.ejps.2005.12.007

10.1021/mp900132e

10.1124/jpet.103.061770

10.1038/clpt.2011.25

10.1021/mp900258z

10.1093/jac/dkm476

10.1124/dmd.104.002436

10.1124/dmd.106.010413

10.1124/jpet.111.187112

10.1021/mp200160t

10.2967/jnumed.111.098681

10.1016/j.ijpharm.2010.06.038

Langer O., 2005, J. Nucl. Med, 46, 1835

10.1016/j.vascn.2004.09.001

10.1016/j.jchromb.2008.05.035

10.1007/s00216-006-0690-0

10.1002/elps.200700917

Ilinski P., 2003, Cancer Res, 63, 1776

10.1111/j.1349-7006.2008.00755.x

10.1007/s11095-005-6627-z

10.1007/s11095-006-9135-x

10.1124/dmd.111.044289

10.1124/dmd.107.015321

10.1007/s11095-009-0026-9

10.1038/nature11448

10.1124/dmd.111.042994

10.1124/jpet.109.156653

10.1124/dmd.112.046193

10.1021/mp8002495

10.2165/00003088-200342100-00002

10.1146/annurev-pharmtox-010510-100540

10.1007/s11095-012-0918-y

Kawai R., 1998, J. Pharmacol. Exp. Ther, 287, 457

10.1124/dmd.109.030254

10.1172/JCI42168

10.1038/clpt.2011.142

10.1038/psp.2012.21

10.1080/00498250801986951

10.1007/s10928-009-9139-3

10.1517/17425255.2013.741589

Thông tin
Thông tin xuất bản

Clinical Pharmacology and Therapeutics

Tập 94 Số 1

126-141

Thông tin tác giả