Clinical Cancer Research
SCOPUS (1995-2025)SCIE-ISI
1078-0432
1557-3265
Mỹ
Cơ quản chủ quản: American Association for Cancer Research Inc. , AMER ASSOC CANCER RESEARCH
Lĩnh vực:
OncologyCancer Research
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence
Tập 13 Số 15 - Trang 4429-4434 - 2007
Abstract Purpose: To compare the clinical features, natural history, and
outcomes for women with “triple-negative” breast cancer with women with other
types of breast cancer. Experimental Design: We studied a cohort of 1,601
patients with breast cancer, diagnosed between January 1987 and December 1997 at
Women's College Hospital in Toronto. Triple-negative breast cancers were defined
as those that...
Therapeutic Nanoparticles for Drug Delivery in Cancer
Tập 14 Số 5 - Trang 1310-1316 - 2008
Abstract Cancer nanotherapeutics are rapidly progressing and are being
implemented to solve several limitations of conventional drug delivery systems
such as nonspecific biodistribution and targeting, lack of water solubility,
poor oral bioavailability, and low therapeutic indices. To improve the
biodistribution of cancer drugs, nanoparticles have been designed for optimal
size and surface charact...
Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
Tập 10 Số 16 - Trang 5367-5374 - 2004
Abstract Purpose: Expression profiling studies classified breast carcinomas into
estrogen receptor (ER)+/luminal, normal breast-like, HER2 overexpressing, and
basal-like groups, with the latter two associated with poor outcomes. Currently,
there exist clinical assays that identify ER+/luminal and HER2-overexpressing
tumors, and we sought to develop a clinical assay for breast basal-like tumors.
Ex...
Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases
Tập 10 Số 20 - Trang 6897-6904 - 2004
Abstract Purpose: The purpose of this study was to determine the accuracy,
precision, and linearity of the CellSearch system and evaluate the number of
circulating tumor cells (CTCs) per 7.5 mL of blood in healthy subjects, patients
with nonmalignant diseases, and patients with a variety of metastatic
carcinomas. Experimental Design: The CellSearch system was used to enumerate
CTCs in 7.5 mL of bl...
Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers
Tập 19 Số 8 - Trang 2240-2247 - 2013
Abstract Purpose: All patients with EGF receptor (EGFR)–mutant lung cancers
eventually develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI).
Smaller series have identified various mechanisms of resistance, but systematic
evaluation of a large number of patients to definitively establish the frequency
of various mechanisms has not been conducted. Experimental Design: Patients with
l...
Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer
Tập 14 Số 19 - Trang 6302-6309 - 2008
Abstract Purpose: A method for enumerating circulating tumor cells (CTC) has
received regulatory clearance. The primary objective of this prospective study
was to establish the relationship between posttreatment CTC count and overall
survival (OS) in castration-resistant prostate cancer (CRPC). Secondary
objectives included determining the prognostic utility of CTC measurement before
initiating th...
The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes
Tập 13 Số 8 - Trang 2329-2334 - 2007
Abstract Purpose: Gene expression analysis identifies several breast cancer
subtypes. We examined the relationship of neoadjuvant chemotherapy response to
outcome among these breast cancer subtypes. Experimental Design: We used
immunohistochemical profiles [human epidermal growth factor receptor 2–positive
(HER2+)/hormone receptor–negative for HER2+/estrogen receptor–negative (ER−),
hormone recept...
Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome
Tập 14 Số 16 - Trang 5198-5208 - 2008
AbstractPurpose: The study aim to identify novel molecular subtypes of ovarian
cancer by gene expression profiling with linkage to clinical and pathologic
features.Experimental Design: Microarray gene expression profiling was done on
285 serous and endometrioid tumors of the ovary, peritoneum, and fallopian tube.
K-means clustering was applied to identify robust molecular subtypes.
Statistical ana...
Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype
Tập 14 Số 5 - Trang 1368-1376 - 2008
Abstract Purpose: Basal-like breast cancer is associated with high grade, poor
prognosis, and younger patient age. Clinically, a triple-negative phenotype
definition [estrogen receptor, progesterone receptor, and human epidermal growth
factor receptor (HER)-2, all negative] is commonly used to identify such cases.
EGFR and cytokeratin 5/6 are readily available positive markers of basal-like
breast...
The Double-Edged Sword of Autophagy Modulation in Cancer
Tập 15 Số 17 - Trang 5308-5316 - 2009
Abstract Macroautophagy (autophagy) is a lysosomal degradation pathway for the
breakdown of intracellular proteins and organelles. Although constitutive
autophagy is a homeostatic mechanism for intracellular recycling and metabolic
regulation, autophagy is also stress responsive, in which it is important for
the removal of damaged proteins and organelles. Autophagy thereby confers stress
tolerance...