Clinical Cancer Research
SCOPUS (1995-2023)SCIE-ISI
1078-0432
1557-3265
Mỹ
Cơ quản chủ quản: American Association for Cancer Research Inc. , AMER ASSOC CANCER RESEARCH
Lĩnh vực:
OncologyCancer Research
Các bài báo tiêu biểu
Triple-Negative Breast Cancer: Clinical Features and Patterns of RecurrenceAbstract
Purpose: To compare the clinical features, natural history, and outcomes for women with “triple-negative” breast cancer with women with other types of breast cancer.
Experimental Design: We studied a cohort of 1,601 patients with breast cancer, diagnosed between January 1987 and December 1997 at Women's Colleg... ... hiện toàn bộ
Tập 13 Số 15 - Trang 4429-4434 - 2007
Therapeutic Nanoparticles for Drug Delivery in CancerAbstract
Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability, and low therapeutic indices. To improve the biodistribution of cancer drugs, nanoparticles have be... ... hiện toàn bộ
Tập 14 Số 5 - Trang 1310-1316 - 2008
Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast CarcinomaAbstract
Purpose: Expression profiling studies classified breast carcinomas into estrogen receptor (ER)+/luminal, normal breast-like, HER2 overexpressing, and basal-like groups, with the latter two associated with poor outcomes. Currently, there exist clinical assays that identify ER+/luminal and HER2-overexpressing tumors, and we sought to develop a... ... hiện toàn bộ
Tập 10 Số 16 - Trang 5367-5374 - 2004
Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant DiseasesAbstract
Purpose: The purpose of this study was to determine the accuracy, precision, and linearity of the CellSearch system and evaluate the number of circulating tumor cells (CTCs) per 7.5 mL of blood in healthy subjects, patients with nonmalignant diseases, and patients with a variety of metastatic carcinomas.
Exper... ... hiện toàn bộ
Tập 10 Số 20 - Trang 6897-6904 - 2004
Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung CancersAbstract
Purpose: All patients with EGF receptor (EGFR)–mutant lung cancers eventually develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI). Smaller series have identified various mechanisms of resistance, but systematic evaluation of a large number of patients to definitively establish the frequency of various mechanisms has not been... ... hiện toàn bộ
Tập 19 Số 8 - Trang 2240-2247 - 2013
Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate CancerAbstract
Purpose: A method for enumerating circulating tumor cells (CTC) has received regulatory clearance. The primary objective of this prospective study was to establish the relationship between posttreatment CTC count and overall survival (OS) in castration-resistant prostate cancer (CRPC). Secondary objectives included determining the prognostic... ... hiện toàn bộ
Tập 14 Số 19 - Trang 6302-6309 - 2008
The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer SubtypesAbstract
Purpose: Gene expression analysis identifies several breast cancer subtypes. We examined the relationship of neoadjuvant chemotherapy response to outcome among these breast cancer subtypes.
Experimental Design: We used immunohistochemical profiles [human epidermal growth factor receptor 2–positive (HER2+)/horm... ... hiện toàn bộ
Tập 13 Số 8 - Trang 2329-2334 - 2007
Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical OutcomeAbstract Purpose: The study aim to identify novel molecular subtypes of ovarian cancer by gene expression profiling with linkage to clinical and pathologic features. Experimental Design: Microarray gene expression profiling was done on 285 serous and endometrioid tumors of the ovary, peritoneum, and fallopian tube. K-means clustering was applied to i... ... hiện toàn bộ
Tập 14 Số 16 - Trang 5198-5208 - 2008
Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative PhenotypeAbstract
Purpose: Basal-like breast cancer is associated with high grade, poor prognosis, and younger patient age. Clinically, a triple-negative phenotype definition [estrogen receptor, progesterone receptor, and human epidermal growth factor receptor (HER)-2, all negative] is commonly used to identify such cases. EGFR and cytokeratin 5/6 are readily... ... hiện toàn bộ
Tập 14 Số 5 - Trang 1368-1376 - 2008
The Double-Edged Sword of Autophagy Modulation in CancerAbstract
Macroautophagy (autophagy) is a lysosomal degradation pathway for the breakdown of intracellular proteins and organelles. Although constitutive autophagy is a homeostatic mechanism for intracellular recycling and metabolic regulation, autophagy is also stress responsive, in which it is important for the removal of damaged proteins and organe... ... hiện toàn bộ
Tập 15 Số 17 - Trang 5308-5316 - 2009