Clinical Cancer Research

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Antitumor Activity of Lurbinectedin, a Selective Inhibitor of Oncogene Transcription, in Patients with Relapsed Ewing Sarcoma: Results of a Basket Phase II Study
Clinical Cancer Research - Tập 28 Số 13 - Trang 2762-2770 - 2022
Vivek Subbiah, Irene Braña, Alessandra Longhi, Valentina Boni, Jean‐Pierre Delord, Ahmad Awada, Pascaline Boudou‐Rouquette, John Sarantopoulos, Geoffrey I. Shapiro, Anthony Elias, Ravin Ratan, Cristian Fernández, Carmen Kahatt, Martín Cullell-Young, Mariano Siguero, Ali Zeaiter, Sant P. Chawla
Abstract Purpose: Lurbinectedin suppresses the oncogenic transcription factor EWS-FLI1 through relocalization to the nucleolus, and delays tumor growth in mice bearing Ewing sarcoma xenografts. On the basis of this rationale, lurbinectedin was evaluated in patients with relapsed ...... hiện toàn bộ
Comprehensive Genomic Analysis Reveals Clinically Relevant Molecular Distinctions between Thymic Carcinomas and Thymomas
Clinical Cancer Research - Tập 15 Số 22 - Trang 6790-6799 - 2009
Nicolas Girard, Ronglai Shen, Tianhua Guo, Maureen F. Zakowski, Adriana Heguy, Gregory J. Riely, James Huang, Carmen Lau, Alex E. Lash, Marc Ladanyi, Agnès Viale, Cristina R. Antonescu, William D. Travis, Valerie W. Rusch, Mark G. Kris, William Pao
Abstract Purpose: Thymomas and thymic carcinomas are rare intrathoracic malignancies that can be invasive and refractory to conventional treatment. Because these tumors both originate from the thymus, they are often grouped together clinically. However, whether the underlying biology of these tumors warrants such clustering is unclear, and the optimu...... hiện toàn bộ
High-Resolution DNA Copy Number Profiling of Malignant Peripheral Nerve Sheath Tumors Using Targeted Microarray-Based Comparative Genomic Hybridization
Clinical Cancer Research - Tập 14 Số 4 - Trang 1015-1024 - 2008
Kiran K. Mantripragada, Gillian Spurlock, Lan Kluwe, Nadia Chuzhanova, Rosalie E. Ferner, Ian M. Frayling, Jan P. Dumanski, Abhijit Guha, D.N. Cooper, Meena Upadhyaya
AbstractPurpose: Neurofibromatosis type 1 (NF1) is an autosomal dominant condition that predisposes to benign and malignant tumors. The lifetime risk of a malignant peripheral nerve sheath tumor (MPNST) in NF1 is ∼10%. These tumors have a poor survival rate and their molecular basis remains unclear. We report the first comprehensive investigation of DNA copy number...... hiện toàn bộ
A Phase I and Pharmacologic Trial of Two Schedules of the Proteasome Inhibitor, PS-341 (Bortezomib, Velcade), in Patients with Advanced Cancer
Clinical Cancer Research - Tập 11 Số 9 - Trang 3410-3416 - 2005
Grace K. Dy, James P. Thomas, George Wilding, Laura M. Bruzek, Sumithra J. Mandrekar, Charles Erlichman, Dona Alberti, Kim Binger, Henry C. Pitot, Steven R. Alberts, Lorelei J. Hanson, Rebecca Marnocha, Kendra D. Tutsch, Scott H. Kaufmann, Alex A. Adjei
Abstract Purpose: To define the toxicities, pharmacodynamics, and clinical activity of the proteasome inhibitor, PS-341 (bortezomib), in patients with advanced malignancies. Patients and Methods: Twenty-eight patients (14 male and 14 female) received PS-341 twice weekly for 4 of 6 weeks (schedule I). Because toxicity n...... hiện toàn bộ
Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage Activating Agents
Clinical Cancer Research - Tập 17 Số 8 - Trang 2110-2119 - 2011
Emilie P. Buddingh, Marieke L. Kuijjer, R.A.J. Duim, Horst Bürger, Konstantin Agelopoulos, Ola Myklebost, Massimo Serra, Fredrik Mertens, Pancras C.W. Hogendoorn, Arjan C. Lankester, Anne‐Marie Cleton‐Jansen
AbstractPurpose: High-grade osteosarcoma is a malignant primary bone tumor with a peak incidence in adolescence. Overall survival (OS) of patients with resectable metastatic disease is approximately 20%. The exact mechanisms of development of metastases in osteosarcoma remain unclear. Most studies focus on tumor cells, but it is increasingly evident that stroma pla...... hiện toàn bộ
DNA Aneuploidy and Integration of Human Papillomavirus Type 16 E6/E7 Oncogenes in Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the Cervix Uteri
Clinical Cancer Research - Tập 10 Số 9 - Trang 3059-3063 - 2004
Peter Melsheimer, Svetlana Vinokurova, Nicolas Wentzensen, G. Bastert, Magnus von Knebel Doeberitz
Abstract Purpose: Increasingly deregulated expression of the E6-E7 oncogenes of high-risk human papillomaviruses (HR-HPVs) has been identified as the major transforming factor in the pathogenesis of cervical dysplasia and derived cancers. The expression of these genes in epithelial stem cells first results in chromosomal instability and induces chrom...... hiện toàn bộ
CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors
Clinical Cancer Research - Tập 25 Số 8 - Trang 2560-2574 - 2019
Robbie G. Majzner, Johanna Theruvath, Anandani Nellan, Sabine Heitzeneder, Yongzhi Cui, Christopher W. Mount, Skyler P. Rietberg, Miles H. Linde, Peng Xu, Christopher Rota, Elena Sotillo, Louai Labanieh, Daniel W. Lee, Rimas J. Orentas, Dimiter S. Dimitrov, Zhongyu Zhu, Brad St. Croix, Alberto Delaidelli, Alla Sekunova, Ezio Bonvini, Siddhartha S. Mitra, Martha Quezado, Ravindra Majeti, Michelle Monje, Poul H. Sorensen, John M. Maris, Crystal L. Mackall
Abstract Purpose: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute lymphoblastic leukemia...... hiện toàn bộ
Blockade of Programmed Death 1 Augments the Ability of Human T Cells Engineered to Target NY-ESO-1 to Control Tumor Growth after Adoptive Transfer
Clinical Cancer Research - Tập 22 Số 2 - Trang 436-447 - 2016
Edmund K. Moon, Raghuveer Ranganathan, Evgeniy Eruslanov, Soyeon Kim, Kheng Newick, Shaun O’Brien, Albert Lo, Xiaojun Liu, Yangbing Zhao, Steven Μ. Albelda
AbstractPurpose: Tumor-infiltrating lymphocytes (TILs) become hypofunctional, although the mechanisms are not clear. Our goal was to generate a model of human tumor-induced TIL hypofunction to study mechanisms and to test anti-human therapeutics.Experimental Design: We transduced human T cells with a published, optimized T-cell receptor (TCR) that ...... hiện toàn bộ
Molecular Pathways: Adiponectin and Leptin Signaling in Cancer
Clinical Cancer Research - Tập 19 Số 8 - Trang 1926-1932 - 2013
Michael N. VanSaun
Abstract The increasing percentage of obese individuals in the population and its independent association of increased risk for the development of cancer have heightened the necessity to understand the molecular mechanisms that underlie this connection. The deregulation of adipokines in the setting of obesity and their impact on cancer progression an...... hiện toàn bộ
Modeling the Impact of Cardiopulmonary Irradiation on Overall Survival in NRG Oncology Trial RTOG 0617
Clinical Cancer Research - Tập 26 Số 17 - Trang 4643-4650 - 2020
Maria Thor, Joseph O. Deasy, Chen Hu, Elizabeth Gore, Voichita Bar‐Ad, Clifford G. Robinson, Matthew Wheatley, Jung Hun Oh, Jeffrey A. Bogart, Yolanda I. Garces, Vivek S. Kavadi, Samir Narayan, Puneeth Iyengar, Jacob S. Witt, James W. Welsh, Cristopher D. Koprowski, James M. Larner, Ying Xiao, Jeffrey D. Bradley
Abstract Purpose: To quantitatively predict the impact of cardiopulmonary dose on overall survival (OS) after radiotherapy for locally advanced non–small cell lung cancer. Experimental Des...... hiện toàn bộ
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