Clinical Cancer Research
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Ki-67 Is an Independent Predictor of Bladder Cancer Outcome in Patients Treated with Radical Cystectomy for Organ-Confined Disease
Clinical Cancer Research - Tập 12 Số 24 - Trang 7369-7373 - 2006
Abstract Purpose: To determine the association of the cell proliferative marker
Ki-67 with pathologic features and disease prognosis in patients with
transitional cell carcinoma (TCC) of the urinary bladder. Methods:
Immunohistochemical staining for Ki-67 was done on serial cuts from tissue
microarrays containing cystectomy specimens from 9 patients without bladder
cancer and 226 consecutive patie...
Development of Molecularly Targeted Therapies in Hepatocellular Carcinoma: Where Do We Go Now?
Clinical Cancer Research - Tập 16 Số 2 - Trang 390-397 - 2010
Abstract Hepatocellular carcinoma (HCC), once considered an orphan disease in
the West, has become a global health concern. It is the third leading cause of
cancer death worldwide, and its incidence continues to increase. Historically,
the development of new systemic agents for advanced HCC has been lacking despite
no clear benefit with traditional cytotoxic therapies. Although two randomized
stud...
Resveratrol Inhibits Tumor Growth of Human Neuroblastoma and Mediates Apoptosis by Directly Targeting Mitochondria
Clinical Cancer Research - Tập 13 Số 17 - Trang 5162-5169 - 2007
Abstract Purpose: Neuroblastoma is an aggressive childhood disease of the
sympathetic nervous system. Treatments are often ineffective and have serious
side effects. Because resveratrol, a natural plant product, has been reported to
have limited toxicity at chemotherapeutic levels, we investigated its efficacy
in the treatment of neuroblastoma as well as its underlying mechanism of action.
Experim...
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells
Clinical Cancer Research - Tập 15 Số 8 - Trang 2657-2665 - 2009
Abstract Purpose: Besides its therapeutic effects, chemotherapeutic agents also
enhance the malignancy of treated cancers in clinical situations. Recently,
epithelial-mesenchymal transition (EMT) has attracted attention in studies of
tumor progression. We aimed to test whether transient Adriamycin treatment
induces EMT and apoptosis simultaneously in cancer cells, clarify why the same
type of cell...
Resveratrol Suppresses the Angiogenesis and Tumor Growth of Gliomas in Rats
Clinical Cancer Research - Tập 10 Số 6 - Trang 2190-2202 - 2004
Abstract Purpose: We wanted to investigate the antitumor effects and effect on
angiogenesis of resveratrol in rat RT-2 gliomas. Experimental Design: RT-2
glioma cells were treated with resveratrol, and then cytotoxicity was assayed,
apoptosis was measured by flow-activated cell sorter flow cytometry, and
expression of vascular endothelial growth factor was measured by reverse
transcription-PCR. Tu...
MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls
Clinical Cancer Research - Tập 19 Số 13 - Trang 3600-3610 - 2013
AbstractPurpose: Our goal was to identify circulating micro RNA (miRNA) levels
that could distinguish patients with low-stage pancreatic cancer from healthy
and disease controls.Experimental Design: We measured 735 miRNAs in pancreatic
cancer case and control sera by QRTPCR using TaqMan MicroRNA Arrays. After array
analysis, we selected 18 miRNA candidates for validation in an independent set
of c...
Early Changes in Circulating Tumor Cells Are Associated with Response and Survival Following Treatment of Metastatic Neuroendocrine Neoplasms
Clinical Cancer Research - Tập 22 Số 1 - Trang 79-85 - 2016
Abstract Purpose: To investigate posttreatment circulating tumor cell (CTC)
counts in patients with neuroendocrine neoplasms (NENs) as a predictive
biomarker for disease progression and overall survival (OS). Experimental
Design: Patients with metastatic NENs commencing therapy were prospectively
recruited (n = 138). Blood samples were obtained for evaluation of CTCs using
the CellSearch platform ...
Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors
Clinical Cancer Research - Tập 17 Số 2 - Trang 337-345 - 2011
Abstract Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with
widely variable survival. It is unknown whether they express EpCAM (epithelial
cell adhesion molecule) and thus whether NET circulating tumor cells (CTC) are
detectable. We systematically investigated EpCAM expression and CTC detection in
patients with metastatic NETs and evaluated the potential of CTCs to predict
radiolog...
Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
Clinical Cancer Research - Tập 10 Số 16 - Trang 5367-5374 - 2004
Abstract Purpose: Expression profiling studies classified breast carcinomas into
estrogen receptor (ER)+/luminal, normal breast-like, HER2 overexpressing, and
basal-like groups, with the latter two associated with poor outcomes. Currently,
there exist clinical assays that identify ER+/luminal and HER2-overexpressing
tumors, and we sought to develop a clinical assay for breast basal-like tumors.
Ex...
KIT (CD117)-Positive Breast Cancers Are Infrequent and Lack KIT Gene Mutations
Clinical Cancer Research - Tập 10 Số 1 - Trang 178-183 - 2004
Abstract Purpose: KIT (CD117) is a transmembrane tyrosine kinase representing a
target for STI571 (Glivec) therapy. Some KIT-overexpressing solid tumors have
responded favorably to STI571, potentially because of the presence of
KIT-activating mutations. Experimental Design: To investigate the epidemiology
of KIT overexpression and mutations, we investigated a series of 1654 breast
cancers. All tum...
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