Clinical Cancer Research

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Development of Molecularly Targeted Therapies in Hepatocellular Carcinoma: Where Do We Go Now?
Clinical Cancer Research - Tập 16 Số 2 - Trang 390-397 - 2010
Richard S. Finn
Abstract Hepatocellular carcinoma (HCC), once considered an orphan disease in the West, has become a global health concern. It is the third leading cause of cancer death worldwide, and its incidence continues to increase. Historically, the development of new systemic agents for advanced HCC has been lacking despite no clear benefit with traditional c...... hiện toàn bộ
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells
Clinical Cancer Research - Tập 15 Số 8 - Trang 2657-2665 - 2009
Qingquan Li, Jingda Xu, Wenjuan Wang, Xi-Xi Cao, Qi Chen, Feng Tang, Zhongqing Chen, Xiuping Liu, Zu‐De Xu
Abstract Purpose: Besides its therapeutic effects, chemotherapeutic agents also enhance the malignancy of treated cancers in clinical situations. Recently, epithelial-mesenchymal transition (EMT) has attracted attention in studies of tumor progression. We aimed to test whether transient Adriamycin treatment induces EMT and apoptosis simultaneously in...... hiện toàn bộ
Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors
Clinical Cancer Research - Tập 17 Số 2 - Trang 337-345 - 2011
Mohid S. Khan, Theodora Tsigani, Mohammed Rashid, Jeremy S. Rabouhans, Dominic Yu, Tu Vinh Luong, Martyn Caplin, Tim Meyer
Abstract Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It is unknown whether they express EpCAM (epithelial cell adhesion molecule) and thus whether NET circulating tumor cells (CTC) are detectable. We systematically investigated EpCAM expression and CTC detection in patients with metastatic NETs and eva...... hiện toàn bộ
Dendritic Cells Fused with Allogeneic Colorectal Cancer Cell Line Present Multiple Colorectal Cancer–Specific Antigens and Induce Antitumor Immunity against Autologous Tumor Cells
Clinical Cancer Research - Tập 11 Số 21 - Trang 7891-7900 - 2005
Shigeo Koido, Eiichi Hara, Sadamu Homma, Akihiro Torii, Yoichi Toyama, Hidejiro Kawahara, Michiaki Watanabe, Katsuhiko Yanaga, Kiyotaka Fujise, Hisao Tajiri, Jianlin Gong, Gotaro Toda
Abstract The aim of antitumor immunotherapy is to induce CTL responses against autologous tumors. Previous work has shown that fusion of human dendritic cells and autologous tumor cells induce CTL responses against autologous tumor cells in vitro. However, in the clinical setting of patients with colorectal carcinoma, a major difficulty is the prepar...... hiện toàn bộ
TP53, STK11, and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti–PD-1 in Lung Adenocarcinoma
Clinical Cancer Research - Tập 24 Số 22 - Trang 5710-5723 - 2018
Jérôme Biton, Audrey Mansuet‐Lupo, Nicolas Pécuchet, Marco Alifano, Hanane Ouakrim, Jennifer Arrondeau, Pascaline Boudou‐Rouquette, François Goldwasser, Karen Leroy, Jérémy Goc, Marie Wislez, Claire Germain, Pierre Laurent‐Puig, Marie‐Caroline Dieu‐Nosjean, Isabelle Cremer, Ronald Herbst, Hélène Blons, Diane Damotte
Abstract Purpose: By unlocking antitumor immunity, antibodies targeting programmed cell death 1 (PD-1) exhibit impressive clinical results in non–small cell lung cancer, underlining the strong interactions between tumor and immune cells. However, factors that can robustly predict long-lasting responses are still needed. ... hiện toàn bộ
Pseudolaric Acid B, a Novel Microtubule-Destabilizing Agent That Circumvents Multidrug Resistance Phenotype and Exhibits Antitumor Activity In vivo
Clinical Cancer Research - Tập 11 Số 16 - Trang 6002-6011 - 2005
Vincent Kam Wai Wong, Pauline Chiu, Stephen S.M. Chung, Larry M. C. Chow, Yunzhe Zhao, Burton B. Yang, Ben C.B. Ko
Abstract Purpose: Pseudolaric acid B (PAB) is the major bioactive constituent in the root bark of Pseudolarix kaempferi that has been used as an antifungal remedy in traditional Chinese medicine. Previous studies showed that PAB exhibited substantial cytotoxicity. The aims of this study were to elucidate the molecular target of PAB, to examine its me...... hiện toàn bộ
Distinguishing Clinicopathologic Features of Patients with V600E and V600K BRAF-Mutant Metastatic Melanoma
Clinical Cancer Research - Tập 18 Số 12 - Trang 3242-3249 - 2012
Alexander M. Menzies, Lauren E. Haydu, Lydia Visintin, Matteo S. Carlino, Julie R. Howle, John F. Thompson, Richard Kefford, Richard A. Scolyer, Georgina V. Long
Abstract Purpose: Certain clinicopathologic features correlate with BRAF mutation status in melanoma including younger age and primary subtype. This study sought to determine the BRAF mutation status by age-decade and whether BRAF-mutant genotypes correlated with clinicopathologic features and outcome in patients with metastatic melanoma. ...... hiện toàn bộ
Prognostic Analysis of E-Cadherin Gene Promoter Hypermethylation in Patients with Surgically Resected, Node-Positive, Diffuse Gastric Cancer
Clinical Cancer Research - Tập 10 Số 8 - Trang 2784-2789 - 2004
Francesco Graziano, Federica Arduini, Annamaria Ruzzo, Italo Bearzi, Bostjan Humar, Helen More, Rosarita Silva, P Muretto, Parry Guilford, E. Testa, Davide Mari, Mauro Magnani, Stefano Cascinu
Abstract Purpose: Recent investigations have demonstrated that hypermethylation is a frequent mechanism for silencing tumor suppressor genes. This is a potentially reversible epigenetic change, and it is the target of a novel class of anticancer compounds with demethylating activity. Better understanding of the clinical implications of hypermethylati...... hiện toàn bộ
Metformin: A Therapeutic Opportunity in Breast Cancer
Clinical Cancer Research - Tập 16 Số 6 - Trang 1695-1700 - 2010
Ana María González-Angulo, Funda Meric‐Bernstam
Abstract Two important, related pathways are involved in cancer growth: the insulin/insulin-like growth factor-1 (IGF1) signaling pathway, which is activated when nutrients are available, and the adenosine mono-phosphate-activated protein kinase (AMPK) pathway, activated when cells are starved for carbohydrates. Metformin inhibits transcription of ke...... hiện toàn bộ
Comprehensive Genomic Analysis Reveals Clinically Relevant Molecular Distinctions between Thymic Carcinomas and Thymomas
Clinical Cancer Research - Tập 15 Số 22 - Trang 6790-6799 - 2009
Nicolas Girard, Ronglai Shen, Tianhua Guo, Maureen F. Zakowski, Adriana Heguy, Gregory J. Riely, James Huang, Carmen Lau, Alex E. Lash, Marc Ladanyi, Agnès Viale, Cristina R. Antonescu, William D. Travis, Valerie W. Rusch, Mark G. Kris, William Pao
Abstract Purpose: Thymomas and thymic carcinomas are rare intrathoracic malignancies that can be invasive and refractory to conventional treatment. Because these tumors both originate from the thymus, they are often grouped together clinically. However, whether the underlying biology of these tumors warrants such clustering is unclear, and the optimu...... hiện toàn bộ
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