Clinical Cancer Research

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Ki-67 Is an Independent Predictor of Bladder Cancer Outcome in Patients Treated with Radical Cystectomy for Organ-Confined Disease
Clinical Cancer Research - Tập 12 Số 24 - Trang 7369-7373 - 2006
Vitaly Margulis, Shahrokh F. Shariat, Raheela Ashfaq, Arthur I. Sagalowsky, Yair Lotan
Abstract Purpose: To determine the association of the cell proliferative marker Ki-67 with pathologic features and disease prognosis in patients with transitional cell carcinoma (TCC) of the urinary bladder. Methods: Immunohistochemical staining for Ki-67 was done on serial cuts from tissue microarrays containing cyste...... hiện toàn bộ
Development of Molecularly Targeted Therapies in Hepatocellular Carcinoma: Where Do We Go Now?
Clinical Cancer Research - Tập 16 Số 2 - Trang 390-397 - 2010
Richard S. Finn
Abstract Hepatocellular carcinoma (HCC), once considered an orphan disease in the West, has become a global health concern. It is the third leading cause of cancer death worldwide, and its incidence continues to increase. Historically, the development of new systemic agents for advanced HCC has been lacking despite no clear benefit with traditional c...... hiện toàn bộ
Resveratrol Inhibits Tumor Growth of Human Neuroblastoma and Mediates Apoptosis by Directly Targeting Mitochondria
Clinical Cancer Research - Tập 13 Số 17 - Trang 5162-5169 - 2007
Paul R. van Ginkel, Dhruv Sareen, Lalita Subramanian, Quintisha Walker, Soesiawati R. Darjatmoko, Mary J. Lindstrom, Amol D. Kulkarni, Daniel M. Albert, Arthur S. Polans
Abstract Purpose: Neuroblastoma is an aggressive childhood disease of the sympathetic nervous system. Treatments are often ineffective and have serious side effects. Because resveratrol, a natural plant product, has been reported to have limited toxicity at chemotherapeutic levels, we investigated its efficacy in the treatment of neuroblastoma as wel...... hiện toàn bộ
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells
Clinical Cancer Research - Tập 15 Số 8 - Trang 2657-2665 - 2009
Qingquan Li, Jingda Xu, Wenjuan Wang, Xi-Xi Cao, Qi Chen, Feng Tang, Zhongqing Chen, Xiuping Liu, Zu‐De Xu
Abstract Purpose: Besides its therapeutic effects, chemotherapeutic agents also enhance the malignancy of treated cancers in clinical situations. Recently, epithelial-mesenchymal transition (EMT) has attracted attention in studies of tumor progression. We aimed to test whether transient Adriamycin treatment induces EMT and apoptosis simultaneously in...... hiện toàn bộ
Resveratrol Suppresses the Angiogenesis and Tumor Growth of Gliomas in Rats
Clinical Cancer Research - Tập 10 Số 6 - Trang 2190-2202 - 2004
Sheng-Hong Tseng, Swei-Ming Lin, Jin-Cherng Chen, Yen‐Hao Su, Hsin‐Yi Huang, Chia-Kang Chen, Po-Yin Lin, Yun Chen
Abstract Purpose: We wanted to investigate the antitumor effects and effect on angiogenesis of resveratrol in rat RT-2 gliomas. Experimental Design: RT-2 glioma cells were treated with resveratrol, and then cytotoxicity was assayed, apoptosis was measured by flow-activated cell sorter flow cytometry, and expression of ...... hiện toàn bộ
MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls
Clinical Cancer Research - Tập 19 Số 13 - Trang 3600-3610 - 2013
Ang Li, Jun Yu, Haeryoung Kim, Christopher L. Wolfgang, Marcia I. Canto, Ralph H. Hruban, Michael Goggins
AbstractPurpose: Our goal was to identify circulating micro RNA (miRNA) levels that could distinguish patients with low-stage pancreatic cancer from healthy and disease controls.Experimental Design: We measured 735 miRNAs in pancreatic cancer case and control sera by QRTPCR using TaqMan MicroRNA Arrays. After array analysis, we selected 18 miRNA ca...... hiện toàn bộ
Early Changes in Circulating Tumor Cells Are Associated with Response and Survival Following Treatment of Metastatic Neuroendocrine Neoplasms
Clinical Cancer Research - Tập 22 Số 1 - Trang 79-85 - 2016
Mohid S. Khan, Amy A. Kirkwood, Theodora Tsigani, Helen L. Lowe, Robert M. Goldstein, John A. Hartley, Martyn Caplin, Tim Meyer
Abstract Purpose: To investigate posttreatment circulating tumor cell (CTC) counts in patients with neuroendocrine neoplasms (NENs) as a predictive biomarker for disease progression and overall survival (OS). Experimental Design: Patients with metastatic NENs commencing therapy were prospectively recruited (n = 138). B...... hiện toàn bộ
Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors
Clinical Cancer Research - Tập 17 Số 2 - Trang 337-345 - 2011
Mohid S. Khan, Theodora Tsigani, Mohammed Rashid, Jeremy S. Rabouhans, Dominic Yu, Tu Vinh Luong, Martyn Caplin, Tim Meyer
Abstract Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It is unknown whether they express EpCAM (epithelial cell adhesion molecule) and thus whether NET circulating tumor cells (CTC) are detectable. We systematically investigated EpCAM expression and CTC detection in patients with metastatic NETs and eva...... hiện toàn bộ
Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
Clinical Cancer Research - Tập 10 Số 16 - Trang 5367-5374 - 2004
Torsten O. Nielsen, Forrest D. Hsu, Kristin C. Jensen, Maggie C.U. Cheang, Gamze Karaca, Zhiyuan Hu, Tina Hernandez‐Boussard, Chad Livasy, David Cowan, Lynn G. Dressler, Lars A. Akslen, Joseph Ragaz, Allen M. Gown, C. Blake Gilks, Matt van de Rijn, Charles M. Perou
Abstract Purpose: Expression profiling studies classified breast carcinomas into estrogen receptor (ER)+/luminal, normal breast-like, HER2 overexpressing, and basal-like groups, with the latter two associated with poor outcomes. Currently, there exist clinical assays that identify ER+/luminal and HER2-overexpressing tumors, and we sought to develop a...... hiện toàn bộ
KIT (CD117)-Positive Breast Cancers Are Infrequent and Lack KIT Gene Mutations
Clinical Cancer Research - Tập 10 Số 1 - Trang 178-183 - 2004
Ronald Simon, S. Panussis, Robert Maurer, Hanspeter Spichtin, Kathrin Glatz, Coya Tapia, Martina Mirlacher, Alex Rufle, J. Torhorst, Guido Sauter
Abstract Purpose: KIT (CD117) is a transmembrane tyrosine kinase representing a target for STI571 (Glivec) therapy. Some KIT-overexpressing solid tumors have responded favorably to STI571, potentially because of the presence of KIT-activating mutations. Experimental Design: To investigate the epidemiology of KIT overex...... hiện toàn bộ
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