Clinical Cancer Research

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Ki-67 Is an Independent Predictor of Bladder Cancer Outcome in Patients Treated with Radical Cystectomy for Organ-Confined Disease
Clinical Cancer Research - Tập 12 Số 24 - Trang 7369-7373 - 2006
Vitaly Margulis, Shahrokh F. Shariat, Raheela Ashfaq, Arthur I. Sagalowsky, Yair Lotan
Abstract Purpose: To determine the association of the cell proliferative marker Ki-67 with pathologic features and disease prognosis in patients with transitional cell carcinoma (TCC) of the urinary bladder. Methods: Immunohistochemical staining for Ki-67 was done on serial cuts from tissue microarrays containing cyste...... hiện toàn bộ
Development of Molecularly Targeted Therapies in Hepatocellular Carcinoma: Where Do We Go Now?
Clinical Cancer Research - Tập 16 Số 2 - Trang 390-397 - 2010
Richard S. Finn
Abstract Hepatocellular carcinoma (HCC), once considered an orphan disease in the West, has become a global health concern. It is the third leading cause of cancer death worldwide, and its incidence continues to increase. Historically, the development of new systemic agents for advanced HCC has been lacking despite no clear benefit with traditional c...... hiện toàn bộ
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells
Clinical Cancer Research - Tập 15 Số 8 - Trang 2657-2665 - 2009
Qingquan Li, Jingda Xu, Wenjuan Wang, Xi-Xi Cao, Qi Chen, Feng Tang, Zhongqing Chen, Xiuping Liu, Zu‐De Xu
Abstract Purpose: Besides its therapeutic effects, chemotherapeutic agents also enhance the malignancy of treated cancers in clinical situations. Recently, epithelial-mesenchymal transition (EMT) has attracted attention in studies of tumor progression. We aimed to test whether transient Adriamycin treatment induces EMT and apoptosis simultaneously in...... hiện toàn bộ
MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls
Clinical Cancer Research - Tập 19 Số 13 - Trang 3600-3610 - 2013
Ang Li, Jun Yu, Haeryoung Kim, Christopher L. Wolfgang, Marcia I. Canto, Ralph H. Hruban, Michael Goggins
AbstractPurpose: Our goal was to identify circulating micro RNA (miRNA) levels that could distinguish patients with low-stage pancreatic cancer from healthy and disease controls.Experimental Design: We measured 735 miRNAs in pancreatic cancer case and control sera by QRTPCR using TaqMan MicroRNA Arrays. After array analysis, we selected 18 miRNA ca...... hiện toàn bộ
Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors
Clinical Cancer Research - Tập 17 Số 2 - Trang 337-345 - 2011
Mohid S. Khan, Theodora Tsigani, Mohammed Rashid, Jeremy S. Rabouhans, Dominic Yu, Tu Vinh Luong, Martyn Caplin, Tim Meyer
Abstract Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It is unknown whether they express EpCAM (epithelial cell adhesion molecule) and thus whether NET circulating tumor cells (CTC) are detectable. We systematically investigated EpCAM expression and CTC detection in patients with metastatic NETs and eva...... hiện toàn bộ
KIT (CD117)-Positive Breast Cancers Are Infrequent and Lack KIT Gene Mutations
Clinical Cancer Research - Tập 10 Số 1 - Trang 178-183 - 2004
Ronald Simon, S. Panussis, Robert Maurer, Hanspeter Spichtin, Kathrin Glatz, Coya Tapia, Martina Mirlacher, Alex Rufle, J. Torhorst, Guido Sauter
Abstract Purpose: KIT (CD117) is a transmembrane tyrosine kinase representing a target for STI571 (Glivec) therapy. Some KIT-overexpressing solid tumors have responded favorably to STI571, potentially because of the presence of KIT-activating mutations. Experimental Design: To investigate the epidemiology of KIT overex...... hiện toàn bộ
p53MVA Therapy in Patients with Refractory Gastrointestinal Malignancies Elevates p53-Specific CD8+ T-cell Responses
Clinical Cancer Research - Tập 20 Số 17 - Trang 4459-4470 - 2014
Nicola Hardwick, Mary Carroll, Teodora Kaltcheva, Dajun Qian, Dean Lim, Lucille Leong, Peiguo Chu, Joseph Kim, Joseph Chao, Marwan Fakih, Yun Yen, Jonathan Espenschied, Joshua D.I. Ellenhorn, Don J. Diamond, Vincent Chung
AbstractPurpose: To conduct a phase I trial of a modified vaccinia Ankara (MVA) vaccine delivering wild-type human p53 (p53MVA) in patients with refractory gastrointestinal cancers.Experimental Design: Three patients were vaccinated with 1.0 × 108 plaque-forming unit (pfu) p53MVA followed by nine patients at 5.6 × 108 pfu. Toxicity was classified u...... hiện toàn bộ
Dendritic Cells Fused with Allogeneic Colorectal Cancer Cell Line Present Multiple Colorectal Cancer–Specific Antigens and Induce Antitumor Immunity against Autologous Tumor Cells
Clinical Cancer Research - Tập 11 Số 21 - Trang 7891-7900 - 2005
Shigeo Koido, Eiichi Hara, Sadamu Homma, Akihiro Torii, Yoichi Toyama, Hidejiro Kawahara, Michiaki Watanabe, Katsuhiko Yanaga, Kiyotaka Fujise, Hisao Tajiri, Jianlin Gong, Gotaro Toda
Abstract The aim of antitumor immunotherapy is to induce CTL responses against autologous tumors. Previous work has shown that fusion of human dendritic cells and autologous tumor cells induce CTL responses against autologous tumor cells in vitro. However, in the clinical setting of patients with colorectal carcinoma, a major difficulty is the prepar...... hiện toàn bộ
TP53, STK11, and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti–PD-1 in Lung Adenocarcinoma
Clinical Cancer Research - Tập 24 Số 22 - Trang 5710-5723 - 2018
Jérôme Biton, Audrey Mansuet‐Lupo, Nicolas Pécuchet, Marco Alifano, Hanane Ouakrim, Jennifer Arrondeau, Pascaline Boudou‐Rouquette, François Goldwasser, Karen Leroy, Jérémy Goc, Marie Wislez, Claire Germain, Pierre Laurent‐Puig, Marie‐Caroline Dieu‐Nosjean, Isabelle Cremer, Ronald Herbst, Hélène Blons, Diane Damotte
Abstract Purpose: By unlocking antitumor immunity, antibodies targeting programmed cell death 1 (PD-1) exhibit impressive clinical results in non–small cell lung cancer, underlining the strong interactions between tumor and immune cells. However, factors that can robustly predict long-lasting responses are still needed. ... hiện toàn bộ
Pseudolaric Acid B, a Novel Microtubule-Destabilizing Agent That Circumvents Multidrug Resistance Phenotype and Exhibits Antitumor Activity In vivo
Clinical Cancer Research - Tập 11 Số 16 - Trang 6002-6011 - 2005
Vincent Kam Wai Wong, Pauline Chiu, Stephen S.M. Chung, Larry M. C. Chow, Yunzhe Zhao, Burton B. Yang, Ben C.B. Ko
Abstract Purpose: Pseudolaric acid B (PAB) is the major bioactive constituent in the root bark of Pseudolarix kaempferi that has been used as an antifungal remedy in traditional Chinese medicine. Previous studies showed that PAB exhibited substantial cytotoxicity. The aims of this study were to elucidate the molecular target of PAB, to examine its me...... hiện toàn bộ
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