Clinical Cancer Research

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Development of Molecularly Targeted Therapies in Hepatocellular Carcinoma: Where Do We Go Now?
Clinical Cancer Research - Tập 16 Số 2 - Trang 390-397 - 2010
Richard S. Finn
Abstract Hepatocellular carcinoma (HCC), once considered an orphan disease in the West, has become a global health concern. It is the third leading cause of cancer death worldwide, and its incidence continues to increase. Historically, the development of new systemic agents for advanced HCC has been lacking despite no clear benefit with traditional c...... hiện toàn bộ
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells
Clinical Cancer Research - Tập 15 Số 8 - Trang 2657-2665 - 2009
Qingquan Li, Jingda Xu, Wenjuan Wang, Xi-Xi Cao, Qi Chen, Feng Tang, Zhongqing Chen, Xiuping Liu, Zu‐De Xu
Abstract Purpose: Besides its therapeutic effects, chemotherapeutic agents also enhance the malignancy of treated cancers in clinical situations. Recently, epithelial-mesenchymal transition (EMT) has attracted attention in studies of tumor progression. We aimed to test whether transient Adriamycin treatment induces EMT and apoptosis simultaneously in...... hiện toàn bộ
Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors
Clinical Cancer Research - Tập 17 Số 2 - Trang 337-345 - 2011
Mohid S. Khan, Theodora Tsigani, Mohammed Rashid, Jeremy S. Rabouhans, Dominic Yu, Tu Vinh Luong, Martyn Caplin, Tim Meyer
Abstract Purpose: Neuroendocrine tumors (NET) are heterogeneous tumors with widely variable survival. It is unknown whether they express EpCAM (epithelial cell adhesion molecule) and thus whether NET circulating tumor cells (CTC) are detectable. We systematically investigated EpCAM expression and CTC detection in patients with metastatic NETs and eva...... hiện toàn bộ
Dendritic Cells Fused with Allogeneic Colorectal Cancer Cell Line Present Multiple Colorectal Cancer–Specific Antigens and Induce Antitumor Immunity against Autologous Tumor Cells
Clinical Cancer Research - Tập 11 Số 21 - Trang 7891-7900 - 2005
Shigeo Koido, Eiichi Hara, Sadamu Homma, Akihiro Torii, Yoichi Toyama, Hidejiro Kawahara, Michiaki Watanabe, Katsuhiko Yanaga, Kiyotaka Fujise, Hisao Tajiri, Jianlin Gong, Gotaro Toda
Abstract The aim of antitumor immunotherapy is to induce CTL responses against autologous tumors. Previous work has shown that fusion of human dendritic cells and autologous tumor cells induce CTL responses against autologous tumor cells in vitro. However, in the clinical setting of patients with colorectal carcinoma, a major difficulty is the prepar...... hiện toàn bộ
Distinguishing Clinicopathologic Features of Patients with V600E and V600K BRAF-Mutant Metastatic Melanoma
Clinical Cancer Research - Tập 18 Số 12 - Trang 3242-3249 - 2012
Alexander M. Menzies, Lauren E. Haydu, Lydia Visintin, Matteo S. Carlino, Julie R. Howle, John F. Thompson, Richard Kefford, Richard A. Scolyer, Georgina V. Long
Abstract Purpose: Certain clinicopathologic features correlate with BRAF mutation status in melanoma including younger age and primary subtype. This study sought to determine the BRAF mutation status by age-decade and whether BRAF-mutant genotypes correlated with clinicopathologic features and outcome in patients with metastatic melanoma. ...... hiện toàn bộ
Metformin: A Therapeutic Opportunity in Breast Cancer
Clinical Cancer Research - Tập 16 Số 6 - Trang 1695-1700 - 2010
Ana María González-Angulo, Funda Meric‐Bernstam
Abstract Two important, related pathways are involved in cancer growth: the insulin/insulin-like growth factor-1 (IGF1) signaling pathway, which is activated when nutrients are available, and the adenosine mono-phosphate-activated protein kinase (AMPK) pathway, activated when cells are starved for carbohydrates. Metformin inhibits transcription of ke...... hiện toàn bộ
Comprehensive Genomic Analysis Reveals Clinically Relevant Molecular Distinctions between Thymic Carcinomas and Thymomas
Clinical Cancer Research - Tập 15 Số 22 - Trang 6790-6799 - 2009
Nicolas Girard, Ronglai Shen, Tianhua Guo, Maureen F. Zakowski, Adriana Heguy, Gregory J. Riely, James Huang, Carmen Lau, Alex E. Lash, Marc Ladanyi, Agnès Viale, Cristina R. Antonescu, William D. Travis, Valerie W. Rusch, Mark G. Kris, William Pao
Abstract Purpose: Thymomas and thymic carcinomas are rare intrathoracic malignancies that can be invasive and refractory to conventional treatment. Because these tumors both originate from the thymus, they are often grouped together clinically. However, whether the underlying biology of these tumors warrants such clustering is unclear, and the optimu...... hiện toàn bộ
Association of HER2/ErbB2 Expression and Gene Amplification with Pathologic Features and Prognosis in Esophageal Adenocarcinomas
Clinical Cancer Research - Tập 18 Số 2 - Trang 546-554 - 2012
Harry H. Yoon, Qian Shi, William R. Sukov, Anne E. Wiktor, Maliha Khan, Christopher A. Sattler, Axel Grothey, Tsung‐Teh Wu, Robert B. Diasio, Robert B. Jenkins, Frank A. Sinicrope
Abstract Purpose: We examined the frequency, tumor characteristics, and prognostic impact of HER2 protein expression and gene amplification in patients with curatively resected esophageal adenocarcinoma (EAC). Experimental Design: HER2 expression was analyzed by immunohistochemistry (IHC) in surgical EAC specimens (n =...... hiện toàn bộ
A Phase I and Pharmacologic Trial of Two Schedules of the Proteasome Inhibitor, PS-341 (Bortezomib, Velcade), in Patients with Advanced Cancer
Clinical Cancer Research - Tập 11 Số 9 - Trang 3410-3416 - 2005
Grace K. Dy, James P. Thomas, George Wilding, Laura M. Bruzek, Sumithra J. Mandrekar, Charles Erlichman, Dona Alberti, Kim Binger, Henry C. Pitot, Steven R. Alberts, Lorelei J. Hanson, Rebecca Marnocha, Kendra D. Tutsch, Scott H. Kaufmann, Alex A. Adjei
Abstract Purpose: To define the toxicities, pharmacodynamics, and clinical activity of the proteasome inhibitor, PS-341 (bortezomib), in patients with advanced malignancies. Patients and Methods: Twenty-eight patients (14 male and 14 female) received PS-341 twice weekly for 4 of 6 weeks (schedule I). Because toxicity n...... hiện toàn bộ
Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Clinical Cancer Research - Tập 23 Số 14 - Trang 3918-3928 - 2017
Wenhao Weng, Qing Wei, Shusuke Toden, Kazuhiro Yoshida, Takeshi Nagasaka, Toshiyoshi Fujiwara, Sanjun Cai, Huanlong Qin, Yanlei Ma, Ajay Goel
Abstract Purpose: Colorectal cancer is one of the most common malignancies worldwide. Recently, a novel circular RNA, ciRS-7, was proposed to be a potential miR-7 sponge. As miR-7, a putative tumor-suppressor, regulates the expression of several important drivers of colorectal cancer, we analyzed the clinical significance of ciRS-7 in colorectal canc...... hiện toàn bộ
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