Cellular and Molecular Life Sciences
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Methylmalonic acid — an endogenous toxin?
Cellular and Molecular Life Sciences - Tập 62 - Trang 621-624 - 2005
Methylmalonic acid was previously considered as major neurotoxin in methylmalonic acidurias. In contrast, recent studies support the notion that other metabolites deriving from propionyl-coenzyme A, inducing synergistic inhibition of mitochondrial energy metabolism, are more important than methylmalonic acid to understand the neuropathogenesis of this disease. However, it is not yet known whether ......
Disaccharidase rhythm in rat small intestine; no relationship with mitosis rhythm
Cellular and Molecular Life Sciences - Tập 34 - Trang 700-701 - 1978
Same circadian difference in the specific activities of sucrase and maltase was observed in the purified brush border fraction as in the crude homogenate of the mucosa of rat small intestine, suggesting that the disaccharidase rhythm is not due to the mitosis rhythm of epithelial cells.
Guidance of circular RNAs to proteins’ behavior as binding partners
Cellular and Molecular Life Sciences - Tập 76 - Trang 4233-4243 - 2019
Circular RNAs (circRNAs) are single-stranded and covalently closed back-splicing products of pre-mRNAs. They can be derived from exons, introns, or exons with intron retained between exons of transcripts, as well as antisense transcripts. CircRNAs have been reported to function as microRNA sponges, regulate gene transcription mediated by RNA polymerase II, and modulate the splicing or stability of......
The role of chemokines and their receptors in angiogenesis
Cellular and Molecular Life Sciences - Tập 68 - Trang 2811-2830 - 2011
Chemokines are a vertebrate-specific group of small molecules that regulate cell migration and behaviour in diverse contexts. So far, around 50 chemokines have been identified in humans, which bind to 18 different chemokine receptors. These are members of the seven-transmembrane receptor family. Initially, chemokines were identified as modulators of the immune response. Subsequently, they were als......
Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells
Cellular and Molecular Life Sciences - - 2002
Avian influenza viruses infecting humans
Cellular and Molecular Life Sciences - Tập 57 Số 12 - Trang 1770-1784 - 2000
More than just scanning: the importance of cap-independent mRNA translation initiation for cellular stress response and cancer
Cellular and Molecular Life Sciences - - 2017
The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice
Cellular and Molecular Life Sciences - Tập 79 - Trang 1-15 - 2022
The gut and brain link via various metabolic and signalling pathways, each with the potential to influence mental, brain and cognitive health. Over the past decade, the involvement of the gut microbiota in gut–brain communication has become the focus of increased scientific interest, establishing the microbiota–gut–brain axis as a field of research. There is a growing number of association studies......
Ctenidins: antimicrobial glycine-rich peptides from the hemocytes of the spider Cupiennius salei
Cellular and Molecular Life Sciences - Tập 67 - Trang 2787-2798 - 2010
Three novel glycine-rich peptides, named ctenidin 1–3, with activity against the Gram-negative bacterium E. coli, were isolated and characterized from hemocytes of the spider Cupiennius salei. Ctenidins have a high glycine content (>70%), similarly to other glycine-rich peptides, the acanthoscurrins, from another spider, Acanthoscurria gomesiana. A combination of mass spectrometry, Edman degradati......
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