Cellular and Molecular Life Sciences
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Methylmalonic acid — an endogenous toxin?
Cellular and Molecular Life Sciences - Tập 62 - Trang 621-624 - 2005
Methylmalonic acid was previously considered as major neurotoxin in methylmalonic acidurias. In contrast, recent studies support the notion that other metabolites deriving from propionyl-coenzyme A, inducing synergistic inhibition of mitochondrial energy metabolism, are more important than methylmalonic acid to understand the neuropathogenesis of this disease. However, it is not yet known whether ......
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
Cellular and Molecular Life Sciences - Tập 78 - Trang 1233-1261 - 2020
Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide (LPS, endotoxin) of Gram-negative bacteria and sequentially triggers two signaling cascades: the first one involving TIRAP and MyD88 adaptor proteins is induced in the plasma membrane, whereas the second engaging adaptor proteins TRAM ......
Transposase and cointegrase: specialized transposition proteins of the bacterial insertion sequence IS21 and related elements
Cellular and Molecular Life Sciences - Tập 58 Số 3 - Trang 403-419 - 2001
The bacterial insertion sequence IS21 shares with many insertion sequences a two-step, reactive junction transposition pathway, for which a model is presented in this review: a reactive junction with abutted inverted repeats is first formed and subsequently integrated into the target DNA. The reactive junction occurs in IS21-IS21 tandems and IS21 minicircles. In addition, IS21 shows a unique speci......
Regulatory mechanisms of EGFR signalling during Drosophila eye development
Cellular and Molecular Life Sciences - Tập 73 Số 9 - Trang 1825-1843 - 2016
Disaccharidase rhythm in rat small intestine; no relationship with mitosis rhythm
Cellular and Molecular Life Sciences - Tập 34 - Trang 700-701 - 1978
Same circadian difference in the specific activities of sucrase and maltase was observed in the purified brush border fraction as in the crude homogenate of the mucosa of rat small intestine, suggesting that the disaccharidase rhythm is not due to the mitosis rhythm of epithelial cells.
Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2
Cellular and Molecular Life Sciences - Tập 63 - Trang 235-245 - 2006
Cyclotides are cyclic plant proteins with potent cytotoxic effects. Here we systematically probed the importance of surface-exposed charged amino acid residues of the cyclotide cycloviolacin O2, using a strategy involving chemical modifications. We show that the single glutamic acid plays a key role for the cytotoxicity: methylation of this residue produced a 48-fold decrease in potency. Virtually......
Circadian rhythmicity is involved in photoperiodic time measurement in the aphidMegoura viciae
Cellular and Molecular Life Sciences - Tập 49 - Trang 711-713 - 1993
The photoperiodic clock in the vetch aphidMegoura viciae is generally accepted to be based on a non-circadian mechanism or “hourglass”, as no evidence has been found for the involvement of the circadian system in the photoperiodic response. By using a recently-devised protocol which discriminates between single and repeated night length measurement, we demonstrate here that long-night measurement ......
Guidance of circular RNAs to proteins’ behavior as binding partners
Cellular and Molecular Life Sciences - Tập 76 - Trang 4233-4243 - 2019
Circular RNAs (circRNAs) are single-stranded and covalently closed back-splicing products of pre-mRNAs. They can be derived from exons, introns, or exons with intron retained between exons of transcripts, as well as antisense transcripts. CircRNAs have been reported to function as microRNA sponges, regulate gene transcription mediated by RNA polymerase II, and modulate the splicing or stability of......
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