Cellular and Molecular Life Sciences
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Lipids in the cell: organisation regulates function
Cellular and Molecular Life Sciences - Tập 75 Số 11 - Trang 1909-1927 - 2018
Reply to Dr. Götz and colleagues
Cellular and Molecular Life Sciences - Tập 66 - Trang 2947-2947 - 2009
The defensive function of cyanogenesis in natural populations
Cellular and Molecular Life Sciences - Tập 33 Số 3 - Trang 309-311 - 1977
GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation
Cellular and Molecular Life Sciences - - 2011
Granulin-epithelin precursor (GEP) is an autocrine growth factor that has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation. Here we report that GEP was expressed in skeletal muscle tissue and its level was differentially altered in the course of C2C12 myoblast fusion. The GEP expression during myoblast fusion was a consequence of MyoD transcription factor binding to several E-box (CANNTG) sequences in the 5′-flanking regulatory region of GEP gene, followed by transcription. Recombinant GEP potently inhibited myotube formation from C2C12 myoblasts whereas the knockdown of endogenous of GEP via a siRNA approach accelerated the fusion of myoblasts to myotubes. Interestingly, the muscle fibers of GEP knockdown mice were larger in number but noticeably smaller in size when compared to the wild-type. Mechanistic studies revealed that during myoblast fusion, the addition of GEP led to remarkable reductions in the expressions of muscle-specific transcription factors, including MyoD. In addition, the regulation of myotube formation by GEP is mediated by the anti-myogenic factor JunB, which is upregulated following GEP stimulation. Thus, GEP growth factor, JunB, and MyoD transcription factor form a regulatory loop and act in concert in the course of myogenesis.
Localization of monoamines in the lower brain stem
Cellular and Molecular Life Sciences - Tập 20 Số 7 - Trang 398-399 - 1964
Neurosteroid enhances glutamate release in rat prelimbic cortex via activation of α1-adrenergic and σ1 receptors
Cellular and Molecular Life Sciences - Tập 62 Số 9 - Trang 1003-1014 - 2005
γ-Aminobutyric acid (GABA) signalling in plants
Cellular and Molecular Life Sciences - Tập 74 Số 9 - Trang 1577-1603 - 2017
Metabolic studies on the accumulation of tetraphenylporphinesulfonate in tumors
Cellular and Molecular Life Sciences - Tập 23 Số 11 - Trang 949-950 - 1967
Histone chaperone CAF-1: essential roles in multi-cellular organism development
Cellular and Molecular Life Sciences - Tập 72 - Trang 327-337 - 2014
More and more studies have shown chromatin remodelers and histone modifiers play essential roles in regulating developmental patterns by organizing specific chromosomal architecture to establish programmed transcriptional profiles, with implications that histone chaperones execute a coordinating role in these processes. Chromatin assembly factor-1 (CAF-1), an evolutionarily conserved three-subunit protein complex, was identified as a histone chaperone coupled with DNA replication and repair in cultured mammalian cells and yeasts. Interestingly, recent findings indicate CAF-1 may have important regulatory roles during development by interacting with specific transcription factors and epigenetic regulators. In this review, we focus on the essential roles of CAF-1 in regulating heterochromatin organization, asymmetric cell division, and specific signal transduction through epigenetic modulations of the chromatin. In the end, we aim at providing a current image of facets of CAF-1 as a histone chaperone to orchestrate cell proliferation and differentiation during multi-cellular organism development.
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