Tissue‐specific expression of dentin sialophosphoprotein (DSPP) and its polymorphisms in mouse tissuesCell Biology International - Tập 33 - Trang 816-829 - 2009
Guohua Yuan, Yinghua Wang, Jelica Gluhak-Heinrich, Guobin Yang, Lei Chen, Tong Li, Li-An Wu, Zhi Chen, Mary MacDougall, Shuo Chen
AbstractDentin sialophosphoprotein (DSPP) consists of dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). DSPP is highly expressed in mineralized tissues. However, recent studies have shown that DSPP is also expressed in several active metabolic ductal epithelial tissues and exists in a variety of sequences. We have investigated DSPP expression in various mo...... hiện toàn bộ
Realgar‐induced differentiation is associated with MAPK pathways in HL‐60 cellsCell Biology International - Tập 32 - Trang 1497-1505 - 2008
Nan Wang, Li-Wen Wang, Bao-Di Gou, Tian-Lan Zhang, Kui Wang
AbstractThe clinical efficacy and safety of realgar (arsenic sulfide, As4S4) in the treatment of acute promyelocytic leukemia in China have given rise to an upsurge in research on the underlying mechanism. We prepared realgar nanoparticles (RNPs) to examine their effect on the differentiation of H...... hiện toàn bộ
ROTOKINESIS, A NOVEL PHENOMENON OF CELL LOCOMOTION‐ASSISTED CYTOKINESIS IN THE CILIATE TETRAHYMENA THERMOPHILACell Biology International - Tập 23 - Trang 841-848 - 1999
Jason M Brown, Clyde Hardin, Jacek Gaertig
AbstractThe mechanism responsible for final cell separation at the end of cytokinesis is currently unknown. Knockout strains of the ciliate, Tetrahymena thermophila lacking the kinesin‐II homologous molecular motors, Kin1p and Kin2p are paralyzed due to their complete loss of cilia and undergo frequent cytokinesis failures. Observations o...... hiện toàn bộ
THE EFFECT OF CYTOCHALASIN J ON KINETOCHORE STRUCTURE IN PTK1CELLS IS MITOTIC CYCLE DEPENDENTCell Biology International - Tập 25 - Trang 815-820 - 2001
Gregory A. Wrench, Judith A. Snyder
Mitotic PtK1cells were arrested in mitosis with nocodazole to determine the effect of cytochalasin J (CJ) on kinetochore structure in arrested and nocodazole‐released cells. In previous studies it was shown that CJ had a more pronounced effect on alteration of kinetochore structure and spindle microtubule (MT) architecture when applied during prophase or prometaphase. ...... hiện toàn bộ
Changes in signaling pathways of cell proliferation and apoptosis during NK/Ly lymphoma agingCell Biology International - Tập 32 - Trang 1057-1063 - 2008
R.R. Panchuk, N.M. Boiko, M.D. Lootsik, R.S. Stoika
AbstractExpression of specific proteins involved in regulation of cell proliferation and apoptosis was studied at the initial (7–8 days after tumor inoculation), median (13–14 days), and terminal (20–21 days) stages of murine NK/Ly lymphoma development. Western‐blot analysis using antibodies to MEK—ERK signaling pathway, E2F‐1/2 and c‐Myc, pSTAT1, pSTAT3, pSTAT5, a...... hiện toàn bộ
OESTRADIOL REGULATED PROGRAMMED CELL DEATH IN RAT VAGINA: TERMINAL DIFFERENTIATION OR APOPTOSIS?Cell Biology International - Tập 22 - Trang 105-113 - 1998
K.SRIDHAR RAO, S ZANOTTI, A.G REDDY, F RAUCH, H.G MANNHERZ, P.D GUPTA
Rat vaginal epithelial cells (VEC) undergo division and differentiation under the influence of oestradiol in a programmed manner. The differentiation process of VEC leads to keratinization, cornification and subsequent desquamation of the dead cells. This process of programmed cell death, referred to as terminal differentiation may share some common pathways with cell death by apoptosis bu...... hiện toàn bộ
Three‐dimensional matrix induces sustained activation of ERK1/2 via Src/Ras/Raf signaling pathwayCell Biology International - Tập 32 - Trang 229-234 - 2008
Ralica Damianova, Nadezhda Stefanova, Edna Cukierman, Albena Momchilova, Roumen Pankov
AbstractResearch in cell signaling often depends on tissue culture, but the artificial substrates used to grow cells in vitro are likely to distort the conclusions, particularly when adhesion‐mediated signaling events are investigated. Studies of signal transduction pathways operating in cells grown in three‐dimensional (3D) matrices prov...... hiện toàn bộ
Transglutaminase 2 activity promotes membrane resealing after mechanical damage in the lung cancer cell line A549Cell Biology International - Tập 32 - Trang 928-934 - 2008
Yoshiki Kawai, Fumitaka Wada, Yoshiaki Sugimura, Masatoshi Maki, Kiyotaka Hitomi
AbstractTransglutaminase is a Ca2+‐dependent enzyme catalyzing protein cross‐linking reactions. We investigated the contribution of this enzyme to the resealing of the injured plasma membrane in animal cells, using a lung cancer‐derived cell line, A549. After mechanical injury by razor‐scratching, the level of membrane resealing was estimated b...... hiện toàn bộ