Cancer Research

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Fibronectin Stimulates Non–Small Cell Lung Carcinoma Cell Growth through Activation of Akt/Mammalian Target of Rapamycin/S6 Kinase and Inactivation of LKB1/AMP-Activated Protein Kinase Signal Pathways
Cancer Research - Tập 66 Số 1 - Trang 315-323 - 2006
ShouWei Han, Fadlo R. Khuri, Jesse Roman
Abstract The Akt/mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K) pathway is considered a central regulator of protein synthesis and of cell proliferation, differentiation, and survival. However, the role of the Akt/mTOR/p70S6K pathway in lung carcinoma remains unknown. We previously showed that fibronectin, a matrix glycopro...... hiện toàn bộ
Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness
Cancer Research - Tập 71 Số 11 - Trang 3980-3990 - 2011
Jun Ki Hong, Jian Zhou, Junjiang Fu, Tao He, Jun Qin, Li Wang, Lan Liao, Jianming Xu
Abstract Twist1, a basic helix–loop–helix transcription factor, promotes breast tumor cell epithelial–mesenchymal transition (EMT), invasiveness, and metastasis. However, the mechanisms responsible for regulating Twist1 stability are unknown in these cells. We identified the serine 68 (Ser 68) as a major phosphorylation site of Twist1 by mass spectro...... hiện toàn bộ
Defining the Hallmarks of Metastasis
Cancer Research - Tập 79 Số 12 - Trang 3011-3027 - 2019
Danny R. Welch, Douglas R. Hurst
AbstractMetastasis is the primary cause of cancer morbidity and mortality. The process involves a complex interplay between intrinsic tumor cell properties as well as interactions between cancer cells and multiple microenvironments. The outcome is the development of a nearby or distant discontiguous secondary mass. To successfully disseminate, metastatic cells acqu...... hiện toàn bộ
Circular RNA and miR-7 in Cancer
Cancer Research - Tập 73 Số 18 - Trang 5609-5612 - 2013
Thomas B. Hansen, Jørgen Kjems, Christian Kroun Damgaard
Abstract MicroRNAs (miRNA) play important roles in fine-tuning gene expression and are often deregulated in cancer. The identification of competing endogenous RNA and circular RNA (circRNA) as important regulators of miRNA activity underscores the increasing complexity of ncRNA-mediated regulatory networks. Particularly, the recently identified circu...... hiện toàn bộ
Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors
Cancer Research - Tập 83 Số 9 - Trang 1393-1409 - 2023
Takeru Oka, Tsunaki Higa, Osamu Sugahara, Daisuke Koga, Shogo Nakayama, Keiichi I. Nakayama
Abstract Quiescent cancer stem cells (CSC) are resistant to conventional anticancer treatments and have been shown to contribute to disease relapse after therapy in some cancer types. The identification and characterization of quiescent CSCs could facilitate the development of strategies t...... hiện toàn bộ
MUC4 Mucin Interacts with and Stabilizes the HER2 Oncoprotein in Human Pancreatic Cancer Cells
Cancer Research - Tập 68 Số 7 - Trang 2065-2070 - 2008
Pallavi Chaturvedi, Ajay P. Singh, Subhankar Chakraborty, Subhash C. Chauhan, Sangeeta Bafna, Jane L. Meza, Pankaj K. Singh, Michael A. Hollingsworth, Parmender P. Mehta, Surinder K. Batra
Abstract MUC4, a high–molecular weight transmembrane glycoprotein, is overexpressed in pancreatic cancer and is implicated in its pathogenesis. It is a heterodimeric protein containing a large extracellular, heavily glycosylated subunit, MUC4α, and a transmembrane growth factor–like subunit, MUC4β. In the present study, we have shown the interaction ...... hiện toàn bộ
Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy
Cancer Research - Tập 75 Số 22 - Trang 4669-4674 - 2015
Srustidhar Das, Surinder K. Batra
Abstract CA125, the most widely used ovarian cancer biomarker, was first identified approximately 35 years ago in an antibody screen against ovarian cancer antigen. Two decades later, it was cloned and characterized to be a transmembrane mucin, MUC16. Since then, several studies have investigated its expression, functional, and mechanistic involvemen...... hiện toàn bộ
Aberrant Activation of Notch Signaling in Human Breast Cancer
Cancer Research - Tập 66 Số 3 - Trang 1517-1525 - 2006
Spyros Stylianou, Robert B. Clarke, Keith Brennan
Abstract A role for Notch signaling in human breast cancer has been suggested by both the development of adenocarcinomas in the murine mammary gland following pathway activation and the loss of Numb expression, a negative regulator of the Notch pathway, in a large proportion of breast carcinomas. However, it is not clear currently whether Notch signa...... hiện toàn bộ
Molecular Dependence of Estrogen Receptor–Negative Breast Cancer on a Notch-Survivin Signaling Axis
Cancer Research - Tập 68 Số 13 - Trang 5273-5281 - 2008
Connie W. Lee, Christopher M. Raskett, Igor Prudovsky, Dario C. Altieri
Abstract Despite progress in the management of breast cancer, the molecular underpinnings of clinically aggressive subtypes of the disease are not well-understood. Here, we show that activation of Notch developmental signaling in estrogen receptor (ER)–negative breast cancer cells results in direct transcriptional up-regulation of the apoptosis inhib...... hiện toàn bộ
Role of Survivin in EGFR Inhibitor–Induced Apoptosis in Non–Small Cell Lung Cancers Positive for EGFR Mutations
Cancer Research - Tập 70 Số 24 - Trang 10402-10410 - 2010
Kunio Okamoto, Isamu Okamoto, Wataru Okamoto, Kaoru Tanaka, Ken Takezawa, Kiyoko Kuwata, Haruka Yamaguchi, Kazuto Nishio, Kazuhiko Nakagawa
Abstract The molecular mechanism by which epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR-TKI) induce apoptosis in non–small cell-lung cancer (NSCLC) cells that are positive for activating mutations of the EGFR remains unclear. In this study, we report the effects of the EGFR-TKI gefitinib on expression of the antiapoptotic protein ...... hiện toàn bộ
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