Cancer Research

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Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy
Cancer Research - Tập 75 Số 22 - Trang 4669-4674 - 2015
Srustidhar Das, Surinder K. Batra
Abstract CA125, the most widely used ovarian cancer biomarker, was first identified approximately 35 years ago in an antibody screen against ovarian cancer antigen. Two decades later, it was cloned and characterized to be a transmembrane mucin, MUC16. Since then, several studies have investigated its expression, functional, and mechanistic involvemen...... hiện toàn bộ
Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2 Checkpoint and Inhibition of Homologous Recombinational DNA Repair
Cancer Research - Tập 70 Số 12 - Trang 4972-4981 - 2010
Meredith A. Morgan, Leslie A. Parsels, Lili Zhao, Joshua D. Parsels, Mary A. Davis, Maria Hassan, Sankari Arumugarajah, Linda Hylander-Gans, Deborah Morosini, Diane M. Simeone, Christine E. Canman, Daniel P. Normolle, Sonya Zabludoff, Jonathan Maybaum, Theodore S. Lawrence
Abstract The median survival for patients with locally advanced pancreatic cancer treated with gemcitabine and radiation is approximately 1 year. To develop improved treatment, we have combined a Chk1/2-targeted agent, AZD7762, currently in phase I clinical trials, with gemcitabine and ionizing radiation in preclinical pancreatic tumor models. We fou...... hiện toàn bộ
Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties
Cancer Research - Tập 65 Số 13 - Trang 5506-5511 - 2005
Dario Ponti, Aurora Costa, Nadia Zaffaroni, Graziella Pratesi, Giovanna Petrangolini, Danila Coradini, Silvana Pilotti, Marco A. Pierotti, Maria Grazia Daidone
Abstract Breast cancer–initiating cells have been recently identified in breast carcinoma as CD44+/CD24−/low cells, which exclusively retain tumorigenic activity and display stem cell–like properties. However, at present, direct evidence that breast cancer–initiating cells can be propagated in vitro is still lacking. We report here the isolation and ...... hiện toàn bộ
Sleep Duration and Breast Cancer: A Prospective Cohort Study
Cancer Research - Tập 65 Số 20 - Trang 9595-9600 - 2005
Pia K. Verkasalo, Kirsi Lillberg, Richard G. Stevens, Christer Hublin, Markku Partinen, Markku Koskenvuo, Jaakko Kaprio
Abstract Breast cancer incidence has increased during recent decades for reasons that are only partly understood. Prevalence of sleeping difficulties and sleepiness has increased, whereas sleeping duration per night has decreased. We hypothesized that there is an inverse association between sleep duration and breast cancer risk, possibly due to great...... hiện toàn bộ
Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma
Cancer Research - Tập 72 Số 7 - Trang 1773-1783 - 2012
Yu-Long Hu, Michael DeLay, Arman Jahangiri, Annette M. Molinaro, Samuel D. Rose, W. Shawn Carbonell, Manish K. Aghi
Abstract Antiangiogenic therapy leads to devascularization that limits tumor growth. However, the benefits of angiogenesis inhibitors are typically transient and resistance often develops. In this study, we explored the hypothesis that hypoxia caused by antiangiogenic therapy induces tumor cell autophagy as a cytoprotective adaptive response, thereby...... hiện toàn bộ
Faciogenital Dysplasia Protein Fgd1 Regulates Invadopodia Biogenesis and Extracellular Matrix Degradation and Is Up-regulated in Prostate and Breast Cancer
Cancer Research - Tập 69 Số 3 - Trang 747-752 - 2009
Inmaculada Ayala, Giada Giacchetti, Giusi Caldieri, Francesca Attanasio, Stefania Mariggiò, Stefano Tetè, Roman Polishchuk, Vincent Castronovo, Roberto Buccione
Abstract Invadopodia are proteolytically active membrane protrusions that extend from the ventral surface of invasive tumoral cells grown on an extracellular matrix (ECM). The core machinery controlling invadopodia biogenesis is regulated by the Rho GTPase Cdc42. To understand the upstream events regulating invadopodia biogenesis, we investigated the...... hiện toàn bộ
An EGFR–Src–Arg–Cortactin Pathway Mediates Functional Maturation of Invadopodia and Breast Cancer Cell Invasion
Cancer Research - Tập 71 Số 5 - Trang 1730-1741 - 2011
Christopher C. Mader, Matthew G. Oser, Marco Magalhaes, Jose Javier Bravo‐Cordero, John S. Condeelis, Anthony J. Koleske, Hava Gil-Henn
AbstractInvasive carcinoma cells use specialized actin polymerization–driven protrusions called invadopodia to degrade and possibly invade through the extracellular matrix (ECM) during metastasis. Phosphorylation of the invadopodium protein cortactin is a master switch that activates invadopodium maturation and function. Cortactin was originally identified as a hyp...... hiện toàn bộ
JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms
Cancer Research - Tập 75 Số 11 - Trang 2187-2199 - 2015
Kathrin Schönberg, Janna Rudolph, Maria Vonnahme, Sowmya Parampalli Yajnanarayana, Isabelle Cornez, Maryam Hejazi, Angela R. Manser, Markus Uhrberg, Walter Verbeek, Steffen Koschmieder, Tim H. Brümmendorf, Peter Brossart, Annkristin Heine, Dominik Wolf‎
Abstract Ruxolitinib is a small-molecule inhibitor of the JAK kinases, which has been approved for the treatment of myelofibrosis, a rare myeloproliferative neoplasm (MPN), but clinical trials are also being conducted in inflammatory-driven solid tumors. Increased infection rates have been reported in ruxolitinib-treated patients, and natural killer ...... hiện toàn bộ
Twist Overexpression Induces In vivo Angiogenesis and Correlates with Chromosomal Instability in Breast Cancer
Cancer Research - Tập 65 Số 23 - Trang 10801-10809 - 2005
Yelena Mironchik, Paul T. Winnard, Farhad Vesuna, Yoshinori Katō, Flonné Wildes, Arvind P. Pathak, Scott L. Kominsky, Dmitri Artemov, Zaver M. Bhujwalla, Paul van Diest, Horst Bürger, Carlotta A. Glackin, Venu Raman
Abstract Aggressive cancer phenotypes are a manifestation of many different genetic alterations that promote rapid proliferation and metastasis. In this study, we show that stable overexpression of Twist in a breast cancer cell line, MCF-7, altered its morphology to a fibroblastic-like phenotype, which exhibited protein markers representative of a me...... hiện toàn bộ
The Connectivity Map Links Iron Regulatory Protein-1–Mediated Inhibition of Hypoxia-Inducible Factor-2a Translation to the Anti-inflammatory 15-deoxy-Δ12,14-Prostaglandin J2
Cancer Research - Tập 70 Số 8 - Trang 3071-3079 - 2010
Michael Zimmer, Justin Lamb, Benjamin L. Ebert, Mary C. Lynch, Neil Christopher, Emmett V. Schmidt, Todd R. Golub, Othon Iliopoulos
Abstract Hypoxia-inducible factors 1 and 2 (HIF1 and HIF2) are heterodimeric transcription factors consisting of α regulatory subunits and a constitutively expressed β subunit. The expression of α regulatory subunits is promoted by hypoxia, cancer-associated mutations, and inflammatory cytokines. Thus, HIF1 and HIF2 provide a molecular link between c...... hiện toàn bộ
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