Cancer Research

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Fibronectin Stimulates Non–Small Cell Lung Carcinoma Cell Growth through Activation of Akt/Mammalian Target of Rapamycin/S6 Kinase and Inactivation of LKB1/AMP-Activated Protein Kinase Signal Pathways
Cancer Research - Tập 66 Số 1 - Trang 315-323 - 2006
ShouWei Han, Fadlo R. Khuri, Jesse Roman
Abstract The Akt/mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K) pathway is considered a central regulator of protein synthesis and of cell proliferation, differentiation, and survival. However, the role of the Akt/mTOR/p70S6K pathway in lung carcinoma remains unknown. We previously showed that fibronectin, a matrix glycopro...... hiện toàn bộ
Defining the Hallmarks of Metastasis
Cancer Research - Tập 79 Số 12 - Trang 3011-3027 - 2019
Danny R. Welch, Douglas R. Hurst
AbstractMetastasis is the primary cause of cancer morbidity and mortality. The process involves a complex interplay between intrinsic tumor cell properties as well as interactions between cancer cells and multiple microenvironments. The outcome is the development of a nearby or distant discontiguous secondary mass. To successfully disseminate, metastatic cells acqu...... hiện toàn bộ
Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors
Cancer Research - Tập 83 Số 9 - Trang 1393-1409 - 2023
Takeru Oka, Tsunaki Higa, Osamu Sugahara, Daisuke Koga, Shogo Nakayama, Keiichi I. Nakayama
Abstract Quiescent cancer stem cells (CSC) are resistant to conventional anticancer treatments and have been shown to contribute to disease relapse after therapy in some cancer types. The identification and characterization of quiescent CSCs could facilitate the development of strategies t...... hiện toàn bộ
Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy
Cancer Research - Tập 75 Số 22 - Trang 4669-4674 - 2015
Srustidhar Das, Surinder K. Batra
Abstract CA125, the most widely used ovarian cancer biomarker, was first identified approximately 35 years ago in an antibody screen against ovarian cancer antigen. Two decades later, it was cloned and characterized to be a transmembrane mucin, MUC16. Since then, several studies have investigated its expression, functional, and mechanistic involvemen...... hiện toàn bộ
Aberrant Activation of Notch Signaling in Human Breast Cancer
Cancer Research - Tập 66 Số 3 - Trang 1517-1525 - 2006
Spyros Stylianou, Robert B. Clarke, Keith Brennan
Abstract A role for Notch signaling in human breast cancer has been suggested by both the development of adenocarcinomas in the murine mammary gland following pathway activation and the loss of Numb expression, a negative regulator of the Notch pathway, in a large proportion of breast carcinomas. However, it is not clear currently whether Notch signa...... hiện toàn bộ
Molecular Dependence of Estrogen Receptor–Negative Breast Cancer on a Notch-Survivin Signaling Axis
Cancer Research - Tập 68 Số 13 - Trang 5273-5281 - 2008
Connie W. Lee, Christopher M. Raskett, Igor Prudovsky, Dario C. Altieri
Abstract Despite progress in the management of breast cancer, the molecular underpinnings of clinically aggressive subtypes of the disease are not well-understood. Here, we show that activation of Notch developmental signaling in estrogen receptor (ER)–negative breast cancer cells results in direct transcriptional up-regulation of the apoptosis inhib...... hiện toàn bộ
Basal Cell Carcinoma and Its Development
Cancer Research - Tập 64 Số 3 - Trang 934-941 - 2004
Mariateresa Mancuso, Simonetta Pazzaglia, Mirella Tanori, Heidi Hahn, Paola Merola, Simonetta Rebessi, Michael J. Atkinson, Vincenzo Di Majo, Vincenzo Covelli, Anna Saran
Abstract Loss-of-function mutations in Patched (Ptch1) are implicated in constitutive activation of the Sonic hedgehog pathway in human basal cell carcinomas (BCCs), and inherited Ptch1 mutations underlie basal cell nevus syndrome in which a typical feature is multiple BCC occurring with greater incidence in portals of radiotherapy. Mice in which one...... hiện toàn bộ
Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2 Checkpoint and Inhibition of Homologous Recombinational DNA Repair
Cancer Research - Tập 70 Số 12 - Trang 4972-4981 - 2010
Meredith A. Morgan, Leslie A. Parsels, Lili Zhao, Joshua D. Parsels, Mary A. Davis, Maria Hassan, Sankari Arumugarajah, Linda Hylander-Gans, Deborah Morosini, Diane M. Simeone, Christine E. Canman, Daniel P. Normolle, Sonya Zabludoff, Jonathan Maybaum, Theodore S. Lawrence
Abstract The median survival for patients with locally advanced pancreatic cancer treated with gemcitabine and radiation is approximately 1 year. To develop improved treatment, we have combined a Chk1/2-targeted agent, AZD7762, currently in phase I clinical trials, with gemcitabine and ionizing radiation in preclinical pancreatic tumor models. We fou...... hiện toàn bộ
Quantitative In situ Analysis of β-Catenin Expression in Breast Cancer Shows Decreased Expression Is Associated with Poor Outcome
Cancer Research - Tập 66 Số 10 - Trang 5487-5494 - 2006
Marisa Dolled‐Filhart, Anthony McCabe, Jennifer M. Giltnane, Melissa A. Cregger, Robert L. Camp, David L. Rimm
Abstract The role of β-catenin in breast cancer and its prognostic value is controversial. The prognostic value had been assessed previously in a series of nonquantitative immunohistochemical studies with conflicting results. In efforts to clarify the relationship between β-catenin protein expression and breast cancer prognosis, we have assessed a re...... hiện toàn bộ
Identifying Cancer Stem Cells in Solid Tumors: Case Not Proven
Cancer Research - Tập 66 Số 4 - Trang 1891-1896 - 2006
Rićhard P. Hill
AbstractBuilding on studies of leukemia, a number of recent articles have reported data suggesting that cancer stem cells could be isolated from solid human cancers. Some of these reports have speculated that the isolation of these cells will allow the identification of the specific molecular properties that can be targeted for therapeutic purposes. Although previo...... hiện toàn bộ
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