Cancer Research
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Fibronectin Stimulates Non–Small Cell Lung Carcinoma Cell Growth through Activation of Akt/Mammalian Target of Rapamycin/S6 Kinase and Inactivation of LKB1/AMP-Activated Protein Kinase Signal Pathways
Cancer Research - Tập 66 Số 1 - Trang 315-323 - 2006
Abstract The Akt/mammalian target of rapamycin (mTOR)/ribosomal protein S6
kinase (p70S6K) pathway is considered a central regulator of protein synthesis
and of cell proliferation, differentiation, and survival. However, the role of
the Akt/mTOR/p70S6K pathway in lung carcinoma remains unknown. We previously
showed that fibronectin, a matrix glycoprotein highly expressed in
tobacco-related lung di...
Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness
Cancer Research - Tập 71 Số 11 - Trang 3980-3990 - 2011
Abstract Twist1, a basic helix–loop–helix transcription factor, promotes breast
tumor cell epithelial–mesenchymal transition (EMT), invasiveness, and
metastasis. However, the mechanisms responsible for regulating Twist1 stability
are unknown in these cells. We identified the serine 68 (Ser 68) as a major
phosphorylation site of Twist1 by mass spectrometry and with specific
antibodies. This Ser 68 ...
Defining the Hallmarks of Metastasis
Cancer Research - Tập 79 Số 12 - Trang 3011-3027 - 2019
AbstractMetastasis is the primary cause of cancer morbidity and mortality. The
process involves a complex interplay between intrinsic tumor cell properties as
well as interactions between cancer cells and multiple microenvironments. The
outcome is the development of a nearby or distant discontiguous secondary mass.
To successfully disseminate, metastatic cells acquire properties in addition to
tho...
Circular RNA and miR-7 in Cancer
Cancer Research - Tập 73 Số 18 - Trang 5609-5612 - 2013
Abstract MicroRNAs (miRNA) play important roles in fine-tuning gene expression
and are often deregulated in cancer. The identification of competing endogenous
RNA and circular RNA (circRNA) as important regulators of miRNA activity
underscores the increasing complexity of ncRNA-mediated regulatory networks.
Particularly, the recently identified circular RNA, ciRS-7, which acts as a
designated miR-...
Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors
Cancer Research - Tập 83 Số 9 - Trang 1393-1409 - 2023
Abstract Quiescent cancer stem cells (CSC) are resistant to conventional
anticancer treatments and have been shown to contribute to disease relapse after
therapy in some cancer types. The identification and characterization of
quiescent CSCs could facilitate the development of strategies to target this
cell population and block recurrence. Here, we established a syngeneic
orthotopic transplantatio...
MUC4 Mucin Interacts with and Stabilizes the HER2 Oncoprotein in Human Pancreatic Cancer Cells
Cancer Research - Tập 68 Số 7 - Trang 2065-2070 - 2008
Abstract MUC4, a high–molecular weight transmembrane glycoprotein, is
overexpressed in pancreatic cancer and is implicated in its pathogenesis. It is
a heterodimeric protein containing a large extracellular, heavily glycosylated
subunit, MUC4α, and a transmembrane growth factor–like subunit, MUC4β. In the
present study, we have shown the interaction of human MUC4 with the receptor
tyrosine kinase ...
Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy
Cancer Research - Tập 75 Số 22 - Trang 4669-4674 - 2015
Abstract CA125, the most widely used ovarian cancer biomarker, was first
identified approximately 35 years ago in an antibody screen against ovarian
cancer antigen. Two decades later, it was cloned and characterized to be a
transmembrane mucin, MUC16. Since then, several studies have investigated its
expression, functional, and mechanistic involvement in multiple cancer types.
Antibody-based thera...
Aberrant Activation of Notch Signaling in Human Breast Cancer
Cancer Research - Tập 66 Số 3 - Trang 1517-1525 - 2006
Abstract A role for Notch signaling in human breast cancer has been suggested by
both the development of adenocarcinomas in the murine mammary gland following
pathway activation and the loss of Numb expression, a negative regulator of the
Notch pathway, in a large proportion of breast carcinomas. However, it is not
clear currently whether Notch signaling is frequently activated in breast
tumors, a...
Molecular Dependence of Estrogen Receptor–Negative Breast Cancer on a Notch-Survivin Signaling Axis
Cancer Research - Tập 68 Số 13 - Trang 5273-5281 - 2008
Abstract Despite progress in the management of breast cancer, the molecular
underpinnings of clinically aggressive subtypes of the disease are not
well-understood. Here, we show that activation of Notch developmental signaling
in estrogen receptor (ER)–negative breast cancer cells results in direct
transcriptional up-regulation of the apoptosis inhibitor and cell cycle
regulator survivin. This res...
Role of Survivin in EGFR Inhibitor–Induced Apoptosis in Non–Small Cell Lung Cancers Positive for EGFR Mutations
Cancer Research - Tập 70 Số 24 - Trang 10402-10410 - 2010
Abstract The molecular mechanism by which epidermal growth factor
receptor–tyrosine kinase inhibitors (EGFR-TKI) induce apoptosis in non–small
cell-lung cancer (NSCLC) cells that are positive for activating mutations of the
EGFR remains unclear. In this study, we report the effects of the EGFR-TKI
gefitinib on expression of the antiapoptotic protein survivin that have
functional consequences in EG...
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