Sleep Duration and Breast Cancer: A Prospective Cohort Study

Cancer Research - Tập 65 Số 20 - Trang 9595-9600 - 2005
Pia K. Verkasalo1, Kirsi Lillberg2, Richard G. Stevens3, Christer Hublin4, Markku Partinen5, Markku Koskenvuo6, Jaakko Kaprio7,8
11Department of Environmental Health, National Public Health Institute, Kuopio;
22Department of Public Health, University of Turku, Turku;
37Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut
43Finnish Institute of Occupational Health;
56Rinnekoti Research Centre, Espoo, Finland; and
64Department of Public Health, University of Helsinki;
74Department of Public Health, University of Helsinki;; 5Mental Health and Alcohol Research, National Public Health Institute, Helsinki;
85Mental Health and Alcohol Research, National Public Health Institute, Helsinki;

Tóm tắt

Abstract Breast cancer incidence has increased during recent decades for reasons that are only partly understood. Prevalence of sleeping difficulties and sleepiness has increased, whereas sleeping duration per night has decreased. We hypothesized that there is an inverse association between sleep duration and breast cancer risk, possibly due to greater overall melatonin production in longer sleepers. This population-based study includes information from women born in Finland before 1958. Sleep duration, other sleep variables, and breast cancer risk factors were assessed by self-administered questionnaires given in 1975 and in 1981. Breast cancer incidence data for 1976 to 1996 was obtained from the Finnish Cancer Registry. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained from Cox proportional hazards models adjusting for potential confounders. Altogether, 242 cases of breast cancer occurred over the study period among the 12,222 women with sleep duration data in 1975. For these women, the HRs for breast cancer in the short (≤6 hours), average (7-8 hours), and long sleep (≥9 hours) duration groups were 0.85 (CI, 0.54-1.34), 1.0 (referent), and 0.69 (CI, 0.45-1.06), respectively. Analysis restricted to the 7,396 women (146 cases) whose sleep duration in 1975 and 1981 were in the same duration group (stable sleepers) yielded HRs of 1.10 (CI, 0.59-2.05), 1.0, and 0.28 (CI, 0.09-0.88), with a decreasing trend (P = 0.03). This study provides some support for a decreased risk of breast cancer in long sleepers.

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Cancer Research

Tập 65 Số 20

9595-9600

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