Cancer Immunology Research

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Machine-Learning Prediction of Tumor Antigen Immunogenicity in the Selection of Therapeutic Epitopes
Cancer Immunology Research - Tập 7 Số 10 - Trang 1591-1604 - 2019
Christof C. Smith, Shengjie Chai, Amber R. Washington, Samuel Lee, Elisa Landoni, Kevin Field, Jason Garness, Lisa M. Bixby, Sara R. Selitsky, Joel S. Parker, Barbara Savoldo, Jonathan S. Serody, Benjamin G. Vincent
Abstract Current tumor neoantigen calling algorithms primarily rely on epitope/major histocompatibility complex (MHC) binding affinity predictions to rank and select for potential epitope targets. These algorithms do not predict for epitope immunogenicity using approaches modeled from tumor-specific antigen data. Here, we describe peptide-intrinsic biochemical features associated with neoantigen a... hiện toàn bộ
Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation
Cancer Immunology Research - Tập 2 Số 7 - Trang 616-631 - 2014
Eric R. Lutz, Annie A. Wu, Elaine Bigelow, Rajni Sharma, Guanglan Mo, Kevin C. Soares, Sara Solt, Alvin Dorman, Anthony Wamwea, Allison Yager, Daniel A. Laheru, Christopher L. Wolfgang, Jiang Wang, Ralph H. Hruban, Robert A. Anders, Elizabeth M. Jaffee, Lei Zheng
AbstractPancreatic ductal adenocarcinoma (PDAC) is considered a “nonimmunogenic” neoplasm. Single-agent immunotherapies have failed to demonstrate significant clinical activity in PDAC and other “nonimmunogenic” tumors, in part due to a complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. We designed a neoadjuvant and adjuvant clinical trial ... hiện toàn bộ
Decitabine Tăng Cường Sự Di Chuyển và Chức Năng của Lymphocyte và Hợp Tác Với Sự Chặn CTLA-4 Trong Mô Hình Ung Thư Buồng Trứng Ở Chuột Dịch bởi AI
Cancer Immunology Research - Tập 3 Số 9 - Trang 1030-1041 - 2015
Li Wang, Zohreh Amoozgar, Jing Huang, Mohammad H. Saleh, Deyin Xing, Sandra Oršulić, Michael S. Goldberg
Tóm tắtThiếu các liệu pháp điều trị hàng thứ hai cho ung thư buồng trứng tái phát cần thiết phải phát triển các liệu pháp kết hợp được cải thiện. Liệu pháp nhắm đích và liệu pháp miễn dịch mỗi loại đều mang lại lợi ích lâm sàng, mặc dù hạn chế khi làm liệu pháp đơn. Ung thư buồng trứng không đặc biệt nhạy cảm với sự chặn điểm kiểm soát miễn dịch, vì vậy việc kết hợp với liệu pháp bổ sung có thể có... hiện toàn bộ
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma
Cancer Immunology Research - Tập 3 Số 4 - Trang 399-411 - 2015
Rafael Winograd, Katelyn T. Byrne, Rebecca A. Evans, Pamela M. Odorizzi, Anders R.L. Meyer, David L. Bajor, Cynthia Clendenin, Ben Z. Stanger, Emma E. Furth, E. John Wherry, Robert H. Vonderheide
Abstract Disabling the function of immune checkpoint molecules can unlock T-cell immunity against cancer, yet despite remarkable clinical success with monoclonal antibodies (mAb) that block PD-1 or CTLA-4, resistance remains common and essentially unexplained. To date, pancreatic carcinoma is fully refractory to these antibodies. Here, using a genetically engineered mouse model of pancreatic ducta... hiện toàn bộ
Mechanisms by Which Dendritic Cells Present Tumor Microparticle Antigens to CD8+ T Cells
Cancer Immunology Research - Tập 6 Số 9 - Trang 1057-1068 - 2018
Jingwei Ma, Keke Wei, Xiao‐Hui Zhang, Ke Tang, Fei Li, Junwei Liu, Pingwei Xu, Yuandong Yu, Weiwei Sun, Liyan Zhu, Jie Chen, Li Zhou, Xiaoyu Liang, Jiadi Lv, Roland Fiskesund, Yuying Liu, Bo Huang
Abstract Tumor cell–derived microparticles (T-MP) contain tumor antigen profiles as well as innate signals, endowing them with vaccine potential; however, the precise mechanism by which DCs present T-MP antigens to T cells remains unclear. Here, we show that T-MPs activate a lysosomal pathway that is required for DCs presenting tumor antigens of T-MPs. DCs endocytose T-MPs to lysosomes, where T-MP... hiện toàn bộ
Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer
Cancer Immunology Research - Tập 6 Số 12 - Trang 1486-1498 - 2018
Caterina Bartolacci, Cristina Andreani, Claudia Curcio, Sergio Occhipinti, Luca Massaccesi, Mirella Giovarelli, Roberta Galeazzi, Manuela Iezzi, Martina Tilio, Valentina Gambini, Junbiao Wang, Cristina Marchini, Augusto Amici
Abstract Δ16HER2 is a splice variant of HER2 and defined as the transforming isoform in HER2-positive breast cancer. It has been shown that Δ16HER2 promotes breast cancer aggressiveness and drug resistance. In the present work, we used in silico modeling to identify structural differences between Δ16HER2 and the wild-type HER2 proteins. We then developed DNA vaccines specifically against the Δ16HE... hiện toàn bộ
Mast Cells: Potential Positive and Negative Roles in Tumor Biology
Cancer Immunology Research - Tập 1 Số 5 - Trang 269-279 - 2013
Thomas Marichal, Mindy Tsai, Stephen J. Galli
Abstract Mast cells are immune cells that reside in virtually all vascularized tissues. Upon activation by diverse mechanisms, mast cells can secrete a broad array of biologically active products that either are stored in the cytoplasmic granules of the cells (e.g., histamine, heparin, various proteases) or are produced de novo upon cell stimulation (e.g., prostaglandins, leukotrienes, cytokines, ... hiện toàn bộ
NF-κB, an Active Player in Human Cancers
Cancer Immunology Research - Tập 2 Số 9 - Trang 823-830 - 2014
Yifeng Xia, Shen Shen, Inder M. Verma
Abstract NF-κB comprises a family of five transcription factors that form distinct protein complexes, which bind to consensus DNA sequences at promoter regions of responsive genes regulating cellular processes. The past three decades have witnessed remarkable progress in understanding the NF-κB signaling pathway in physiologic and pathologic conditions. The role of NF-κB in human cancer initiation... hiện toàn bộ
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer
Cancer Immunology Research - Tập 7 Số 4 - Trang 534-543 - 2019
Winifred Lo, Maria R. Parkhurst, Paul F. Robbins, Eric Tran, Yong‐Chen Lu, Lee Jia, Jared J. Gartner, Anna Pasetto, Drew C. Deniger, Parisa Malekzadeh, Thomas E. Shelton, Todd D. Prickett, Satyajit Ray, Scott Kivitz, Biman C. Paria, Isaac Kriley, David S. Schrump, Steven A. Rosenberg
Abstract Adoptive cell therapy (ACT) with T cells targeting neoantigens can mediate durable responses in patients with metastatic cancer. Cell therapies targeting common shared antigens for epithelial cancers are not yet broadly available. Here, we report the identification and characterization in one patient of T-cell receptors (TCRs) recognizing mutated p53 p.R175H, which is shared among a subse... hiện toàn bộ
Possible Interaction of Anti–PD-1 Therapy with the Effects of Radiosurgery on Brain Metastases
Cancer Immunology Research - Tập 4 Số 6 - Trang 481-487 - 2016
Ahmed Al‐Omari, Justine V. Cohen, Alexander O. Vortmeyer, Anne C. Chiang, Scott Gettinger, Sarah B. Goldberg, Harriet M. Kluger, Veronica Chiang
Abstract Delayed radiation-induced vasculitic leukoencephalopathy related to stereotactic radiosurgery (SRS) of brain metastases has been reported to manifest clinically 9 to 18 months after treatment. Immune-modulating therapies have been introduced to treatment regimens for malignancies with metastatic predilection to the brain. The interaction of these systemic therapies with other modalities o... hiện toàn bộ
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