Machine-Learning Prediction of Tumor Antigen Immunogenicity in the Selection of Therapeutic EpitopesCancer Immunology Research - Tập 7 Số 10 - Trang 1591-1604 - 2019
Christof C. Smith, Shengjie Chai, Amber R. Washington, Samuel Lee, Elisa Landoni, Kevin Field, Jason Garness, Lisa M. Bixby, Sara R. Selitsky, Joel S. Parker, Barbara Savoldo, Jonathan S. Serody, Benjamin G. Vincent
Abstract
Current tumor neoantigen calling algorithms primarily rely on epitope/major histocompatibility complex (MHC) binding affinity predictions to rank and select for potential epitope targets. These algorithms do not predict for epitope immunogenicity using approaches modeled from tumor-specific antigen data. Here, we describe peptide-intrinsic b...... hiện toàn bộ
Mechanisms by Which Dendritic Cells Present Tumor Microparticle Antigens to CD8+ T CellsCancer Immunology Research - Tập 6 Số 9 - Trang 1057-1068 - 2018
Jingwei Ma, Keke Wei, Xiao‐Hui Zhang, Ke Tang, Fei Li, Junwei Liu, Pingwei Xu, Yuandong Yu, Weiwei Sun, Liyan Zhu, Jie Chen, Li Zhou, Xiaoyu Liang, Jiadi Lv, Roland Fiskesund, Yuying Liu, Bo Huang
Abstract
Tumor cell–derived microparticles (T-MP) contain tumor antigen profiles as well as innate signals, endowing them with vaccine potential; however, the precise mechanism by which DCs present T-MP antigens to T cells remains unclear. Here, we show that T-MPs activate a lysosomal pathway that is required for DCs presenting tumor antigens of T-MP...... hiện toàn bộ
Mast Cells: Potential Positive and Negative Roles in Tumor BiologyCancer Immunology Research - Tập 1 Số 5 - Trang 269-279 - 2013
Thomas Marichal, Mindy Tsai, Stephen J. Galli
Abstract
Mast cells are immune cells that reside in virtually all vascularized tissues. Upon activation by diverse mechanisms, mast cells can secrete a broad array of biologically active products that either are stored in the cytoplasmic granules of the cells (e.g., histamine, heparin, various proteases) or are produced de novo upon cell stimulation ...... hiện toàn bộ
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal CancerCancer Immunology Research - Tập 7 Số 4 - Trang 534-543 - 2019
Winifred Lo, Maria R. Parkhurst, Paul F. Robbins, Eric Tran, Yong‐Chen Lu, Lee Jia, Jared J. Gartner, Anna Pasetto, Drew C. Deniger, Parisa Malekzadeh, Thomas E. Shelton, Todd D. Prickett, Satyajit Ray, Scott Kivitz, Biman C. Paria, Isaac Kriley, David S. Schrump, Steven A. Rosenberg
Abstract
Adoptive cell therapy (ACT) with T cells targeting neoantigens can mediate durable responses in patients with metastatic cancer. Cell therapies targeting common shared antigens for epithelial cancers are not yet broadly available. Here, we report the identification and characterization in one patient of T-cell receptors (TCRs) recognizing mu...... hiện toàn bộ
Possible Interaction of Anti–PD-1 Therapy with the Effects of Radiosurgery on Brain MetastasesCancer Immunology Research - Tập 4 Số 6 - Trang 481-487 - 2016
Ahmed Al‐Omari, Justine V. Cohen, Alexander O. Vortmeyer, Anne C. Chiang, Scott Gettinger, Sarah B. Goldberg, Harriet M. Kluger, Veronica Chiang
Abstract
Delayed radiation-induced vasculitic leukoencephalopathy related to stereotactic radiosurgery (SRS) of brain metastases has been reported to manifest clinically 9 to 18 months after treatment. Immune-modulating therapies have been introduced to treatment regimens for malignancies with metastatic predilection to the brain. The interaction of ...... hiện toàn bộ
Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell EngagerCancer Immunology Research - Tập 6 Số 5 - Trang 605-616 - 2018
Anna Wing, Carlos Alberto Fajardo, Avery D. Posey, Carolyn E. Shaw, Tong Da, Regina M. Young, Ramón Alemany, Carl H. June, Sònia Guedan
Abstract
T cells expressing chimeric antigen receptors (CART) have shown significant promise in clinical trials to treat hematologic malignancies, but their efficacy in solid tumors has been limited. Oncolytic viruses have the potential to act in synergy with immunotherapies due to their immunogenic oncolytic properties and the opportunity of incorpo...... hiện toàn bộ
Angiopoietin-2 như một chỉ số sinh học và mục tiêu cho liệu pháp kiểm soát điểm miễn dịch Dịch bởi AI Cancer Immunology Research - Tập 5 Số 1 - Trang 17-28 - 2017
Xinqi Wu, Anita Giobbie‐Hurder, Xiaoyun Liao, Courtney Connelly, Erin M. Connolly, Jingjing Li, Michael P. Manos, Donald P. Lawrence, David F. McDermott, Mariano Severgnini, Jun Zhou, Evisa Gjini, Ana Lako, Mikel Lipschitz, Christine J. Pak, Sara Abdelrahman, Scott J. Rodig, F. Stephen Hodi
Tóm tắtCác liệu pháp kiểm soát điểm miễn dịch nhằm vào CTLA-4 và PD-1 đã chứng minh hiệu quả trong điều trị ung thư. Tuy nhiên, việc xác định các chỉ số sinh học để dự đoán kết quả lâm sàng và các cơ chế để vượt qua sự kháng thuốc vẫn là những nhu cầu quan trọng. Quá trình sinh mạch ngày càng được đánh giá cao như một yếu tố điều chỉnh miễn dịch với tiềm năng sử dụ...... hiện toàn bộ
CD4+ T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 TherapyCancer Immunology Research - Tập 8 Số 3 - Trang 334-344 - 2020
Hiroshi Kagamu, Shigehisa Kitano, Ou Yamaguchi, Kenichi Yoshimura, Katsuhisa Horimoto, Masashi Kitazawa, Kazuhiko Fukui, Ayako Shiono, Atsuhito Mouri, Fuyumi Nishihara, Yu Miura, Kosuke Hashimoto, Yoshitake Murayama, Kyoichi Kaira, Kunihiko Kobayashi
AbstractAccumulating evidence indicates that CD8+ T cells in the tumor microenvironment and systemic CD4+ T-cell immunity play an important role in mediating durable antitumor responses. We longitudinally examined T-cell immunity in the peripheral blood of patients with non–small lung cancer and found that responders had significantly (P < 0.0001) higher per...... hiện toàn bộ