Cancer Control

SCOPUS (1995-2023)SCIE-ISI

  1073-2748

  1526-2359

  Mỹ

Cơ quản chủ quản:  SAGE Publications Ltd , SAGE Publications Inc.

Lĩnh vực:
Medicine (miscellaneous)HematologyOncology

Các bài báo tiêu biểu

Epidemiology of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
Tập 24 Số 3 - Trang 107327481772924 - 2017
Nader N. Massarweh, Hashem B. El‐Serag

Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most frequently occurring types of primary liver cancer and together are among the most common incident cancers worldwide. There are a number of modifiable and nonmodifiable HCC and ICC risk factors that have been reported. A review of the existing literature the epidemiology and risk factors for HCC and ICC was performed. There are a number of major infectious, lifestyle, metabolic, and heritable risk factors for both HCC and ICC. Some of these risk factors are either potentially preventable (eg, alcohol and tobacco use) or are currently treatable (eg hepatitis infection). In most cases, the molecular pathway or mechanism by which these etiologic factors cause primary liver cancer has not been well delineated. However, in nearly all cases, it is believed that a given risk factor causes liver injury and inflammation which results in chronic liver disease. Given the rising prevalence of several common HCC and ICC risk factors in the western world, the best opportunities for improving the care of these patients are either through the prevention of modifiable risk factors that are associated with the development of chronic liver disease or the identification of at risk patients, ensuring they are appropriately screened for the development of primary liver cancer, and initiating treatment early.

Endometrial Cancer and Lynch Syndrome: Clinical and Pathologic Considerations
Tập 16 Số 1 - Trang 14-22 - 2009
Larissa A. Meyer, Russell R. Broaddus, Karen H. Lu
Background

Approximately 2% to 5% of endometrial cancers may be due to an inherited susceptibility. Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, an autosomal-dominant inherited cancer susceptibility syndrome caused by a germline mutation in one of the DNA mismatch repair genes, accounts for the majority of inherited cases. Lynch syndrome is associated with early onset of cancer and the development of multiple cancer types, particularly colon and endometrial cancer.

Methods

The current status of knowledge regarding Lynch syndrome-associated endometrial cancer and methods for diagnosis, screening, and prevention of cancers is reviewed.

Results

The lifetime cumulative risk of endometrial cancer for women with Lynch syndrome is 40% to 60%, which equals or exceeds their risk of colorectal cancer. No current evidence suggests either a survival advantage or disadvantage to endometrial cancer that is associated with Lynch syndrome when these cases are compared with sporadic cases. A combination of family and personal medical history and tumor testing provides an efficient basis for diagnosing Lynch syndrome in women with endometrial cancer. Current gynecologic cancer screening guidelines for women with Lynch syndrome include annual endometrial sampling and transvaginal ultrasonography beginning at age 30 to 35 years.

Conclusions

Diagnosing endometrial cancer patients with Lynch syndrome has important clinical implications for the individual and family members. Screening and prevention practices can decrease the likelihood of developing additional cancers.

Spectrum of Activity and Mechanism of Action of VEGF/PDGF Inhibitors
Tập 14 Số 3 - Trang 285-294 - 2007
Jade Homsi, Adil Daud
Nucleotide Excision Repair Pathways Involved in Cisplatin Resistance in Non-Small-Cell Lung Cancer
Tập 10 Số 4 - Trang 297-305 - 2003
Rafael Rosell, Miquel Tarón, Agustí Barnadas, Giorgio V. Scagliotti, Carme Sarries, Bárbara Roig
Barriers and Facilitators for Colorectal Cancer Screening Practices in the Latino Community: Perspectives from Community Leaders
Tập 15 Số 2 - Trang 157-165 - 2008
Ana Natale‐Pereira, Jonnie Marks, Marielos Vega, Dawne M. Mouzon, Shawna V. Hudson, Debbie Salas‐Lopez
Understanding Quality-of-Life Issues in Chinese Women with Breast Cancer: A Qualitative Investigation
Tập 12 Số 4_suppl - Trang 6-12 - 2005
Evaon Wong-Kim, Angela Sun, Joseph R. Merighi, Edward A. Chow

Little is known about the cultural beliefs and quality of life (QOL) of US-born and foreign-born Chinese women with breast cancer. We conducted individual semistructured qualitative interviews to explore the meaning of QOL, identify beliefs about cancer, and make comparison between US-born and foreign-born survivors. Women in this study identified the stigma of breast cancer that exists in the Asian community. They also described interpersonal support as central to a good QOL. However, when describing QOL, foreign-born Chinese women referred to wealth more frequently, while US-born Chinese women indicated friendship more frequently. The study findings support the need for culturally appropriate interventions that take into consideration the cancer-related beliefs and QOL of breast cancer survivors in the Chinese community.

Impact of Age and Colony-Stimulating Factor Use on Hospital Length of Stay for Febrile Neutropenia in CHOP-Treated Non-Hodgkin's Lymphoma
Tập 9 Số 3 - Trang 203-211 - 2002
Elizabeth A. Chrischilles, David J. Delgado, Bradley S. Stolshek, Grant Lawless, Moshe Fridman, William B. Carter
Background

In intermediate-grade non-Hodgkin's lymphoma (NHL) patients, full-dose CHOP improves survival but increases myelosuppression, causing febrile neutropenia hospitalization (FNH) in 28% of patients 65 years of age or greater. Several risk factors for FNH are known, but their relationship to length of stay (LOS), an indicator of the total burden of FNH, is unclear.

Methods

We conducted a study to identify factors associated with the incidence, recurrence, and duration of hospitalizations for FN and to describe the frequency of administration of colony-stimulating factor (CSF) as primary and secondary prophylaxis and its association with repeated hospitalization episodes.

Results

Compared with patients who did not experience hospitalizations for FN, those who did were significantly older, had more comorbid conditions, were planned for standard dose intensity, and received CSF less often during the first 5 days of cycle 1 (early CSF). Overall, 73% of these hospitalizations occurred within the first 2 cycles of chemotherapy, with 56% occurring within the first cycle. Patients age ≥65 years accounted for 66% of cycle 1 FNH. Patients receiving early CSF were less likely to experience repeated hospitalizations (0% vs 12%; P.05). Multiple regression analysis of those hospitalized found a 3.9-day longer LOS for patients age ≥65 years and a 5.13-day longer LOS for those not receiving early CSF.

Conclusions

Older NHL patients have a higher risk of hospitalization for FN and longer LOS. The majority of hospitalization days occur in the first 2 cycles of chemotherapy. Early CSF use is associated with decreased risk of repeated hospitalizations and shorter total LOS. Secondary CSF use is also associated with reduced risk of repeated FNH.

Disseminated Mycobacterium Bovis after Intravesicular Bacillus Calmette-Guérin Treatments for Bladder Cancer
Tập 7 Số 5 - Trang 476-481 - 2000
Magda Elkabani, John N. Greene, Albert L. Vincent, Steven Vanhook, Ramón L. Sandin
Lymphatic Mapping and Sentinel Node Analysis to Optimize Laparoscopic Resection and Staging of Colorectal Cancer: An Update
Tập 10 Số 3 - Trang 219-223 - 2003
Anton J. Bilchik, Steven D. Trocha
Anemia of Aging: A Model of Erythropoiesis in Cancer Patients
Tập 5 Số 2_suppl - Trang 17-21 - 1998
Lodovico Balducci, Cheryl L. Hardy

Anemia produces deleterious effects in the older patient with cancer and corresponds with an increasing prevalence of comorbid conditions. Erythropoietin can improve anemia of chronic disease, the most common form of anemia in the elderly.