Epidemiology of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

Cancer Control - Tập 24 Số 3 - Trang 107327481772924 - 2017
Nader N. Massarweh1,2, Hashem B. El‐Serag3,2
1Michael E. DeBakey Department of Surgery, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, USA
2U.S. Department of Veterans Affairs Health Services Research and Development Center of Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA
3Department of Medicine, Baylor College of Medicine, Houston, TX, USA

Tóm tắt

Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most frequently occurring types of primary liver cancer and together are among the most common incident cancers worldwide. There are a number of modifiable and nonmodifiable HCC and ICC risk factors that have been reported. A review of the existing literature the epidemiology and risk factors for HCC and ICC was performed. There are a number of major infectious, lifestyle, metabolic, and heritable risk factors for both HCC and ICC. Some of these risk factors are either potentially preventable (eg, alcohol and tobacco use) or are currently treatable (eg hepatitis infection). In most cases, the molecular pathway or mechanism by which these etiologic factors cause primary liver cancer has not been well delineated. However, in nearly all cases, it is believed that a given risk factor causes liver injury and inflammation which results in chronic liver disease. Given the rising prevalence of several common HCC and ICC risk factors in the western world, the best opportunities for improving the care of these patients are either through the prevention of modifiable risk factors that are associated with the development of chronic liver disease or the identification of at risk patients, ensuring they are appropriately screened for the development of primary liver cancer, and initiating treatment early.

Từ khóa


Tài liệu tham khảo

Altekruse SF, 2011, J Registry Manag, 38, 201

10.7326/0003-4819-139-10-200311180-00009

10.1111/hepr.12605

10.1200/JCO.2015.64.7412

10.1016/j.jhep.2003.11.030

10.1158/0008-5472.CAN-14-0155

10.3322/caac.21332

10.1016/S0016-5085(12)63549-5

10.1016/j.annepidem.2007.05.013

10.1002/hep.23594

10.1111/j.1365-2036.2011.04724.x

10.1002/1097-0142(19911101)68:9<2051::AID-CNCR2820680934>3.0.CO;2-M

10.1007/s10620-014-3276-2

10.1371/journal.pone.0107177

10.1016/j.cgh.2007.05.020

10.1016/j.jhep.2012.02.022

10.1158/1940-6207.CAPR-12-0046

10.1097/MCG.0b013e3182872f29

10.1016/j.jhep.2006.05.013

10.1002/cncr.29971

10.1053/j.gastro.2011.12.061

10.1002/hep.22606

10.1038/sj.bjc.6605063

10.1002/ijc.21731

10.1002/(SICI)1097-0215(19980130)75:3<347::AID-IJC4>3.0.CO;2-2

10.1038/sj.bjc.6602333

10.1016/j.cgh.2010.08.019

10.1016/j.bpg.2014.08.007

10.1056/NEJMoa033364

10.1245/s10434-010-1458-5

10.1111/jvh.12005

10.1093/aje/155.4.323

10.1002/hep.510310332

10.1053/j.gastro.2009.09.067

10.1053/jhep.2001.27831

10.1016/S0140-6736(96)07642-8

10.1053/j.gastro.2012.01.045

10.1053/j.gastro.2010.11.050

10.1186/s12957-015-0583-9

10.3748/wjg.v21.i45.12896

10.1038/bjc.2013.564

10.1002/hep.27095

10.1016/j.jhep.2009.01.019

10.1007/s12072-016-9748-z

10.1002/hep.28535

10.1016/j.cgh.2009.10.026

10.1001/archpsyc.61.8.807

10.1038/ajg.2013.160

10.1016/S1542-3565(05)00407-6

10.1111/j.1360-0443.2005.01205.x

10.1093/ije/dyp280

10.1002/ijc.23730

10.1001/jama.2012.39

10.1001/jama.2016.6458

10.2337/dc12-0336

10.1002/hep.24397

10.1002/hep.26031

10.1053/j.gastro.2010.09.038

10.1016/j.cgh.2012.10.001

10.1002/hep.28123

10.1016/j.cgh.2015.07.019

10.1016/j.cgh.2005.12.007

10.1097/CEJ.0000000000000038

10.1097/MD.0000000000001013

10.1136/gutjnl-2011-301708

10.1111/j.1478-3231.2010.02223.x

10.1002/cncr.24982

10.1038/ajg.2013.5

10.1136/bmj.g7607

10.1002/hep.26092

10.1016/j.ccr.2014.07.001

10.1038/nature12347

10.1038/sj.bjc.6603932

10.1002/ijc.27645

10.1016/j.cld.2013.09.019

10.1056/NEJMoa066254

10.1002/ijc.22283

10.1016/j.mcna.2004.08.005

10.1053/j.gastro.2003.09.035

10.1111/j.1572-0241.2008.01955.x

10.1093/oxfordjournals.aje.a009745

10.21037/cco.2016.10.09

10.1016/0002-9610(77)90359-2

10.1155/1997/38416

10.1001/archsurg.1983.01390090052012

10.1016/S0039-6060(99)70090-5

Komi N, 1984, Surg Gastroenterol, 3, 69

10.1007/s005340050108

10.1111/j.1872-034X.2007.00229.x

10.1007/BF01391633

10.1055/s-2004-828889

10.1002/jhbp.62

10.1002/ijc.30506

10.1038/srep33743

10.1158/1940-6207.CAPR-15-0126

10.1097/CEJ.0000000000000252

10.1158/1055-9965.EPI-15-0137

10.1053/j.gastro.2016.11.020