Recommendations for the registration of new chemical entities used in the prevention and treatment of osteoporosisCalcified Tissue International - Tập 57 - Trang 247-250 - 1995
J. Y. Reginster, J. E. Compston, E. A. Jones, J. M. Kaufman, M. Audran, G. Bouvenot, L. Frati, G. Mazzuoli, C. Gennari, E. -M. Lemmel, J. D. Ringe, J. -L. Sebert, L. Vanhaelst, B. Avouac
Neurotransmitter regulation of cytosolic calcium in osteoblast-like bone cellsCalcified Tissue International - Tập 45 - Trang 251-254 - 1989
Hiromichi Kumagai, Hisato Sakamoto, Sandra Guggino, Charles R. Filburn, Bertram Sacktor
The nervous system may play a role in regulation of bone metabolism. The effects of norepinephrine(NE), vasoactive intestinal peptide(VIP), and ATP on cytosolic Ca2+ were assessed in a rat osteoblast-like osteosarcoma cell line (UMR-106) responsive to PTH. All three transmitters transiently increased Ca2+, with ATP≫PTH>NE=VIP, and then caused sustained increases in Ca2+. The ATP-induced transient ...... hiện toàn bộ
Bone Marrow Microenvironment as a Regulator and Therapeutic Target for Prostate Cancer Bone MetastasisCalcified Tissue International - Tập 102 - Trang 152-162 - 2017
Sun H. Park, Evan T. Keller, Yusuke Shiozawa
Bone is the most common site of prostate cancer metastasis. Once prostate cancer cells metastasize to bone, the mortality rate of prostate cancer patients increases significantly. Furthermore, bone metastases produce multiple skeletal complications, including bone pain that impairs the patients’ quality of life. Effective therapies for bone metastatic disease are underdeveloped with most current t...... hiện toàn bộ
EditorialCalcified Tissue International - Tập 39 - Trang 1-1 - 1986
Louis V. Avioli
Osteogenesis Depending on Geometry of Porous Hydroxyapatite ScaffoldsCalcified Tissue International - Tập 83 - Trang 139-145 - 2008
Masataka Yoshikawa, Norimasa Tsuji, Yasunori Shimomura, Hiroyuki Hayashi, Hajime Ohgushi
The effect of the configuration of porous cylindrical hydroxyapatite (HA) scaffold and laminin preparation of the scaffold on bone formation was estimated. HA scaffolds with a hollow center of 2 or 4 mm in diameter and those without a hollow center were used. The scaffolds were immersed in laminin solution or in culture medium. Bone marrow cells were obtained from the femora of male Fischer 344 ra...... hiện toàn bộ
Parathyroid Hormone (1–34) Transiently Protects Against Radiation-Induced Bone FragilityCalcified Tissue International - Tập 98 - Trang 619-630 - 2016
Megan E. Oest, Kenneth A. Mann, Nicholas D. Zimmerman, Timothy A. Damron
Radiation therapy for soft tissue sarcoma or tumor metastases is frequently associated with damage to the underlying bone. Using a mouse model of limited field hindlimb irradiation, we assessed the ability of parathyroid hormone (1–34) fragment (PTH) delivery to prevent radiation-associated bone damage, including loss of mechanical strength, trabecular architecture, cortical bone volume, and miner...... hiện toàn bộ