Recommendations for the registration of new chemical entities used in the prevention and treatment of osteoporosisCalcified Tissue International - Tập 57 - Trang 247-250 - 1995
J. Y. Reginster, J. E. Compston, E. A. Jones, J. M. Kaufman, M. Audran, G. Bouvenot, L. Frati, G. Mazzuoli, C. Gennari, E. -M. Lemmel, J. D. Ringe, J. -L. Sebert, L. Vanhaelst, B. Avouac
Neurotransmitter regulation of cytosolic calcium in osteoblast-like bone cellsCalcified Tissue International - Tập 45 - Trang 251-254 - 1989
Hiromichi Kumagai, Hisato Sakamoto, Sandra Guggino, Charles R. Filburn, Bertram Sacktor
The nervous system may play a role in regulation of bone metabolism. The effects of norepinephrine(NE), vasoactive intestinal peptide(VIP), and ATP on cytosolic Ca2+ were assessed in a rat osteoblast-like osteosarcoma cell line (UMR-106) responsive to PTH. All three transmitters transiently increased Ca2+, with ATP≫PTH>NE=VIP, and then caused sustained increases in Ca2+. The ATP-induced transient ...... hiện toàn bộ
Serum bone GLA-protein is not a sensitive marker of bone turnover in Paget's disease of boneCalcified Tissue International - Tập 38 - Trang 60-61 - 1986
P. D. Delmas, B. Demiaux, L. Malaval, M. C. Chapuy, P. J. Meunier
Serum bone Gla-protein (sBGP) was measured in 32 patients with untreated Paget's disease of bone. Despite clinical and biological symptoms of active disease in all patients, sBGP was normal in 13/32 patients (41%). There was a striking discrepancy between the moderate increase of sBGP above normal values (11.4±4.5 vs 6.0±2.1 ng/ml) and the marked increase of both serum alkaline phosphatase (sAP) a...... hiện toàn bộ
Bone Marrow Microenvironment as a Regulator and Therapeutic Target for Prostate Cancer Bone MetastasisCalcified Tissue International - Tập 102 - Trang 152-162 - 2017
Sun H. Park, Evan T. Keller, Yusuke Shiozawa
Bone is the most common site of prostate cancer metastasis. Once prostate cancer cells metastasize to bone, the mortality rate of prostate cancer patients increases significantly. Furthermore, bone metastases produce multiple skeletal complications, including bone pain that impairs the patients’ quality of life. Effective therapies for bone metastatic disease are underdeveloped with most current t...... hiện toàn bộ
EditorialCalcified Tissue International - Tập 39 - Trang 1-1 - 1986
Louis V. Avioli