Recommendations for the registration of new chemical entities used in the prevention and treatment of osteoporosisCalcified Tissue International - Tập 57 - Trang 247-250 - 1995
J. Y. Reginster, J. E. Compston, E. A. Jones, J. M. Kaufman, M. Audran, G. Bouvenot, L. Frati, G. Mazzuoli, C. Gennari, E. -M. Lemmel, J. D. Ringe, J. -L. Sebert, L. Vanhaelst, B. Avouac
Neurotransmitter regulation of cytosolic calcium in osteoblast-like bone cellsCalcified Tissue International - Tập 45 - Trang 251-254 - 1989
Hiromichi Kumagai, Hisato Sakamoto, Sandra Guggino, Charles R. Filburn, Bertram Sacktor
The nervous system may play a role in regulation of bone metabolism. The effects of norepinephrine(NE), vasoactive intestinal peptide(VIP), and ATP on cytosolic Ca2+ were assessed in a rat osteoblast-like osteosarcoma cell line (UMR-106) responsive to PTH. All three transmitters transiently increased Ca2+, with ATP≫PTH>NE=VIP, and then caused sustained increases in Ca2+. The ATP-induced transient ...... hiện toàn bộ
Osteogenesis Depending on Geometry of Porous Hydroxyapatite ScaffoldsCalcified Tissue International - Tập 83 - Trang 139-145 - 2008
Masataka Yoshikawa, Norimasa Tsuji, Yasunori Shimomura, Hiroyuki Hayashi, Hajime Ohgushi
The effect of the configuration of porous cylindrical hydroxyapatite (HA) scaffold and laminin preparation of the scaffold on bone formation was estimated. HA scaffolds with a hollow center of 2 or 4 mm in diameter and those without a hollow center were used. The scaffolds were immersed in laminin solution or in culture medium. Bone marrow cells were obtained from the femora of male Fischer 344 ra...... hiện toàn bộ
Parathyroid Hormone (1–34) Transiently Protects Against Radiation-Induced Bone FragilityCalcified Tissue International - Tập 98 - Trang 619-630 - 2016
Megan E. Oest, Kenneth A. Mann, Nicholas D. Zimmerman, Timothy A. Damron
Radiation therapy for soft tissue sarcoma or tumor metastases is frequently associated with damage to the underlying bone. Using a mouse model of limited field hindlimb irradiation, we assessed the ability of parathyroid hormone (1–34) fragment (PTH) delivery to prevent radiation-associated bone damage, including loss of mechanical strength, trabecular architecture, cortical bone volume, and miner...... hiện toàn bộ
Immunohistochemical demonstration of extracellular carbonic anhydrase in epiphyseal growth cartilageCalcified Tissue International - Tập 34 - Trang 428-430 - 1982
Timo Kumpulainen, H. K. Väänänen
The distribution of carbonic anhydrase isoenzymes C and B in the rat epiphyseal growth cartilage was demonstrated by an immunohistochemical method. The isoenzymes were found in different locations. Isoenzyme C was in the extracellular matrix of the hypertrophic and calcifying cartilage, and no reaction was observed in the chondrocytes. In contrast, the antiserum against isoenzyme B revealed only a...... hiện toàn bộ
Acute and Subacute Changes in the Ultrasound Measurements of the Calcaneus Following Intense ExerciseCalcified Tissue International - Tập 63 - Trang 505-509 - 1998
K. L. Bennell, P. Hart, C. Nattrass, J. D. Wark
The amount of exercise necessary to cause bone structural change in humans is unknown. We examined whether a single bout of intense exercise in vivo leads to acute and subacute changes in the physical properties of bone as measured by ultrasound. It was hypothesized that structural changes such as accumulation of fatigue microdamage would result in a decrease in velocity of sound (VOS) and broadb...... hiện toàn bộ
Effects of Extracellular Phosphate on Gene Expression in Murine OsteoblastsCalcified Tissue International - Tập 94 - Trang 474-483 - 2013
C. Rendenbach, T. A. Yorgan, T. Heckt, B. Otto, C. Baldauf, A. Jeschke, T. Streichert, J. P. David, M. Amling, T. Schinke
That phosphate homeostasis is tightly linked to skeletal mineralization is probably best underscored by the fact that the phosphaturic hormone FGF23 is primarily expressed by terminally differentiated osteoblasts/osteocytes and that increased circulating FGF23 levels are causative for different types of hypophosphatemic rickets. In contrast, FGF23 inactivation results in hyperphosphatemia, and une...... hiện toàn bộ