The potential use of vitamin D analogs in the treatment of cancer

Fukumoto S, Matsumoto T, Yamoto H, Kawashima H, Ueyama Y, Tamaoki N, Ogata E (1989) Suppression of serum 1,25-dihydroxyvitamin D in humoral hypercalcemia of malignancy is caused by elaboration of a factor that inhibits renal 1,25-dihydroxyvitamin D3 production. Endocrinology 124(5):2057–2062

Ikeda K, Ogata E (1995) Humoral hypercalcemia of malignancy: some enigmas on the clinical features. J Cell Biochem 57:384–391

Abe J, Morikawa M, Miyamoto K, Kaiho S, Fukushima M, Miyaura C, Abe E, Suda T, Nishii Y (1987) Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton. FEBS Lett 226:58–62

Ikeda K, Lu C, Weir EC, Mangin M, Broadus AE (1989) Transcriptional regulation of the parathyroid hormone-related peptide gene by glucocorticoids and vitamin D in a human C-cell line. J Biol Chem 264(27): 15743–15746

DeMay MB, Kiernan MS, DeLuca HF, Kronenberg HM (1992) Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 89:8097–8101

Mackey SL, Heymont JL, Kronenberg HM, DeMay MB (1996) Vitamin D receptor binding to the negative human parathyroid hormone vitamin D resposne element does not require the retinoid X receptor. Mol Endocrinol 10(3):298–305

Nishishita T, Okazaki T, Igarashi T, Ogata E, Fujita T (1996) Negative vitamin D response element in the human PTHrP gene and its binding nuclear proteins. J Bone Miner Res 11(suppl):

Inoue D, Matsumoto T, Ogata E, Ikeda K (1993) 22-Oxacalcitriol, a noncalcemic analogue of calcitriol, suppresses both cell proliferation and parathyroid hormone-related peptide gene expression in human T cell lymphotrophic virus, type I-infected T cells. J Biol Chem 269(22): 16730–16736

Endo K, Ichikawa F, Uchiyama Y, Katsumata K, Ohkawa H, Kumaki K, Ogata E, Ikeda K (1994) Evidence for the uptake of a vitamine D analouge (OCT) by a human carcinoma and its effect of suppressing the transcription of parathyroid hormone-related peptide gene in vivo. J Biol Chem 269(51):32693–32699