Brazilian Journal of Pharmaceutical Sciences
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Pharmaceutical properties of 'sucupira' (Pterodon spp.)
Brazilian Journal of Pharmaceutical Sciences - Tập 46 Số 4 - Trang 607-616 - 2010
The plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as
'sucupira' or 'faveira', are disseminated throughout the central region of
Brazil and has frequently been used in popular medicine for its anti-rheumatic,
analgesic, and anti-inflammatory properties. In recent years, interest in these
plants has increased considerably. The biological effects of different
phytoextracts and p...
Study of thermal behavior of phytic acid
Brazilian Journal of Pharmaceutical Sciences - Tập 49 Số 2 - Trang 275-283 - 2013
Phytic acid is a natural compound widely used as depigmenting agent in galenic
cosmetic emulsions. However, we have observed experimentally that phytic acid,
when heated to 150 ºC for around one hour, shows evidence of thermal
decomposition. Few studies investigating this substance alone with regard to its
stability are available in the literature. This fact prompted the present study
to character...
Aggravation of cyclophosphamide-induced reproductive toxicity in mice by aqueous extract of Aegle marmelos (L.)
Brazilian Journal of Pharmaceutical Sciences - Tập 53 Số 3
Thermal behavior and decomposition kinetics of rifampicin polymorphs under isothermal and non-isothermal conditions
Brazilian Journal of Pharmaceutical Sciences - Tập 46 Số 2 - Trang 343-351 - 2010
The thermal behavior of two polymorphic forms of rifampicin was studied by DSC
and TG/DTG. The thermoanalytical results clearly showed the differences between
the two crystalline forms. Polymorph I was the most thermally stable form, the
DSC curve showed no fusion for this species and the thermal decomposition
process occurred around 245 ºC. The DSC curve of polymorph II showed two
consecutive eve...
Antibiotic microbial assay using kinetic-reading microplate system
Brazilian Journal of Pharmaceutical Sciences - Tập 47 Số 3 - Trang 573-584 - 2011
The aim of this study was to determine the optimal experimental conditions to
develop a methodology for microbiological assay of apramycin employing
microplate and kinetic reading mode, and to validate the developed method,
through evaluation of parameters of selectivity, linearity, linear range, limits
of detection and quantification, accuracy and precision. The turbidimetric assay
principle is s...
Formulation design and characterization of a non-ionic surfactant based vesicular system for the sustained delivery of a new chondroprotective agent
Brazilian Journal of Pharmaceutical Sciences - Tập 51 Số 3 - Trang 607-615 - 2015
Diacerein is used for symptomatic relief and cartilage regeneration in
osteoarthritis. Due to gastrointestinal side effects, poor aqueous solubility
and low bioavailability, its clinical usage has been restricted. The objective
of the present study was to enhance its dissolution profile and to attain
sustained release by designing a novel delivery system based on niosomes. Five
niosomal formulatio...
Thermodynamic study of the solubility of ibuprofen in acetone and dichloromethane
Brazilian Journal of Pharmaceutical Sciences - Tập 46 Số 2 - Trang 227-235 - 2010
Thermodynamic functions, Gibbs energy, enthalpy and entropy for the solution
processes of ibuprofen (IBP) in acetone and dichloromethane (DCM) were
calculated from solubility values obtained at temperatures ranging from 293.15 K
to 313.15 K. The respective thermodynamic functions for mixing and solvation
processes as well as the activity coefficients for the solute were calculated.
IBP solubility ...
Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives
Brazilian Journal of Pharmaceutical Sciences - Tập 49 Số 4 - Trang 903-909 - 2013
Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one
derivatives (4a-f) were synthesized and evaluated as analgesic and
anti-inflammatory agents in mice and rats, respectively. All compounds were
tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema
method for the evaluation of analgesic and anti-inflammatory activities,
respectively. Results showed tha...
Use of medicinal herbs by patients with severe asthma managed at a Referral Center
Brazilian Journal of Pharmaceutical Sciences - Tập 47 Số 3 - Trang 643-649 - 2011
Asthma is a chronic inflammatory disease of the airways that may lead to
limitations in regular activities, to hospitalizations and a decrease in quality
of life. Adherence to drug treatment is crucial for control of the disease. The
use of medicinal herbs can reduce adherence to prescriptions, as the medication
may be replaced by infusions or herbal products. The objective of this study was
to ev...
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