Blood Advances
SCOPUS (2017-2025)SCIE-ISI
2473-9529
Cơ quản chủ quản: Elsevier , Elsevier BV
Lĩnh vực:
Hematology
Các bài báo tiêu biểu
American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19
Tập 5 Số 3 - Trang 872-888 - 2021
Background:Coronavirus disease 2019 (COVID-19)–related critical illness and
acute illness are associated with a risk of venous thromboembolism
(VTE).Objective:These evidence-based guidelines of the American Society of
Hematology (ASH) are intended to support patients, clinicians, and other health
care professionals in decisions about the use of anticoagulation for
thromboprophylaxis for patients w...
Pharmacologic control of CAR-T cell function using dasatinib
Tập 3 Số 5 - Trang 711-717 - 2019
Key Points Dasatinib potently and reversibly suppresses CAR-T cell cytotoxicity,
cytokine secretion, and proliferation. Dasatinib could be repurposed as a safety
switch to mitigate CAR-mediated toxicity in patients.
High metabolic tumor volume is associated with decreased efficacy of axicabtagene ciloleucel in large B-cell lymphoma
Tập 4 Số 14 - Trang 3268-3276 - 2020
Abstract High metabolic tumor volume (MTV) predicts worse outcomes in lymphoma
treated with chemotherapy. However, it is unknown if this holds for patients
treated with axicabtagene ciloleucel (axi-cel), an anti-CD19 targeted chimeric
antigen receptor T-cell therapy. The primary objective of this retrospective
study was to investigate the relationship between MTV and survival (overall
survival [OS...
Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy
Tập 3 Số 15 - Trang 2317-2322 - 2019
Key Points Reexpansion of CAR T cells led to further investigations which
confirmed the clonal nature of this expansion.
Zanubrutinib for the treatment of relapsed or refractory mantle cell lymphoma
Tập 5 Số 12 - Trang 2577-2585 - 2021
Abstract Zanubrutinib, a highly selective Bruton tyrosine kinase inhibitor, was
evaluated in a phase 1/2 study in patients with various B-cell malignancies. In
the subgroup of patients with relapsed/refractory (R/R) mantle cell lymphoma
(MCL), zanubrutinib was administered as 160 mg twice daily (n = 14), 320 mg once
daily (n = 18), or ≤160 mg total dose (n = 5). Herein, we report results for
patie...
Functional and phylogenetic alterations in gut microbiome are linked to graft-versus-host disease severity
Tập 4 Số 9 - Trang 1824-1832 - 2020
AbstractAcute graft-versus-host disease (aGVHD) is the main complication of
hematopoietic stem cell transplantation (HSCT). Changes in gut microbiota
composition have been associated with subsequent aGVHD, and reconstitution of
healthy microbiota is currently being explored as a therapeutic approach.
However, the specific actors in the intestinal ecosystem involved in the
pathologic process at the...
INCB84344-201: Ponatinib and steroids in frontline therapy for unfit patients with Ph+ acute lymphoblastic leukemia
Tập 6 Số 6 - Trang 1742-1753 - 2022
AbstractTyrosine kinase inhibitors have improved survival for patients with
Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL).
However, prognosis for old or unfit patients remains poor. In the INCB84344-201
(formerly GIMEMA LAL 1811) prospective, multicenter, phase 2 trial, we tested
the efficacy and safety of ponatinib plus prednisone in newly diagnosed patients
with Ph+ A...
Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia
Tập 3 Số 20 - Trang 3123-3131 - 2019
Key PointsFlu/Cy/ATG and Cy/ATG regimens offer the best survival for
matched-sibling BMT. Transplantation in patients aged ≥30 years is associated
with higher mortality after matched-sibling and unrelated donor BMT.
Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients
Tập 4 Số 22 - Trang 5797-5809 - 2020
Abstract Acute graft-versus-host disease (aGVHD) is a leading cause of
transplantation-related mortality after allogeneic hematopoietic stem cell
transplantation (aHSCT). 16S ribosomal RNA (16S rRNA) gene-based studies have
reported that lower gut bacterial diversity and the relative abundance of
certain bacteria after aHSCT are associated with aGVHD. Using shotgun
metagenomic sequencing and a lar...
Clinical, laboratory, and genetic risk factors for thrombosis in sickle cell disease
Tập 4 - Trang 1978-1986 - 2020
Abstract Sickle cell disease (SCD) patients are at a four- to 100-fold increased
risk for thrombosis compared with the general population, although the
mechanisms and risk factors are not clear. We investigated the incidence and
predictors for thrombosis in a retrospective, longitudinal cohort of 1193
pediatric and adult SCD patients treated at our institution between January 2008
and December 201...