Blood Advances
SCOPUS (2017-2023)SCIE-ISI
2473-9529
Cơ quản chủ quản: Elsevier , Elsevier BV
Lĩnh vực:
Hematology
Các bài báo tiêu biểu
American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19Background: Coronavirus disease 2019 (COVID-19)–related critical illness and acute illness are associated with a risk of venous thromboembolism (VTE). Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other hea...
Tập 5 Số 3 - Trang 872-888 - 2021
Pharmacologic control of CAR-T cell function using dasatinibKey Points
Dasatinib potently and reversibly suppresses CAR-T cell cytotoxicity, cytokine secretion, and proliferation. Dasatinib could be repurposed as a safety switch to mitigate CAR-mediated toxicity in patients.
Tập 3 Số 5 - Trang 711-717 - 2019
High metabolic tumor volume is associated with decreased efficacy of axicabtagene ciloleucel in large B-cell lymphomaAbstract
High metabolic tumor volume (MTV) predicts worse outcomes in lymphoma treated with chemotherapy. However, it is unknown if this holds for patients treated with axicabtagene ciloleucel (axi-cel), an anti-CD19 targeted chimeric antigen receptor T-cell therapy. The primary objective of this retrospective study was to investigate the relationshi... ... hiện toàn bộ
Tập 4 Số 14 - Trang 3268-3276 - 2020
Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapyKey Points
Reexpansion of CAR T cells led to further investigations which confirmed the clonal nature of this expansion.
Tập 3 Số 15 - Trang 2317-2322 - 2019
Zanubrutinib for the treatment of relapsed or refractory mantle cell lymphomaAbstract
Zanubrutinib, a highly selective Bruton tyrosine kinase inhibitor, was evaluated in a phase 1/2 study in patients with various B-cell malignancies. In the subgroup of patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL), zanubrutinib was administered as 160 mg twice daily (n = 14), 320 mg once daily (n = 18), or ≤160 mg total d... ... hiện toàn bộ
Tập 5 Số 12 - Trang 2577-2585 - 2021
Functional and phylogenetic alterations in gut microbiome are linked to graft-versus-host disease severityAbstract Acute graft-versus-host disease (aGVHD) is the main complication of hematopoietic stem cell transplantation (HSCT). Changes in gut microbiota composition have been associated with subsequent aGVHD, and reconstitution of healthy microbiota is currently being explored as a therapeutic approach. However, the specific actors in the intestinal ecosystem involved... ... hiện toàn bộ
Tập 4 Số 9 - Trang 1824-1832 - 2020
INCB84344-201: Ponatinib and steroids in frontline therapy for unfit patients with Ph+ acute lymphoblastic leukemiaAbstract Tyrosine kinase inhibitors have improved survival for patients with Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). However, prognosis for old or unfit patients remains poor. In the INCB84344-201 (formerly GIMEMA LAL 1811) prospective, multicenter, phase 2 trial, we tested the efficacy and safety of ponatinib plus prednisone in ne... ... hiện toàn bộ
Tập 6 Số 6 - Trang 1742-1753 - 2022
Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemiaKey Points Flu/Cy/ATG and Cy/ATG regimens offer the best survival for matched-sibling BMT. Transplantation in patients aged ≥30 years is associated with higher mortality after matched-sibling and unrelated donor BMT.
Tập 3 Số 20 - Trang 3123-3131 - 2019
Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipientsAbstract
Acute graft-versus-host disease (aGVHD) is a leading cause of transplantation-related mortality after allogeneic hematopoietic stem cell transplantation (aHSCT). 16S ribosomal RNA (16S rRNA) gene-based studies have reported that lower gut bacterial diversity and the relative abundance of certain bacteria after aHSCT are associated with aGVHD... ... hiện toàn bộ
Tập 4 Số 22 - Trang 5797-5809 - 2020
Clinical, laboratory, and genetic risk factors for thrombosis in sickle cell diseaseAbstract
Sickle cell disease (SCD) patients are at a four- to 100-fold increased risk for thrombosis compared with the general population, although the mechanisms and risk factors are not clear. We investigated the incidence and predictors for thrombosis in a retrospective, longitudinal cohort of 1193 pediatric and adult SCD patients treated at our i... ... hiện toàn bộ
Tập 4 - Trang 1978-1986 - 2020