Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy

Blood Advances - Tập 3 Số 15 - Trang 2317-2322 - 2019
Nirali N. Shah1, Haiying Qin1, Bonnie Yates1, Ling Su2, Haneen Shalabi1, Mark Raffeld3, Mark A. Ahlman4, Maryalice Stetler‐Stevenson5, Constance M. Yuan5, Shuang Guo2, Siyuan Liu2, Stephen H. Hughes6, Terry J. Fry7,8,1, Xiaolin Wu2
1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD;
2Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD
3Molecular Diagnostics Section, Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD;
4Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD;
5Flow Cytometry, Department of Pathology, NCI, NIH, Bethesda, MD;
6HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD;
7Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO
8Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO; and

Tóm tắt

Key Points

Reexpansion of CAR T cells led to further investigations which confirmed the clonal nature of this expansion.

Từ khóa


Tài liệu tham khảo

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