Blood Advances

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Valproate in combination with rituximab and CHOP as first-line therapy in diffuse large B-cell lymphoma (VALFRID)
Blood Advances - Tập 2 - Trang 1386-1392 - 2018
Kristina Drott, Hans Hagberg, Karin Papworth, Thomas Relander, Mats Jerkeman
Key Points This trial evaluates addition of the histone deacetylase inhibitor valproate to standard R-CHOP therapy in DLBCL. Addition of valproate to R-CHOP is a promising strategy in DLBCL, but auditory side effects warrant monitoring.
Portable medical orders and end-of-life measures in acute myeloid leukemia and myelodysplastic syndromes
Blood Advances - Tập 5 - Trang 5554-5564 - 2021
Marissa LoCastro, Andrea M. Baran, Jane L. Liesveld, Eric Huselton, Michael W. Becker, Kristen Marie O'Dwyer, Omar S. Aljitawi, Megan Baumgart, Eric Snyder, Benzi Kluger, Kah Poh Loh, Jason H. Mendler
Abstract Patients with acute myeloid leukemia (AML) or a myelodysplastic syndrome (MDS) experience high rates of hospitalization, intensive care unit (ICU) admission, and in-hospital death at the end of life. Early goals-of-care (GOC) discussions may reduce the intensity of end-of-life (EOL) care. Portable Medical Order forms, known as Medical Orders...... hiện toàn bộ
Chromosome 1 abnormalities and survival of patients with multiple myeloma in the era of novel agents
Blood Advances - Tập 4 - Trang 2245-2253 - 2020
Smith Giri, Scott F. Huntington, Rong Wang, Amer M. Zeidan, Nikolai Podoltsev, Steven D. Gore, Xiaomei Ma, Cary P. Gross, Amy J. Davidoff, Natalia Neparidze
AbstractChromosome 1 abnormalities (C1As) are common genetic aberrations among patients with multiple myeloma (MM). We aimed to evaluate the significance of C1As among a contemporary cohort of patients with MM in the United States. We used electronic health records from the Flatiron Health database to select patients newly diagnosed with MM from January 2011 to Mar...... hiện toàn bộ
Single-cell heterogeneity in Sézary syndrome
Blood Advances - Tập 2 - Trang 2115-2126 - 2018
Terkild Brink Buus, Andreas Willerslev-Olsen, Simon Fredholm, Edda Blümel, Claudia Nastasi, Maria Gluud, Tengpeng Hu, Lise M. Lindahl, Lars Iversen, Hanne Fogh, Robert Gniadecki, Ivan V. Litvinov, Jenny L. Persson, Charlotte Menné Bonefeld, Carsten Geisler, Jan Pravsgaard Christensen, Thorbjørn Krejsgaard, Thomas Litman, Anders Woetmann, Niels Ødum
Key Points Individual patients with Sézary syndrome contain several distinct malignant subpopulations and show marked single-cell heterogeneity. Malignant subpopulations exhibit differences in their sensitivity to treatment warranting precision therapy.
Nivolumab combined with brentuximab vedotin for R/R primary mediastinal large B-cell lymphoma: a 3-year follow-up
Blood Advances - Tập 7 - Trang 5272-5280 - 2023
Pier Luigi Zinzani, Armando Santoro, Giuseppe Gritti, Pauline Brice, Paul M. Barr, John Kuruvilla, David Cunningham, Justin Kline, Nathalie A. Johnson, Neha Mehta-Shah, Julie Lisano, Rachael Wen, Alev Akyol, Alison J. Moskowitz
Abstract Patients with relapsed/refractory primary mediastinal large B-cell lymphoma (R/R PMBL) have poor responses to salvage therapy. Nivolumab and brentuximab vedotin (BV) showed promising early efficacy in patients with R/R PMBL in the phase 1/2 open-label, multicenter CheckMate 436 study; we report safety and efficacy findings from the 3-year fo...... hiện toàn bộ
Prevalence and risk factors for venous thromboembolism in children with sickle cell disease: an administrative database study
Blood Advances - Tập 2 Số 3 - Trang 285-291 - 2018
Riten Kumar, Joseph Stanek, Susan E. Creary, Amy L. Dunn, Sarah H. O’Brien
Key Points Adults with SCD have an increased incidence of VTE, but similar data in children are lacking. In this 7-year, multicenter retrospective study, 1.7% of children with SCD developed VTE.
Respiratory infections predominate after day 100 following B-cell maturation antigen–directed CAR T-cell therapy
Blood Advances - Tập 7 - Trang 5485-5495 - 2023
Jessica S. Little, Megha Tandon, Joseph Seungpyo Hong, Omar Nadeem, Adam S. Sperling, Noopur Raje, Nikhil Munshi, Matthew Frigault, Sara Barmettler, Sarah P. Hammond
Abstract Infections are an important complication after B-cell maturation antigen (BCMA)–directed chimeric antigen receptor (CAR) T-cell therapy and risks may differ between the early and late periods. We evaluated infections in 99 adults who received a first BCMA–directed CAR T-cell therapy (commercial and investigational autologous BCMA CAR T-cell ...... hiện toàn bộ
Early relapse identifies MCL patients with inferior survival after intensive or less intensive frontline therapy
Blood Advances - Tập 5 - Trang 5179-5189 - 2021
David A. Bond, Jeffrey M. Switchenko, Diego Villa, Kami Maddocks, Michael Churnetski, Alina S. Gerrie, Subir Goyal, Krithika Shanmugasundaram, Oscar Calzada, Bhaskar Kolla, Veronika Bachanova, James N. Gerson, Stefan K. Barta, Brian T. Hill, Yazeed Sawalha, Peter Martin, Edward Maldonado, Max Gordon, Alexey V. Danilov, Natalie S. Grover
Abstract Although an expanding array of effective treatments has resulted in recent improvement in survival of patients with mantle cell lymphoma (MCL), outcomes remain heterogeneous, and identification of prognostic factors remains a priority. We assessed the prognostic impact of time to progression of disease (POD) after first-line therapy among 45...... hiện toàn bộ
BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus–associated T/NK-cell lymphoma
Blood Advances - Tập 4 Số 19 - Trang 4775-4787 - 2020
MAP kinase activating death domain deficiency is a novel cause of impaired lymphocyte cytotoxicity
Blood Advances - Tập 7 - Trang 1531-1535 - 2023
Kerstin Schütze, Miriam Groß, Kerstin Cornils, Katharina Wustrau, Sonja Schneppenheim, Henning Lenhartz, G. Christoph Korenke, Gritta Janka, Svea Ledig, Ingo Müller, Stephan Ehl, Kai Lehmberg
Abstract Most hereditary forms of hemophagocytic lymphohistiocytosis (HLH) are caused by defects of cytotoxicity, including the vesicle trafficking disorder Griscelli syndrome type 2 (GS2, RAB27A deficiency). Deficiency of the mitogen-activated protein kinase activating death domain protein (MADD) results in a protean syndrome with neurological and e...... hiện toàn bộ
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