Single-cell heterogeneity in Sézary syndrome

Blood Advances - Tập 2 - Trang 2115-2126 - 2018
Terkild Brink Buus1, Andreas Willerslev-Olsen1, Simon Fredholm1, Edda Blümel1, Claudia Nastasi, Maria Gluud1, Tengpeng Hu, Lise M. Lindahl2, Lars Iversen2, Hanne Fogh3, Robert Gniadecki3, Ivan V. Litvinov4, Jenny L. Persson5,6, Charlotte Menné Bonefeld1, Carsten Geisler1, Jan Pravsgaard Christensen1, Thorbjørn Krejsgaard1, Thomas Litman1, Anders Woetmann1, Niels Ødum1
1Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
2Department of Dermatology, Aarhus University Hospital, Skejby, Aarhus, Denmark;
3Department of Dermatology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark
4Division of Dermatology, McGill University, Montreal, QC, Canada
5Clinical Research Center, Lund University, Malmö, Sweden
6Department of Molecular Biology, Umeå University, Umeå, Sweden

Tóm tắt

Key Points Individual patients with Sézary syndrome contain several distinct malignant subpopulations and show marked single-cell heterogeneity. Malignant subpopulations exhibit differences in their sensitivity to treatment warranting precision therapy.

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Blood Advances

Tập 2

2115-2126

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