Zinc depletion suppresses tumor growth in miceBiological Trace Element Research - Tập 59 - Trang 23-29 - 1997
Atsüshi Takeda, Kazühiko Goto, Shoji Okada
The hypothesis that in tumor-bearing animals an increase of host hepatic zinc metallothionein (Zn-MT) causes a restriction of zinc in the tumor tissue was studied. Three types of tumors were induced in laboratory mice by cell transplant. Tumor growth appears to be inhibited under zinc-deficient conditions, even in cases where zinc deficiency was started after tumor cell transplant. The survival ti...... hiện toàn bộ
Measurement of Iron in Flour and Commonly-Used Breads Baked in Isfahan, Iran: A Risk Assessment Study with Monte Carlo SimulationBiological Trace Element Research - - Trang 1-8 - 2024
Zahra Esfandiari, Roya Abdei Soleimani, Raziyeh Eshaghi, Fateme Saffari Samani, Mohammad Kazerooni, Arghavan Madani, Sara Mohamadi
Fortification of highly-consumed foods such as bread is an easy and cheap strategy to combat the iron deficiency anemia. However, there have sometimes been some side effects such as iron overload and digestive problems. Accordingly, this study aimed to examine the amount of iron as well as its non-carcinogenic risks in commonly-used types of Iranian flour and breads (Barbary, Lavash, and Tafton) i...... hiện toàn bộ
Maternal and Umbilical Cord Blood Levels of Zinc and Copper in Active Labor Versus Elective Caesarean Delivery at Khartoum Hospital, SudanBiological Trace Element Research - Tập 169 - Trang 52-55 - 2015
Alaeldin Elhadi, Duria A. Rayis, Hala Abdullahi, Leana M. Elbashir, Naji I. Ali, Ishag Adam
A case–control study was conducted in Khartoum Hospital Sudan to determine maternal and umbilical cord blood levels of zinc and copper in active labor versus elective cesarean delivery. Cases were women delivered vaginally and controls were women delivered by elective cesarean (before initiation of labor). Paired maternal and cord zinc and copper were measured using atomic absorption spectrophotom...... hiện toàn bộ
Mechanism of cadmium-induced cytotoxicity in rat hepatocytesBiological Trace Element Research - Tập 42 - Trang 31-41 - 1994
Toshiaki Koizumi, Toshiki Yokota, Kazuo T. Suzuki
Exposure of rat hepatocytes to cadmium below 50 μM for a short period (10 min) resulted in cellular acidification. Conversely, exposure to Cd more than 50 μM for a long period (60 min) caused cellular alkalinization accompanied by membrane damage as reflected by decrease in cellular K content and loss of intracellular lactic dehydrogenase. In hepatocytes exposed to 5 μM Cd, a concentration suffici...... hiện toàn bộ
Selenium-Based Novel Epigenetic Regulators Offer Effective Chemotherapeutic Alternative with Wider Safety Margins in Experimental Colorectal CancerBiological Trace Element Research - Tập 200 - Trang 635-646 - 2021
Preety Ghanghas, Monika Sharma, Dhimant Desai, Kaisar Raza, Aman Bhalla, Pramod Kumar, Dipika Narula, Shantu Amin, Sankar Nath Sanyal, Naveen Kaushal
Colorectal cancer (CRC) is a major cause of morbidity and mortality worldwide. Despite the critical involvement of epigenetic modifications in CRC, the studies on the chemotherapeutic efficacy of various epigenetic regulators remain limited. Considering the key roles of histone deacetylases (HDACs) in the regulation of diverse cellular processes, several HDAC inhibitors are implied as effective th...... hiện toàn bộ
Copper Changes Intestinal Microbiota of the Cecum and Rectum in Female Mice by 16S rRNA Gene SequencingBiological Trace Element Research - Tập 193 - Trang 445-455 - 2019
Sufang Cheng, Huirong Mao, Yezhao Ruan, Cong Wu, Zheng Xu, Guoliang Hu, Xiaoquan Guo, Caiying Zhang, Huabin Cao, Ping Liu
The aim of the present study was to investigate the effects of high concentrations of copper (Cu) on the cecum and rectum of intestinal microbiota in female mice. Twenty-four Kunming mice were weighed and randomly divided into two groups (n = 12 per group) including the control group and Cu group. Cu group was given drinking water with 5 mg/kg-bw copper chloride (CuCl2), while the control group wa...... hiện toàn bộ