Maternal and Umbilical Cord Blood Levels of Zinc and Copper in Active Labor Versus Elective Caesarean Delivery at Khartoum Hospital, Sudan
Tóm tắt
A case–control study was conducted in Khartoum Hospital Sudan to determine maternal and umbilical cord blood levels of zinc and copper in active labor versus elective cesarean delivery. Cases were women delivered vaginally and controls were women delivered by elective cesarean (before initiation of labor). Paired maternal and cord zinc and copper were measured using atomic absorption spectrophotometry. The two groups (52 paired maternal and cord in each arm) were well matched in their basic characteristics. In comparison with cesarean delivery, the median (interquartile range) of both maternal [87.0 (76.1–111.4) vs. 76.1 (65.2–88.3) μg/dL, P = 0.004] and cord zinc [97.8 (87.0–114.1) vs. 81.5(65.2–110.2) μg/dL P = 0.034] levels were significantly higher in the vaginal delivery. While there was no significant difference in the maternal copper [78.8 (48.1–106.1) vs. 92.4 (51.9–114.9) μg/dL, P = 0.759], the cord copper [43.5(29.9–76.1) vs. 32.2(21.7–49.6) μg/dL, P = 0.019] level was significantly higher in vaginal delivery. There was no significant correlation between zinc (both maternal and cord) and copper. While the cord zinc was significantly correlated with maternal zinc, there was no significant correlation between maternal and cord copper. The current study showed significantly higher levels of maternal and cord zinc and cord copper in women who delivered vaginally compared with caesarean delivery.
Tài liệu tham khảo
Paşaoğlu H, Muhtaroğlu S, Güneş M, Utaş C (1996) The role of the oxidative state of glutathione and glutathione-related enzymes in anaemia of hemodialysis patients. Clin Biochem 29:567–572
Van Nhien N, Khan NC, Yabutani T, Ninh NX, Kassu A, Huong BT, Do TT, Motonaka J, Ota F (2006) Serum levels of trace elements and iron-deficiency anaemia in adult Vietnamese. Biol Trace Elem Res (111):1–9
Alebic-Juretic A, Frkovic A (2005) Plasma copper concentrations in pathological pregnancies. J Trace Elem Med Biol 19:191–194
Engle-Stone R, Ndjebayi AO, Nankap M, Killilea DW, Brown KH (2014) Stunting prevalence, plasma zinc concentrations, and dietary zinc intakes in a nationally representative sample suggest a high risk of zinc deficiency among women and young children in Cameroon. J Nutr 144(3):382–391
Perveen S, Altaf W, Vohra N, Bautista ML, Harper RG, Wapnir RA (2002) Effect of gestational age on cord blood plasma copper, zinc, magnesium and albumin. Early Hum Dev 69(1-2):15–23
Al-Saleh E, Nandakumaran M, Al-Shammari M, Al-Falah F, Al-Harouny A (2004) Assessment of maternal-fetal status of some essential trace elements in pregnant women in late gestation: relationship with birth weight and placental weight. J Matern Fetal Neonatal Med 16(1):9–14
Cunningham G, Leveno KJ et al. (2010) Williams obstetrics. 23rd ed. Chapter 6. McGRAW-HILL, Medical Publishing Division. pp 261–277.
Germain AM, Smith J, Casey ML, MacDonald PC (1994) Human fetal membrane contribution to the prevention of parturition: uterotonin degradation. J Clin Endocrinol Metab 78(2):463–470
Lazer T, Paz-Tal O, Katz O, Aricha-Tamir B, Sheleg Y, Maman R, Silberstein T, Mazor M, Wiznitzer A, Sheiner E (2012) Trace elements’ concentrations in maternal and umbilical cord plasma at term gestation: a comparison between active labor and elective cesarean delivery. J Matern Fetal Neonatal Med 25(3):286–289
Mocchegiani E, Costarelli L, Giacconi R, Malavolta M, Basso A, Piacenza F, Ostan R, Cevenini E, Gonos ES, Monti D (2014) Micronutrient-gene interactions related to inflammatory/immune response and antioxidant activity in ageing and Inflammation. A systematic review. Mech Aging Dev 137:29–49
Cheknev SB, Efremova IE, Apresova MA, Babajantz AA (2013) Induction of TNF-α production by metal complexes of γ-globulin fraction proteins and copper and zinc cations. Bull Exp Biol Med 154(6):758–761
Bakheit KH, Bayoumi NK, Adam I (2008) Peripheral, placental and cord cytokines profile in spontaneous labor and elective caesarean section. Iran J Immunol 5(3):185–188
Than NG, Romero R, Tarca AL, Draghici S, Erez O, Chaiworapongsa T, Kim YM, Kim SK, Vaisbuch E, Tromp G (2009) Mitochondrial manganese superoxide dismutase mRNA expression in human chorioamniotic membranes and its association with labor, inflammation, and infection. J Matern Fetal Neonatal Med 22(11):1000–1013
Weiss A, Goldman S, Shalev E (2007) The matrix metalloproteinases (MMPs) in the decidua and fetal membranes. Front Biosci 12:649–659 Review
Vu TD, Feng Y, Placido J, Reznik SE (2008) Placental matrix metalloproteinase–1 expression is increased in labor. Reprod Sci 15:420–424