Biological Chemistry
SCOPUS (1881,1952,1975,1996-2025)SCIE-ISI
1431-6730
1437-4315
Đức
Cơ quản chủ quản: Walter de Gruyter GmbH
Lĩnh vực:
Molecular BiologyClinical BiochemistryBiochemistry
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Glutathione dysregulation and the etiology and progression of human diseases
Tập 390 Số 3 - Trang 191-214 - 2009
AbstractGlutathione (GSH) plays an important role in a multitude of cellular
processes, including cell differentiation, proliferation, and apoptosis, and as
a result, disturbances in GSH homeostasis are implicated in the etiology and/or
progression of a number of human diseases, including cancer, diseases of aging,
cystic fibrosis, and cardiovascular, inflammatory, immune, metabolic, and
neurodege...
Mitophagy: mechanisms, pathophysiological roles, and analysis
Tập 393 Số 7 - Trang 547-564 - 2012
Abstract Mitochondria are essential organelles that regulate cellular energy
homeostasis and cell death. The removal of damaged mitochondria through
autophagy, a process called mitophagy, is thus critical for maintaining proper
cellular functions. Indeed, mitophagy has been recently proposed to play
critical roles in terminal differentiation of red blood cells, paternal
mitochondrial degradation, ...
The role of oxidative stress during inflammatory processes
Tập 395 Số 2 - Trang 203-230 - 2014
AbstractThe production of various reactive oxidant species in excess of
endogenous antioxidant defense mechanisms promotes the development of a state of
oxidative stress, with significant biological consequences. In recent years,
evidence has emerged that oxidative stress plays a crucial role in the
development and perpetuation of inflammation, and thus contributes to the
pathophysiology of a numb...
The coming of age of virus-like particle vaccines
Tập 389 Số 5 - Trang 521-536 - 2008
Abstract Virus-like particles are supra-molecular assemblages, usually
icosahedral or rod-like structures. They incorporate key immunologic features of
viruses which include repetitive surfaces, particulate structures and induction
of innate immunity through activation of pathogen-associated molecular-pattern
recognition receptors. They carry no replicative genetic information and can be
produced ...
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
Tập 394 Số 3 - Trang 393-414 - 2013
Abstract Muscle loss during aging and disuse is a highly prevalent and disabling
condition, but knowledge about cellular pathways mediating muscle atrophy is
still limited. Given the postmitotic nature of skeletal myocytes, the
maintenance of cellular homeostasis relies on the efficiency of cellular quality
control mechanisms. In this scenario, alterations in mitochondrial function are
considered ...
A Unique Cascade of Oxidoreductases Catalyses Trypanothione-Mediated Peroxide Metabolism in Crithidia fasciculata
Tập 378 Số 8 - 1997
An introduction to the molecular basics of aryl hydrocarbon receptor biology
Tập 391 Số 11 - 2010
AbstractDepending on their chemical structure and properties, environmental
chemicals and other xenobiotics that enter the cell can affect cellular function
by either nonselective binding to cellular macromolecules or by interference
with cellular receptors, which would initiate a more defined cell biological
response. One of these intracellular chemosensor molecules is the aryl
hydrocarbon recept...
C-reactive protein and inflammation: conformational changes affect function
Tập 396 Số 11 - Trang 1181-1197 - 2015
Abstract The prototypic acute-phase reactant C-reactive protein (CRP) has long
been recognized as a useful marker and gauge of inflammation. CRP also plays an
important role in host defense against invading pathogens as well as in
inflammation. CRP consists of five identical subunits arranged as a cyclic
pentamer. CRP exists in at least two conformationally distinct forms, i.e.
native pentameric C...