C-reactive protein and inflammation: conformational changes affect function

Griselli, 1999, reactive protein and complement are important mediators of tissue damage in acute myocardial infarction, Exp Med, 190

Asztalos, 2014, Obesity associated molecular forms of reactive protein in human One

Schwedler, 2005, Native reactive protein increases whereas modified reactive protein reduces atherosclerosis in apolipoprotein knockout mice, Circulation, 112

Sjöberg, 2006, Regulation of complement activation by reactive protein : targeting of the inhibitory activity of binding protein, J Immunol, 176

Calabro, 2003, Inflammatory cytokines stimulated reactive protein production by human coronary artery smooth muscle cells, Circulation, 108

Eisenhardt, 2009, von zur Dissociation of pentameric to monomeric reactive protein on activated platelets localizes inflammation to atherosclerotic plaques, Res, 105

Nimmerjahn, 2008, receptors as regulators of immune responses, Nat Rev Immunol, 8

Slevin, 2010, de Modified - reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesisin vitro, Brain Pathol, 20, 151, 10.1111/j.1750-3639.2008.00256.x

Sreeramkumar, 2014, Neutrophils scan for activated platelet to initiate inflammation, Science, 346

Verma, 2006, reactive protein promotes atherothrombosis, Circulation, 113

Koenig, 2013, High - sensitivity reactive protein and atherosclerotic disease : from improved risk prediction to risk - guided therapy, Int J Cardiol, 168

Torzewski, 2000, reactive protein in the arterial intima : role of reactive protein receptor - dependent monocyte recruitment in atherogenesis, Thromb Biol, 20, 2094, 10.1161/01.ATV.20.9.2094

Hammond, 2010, Identification of acidic pH - dependent ligands of pentameric reactive protein, J Biol Chem, 285

Fujii, 2006, reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells, Thromb Biol, 26, 2476, 10.1161/01.ATV.0000242794.65541.02

Zhong, 1998, Effect of human reactive protein on chemokine and chemotactic factor - induced neutrophil chemotaxis and signaling, Immunol, 161

Casas, 2008, reactive protein and coronary heart disease a critical, review Intern Med, 264

Kovacs, 2007, Human - reactive protein slows atherosclerosis development in a mouse model with human - like hypercholesterolemia, Proc Natl Acad Sci USA, 13768, 10.1073/pnas.0706027104

Filep, 2009, affect the structure and function of reactive protein, Platelets Res, 105

Devaraj, 2003, reactive protein increases plasminogen activator inhibitor - expression and activity in human aortic endothelial cells : Implications for the metabolic syndrome and atherothrombosis, Circulation, 1

Verma, 2004, reactive protein attenuates endothelial progenitor cell survival differentiation and functionL further evidence of a mechanistic link between reactive protein and cardiovascular disease, Circulation, 109

Molins, 2008, reactive protein isoforms differ in their effects on thrombus growth, Thromb Biol, 28, 2239, 10.1161/ATVBAHA.108.174359

Kaplan, 2009, Premature vascular damage in systemic lupus erythematosus, Autoimmunity, 580, 10.1080/08916930903002479

Rodic, 2002, Mold Du Protection fromStreptococcus pneumoniaeinfection by reactive protein and natural antibody requires complement but not Fcgamma receptors, Immunol, 168

Pasceri, 2000, Direct proinflammatory effect of reactive protein on human endothelial cells, Circulation, 2165, 10.1161/01.CIR.102.18.2165

Potempa, 1983, electrophoretic and binding alterations of human reactive protein modified selectively in the absence of calcium, Mol Immunol, 20, 1165, 10.1016/0161-5890(83)90140-2

Vigo, 1985, Effect of reactive protein on platelet - activating factor - induced platelet aggregation and membrane stabilization, Biol Chem, 260

Lu, 2008, Du and Structural recognition and functional activation of FcγR by innate pentraxins, Nature, 456

Ma, 2009, reactive protein activates endothelial cells via interaction with lipid raft micro - domains, FASEB J, 23, 1806, 10.1096/fj.08-116962

Han, 2004, reactive protein promotes monocyte chemoattractant protein - - mediated chemotaxis through up - regulating CC chemokine receptor expression in human monocytes, Circulation, 109

Zhou, 1995, Human monocytes produce monocyte chemoattractant protein in response to a synthetic peptide derived from reactive protein, Clin Immunol Immunopathol, 1

Wang, Increased monomeric CRP levels in acute myocardial infarction : a possible new and specific biomarker for diagnosis and severity assessment of disease, Atherosclerosis, 2015

Thiele, 2014, von The dissociation of pentameric to monomeric - reactive protein localizes and aggravates inflammation : in vivoproof of a powerful pro - inflammatory mechanisms and a new anti - inflammatory strategy, Circulation, 130

Kapur, de der reactive protein enhances IgG mediated phagocyte responses and thrombocytopenia, Blood, 2015

Cunninghame Graham, 2004, Polymorphism in the reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus, Russell Hum Mol Genet, 13, 137

Montecucco, 2008, reactive protein induces chemokine secretion via CD interaction in human adherent monocytes, Biol, 11, 1

Kovacs, 2007, Human - reactive protein slows atherosclerosis development in a mouse model with human - like hypercholesterolemia, Proc Natl Acad Sci USA, 13768, 10.1073/pnas.0706027104

Schwedler, 2009, - reactive protein decreases acetylated LDL uptake in human endothelial cells, Clin Chem, 1728, 10.1373/clinchem.2009.125732

Pasceri, 2001, Modulation of reactive protein - mediated monocyte chemoattractant protein induction in human endothelial cells by anti - atherosclerosis drugs, Circulation, 1

Szalai, 2002, Experimental allergic encephalomyelitis is inhibited in transgenic mice expressing human reactive protein, J Immunol, 168

Tanigaki, 2007, reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine - based inhibition motif of FcγRIIB and SHIP, Res, 1

Marnell, 2005, Mold Du reactive protein ligands receptors and role in inflammation, Clin Immunol, 117, 104, 10.1016/j.clim.2005.08.004

Gershov, 2000, - reactive protein binds to apoptotic cells protects the cells from the assembly of the terminal complement components and sustains an antiinflamamtory innate immune response, Exp Med, 192

Kaplan, 2009, Premature vascular damage in systemic lupus erythematosus, Autoimmunity, 580, 10.1080/08916930903002479

Black, 2004, reactive protein, J Biol Chem, 279

Bisoendial, 2005, den Activation of inflammation and coagulation after infusion of reactive protein in humans, Res, 714

Xia, 1997, Transgenic mice expressing rabbit reactive protein are resistant to endotoxemia, Proc Natl Acad Sci USA, 2575, 10.1073/pnas.94.6.2575

Wang, 2011, redox switch in - reactive protein modulates activation of endothelial cells, FASEB J, 25, 3186, 10.1096/fj.11-182741

Filep, 2009, Neutrophil a target for enhancing the resolution of inflammation, apoptosis Cell Biochem, 108

Li, 2012, reactive protein alters fibrin clot properties on endothelial cells, Res, 129

Bisoendial, 2007, Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects, Lipid Res, 952, 10.1194/jlr.P600014-JLR200

Hill, 2003, Circulating endothelial progenitor cells vascular function and cardiovascular risk, Engl J Med, 348

Marnell, 1995, Du reactive protein binds to FcγRI in transfected COS cells, Immunol, 155

van, 2004, den reactive protein - inducedin vivovasorelaxation is an artefect caused by the presence of sodium azide in commercial preparations, Thromb Biol, 24, 158

Zwaka, 2001, Hombach reactive protein - mediated low density lipoprotein uptake by macrophages : implications for atherosclerosis, Circulation, 103

Schwedler, 2005, Native reactive protein increases whereas modified reactive protein reduces atherosclerosis in apolipoprotein knockout mice, Circulation, 112

Gabay, 1999, Acute - phase proteins and other systemic responses to inflammation, Engl J Med, 340

Chang, 2002, reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand : phosphorylcholine of oxidized phospholipids, Proc Natl Acad Sci USA, 99

Rodriguez, 2007, Du reactive protein - mediated suppression of nephrotoxic nephritis : role of macrophages complement receptors, Immunol, 178

Ying, 1989, Identification and partial characterization of multiple native and neoantigenic epitopes of human reactive protein, J Immunol, 143

Hanson, 2006, The immune response in atherosclerosis a double - edged sword, Nat Rev Immunol, 508, 10.1038/nri1882

Ying, 1992, de and Localization of sequence - determined neoepitopes and neutrophil digestion fragments of reactive protein utilizing monoclonal antibodies and synthetic peptides, Mol Immunol, 29, 677, 10.1016/0161-5890(92)90205-C

Stein, 2000, Du reactive protein binding to FcγRIIa on human monocyte sand neutrophils is allele - specific, Clin Invest, 105

Vigo, 1985, Effect of reactive protein on platelet - activating factor - induced platelet aggregation and membrane stabilization, Biol Chem, 260

van, 2004, den reactive protein - inducedin vivovasorelaxation is an artefect caused by the presence of sodium azide in commercial preparations, Thromb Biol, 24, 158

Wang, 2001, Dissociation and subunit rearrangement of membrane - bound human reactive proteins, Biochem Biophys Res Commun, 288

Kardys, 2006, de and reactive protein gene haplotypes and risk of coronary heart disease : the Rotterdam study, Eur Heart J, 27, 1331, 10.1093/eurheartj/ehl018

Gershov, 2000, - reactive protein binds to apoptotic cells protects the cells from the assembly of the terminal complement components and sustains an antiinflamamtory innate immune response, Exp Med, 192

Schwedler, 2007, Native reactive protein induces endothelial dysfunction in ApoE - mice : implications of iNOS and reactive oxygen species, Atherosclerosis, 195

Sternik, 2002, reactive protein relaxes human vesselsin vitro, Thromb Biol, 22, 1865, 10.1161/01.ATV.0000033821.96354.90

Ahrens, 2011, Opposing effects of monomeric and pentameric reactive protein on endothelial progenitor cells Basic, Res Cardiol, 106

Potempa, 1983, electrophoretic and binding alterations of human reactive protein modified selectively in the absence of calcium, Mol Immunol, 20, 1165, 10.1016/0161-5890(83)90140-2

Qamirani, 2005, reactive protein inhibits endothelium dependent NO - mediated dilation in coronary arterioles by activating kinase oxidase, Thromb Biol, 25, 995, 10.1161/01.ATV.0000159890.10526.1e

Bang, 2005, Du and Du Analysis of binding sites in human reactive protein for q by site - directed mutagenesis, Biol Chem, 1

Gill, 2004, Human reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats Flow, Blood, 24, 1214

Szalai, 2003, Delayed lupus onset in mice expressing a human reactive protein transgene, Arthritis Rheum, 1

Paul, 2004, reactive protein accelerates the progression of atherosclerosis in apolipoprotein deficient mice, Circulation, 109

Sreeramkumar, 2014, Neutrophils scan for activated platelet to initiate inflammation, Science, 346

Casas, 2008, reactive protein and coronary heart disease a critical, review Intern Med, 264

Vilahur, 2009, Short - term myocardial ischemia induces cardiac modified reactive protein expression and proinflammatory gene ( cyclo - oxygenase monocyte chemoattractant protein and tissue factor ) upregulation in peripheral blood mononuclear cells, Thromb Haemost, 1

Fu, 2002, Macrophage uptake of low - density lipoprotein bound to aggregated reactive protein : possible mechanism of foam - cell formation in atherosclerotic lesions, Biochem J, 366

Mihlan, 2011, Zipfel reactive protein modulates classic complement activation on necrotic cells, FASEB J, 25, 4198, 10.1096/fj.11-186460

Tsimikas, 2006, reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients, Am Coll Cardiol, 19, 10.1016/j.jacc.2005.10.066

Wang, 2011, a reactive protein aptamer binds to monomeric but not pentameric from of, Anal Bioanal Chem, 401

Wang, 2001, Dissociation and subunit rearrangement of membrane - bound human reactive proteins, Biochem Biophys Res Commun, 288

Li, 2012, reactive protein alters fibrin clot properties on endothelial cells, Res, 129

Noveck, 2014, Effects of an antisense oligonucleotide inhibitor of reactive protein synthesis on the endotoxin challenge response in healthy human male volunteers pii, Heart Assoc, 10.1161/JAHA.114.001084

Pepys, 2003, reactive protein a critical update, Clin Invest, 111

Sjöberg, 2006, Regulation of complement activation by reactive protein : targeting of the inhibitory activity of binding protein, J Immunol, 176

Fu, 2002, Macrophage uptake of low - density lipoprotein bound to aggregated reactive protein : possible mechanism of foam - cell formation in atherosclerotic lesions, Biochem J, 366

Schwedler, 2007, Native reactive protein induces endothelial dysfunction in ApoE - mice : implications of iNOS and reactive oxygen species, Atherosclerosis, 195

Reynolds, 1987, reactive protein immunohistochemical localization in normal and atherosclerotic human aortas, Arch Pathol Lab Med, 111

Szalai, 2002, Experimental allergic encephalomyelitis is inhibited in transgenic mice expressing human reactive protein, J Immunol, 168

Hanriot, 2008, - reactive protein induces pro - and anti - inflammatory effects including activation of the liver receptor α on human monocytes, 99

Zwaka, 2001, Hombach reactive protein - mediated low density lipoprotein uptake by macrophages : implications for atherosclerosis, Circulation, 103

Krijnen, 2005, colocalizes with complement - reactive protein in infarcted myocardium, Clin Pathol, 382, 10.1136/jcp.2004.022988

Rodic, 2002, Mold Du Protection fromStreptococcus pneumoniaeinfection by reactive protein and natural antibody requires complement but not Fcgamma receptors, Immunol, 168

Okemefuna, 2010, reactive protein exists in an NaCl concentration - dependent pentamer - decamer equilibrium in physiological buffer, Biol Chem, 285

Venugopal, 2002, Demonstration that reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells, Circulation, 106

Devaraj, 2006, promotes monocyte - endothelial cell adhesion via Fcγ receptors in human aortic endothelial cells under static and shear flow conditions, Am J Physiol Heart, 291

Khreiss, 2002, Loss of pentameric symmetry of reactive protein is associated with delayed apoptosis of human neutrophils, Biol Chem, 277

Molins, 2008, reactive protein isoforms differ in their effects on thrombus growth, Thromb Biol, 28, 2239, 10.1161/ATVBAHA.108.174359

Torzewski, 1998, reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries, Thromb Biol, 18, 1386, 10.1161/01.ATV.18.9.1386

Schwartz, 2007, reactive protein downregulates endothelial NO synthase and attenuates reendothelializationin vivoin mice, Res, 1452

Scirica, 2006, Is reactive protein an innocent bystander of proatherogenic culprit, Circulation, 113

Tilg, 1993, Antiinflammatory properties of hepatic acute phase proteins : preferential induction of interleukin receptor antagonist over IL β synthesis by human peripheral blood mononuclear cells, IL Exp Med, 1

Ying, 1992, de and Localization of sequence - determined neoepitopes and neutrophil digestion fragments of reactive protein utilizing monoclonal antibodies and synthetic peptides, Mol Immunol, 29, 677, 10.1016/0161-5890(92)90205-C

Okemefuna, 2010, reactive protein exists in an NaCl concentration - dependent pentamer - decamer equilibrium in physiological buffer, Biol Chem, 285

Noveck, 2014, Effects of an antisense oligonucleotide inhibitor of reactive protein synthesis on the endotoxin challenge response in healthy human male volunteers pii, Heart Assoc, 10.1161/JAHA.114.001084

Sjöwall, 2004, Serum levels of autoantibodies against monomeric reactive protein are correlated with disease activity in systemic lupus erythematosus, Arthritis res Ther, 87, 10.1186/ar1032

Lane, 2014, Infusion of pharmaceutical - grade natural human reactive protein is not proinflammatory in healthy adult human volunteers, Res, 114

Heuertz, 1996, Peptides derived from reactive protein inhibit neutrophil alveolitis, Immunol, 156

Pepys, 2006, Targeting reactive protein for the treatment of cardiovascular disease, Nature, 440

Gabay, 1999, Acute - phase proteins and other systemic responses to inflammation, Engl J Med, 340

Heuertz, 1996, Peptides derived from reactive protein inhibit neutrophil alveolitis, Immunol, 156

Szalai, 2014, Inhibiting reactive protein for the treatment of cardiovascular disease : promising evidence from rodent models, Med, 353614

Wu, 2006, a Effect of modified reactive protein on complement activation, Thromb Biol, 26, 935

Marnell, 2005, Mold Du reactive protein ligands receptors and role in inflammation, Clin Immunol, 117, 104, 10.1016/j.clim.2005.08.004

Kakuta, 2006, reactive protein products generated by neutrophil elastase promote neutrophils, apoptosis Arch Med Res, 37

Vilahur, 2009, Short - term myocardial ischemia induces cardiac modified reactive protein expression and proinflammatory gene ( cyclo - oxygenase monocyte chemoattractant protein and tissue factor ) upregulation in peripheral blood mononuclear cells, Thromb Haemost, 1

Devaraj, 2011, reactive protein polarizes human macrophages to an phenotype and inhibits transformation to the phenotype, Thromb Biol, 31, 1397, 10.1161/ATVBAHA.111.225508

Rodriguez, 2007, Du reactive protein - mediated suppression of nephrotoxic nephritis : role of macrophages complement receptors, Immunol, 178

Khreiss, 2004, Opposing effects of reactive protein isoforms on shear - induced neutrophil - platelet adhesion and neutrophil aggregation in whole blood, Circulation, 110

Li, 2004, reactive protein upregulates complement - inhibitory factors in endothelial cells, Circulation, 109

Sun, 2005, reactive protein in atherosclerotic lesions : its origin and pathophysiological significance, Am J Pathol, 167

Ley, 2007, Getting to the site of inflammation : the leukocyte adhesion cascade updated, Nat Rev Immunol, 678, 10.1038/nri2156

Shrive, 1996, Three dimensional structure of human reactive protein, Nat Struct Biol, 346, 10.1038/nsb0496-346

Bisoendial, 2007, Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects, Lipid Res, 952, 10.1194/jlr.P600014-JLR200

Schwedler, 2003, Tubular staining of modified reactive protein in diabetic chronic kidney disease Transplant, 18, 2300

Khreiss, 2004, a Conformational rearrangement in reactive protein is required for proinflammatory actions on human endothelial cells, Circulation, 109

Hage, 2010, reactive protein - mediated vascular injury requires complement, Thromb Biol, 30, 1189, 10.1161/ATVBAHA.110.205377

Monteiro, 2003, den Fc receptors, Annu Rev Immunol, 21, 177, 10.1146/annurev.immunol.21.120601.141011

Kapur, de der reactive protein enhances IgG mediated phagocyte responses and thrombocytopenia, Blood, 2015

Lu, 2011, Du Recognition and functional activation of the human IgA receptor by reactive protein, Proc Natl Acad Sci USA, 108

Yasojima, 2001, Generation of reactive protein and complement components in atherosclerotic, plaques Am J Pathol, 158

Li, 2004, a reactive protein enhances LOX expression in human aortic endothelial cells : relevance of LOX to reactive protein - induced endothelial dysfunction, Res, 1

Walsh, 1996, mapping of the human pentraxin gene region on chromosome q, Immunogenetics, 1

Crawford, 2006, Genetic variation is associated with reactive protein levels in the third national health and nutrition examination survey, Circulation, 114

Gill, 2004, Human reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats Flow, Blood, 24, 1214

Schwedler, 2006, reactive protein : a family of proteins to regulate cardiovascular function, Am J Kidney Dis, 212, 10.1053/j.ajkd.2005.10.028

Lu, 2008, Du and Structural recognition and functional activation of FcγR by innate pentraxins, Nature, 456

Hanson, 2006, The immune response in atherosclerosis a double - edged sword, Nat Rev Immunol, 508, 10.1038/nri1882

Devaraj, 2005, Du and Binding and internalization of - reactive protein by Fc gamma receptors on human aortic endothelial cells mediates biological effects, Thromb Biol, 25, 1359, 10.1161/01.ATV.0000168573.10844.ae

Monteiro, 2003, den Fc receptors, Annu Rev Immunol, 21, 177, 10.1146/annurev.immunol.21.120601.141011

Cunninghame Graham, 2004, Polymorphism in the reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus, Russell Hum Mol Genet, 13, 137

Wu, 2006, The interactions of low density lipoprotein with different forms of reactive protein : implication of an active role of modified reactive protein in the pathogenesis of atherosclerosis, Int J Biochem Cell Biol, 648

Agrawal, 2001, structure of the q - binding site on reactive protein, Topology J Immunol, 1

Chang, 2002, reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand : phosphorylcholine of oxidized phospholipids, Proc Natl Acad Sci USA, 99

Murray, 2011, Protective and pathogenic functions of macrophage subsets, Nat Rev Immunol, 11, 723, 10.1038/nri3073

Sica, 2012, plasticity polarization in vivoveritas, Clin Invest, 122

Krijnen, 2005, colocalizes with complement - reactive protein in infarcted myocardium, Clin Pathol, 382, 10.1136/jcp.2004.022988

Devaraj, 2006, promotes monocyte - endothelial cell adhesion via Fcγ receptors in human aortic endothelial cells under static and shear flow conditions, Am J Physiol Heart, 291

Torzewski, 2000, reactive protein in the arterial intima : role of reactive protein receptor - dependent monocyte recruitment in atherogenesis, Thromb Biol, 20, 2094, 10.1161/01.ATV.20.9.2094

Verma, 2004, reactive protein attenuates endothelial progenitor cell survival differentiation and functionL further evidence of a mechanistic link between reactive protein and cardiovascular disease, Circulation, 109

Pepys, 2003, reactive protein a critical update, Clin Invest, 111

Koenig, 2013, High - sensitivity reactive protein and atherosclerotic disease : from improved risk prediction to risk - guided therapy, Int J Cardiol, 168

Murray, 2011, Protective and pathogenic functions of macrophage subsets, Nat Rev Immunol, 11, 723, 10.1038/nri3073

Hanriot, 2008, - reactive protein induces pro - and anti - inflammatory effects including activation of the liver receptor α on human monocytes, 99

Filep, 2009, Neutrophil a target for enhancing the resolution of inflammation, apoptosis Cell Biochem, 108

Slevin, 2010, de Modified - reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesisin vitro, Brain Pathol, 20, 151, 10.1111/j.1750-3639.2008.00256.x

Sternik, 2002, reactive protein relaxes human vesselsin vitro, Thromb Biol, 22, 1865, 10.1161/01.ATV.0000033821.96354.90

Zhou, 1995, Human monocytes produce monocyte chemoattractant protein in response to a synthetic peptide derived from reactive protein, Clin Immunol Immunopathol, 1

Wu, 2006, The interactions of low density lipoprotein with different forms of reactive protein : implication of an active role of modified reactive protein in the pathogenesis of atherosclerosis, Int J Biochem Cell Biol, 648

Zouki, 2001, Loss of pentameric symmetry of reactive protein is associated with promotion of neutrophil - endothelial cell adhesion, Immunol, 167

Tillett, 1930, Serological reactions in pneumonia with a non - protein somatic fraction of pneumococcus, Exp Med, 561, 10.1084/jem.52.4.561

Black, 2004, reactive protein, J Biol Chem, 279

Fujita, 2009, Oxidized LDL receptor LOX binds to - reactive protein and mediates its vascular effects, Clin Chem, 1

Fadi, 2010, reactive protein - mediated vascular injury requires complement, Thromb Biol, 30, 1189, 10.1161/ATVBAHA.110.205377

Montecucco, 2008, reactive protein induces chemokine secretion via CD interaction in human adherent monocytes, Biol, 11, 1

Teupser, 2011, No reduction of atherosclerosis in reactive protein deficient mice, Biol Chem, 286

Ley, 2007, Getting to the site of inflammation : the leukocyte adhesion cascade updated, Nat Rev Immunol, 678, 10.1038/nri2156

Li, 2004, reactive protein upregulates complement - inhibitory factors in endothelial cells, Circulation, 109

Pepys, 2006, Targeting reactive protein for the treatment of cardiovascular disease, Nature, 440

Kakuta, 2006, reactive protein products generated by neutrophil elastase promote neutrophils, apoptosis Arch Med Res, 37

Walsh, 1996, mapping of the human pentraxin gene region on chromosome q, Immunogenetics, 1

Khreiss, 2002, Loss of pentameric symmetry of reactive protein is associated with delayed apoptosis of human neutrophils, Biol Chem, 277

Perkins, 2010, Nan Unravelling protein - protein interactions between complement factor reactive protein using a multidisciplinary strategy, Biochem Soc Trans, 894, 10.1042/BST0380894

Hirschfield, 2005, Transgenic human reactive protein is not proatherogenic in apoplipoprotein deficient mice, Proc Natl Acad Sci USA, 8309, 10.1073/pnas.0503202102

Vigushin, 1993, Metabolic and scintigraphic studies of raioiodinated human reactive protein in health and disease, Clin Invest, 1351, 10.1172/JCI116336

Zouki, 2001, Loss of pentameric symmetry of reactive protein is associated with promotion of neutrophil - endothelial cell adhesion, Immunol, 167

Xia, 1997, Transgenic mice expressing rabbit reactive protein are resistant to endotoxemia, Proc Natl Acad Sci USA, 2575, 10.1073/pnas.94.6.2575

Zouki, 1997, Prevention ofin vitroneutrophil adhesion to endothelial cells through shedding of selectin by reactive protein and peptides derived from reactive protein, J Clin Invest, 522, 10.1172/JCI119561

Shephard, 1990, de Peptides generated from C - reactive protein by a neutrophil membrane protease Amino acid sequence and effects of peptides on neutrophil oxidative metabolism and chemotaxis, Immunol, 145

Wang, Increased monomeric CRP levels in acute myocardial infarction : a possible new and specific biomarker for diagnosis and severity assessment of disease, Atherosclerosis, 2015

Bang, 2005, Du and Du Analysis of binding sites in human reactive protein for q by site - directed mutagenesis, Biol Chem, 1

Nathan, 2010, inflammation, Cell, 140

Ciubotaru, 2005, Wander Production of modified reactive protein in derived macrophages, Exp Biol Med, 937

Wu, 2006, a Effect of modified reactive protein on complement activation, Thromb Biol, 26, 935

Perkins, 2010, Nan Unravelling protein - protein interactions between complement factor reactive protein using a multidisciplinary strategy, Biochem Soc Trans, 894, 10.1042/BST0380894

Schwartz, 2007, reactive protein downregulates endothelial NO synthase and attenuates reendothelializationin vivoin mice, Res, 1452

Habersberger, 2012, Circulating microparticles generate and transport monomeric reactive protein in patients with myocardial infarction, Res, 96, 64

Schwedler, 2009, - reactive protein decreases acetylated LDL uptake in human endothelial cells, Clin Chem, 1728, 10.1373/clinchem.2009.125732

Kresl, 1998, Conversion of native oligomeric to a modified monomeric form of human reactive protein, Int J Biochem Cell Biol, 30, 1415, 10.1016/S1357-2725(98)00078-8

Habersberger, 2012, Circulating microparticles generate and transport monomeric reactive protein in patients with myocardial infarction, Res, 96, 64

Diehl, 2000, III Immunohistochemical localization of modified reactive protein antigen in normal vascular tissue, Am J Med Sci, 319

Wu, 2007, membranes and liposomes dissociate reactive protein to form a new biologically active structural intermediate mCRP, Cell FASEB J, 21, 284, 10.1096/fj.06-6722com

Strang, 2012, plaques dissociate pentameric to monomeric C - reactive protein : a novel pathomechanism driving cortical inflammation in Alzheimer s disease, Amyloid Brain Pathol, 22, 337, 10.1111/j.1750-3639.2011.00539.x

Pober, 2007, Evolving functions of endothelial cells in inflammation, Nat Rev Immunol, 803, 10.1038/nri2171

Bharadwaj, 1999, Du The major receptor for - reactive protein on leukocytes is Fcγ receptor II, Exp Med, 190

Molins, 2011, de la and Monomeric reactive protein is prothrombotic and dissociates from circulating pentameric reactive protein on adhered activated platelets under flow, Res, 328

Kresl, 1998, Conversion of native oligomeric to a modified monomeric form of human reactive protein, Int J Biochem Cell Biol, 30, 1415, 10.1016/S1357-2725(98)00078-8

Szalai, 2003, Delayed lupus onset in mice expressing a human reactive protein transgene, Arthritis Rheum, 1

Shephard, 1990, de Peptides generated from C - reactive protein by a neutrophil membrane protease Amino acid sequence and effects of peptides on neutrophil oxidative metabolism and chemotaxis, Immunol, 145

Torzewski, 1998, reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries, Thromb Biol, 18, 1386, 10.1161/01.ATV.18.9.1386

Hill, 2003, Circulating endothelial progenitor cells vascular function and cardiovascular risk, Engl J Med, 348

Abernathy, 1941, The occurrence during acute infections of a protein not normally present in the blood Distribution of the reactive protein in patients sera and the effect of calcium on the flocculation reaction with polysaccharide of pneumococcus, Exp Med, 73

Jabs, 2003, a The kidney as a second site of human reactive protein formationin vivo, Eur J Immunol, 152, 10.1002/immu.200390018

Jabs, 2003, a The kidney as a second site of human reactive protein formationin vivo, Eur J Immunol, 152, 10.1002/immu.200390018

Mihlan, 2011, Zipfel reactive protein modulates classic complement activation on necrotic cells, FASEB J, 25, 4198, 10.1096/fj.11-186460

Vigushin, 1993, Metabolic and scintigraphic studies of raioiodinated human reactive protein in health and disease, Clin Invest, 1351, 10.1172/JCI116336

Pasceri, 2000, Direct proinflammatory effect of reactive protein on human endothelial cells, Circulation, 2165, 10.1161/01.CIR.102.18.2165

Ciubotaru, 2005, Wander Production of modified reactive protein in derived macrophages, Exp Biol Med, 937

Molins, 2011, de la and Monomeric reactive protein is prothrombotic and dissociates from circulating pentameric reactive protein on adhered activated platelets under flow, Res, 328

Devaraj, 2005, Du and Binding and internalization of - reactive protein by Fc gamma receptors on human aortic endothelial cells mediates biological effects, Thromb Biol, 25, 1359, 10.1161/01.ATV.0000168573.10844.ae

Devaraj, 2003, reactive protein increases plasminogen activator inhibitor - expression and activity in human aortic endothelial cells : Implications for the metabolic syndrome and atherothrombosis, Circulation, 1

Yasojima, 2001, Generation of reactive protein and complement components in atherosclerotic, plaques Am J Pathol, 158

Khreiss, 2004, Opposing effects of reactive protein isoforms on shear - induced neutrophil - platelet adhesion and neutrophil aggregation in whole blood, Circulation, 110

Bharadwaj, 1999, Du The major receptor for - reactive protein on leukocytes is Fcγ receptor II, Exp Med, 190

Stein, 2000, Du reactive protein binding to FcγRIIa on human monocyte sand neutrophils is allele - specific, Clin Invest, 105

Ahrens, 2011, Opposing effects of monomeric and pentameric reactive protein on endothelial progenitor cells Basic, Res Cardiol, 106

Fujii, 2006, reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells, Thromb Biol, 26, 2476, 10.1161/01.ATV.0000242794.65541.02

Ma, 2009, reactive protein activates endothelial cells via interaction with lipid raft micro - domains, FASEB J, 23, 1806, 10.1096/fj.08-116962

Bisoendial, 2005, den Activation of inflammation and coagulation after infusion of reactive protein in humans, Res, 714

Hage, 2010, reactive protein - mediated vascular injury requires complement, Thromb Biol, 30, 1189, 10.1161/ATVBAHA.110.205377

Tilg, 1993, Antiinflammatory properties of hepatic acute phase proteins : preferential induction of interleukin receptor antagonist over IL β synthesis by human peripheral blood mononuclear cells, IL Exp Med, 1

Zouki, 1997, Prevention ofin vitroneutrophil adhesion to endothelial cells through shedding of selectin by reactive protein and peptides derived from reactive protein, J Clin Invest, 522, 10.1172/JCI119561

Sica, 2012, plasticity polarization in vivoveritas, Clin Invest, 122

Khreiss, 2004, a Conformational rearrangement in reactive protein is required for proinflammatory actions on human endothelial cells, Circulation, 109

Thiele, 2014, von The dissociation of pentameric to monomeric - reactive protein localizes and aggravates inflammation : in vivoproof of a powerful pro - inflammatory mechanisms and a new anti - inflammatory strategy, Circulation, 130

Heuertz, 2005, Native and modified reactive proteins bind different receptors on human neutrophils, Int J Biochem Cell Biol, 37

Chen, 2009, reactive protein upregulates receptor for advanced glycation end products expression and alters antioxidant defenses in rat endothelial progenitor cells, Pharmacol, 53

Lu, 2011, Du Recognition and functional activation of the human IgA receptor by reactive protein, Proc Natl Acad Sci USA, 108

Pasceri, 2001, Modulation of reactive protein - mediated monocyte chemoattractant protein induction in human endothelial cells by anti - atherosclerosis drugs, Circulation, 1

Strang, 2012, plaques dissociate pentameric to monomeric C - reactive protein : a novel pathomechanism driving cortical inflammation in Alzheimer s disease, Amyloid Brain Pathol, 22, 337, 10.1111/j.1750-3639.2011.00539.x

Trion, 2005, de van der and No effect of reactive protein on early atherosclerosis development in apolipoprotein leiden / human reactive protein transgenic mice, Thromb Biol, 25, 1635, 10.1161/01.ATV.0000171992.36710.1e

Fadi, 2010, reactive protein - mediated vascular injury requires complement, Thromb Biol, 30, 1189, 10.1161/ATVBAHA.110.205377

Venugopal, 2002, Demonstration that reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells, Circulation, 106

Li, 2004, a reactive protein enhances LOX expression in human aortic endothelial cells : relevance of LOX to reactive protein - induced endothelial dysfunction, Res, 1

Devaraj, 2011, reactive protein polarizes human macrophages to an phenotype and inhibits transformation to the phenotype, Thromb Biol, 31, 1397, 10.1161/ATVBAHA.111.225508

Singh, 2008, reactive protein - bound enzymatically modified low - density lipoprotein does not transform macrophages into foam cells, Immunol, 180

Nimmerjahn, 2008, receptors as regulators of immune responses, Nat Rev Immunol, 8

Singh, 2008, reactive protein - bound enzymatically modified low - density lipoprotein does not transform macrophages into foam cells, Immunol, 180

Kebir, 2011, reactive protein - derived peptide inhibits neutrophil adhesion to endothelial cells and platelets through CD, Biol, 201

Crawford, 2006, Genetic variation is associated with reactive protein levels in the third national health and nutrition examination survey, Circulation, 114

Paul, 2004, reactive protein accelerates the progression of atherosclerosis in apolipoprotein deficient mice, Circulation, 109

Schwedler, 2006, reactive protein : a family of proteins to regulate cardiovascular function, Am J Kidney Dis, 212, 10.1053/j.ajkd.2005.10.028

Griselli, 1999, reactive protein and complement are important mediators of tissue damage in acute myocardial infarction, Exp Med, 190

Eisenhardt, 2009, von zur Dissociation of pentameric to monomeric reactive protein on activated platelets localizes inflammation to atherosclerotic plaques, Res, 105

Sun, 2005, reactive protein in atherosclerotic lesions : its origin and pathophysiological significance, Am J Pathol, 167

Brennan, 2008, reactive protein binds to αIIbβ, Thromb Haemost, 1239, 10.1111/j.1538-7836.2008.02993.x

Tsimikas, 2006, reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients, Am Coll Cardiol, 19, 10.1016/j.jacc.2005.10.066

Diehl, 2000, III Immunohistochemical localization of modified reactive protein antigen in normal vascular tissue, Am J Med Sci, 319

Calabro, 2003, Inflammatory cytokines stimulated reactive protein production by human coronary artery smooth muscle cells, Circulation, 108

Tillett, 1930, Serological reactions in pneumonia with a non - protein somatic fraction of pneumococcus, Exp Med, 561, 10.1084/jem.52.4.561

Wu, 2007, membranes and liposomes dissociate reactive protein to form a new biologically active structural intermediate mCRP, Cell FASEB J, 21, 284, 10.1096/fj.06-6722com

Nathan, 2010, inflammation, Cell, 140

Teupser, 2011, No reduction of atherosclerosis in reactive protein deficient mice, Biol Chem, 286

Verma, 2006, reactive protein promotes atherothrombosis, Circulation, 113

Hammond, 2010, Identification of acidic pH - dependent ligands of pentameric reactive protein, J Biol Chem, 285

Chen, 2009, reactive protein upregulates receptor for advanced glycation end products expression and alters antioxidant defenses in rat endothelial progenitor cells, Pharmacol, 53

Wang, 2011, a reactive protein aptamer binds to monomeric but not pentameric from of, Anal Bioanal Chem, 401

Sjöwall, 2004, Serum levels of autoantibodies against monomeric reactive protein are correlated with disease activity in systemic lupus erythematosus, Arthritis res Ther, 87, 10.1186/ar1032

Reynolds, 1987, reactive protein immunohistochemical localization in normal and atherosclerotic human aortas, Arch Pathol Lab Med, 111

Tanigaki, 2007, reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine - based inhibition motif of FcγRIIB and SHIP, Res, 1

Brennan, 2008, reactive protein binds to αIIbβ, Thromb Haemost, 1239, 10.1111/j.1538-7836.2008.02993.x

Agrawal, 2001, structure of the q - binding site on reactive protein, Topology J Immunol, 1

Scott, 2007, The liver receptor, atherosclerosis Engl J Med, 357

Zhong, 1998, Effect of human reactive protein on chemokine and chemotactic factor - induced neutrophil chemotaxis and signaling, Immunol, 161

Heuertz, 2005, Native and modified reactive proteins bind different receptors on human neutrophils, Int J Biochem Cell Biol, 37

Hirschfield, 2005, Transgenic human reactive protein is not proatherogenic in apoplipoprotein deficient mice, Proc Natl Acad Sci USA, 8309, 10.1073/pnas.0503202102

Filep, 2009, affect the structure and function of reactive protein, Platelets Res, 105

Marnell, 1995, Du reactive protein binds to FcγRI in transfected COS cells, Immunol, 155

Ying, 1989, Identification and partial characterization of multiple native and neoantigenic epitopes of human reactive protein, J Immunol, 143

Lane, 2014, Infusion of pharmaceutical - grade natural human reactive protein is not proinflammatory in healthy adult human volunteers, Res, 114

Li, 2014, Topological localization of monomeric reactive protein determines pro - inflammatory endothelial cell responses, Biol Chem, 289

CCGC, 2011, - Reactive Protein Coronary Heart Disease Genetics Collaboration between reactive protein and coronary heart disease : mendelian randomisation analysis based on individual participant data, Association Med, 342

Abernathy, 1941, The occurrence during acute infections of a protein not normally present in the blood Distribution of the reactive protein in patients sera and the effect of calcium on the flocculation reaction with polysaccharide of pneumococcus, Exp Med, 73

Scott, 2007, The liver receptor, atherosclerosis Engl J Med, 357

Shrive, 1996, Three dimensional structure of human reactive protein, Nat Struct Biol, 346, 10.1038/nsb0496-346

Schwedler, 2003, Tubular staining of modified reactive protein in diabetic chronic kidney disease Transplant, 18, 2300

Asztalos, 2014, Obesity associated molecular forms of reactive protein in human One

Pober, 2007, Evolving functions of endothelial cells in inflammation, Nat Rev Immunol, 803, 10.1038/nri2171

Jabs, 2003, Local generation of reactive protein in diseased coronary artery venous bypass grafts and normal tissue, Circulation, 108

Kebir, 2011, reactive protein - derived peptide inhibits neutrophil adhesion to endothelial cells and platelets through CD, Biol, 201

Szalai, 2014, Inhibiting reactive protein for the treatment of cardiovascular disease : promising evidence from rodent models, Med, 353614

Han, 2004, reactive protein promotes monocyte chemoattractant protein - - mediated chemotaxis through up - regulating CC chemokine receptor expression in human monocytes, Circulation, 109

Li, 2014, Topological localization of monomeric reactive protein determines pro - inflammatory endothelial cell responses, Biol Chem, 289

Wang, 2011, redox switch in - reactive protein modulates activation of endothelial cells, FASEB J, 25, 3186, 10.1096/fj.11-182741

Kardys, 2006, de and reactive protein gene haplotypes and risk of coronary heart disease : the Rotterdam study, Eur Heart J, 27, 1331, 10.1093/eurheartj/ehl018

Trion, 2005, de van der and No effect of reactive protein on early atherosclerosis development in apolipoprotein leiden / human reactive protein transgenic mice, Thromb Biol, 25, 1635, 10.1161/01.ATV.0000171992.36710.1e

CCGC, 2011, - Reactive Protein Coronary Heart Disease Genetics Collaboration between reactive protein and coronary heart disease : mendelian randomisation analysis based on individual participant data, Association Med, 342

Qamirani, 2005, reactive protein inhibits endothelium dependent NO - mediated dilation in coronary arterioles by activating kinase oxidase, Thromb Biol, 25, 995, 10.1161/01.ATV.0000159890.10526.1e

Fujita, 2009, Oxidized LDL receptor LOX binds to - reactive protein and mediates its vascular effects, Clin Chem, 1

Jabs, 2003, Local generation of reactive protein in diseased coronary artery venous bypass grafts and normal tissue, Circulation, 108

Scirica, 2006, Is reactive protein an innocent bystander of proatherogenic culprit, Circulation, 113