Biological Chemistry

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Effects of Antineoplastic Agents on Cytoplasmic and Membrane-Bound Heat Shock Protein 70 (Hsp70) Levels
Biological Chemistry - Tập 383 Số 11 - 2002
Mathias Gehrmann, K. Kevin Pfister, Peter Hutzler, Robert Gastpar, Т. Д. Власов, Gabriele Multhoff
The Functions of Breast Cancer Susceptibility Gene 1 (BRCA1) Product and Its Associated Proteins
Biological Chemistry - Tập 380 Số 2 - 1999
Irmgard Irminger‐Finger, Beth Siegel, Wai-Choi Leung
AbstractAbout half of the familial breast cancer cases are found to bear mutations in the breast cancer susceptibility gene 1 (
The Molecular Chaperone, α-Crystallin, Protects against Loss of Antigenicity and Activity of Esterase Caused by Sugars, Sugar Phosphate and a Steroid
Biological Chemistry - Tập 384 Số 8 - 2003
Hong Yan, John J. Harding
Zinc Induces Apoptosis That Can Be Suppressed by Lanthanum in C6 Rat Glioma Cells
Biological Chemistry - Tập 382 Số 8 - Trang 1227-1234 - 2001
Hajo Haase, Wim Wätjen, Detmar Beyersmann
AbstractZinc ions have both essential and toxic effects on mammalian cells. Here we report the ability of zinc to act as an inducer of apoptosis in C6 rat glioma cells. Incubation with 150 to 300 M ZnCl2 caused cell death that was characterized as apoptotic by internucleosomal DNA fragmentation, formation of apoptotic bodies, nuclear fragmentation and breakdown of the mitochondrial membrane potent... hiện toàn bộ
Chemical chaperone-mediated protein folding: stabilization of P22 tailspike folding intermediates by glycerol
Biological Chemistry - Tập 388 Số 8 - Trang 797-804
Rajesh Mishra, Rajiv Bhat, Robert Seckler
Abstract Polyol co-solvents such as glycerol increase the thermal stability of proteins. This has been explained by preferential hydration favoring the more compact native over the denatured state. Although polyols are also expected to favor aggregation by the same mechanism, they have been found to increase the folding yields of some large, aggregation-prone proteins. We have used the homotrimeri... hiện toàn bộ
Lipid Composition of Mitochondrial Outer and Inner Membranes of Neurospora crassa
Biological Chemistry - Tập 355 Số 1 - Trang 279-288 - 1974
Gerhard Hallermayer, Walter Neupert
C-reactive protein and inflammation: conformational changes affect function
Biological Chemistry - Tập 396 Số 11 - Trang 1181-1197 - 2015
Yi Wu, Lawrence A. Potempa, Driss El Kebir, János G. Filep
Abstract The prototypic acute-phase reactant C-reactive protein (CRP) has long been recognized as a useful marker and gauge of inflammation. CRP also plays an important role in host defense against invading pathogens as well as in inflammation. CRP consists of five identical subunits arranged as a cyclic pentamer. CRP exists in at least two conformationally distinct forms, i.e. native pentameric C... hiện toàn bộ
On the fate of early endosomes
Biological Chemistry - Tập 390 Số 8 - Trang 753-759 - 2009
Anne Spang
Abstract Proteins are endocytosed by various pathways into the cell. All these pathways converge at the level of the early endosome. The fate of the early endosome and how proteins are sorted into recycling and late endosomes/multi-vesicular body is a matter of debate and intense research. Obviously, the transition from early to late endosome poses an interesting logistic problem and would merit a... hiện toàn bộ
Antiproliferative effects induced by guanine-based purines require hypoxanthine-guanine phosphoribosyltransferase activity
Biological Chemistry - Tập 391 Số 9 - 2010
Rosaria Garozzo, Maria Angela Sortino, Carlo Vancheri, D. F. Condorelli
Abstract Guanine (GUA), guanosine and GMP exert a marked growth inhibition on the U87 glioma cell line that is not seen with other tested nucleotides, nucleosides and nucleobases. This effect could be replicated in several different human tumoral cell lines. Guanine shows a higher potency than guanosine or GMP, and co-treatments with adenosine or adenine are able to antagonize or revert the antipr... hiện toàn bộ
Molecular Models of Acidic PePtides From Pea Bud Chromatin And Seminal Plasma. Divalent Cations-Mediated Interaction With Dna
Biological Chemistry - Tập 380 Số 1 - 1999
Loretta Mancinelli, Francesco Chillemi, Elena Cardellini, Valeria Marsili, Flavio Giavarini, L. De Angelis, G Lugaro, G. Gianfranceschi
AbstractSmall acidic peptides have been isolated from biological fluids (blood and seminal plasma) and from chromatin of several tissues. Their biological activity is related to the control of cell growth and gene expression.This work is an approach to the study of peptide structure-function relationship. Purified fractions from seminal plasma and pea bud chromatin were subjected to fast ion bomba... hiện toàn bộ
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