Biointerphases
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Silica-coated quantum dots and magnetic nanoparticles for bioimaging applications (Mini-Review)
Biointerphases - Tập 5 - Trang FA110-FA115 - 2010
Fluorescent quantum dots (e.g., CdSe–ZnS) and magnetic nanoparticles (e.g., Fe2O3 or Fe3O4) are two important candidate systems that have been emerging as potential probes for bioimaging applications. This review focuses on the development of silica-coated inorganic probes (optical and magnetic) that are originated mainly from the author's laboratory for bioimaging applications. The recent develop......
Phase separation of phospholipid multilayers incorporated with cell penetrating peptides
Biointerphases - Tập 6 - Trang 73-78 - 2011
We used X-ray reflectivity to investigate the structures of phospholipid multilayers with transcription-activating-factor-derived peptide (TDP) as a function of the membrane charge density. Mixed phospholipid multilayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphoserine (DPPS) with different mixing ratios (C:S) were used to elucidate the various c......
X-ray and neutron investigation of self-assembled lipid layers on a titanium surface
Biointerphases - Tập 8 - Trang 1-11 - 2013
Titanium is the most widely preferred metal material for bone reconstruction in orthopedics and dentistry. To improve its biological performance, various coatings can be applied. In this investigation, a biomimetic coating on a model implant surface was studied in X-ray and neutron reflectivity experiments to probe the quality of this coating, which is only few nanometers thick. Titanium was depos......
Continuum model of mechanical interactions between biological cells and artificial nanostructures
Biointerphases - Tập 5 - Trang 37-44 - 2010
The controlled insertion of artificial nanostructures into biological cells has been utilized for patch clamping, targeted drug delivery, cell lysing, and cell mechanics measurements. In this work, an elastic continuum model is implemented to treat the deformation of spherical cells in solution due to their interaction with cylindrical probes. At small deformations, the force varies nonlinearly wi......
Anodic TiO 2 nanotube layers electrochemically filled with MoO 3 and their antimicrobial properties
Biointerphases - Tập 6 - Trang 16-21 - 2011
In the present work, the authors produce a Ti surface with a TiO2 nanotube coating and investigate the electrochemical filling of these layers with MoO3. The authors demonstrate that using a potential cycling technique, a homogenous MoO3 coating can be generated. Controllable and variable coating thicknesses are achieved by a variation of the number of cycles. Thicknesses from a few nanometers to ......
Development of molecular simulation methods to accurately represent protein-surface interactions: Method assessment for the calculation of electrostatic effects
Biointerphases - Tập 4 - Trang 57-64 - 2009
The simulation of the interactions of proteins with charged surfaces in a condensed-phase aqueous solution containing electrolytes using empirical force field based methods is predominantly governed by nonbonded interactions between the atoms of the protein, surface, and the solvent. Electrostatic effects represent the strongest type of these interactions and the type that is most difficult to acc......
Experimental and theoretical investigation of chain length and surface coverage on fouling of surface grafted polypeptoids
Biointerphases - Tập 4 - Trang FA22-FA32 - 2009
Numerous strategies exist to prevent biological fouling of surfaces in physiological environments; the authors’ strategy focuses on the modification of surfaces with poly-N-substituted glycine oligomers (polypeptoids). The authors previously reported the synthesis and characterization of three novel polypeptoid polymers that can be used to modify titanium oxide surfaces, rendering the surfaces res......
Evaluation of Protein Adsorption on Atmospheric Plasma Deposited Coatings Exhibiting Superhydrophilic to Superhydrophobic Properties
Biointerphases - Tập 7 - Trang 1-12 - 2012
Protein adsorption is one of the key parameters influencing the biocompatibility of medical device materials. This study investigates serum protein adsorption and bacterial attachment on polymer coatings deposited using an atmospheric pressure plasma jet system. The adsorption of bovine serum albumin and bovine fibrinogen (Fg) onto siloxane and fluorinated siloxane elastomeric coatings that exhibi......
Model Membrane Platforms for Biomedicine: Case Study on Antiviral Drug Development
Biointerphases - Tập 7 - Trang 1-20 - 2012
As one of the most important interfaces in cellular systems, biological membranes have essential functions in many activities such as cellular protection and signaling. Beyond their direct functions, they also serve as scaffolds to support the association of proteins involved in structural support, adhesion, and transport. Unfortunately, biological processes sometimes malfunction and require thera......
Structures of regenerated cellulose films revealed by grazing incidence small-angle x-ray scattering
Biointerphases - Tập 3 - Trang 117-127 - 2008
The characteristic in-plane length scales of ultrathin films of regenerated cellulose are measured using noncontact atomic force microscopy (NC-AFM) and grazing incidence small-angle x-ray scattering (GISAXS) in ambient atmosphere and under various humidity conditions. The aim is to elucidate the structural basis for the excellent compatibility of cellulose supports to planar lipid membranes. Film......
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