BioChip Journal
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Label-free optical biosensors based on a planar optical waveguide
BioChip Journal - Tập 7 - Trang 295-318 - 2013
We review optical label-free biosensing platforms based on planar optical waveguides with their operation principles and performance characteristics. As the building blocks of refractometric optical transducers and plasmonic optical devices, optical planar waveguides are widely adopted to be core sensing platforms for label-free optical assay of biological and chemical interactions due to the high...... hiện toàn bộ
Development of an Extracellular Matrix Plate for Drug Screening Using Patient-Derived Tumor Organoids
BioChip Journal - Tập 17 - Trang 284-292 - 2023
With the advances in organoid culture, patient-derived organoids are utilized in diverse fields to broaden our understanding of conventional 2-dimensional (2D) culture methods and animal models. Patient-derived organoids have found new applications, such as screening for patient-matching drugs, immune checkpoint drugs, and mutation-target drugs, in the field of drug screening. However, conventiona...... hiện toàn bộ
Development of an Integrated Biochip System Consisting of a Magnetic Particle Washing Station and a Markerless Volumetric Biochip
BioChip Journal - Tập 17 - Trang 68-76 - 2022
As the use of markers in conventional volumetric biochips results in complex biochip structures and assay processes, an integrated biochip system consisting of a magnetic particle (MP) washing station and a markerless volumetric biochip was developed in this study. The biochip was composed of a reaction chamber and a channel connected to the upper side of the chamber. The assay process involved th...... hiện toàn bộ
Locally Controlled Diffusive Release of Bone Morphogenetic Protein-2 Using Micropatterned Gelatin Methacrylate Hydrogel Carriers
BioChip Journal - Tập 14 - Trang 405-420 - 2020
In this work, a novel and simple bone morphogenetic protein (BMP)-2 carrier is developed, which enables localized and controlled release of BMP-2 and facilitates bone regeneration. BMP-2 is localized in the gelatin methacrylate (GelMA) micropatterns on hydrophilic semi-permeable membrane (SNM), and its controlled release is regulated by the concentration of GelMA hydrogel and BMP-2. The controlled...... hiện toàn bộ
Proteomic profiling of differentially expressed proteins after exposure to asbestos
BioChip Journal - Tập 7 - Trang 218-226 - 2013
Chrysotile is the most common type of asbestos produced globally. To gain a better understanding of asbestos toxicity, we used proteomic approaches to investigate the proteins differentially expressed in human airway epithelial carcinoma cells exposed to chrysotile. Comparative analysis revealed that 14 protein spots showed notable differences in expression between control and chrysotile-exposed c...... hiện toàn bộ
Single-Shot Light-Field Microscopy: An Emerging Tool for 3D Biomedical Imaging
BioChip Journal - Tập 16 - Trang 397-408 - 2022
3D microscopy is a useful tool to visualize the detailed structures and mechanisms of biomedical specimens. In particular, biophysical phenomena such as neural activity require fast 3D volumetric imaging because fluorescence signals degrade quickly. A light-field microscope (LFM) has recently attracted attention as a high-speed volumetric imaging technique by recording 3D information in a single-s...... hiện toàn bộ
Enhanced Antitumor Effect of the Combination of Bacille Calmette-Guérin and an Immune Checkpoint Inhibitor in Bladder Cancer-On-a-Chip
BioChip Journal - Tập 17 - Trang 496-506 - 2023
We upgraded preexisting bladder cancer-on-a-chip (BCOC) by adding T cells and evaluated the antitumor effect of a combination of intravesical Bacille Calmette-Guérin (BCG) and pembrolizumab. We fabricated bioprinted BCOC with microfluids, incorporating HT1376, MRC-5, HUVEC, THP-1 and Jurkat cells. We evaluated the effector-to-target cytotoxicity, cytokine, and cell viability in 2D culture, live/de...... hiện toàn bộ
Consideration of the Mechanical Properties of Hydrogels for Brain Tissue Engineering and Brain-on-a-chip
BioChip Journal - Tập 13 - Trang 8-19 - 2019
To present a more physiologically relevant microenvironment for cells, hydrogel-based threedimensional culture platforms have been widely adopted. As noted by multiple pioneering reports, the neural cells are sensitive with the change of mechanical properties of the microenvironment. Therefore, in the context of brain tissue engineering and brain-on-a-chip, there is a need to consider the brain-ti...... hiện toàn bộ
One-Step Immunoassay for the Detection of SARS-CoV-2 Nucleocapsid Protein Using Screened Fv-Antibodies
BioChip Journal - - 2024
Fv-antibodies against the nucleocapsid protein (NP) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were screened from an Fv-antibody library, and a one-step immunoassay was performed to detect SARS-CoV-2 using real viral samples. The Fv-antibody library was prepared using site-directed mutagenesis of the CDR3 region, which was composed of 11 amino acids. To screen the target Esche...... hiện toàn bộ
Performance Characterization of Two-Dimensional Paper Chromatography-based Biosensors for Biodefense, Exemplified by Detection of Bacillus anthracis Spores
BioChip Journal - Tập 12 - Trang 59-68 - 2018
Bacillus anthracis (B. anthracis), the causative agent of anthrax disease, is a Gram-positive spore-forming bacterium which can be used as a threatening bioterrorism agent. We developed enzyme-linked immunosorbent assay (ELISA)-on-a-chip biosensors for rapid, sensitive analysis of B. anthracis spores based on two-dimensional, cross-flow chromatography. In order to establish optimal assay condition...... hiện toàn bộ
Tổng số: 406
- 1
- 2
- 3
- 4
- 5
- 6
- 10