BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models - 2010
Chen Li, Marco Donizelli, Nicolás Rodríguez, Harish Dharuri, Lukas Endler, Vijayalakshmi Chelliah, Lu Li, Enuo He, Arnaud Henry, Melanie I. Stefan, Jacky L. Snoep, Michael Hucka, Nicolas Le Novère, Camille Laibe
Abstract Background Quantitative models of biochemical and cellular systems are
used to answer a variety of questions in the biological sciences. The number of
published quantitative models is growing steadily thanks to increasing interest
in the use of models as well as the development of improved software systems and
the availability of better, cheaper computer hardware. To maximise the benefits... hiện toàn bộ
A review of imaging techniques for systems biology Tập 2 Số 1 - 2008
Armen R. Kherlopian, Ting Song, Qi Duan, Mathew A Neimark, Ming Jack Po, John K. Gohagan, Andrew F. Laine
Abstract This paper presents a review of imaging techniques and of their utility
in system biology. During the last decade systems biology has matured into a
distinct field and imaging has been increasingly used to enable the interplay of
experimental and theoretical biology. In this review, we describe and compare
the roles of microscopy, ultrasound, CT (Computed Tomography), MRI (Magnetic
Resona... hiện toàn bộ
Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis Tập 1 Số 1 - 2007
Laxman Yetukuri, Mikko Katajamaa, Gema Medina-Gómez, Tuulikki Seppänen‐Laakso, Antonio Vidal‐Puig, Matej Orešič
Abstract Background Lipids are an important and highly diverse class of
molecules having structural, energy storage and signaling roles. Modern
analytical technologies afford screening of many lipid molecular species in
parallel. One of the biggest challenges of lipidomics is elucidation of
important pathobiological phenomena from the integration of the large amounts of
new data becoming available... hiện toàn bộ
Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE - 2012
Yuliang Wang, James A. Eddy, Nathan D. Price
Abstract Background Human tissues perform diverse metabolic functions. Mapping
out these tissue-specific functions in genome-scale models will advance our
understanding of the metabolic basis of various physiological and pathological
processes. The global knowledgebase of metabolic functions categorized for the
human genome (Human Recon 1) coupled with abundant high-throughput data now
makes possi... hiện toàn bộ
Extended local similarity analysis (eLSA) of microbial community and other time series data with replicates Tập 5 Số S2 - 2011
Xiaoling Zhang, Joshua A. Steele, Jacob A. Cram, Zoë G. Cardon, Stephanie Simmons, Joseph J. Vallino, Jed A. Fuhrman, Fengzhu Sun
Abstract Background The increasing availability of time series microbial
community data from metagenomics and other molecular biological studies has
enabled the analysis of large-scale microbial co-occurrence and association
networks. Among the many analytical techniques available, the Local Similarity
Analysis (LSA) method is unique in that it captures local and potentially
time-delayed co-occurr... hiện toàn bộ
Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance Tập 3 Số 1 - 2009
Özgür Şahin, Holger Fröhlich, Christian Löbke, Ulrike Korf, Sara Burmester, Meher Majety, Jens Mattern, Ingo Schupp, Claudine Chaouiya, Denis Thieffry, Annemarie Poustka, Stefan Wiemann, Tim Beißbarth, Dorit Arlt