BMC Nephrology
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Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
BMC Nephrology - Tập 15 - Trang 1-7 - 2014
Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, low levels of Klotho, a protein linked to aging, might constitute a key factor in this detrimental relationship. The purpose of the present study was to determine the relationship between serum......
Effect of multidisciplinary care on diabetic kidney disease: a retrospective cohort study
BMC Nephrology - - 2024
Diabetic kidney disease (DKD) is the most common disease among patients requiring dialysis for the first time in Japan. Multidisciplinary care (MDC) may prevent the progression of kidney failure. However, the effectiveness and timing of MDC to preserve kidney function in patients with DKD is unclear. Therefore, the aim of this study was to investigate whether MDC for patients with DKD affects the ......
Metformin in autosomal dominant polycystic kidney disease: experimental hypothesis or clinical fact?
BMC Nephrology - Tập 19 - Trang 1-5 - 2018
Autosomal dominant polycystic kidney disease (ADPKD) accounts for 8–10% of end-stage chronic kidney disease (CKD) patients worldwide. In the last decade, the advanced knowledge in genetics and molecular pathobiology of ADPKD focused some aberrant molecular pathways involved in the pathogenesis of the disease leading to controlled clinical trials aimed to delay its progression with the use of mTOR ......
Clinical value of noninvasive lens advanced glycation end product detection in early screening and severity evaluation of patients with diabetic kidney disease
BMC Nephrology - - 2023
Advanced glycation end products (AGEs) deposited in the lens are correlated with those in the kidneys, indicating a possible value in evaluating diabetic kidney disease (DKD). This study explored the value of noninvasively measuring lens AGEs to diagnose and evaluate the severity of diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM). A total of 134 T2DM patients admitted to the ......
Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studiesAbstract
Background
Vitamin D insufficiency correlates with mortality risk among patients with chronic kidney disease (CKD). The survival benefits of active vitamin D treatment have been assessed in patients with CKD not requiring dialysis and in patients with end stage renal disease (ESRD) requi... ...
BMC Nephrology - - 2013
Typing of hereditary renal amyloidosis presenting with isolated glomerular amyloid deposition
BMC Nephrology - Tập 20 - Trang 1-8 - 2019
The commonly used methods for amyloid typing include immunofluorescence or immunohistochemistry (IHC), which sometimes may come with diagnostic pitfalls. Mass spectrometry (MS)-based proteomics has been recognized as a reliable technique in amyloid typing. We reported two middle-aged patients who presented with proteinuria, hypertension and normal renal function, and both had a family history of r......
Impact of the relationship between hemoglobin levels and renal interstitial fibrosis on long-term outcomes in type 2 diabetes with biopsy-proven diabetic nephropathy
BMC Nephrology - Tập 22 - Trang 1-12 - 2021
Progression of renal anemia has been shown to be associated with advanced renal tubulointerstitial lesions. This retrospective study investigated the impact of lower hemoglobin (Hb) levels and renal interstitial fibrosis and tubular atrophy (IFTA) on long-term outcomes in type 2 diabetes with biopsy-proven diabetic nephropathy. A total of 233 patients were enrolled. The severity of IFTA was scored......
Family-centered empowerment approach to optimize phosphate management among hemodialysis patients: an experimental study
BMC Nephrology - - 2023
This study aimed to investigate the effect of a family-centered empowerment program on hyperphosphatemia management. This experimental study was performed on 80 randomly selected eligible patients with hyperphosphatemia undergoing hemodialysis. Patients were assigned randomly to two groups of family-centered empowerment program (FCEPG) and control group (CG) by coin toss (40 people per group). Dat......
Renal replacement therapy in ADPKD patients: a 25-year survey based on the Catalan registry
BMC Nephrology - Tập 14 - Trang 1-8 - 2013
Some 7-10% of patients on replacement renal therapy (RRT) are receiving it because of autosomal dominant polycystic kidney disease (ADPKD). The age at initiation of RRT is expected to increase over time. Clinical data of 1,586 patients (7.9%) with ADPKD and 18,447 (92.1%) patients with other nephropathies were analysed from 1984 through 2009 (1984–1991, 1992–1999 and 2000–2009). The age at initiat......
Comparison of quality-of-care measures in U.S. patients with end-stage renal disease secondary to lupus nephritis vs. other causes
BMC Nephrology - Tập 16 Số 1 - 2015
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