BMC Nephrology

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Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
BMC Nephrology - Tập 15 - Trang 1-7 - 2014
Maurits S Buiten, Mihály K de Bie, Annet Bouma-de Krijger, Bastiaan van Dam, Friedo W Dekker, J Wouter Jukema, Ton J Rabelink, Joris I Rotmans
Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, low levels of Klotho, a protein linked to aging, might constitute a key factor in this detrimental relationship. The purpose of the present study was to determine the relationship between serum...... hiện toàn bộ
Metformin in autosomal dominant polycystic kidney disease: experimental hypothesis or clinical fact?
BMC Nephrology - Tập 19 - Trang 1-5 - 2018
Antonio Pisani, Eleonora Riccio, Dario Bruzzese, Massimo Sabbatini
Autosomal dominant polycystic kidney disease (ADPKD) accounts for 8–10% of end-stage chronic kidney disease (CKD) patients worldwide. In the last decade, the advanced knowledge in genetics and molecular pathobiology of ADPKD focused some aberrant molecular pathways involved in the pathogenesis of the disease leading to controlled clinical trials aimed to delay its progression with the use of mTOR ...... hiện toàn bộ
Clinical value of noninvasive lens advanced glycation end product detection in early screening and severity evaluation of patients with diabetic kidney disease
BMC Nephrology - - 2023
Xiaodi Zheng, Yuan Gao, Yuhong Huang, Ruihua Dong, Mengxue Yang, Xuemeng Zhang, Miao Zeng, Rui Zhang, Yueyue Wu, Zhiyan Yu, Jun Liu, Bingbing Zha
Advanced glycation end products (AGEs) deposited in the lens are correlated with those in the kidneys, indicating a possible value in evaluating diabetic kidney disease (DKD). This study explored the value of noninvasively measuring lens AGEs to diagnose and evaluate the severity of diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM). A total of 134 T2DM patients admitted to the ...... hiện toàn bộ
The atrial uremic cardiomyopathy regression in patients after kidney transplantation – the prospective echocardiographic study
BMC Nephrology - Tập 20 - Trang 1-15 - 2019
Tomasz Zapolski, Jacek Furmaga, Andrzej P. Wysokiński, Anna Wysocka, Sławomir Rudzki, Andrzej Jaroszyński
In patients with end stage renal disease (ESRD), left ventricular (LV) hypertrophy with impaired LV function, which is called uremic cardiomyopathy (UC) is often observed. The UC historically has been considered a contraindication for kidney transplantation (KTx). Currently, moderate LV dysfunction does not exclude the possibility of KTx. The amelioration of uremia after KTx improved cardiac funct...... hiện toàn bộ
Treatment with intravenous immunoglobulins and methylprednisolone may significantly decrease loss of renal function in chronic-active antibody-mediated rejection
BMC Nephrology - Tập 20 - Trang 1-9 - 2019
Kasia A. Sablik, Marian C. Clahsen-van Groningen, Caspar W. N. Looman, Jeffrey Damman, Madelon van Agteren, Michiel G. H. Betjes
Chronic-active antibody mediated rejection (c-aABMR) is a major contributor to long-term kidney allograft loss. We conducted a retrospective analysis to establish the efficacy of treatment with intravenous immunoglobulins (IVIG) and pulse methylprednisolone (MP) of patients with c-aABMR. Sixty-nine patients, in the period 2005–2017, with the diagnosis (suspicious for) c-aABMR that were treated wit...... hiện toàn bộ
Intracystic magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease: features of severe cyst infection in a case–control study
BMC Nephrology - Tập 17 Số 1 - Trang 1-9 - 2016
Suwabe, Tatsuya, Ubara, Yoshifumi, Ueno, Toshiharu, Hayami, Noriko, Hoshino, Junichi, Imafuku, Aya, Kawada, Masahiro, Hiramatsu, Rikako, Hasegawa, Eiko, Sawa, Naoki, Saitoh, Satoshi, Okuda, Itsuko, Takaichi, Kenmei
The purpose of this study was to investigate the usefulness of intracystic MRI features for detection of severe cyst infection that is usually refractory to antibiotic therapy alone in patients with autosomal dominant polycystic kidney disease. Seventy-six patients (88 episodes) with positive cyst cultures treated from January 2006 to December 2013 were enrolled as the cases for this case–control ...... hiện toàn bộ
Dementia is a risk factor for major adverse cardiac and cerebrovascular events in elderly Korean patients initiating hemodialysis: a Korean national population-based study
BMC Nephrology - Tập 18 - Trang 1-7 - 2017
Sung Min Jung, Clara Tammy Kim, Ea Wha Kang, Kyoung Hoon Kim, Shina Lee, Hyung Jung Oh, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Dong-Ryeol Ryu, Hyunwook Kim
Dementia is common in end-stage renal disease (ESRD) patients on hemodialysis (HD) and is associated with worse outcomes. This study aimed to investigate the risk of major adverse cardiac and cerebrovascular event (MACCE) in elderly patients with dementia initiating HD. Using the database from the Health Insurance Review & Assessment Service, we analyzed 10,171 patients aged 65 years or older who ...... hiện toàn bộ
Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study
BMC Nephrology - Tập 20 - Trang 1-9 - 2019
Xue Bao, Yan Borné, Iram Faqir Muhammad, Christina-Alexandra Schulz, Margaretha Persson, Marju Orho-Melander, Kaijun Niu, Anders Christensson, Gunnar Engström
Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we examined whether elevated C3 concentration is associated with hospitalization due to CKD in the general population, and whether this relationship is mediated by factors such as diabetes and hype...... hiện toàn bộ
Association between routine and standardized blood pressure measurements and left ventricular hypertrophy among patients on hemodialysis
BMC Nephrology - Tập 11 - Trang 1-8 - 2010
Jaspreet Khangura, Bruce F Culleton, Braden J Manns, Jianguo Zhang, Lianne Barnieh, Michael Walsh, Scott W Klarenbach, Marcello Tonelli,, Magdalena Sarna, Brenda R Hemmelgarn
Left ventricular (LV) hypertrophy is common among patients on hemodialysis. While a relationship between blood pressure (BP) and LV hypertrophy has been established, it is unclear which BP measurement method is the strongest correlate of LV hypertrophy. We sought to determine agreement between various blood pressure measurement methods, as well as identify which method was the strongest correlate ...... hiện toàn bộ
Microangiopathy in multiple myeloma: a case of carfilzomib-induced secondary thrombotic microangiopathy successfully treated with plasma exchange and complement inhibition
BMC Nephrology - Tập 24 - Trang 1-8 - 2023
Lorenzo Catanese, Katharina Link, Harald Rupprecht
Thrombotic microangiopathy (TMA) is a potentially organ and life-threatening condition affecting patients with multiple myeloma (MM). Cases of proteasome inhibitor-induced TMA and specifically carfilzomib-induced TMA have been rarely reported and standards for diagnostic workup and treatment are not available. We describe a case of a male MM patient under salvage therapy including proteasome inhib...... hiện toàn bộ
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