BMC Nephrology

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Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
BMC Nephrology - Tập 15 - Trang 1-7 - 2014
Maurits S Buiten, Mihály K de Bie, Annet Bouma-de Krijger, Bastiaan van Dam, Friedo W Dekker, J Wouter Jukema, Ton J Rabelink, Joris I Rotmans
Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, low levels of Klotho, a protein linked to aging, might constitute a key factor in this detrimental relationship. The purpose of the present study was to determine the relationship between serum...... hiện toàn bộ
Clinical value of noninvasive lens advanced glycation end product detection in early screening and severity evaluation of patients with diabetic kidney disease
BMC Nephrology - - 2023
Xiaodi Zheng, Yuan Gao, Yuhong Huang, Ruihua Dong, Mengxue Yang, Xuemeng Zhang, Miao Zeng, Rui Zhang, Yueyue Wu, Zhiyan Yu, Jun Liu, Bingbing Zha
Advanced glycation end products (AGEs) deposited in the lens are correlated with those in the kidneys, indicating a possible value in evaluating diabetic kidney disease (DKD). This study explored the value of noninvasively measuring lens AGEs to diagnose and evaluate the severity of diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM). A total of 134 T2DM patients admitted to the ...... hiện toàn bộ
The atrial uremic cardiomyopathy regression in patients after kidney transplantation – the prospective echocardiographic study
BMC Nephrology - Tập 20 - Trang 1-15 - 2019
Tomasz Zapolski, Jacek Furmaga, Andrzej P. Wysokiński, Anna Wysocka, Sławomir Rudzki, Andrzej Jaroszyński
In patients with end stage renal disease (ESRD), left ventricular (LV) hypertrophy with impaired LV function, which is called uremic cardiomyopathy (UC) is often observed. The UC historically has been considered a contraindication for kidney transplantation (KTx). Currently, moderate LV dysfunction does not exclude the possibility of KTx. The amelioration of uremia after KTx improved cardiac funct...... hiện toàn bộ
Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study
BMC Nephrology - Tập 20 - Trang 1-9 - 2019
Xue Bao, Yan Borné, Iram Faqir Muhammad, Christina-Alexandra Schulz, Margaretha Persson, Marju Orho-Melander, Kaijun Niu, Anders Christensson, Gunnar Engström
Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we examined whether elevated C3 concentration is associated with hospitalization due to CKD in the general population, and whether this relationship is mediated by factors such as diabetes and hype...... hiện toàn bộ
Albumin levels predict mortality in sepsis patients with acute kidney injury undergoing continuous renal replacement therapy: a secondary analysis based on a retrospective cohort study
BMC Nephrology - Tập 23 - Trang 1-10 - 2022
Song Sheng, Yan-Hong Zhang, Hang-Kun Ma, Ye Huang
Albumin (ALB) levels are negatively associated with mortality in patients with sepsis. However, among sepsis patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT), there has been no similar study on the correlation between ALB levels and mortality alone. This study tested the hypothesis that ALB levels are negatively associated with mortality among such pat...... hiện toàn bộ
S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1
BMC Nephrology - Tập 20 - Trang 1-8 - 2019
Wei Chen, Hong Xiang, Ruifang Chen, Jie Yang, Xiaoping Yang, Jianda Zhou, Hengdao Liu, Shaoli Zhao, Jie Xiao, Pan Chen, Alex F. Chen, Shuhua Chen, Hongwei Lu
Sphingosine-1-phosphate receptor 2 (S1PR2) is a G-protein-coupled receptor that regulates sphingosine-1-phosphate-triggered cellular response. However, the role of S1PR2 in diabetes-induced glomerular endothelial cell dysfunction remains unclear. This study aims to investigate the effect of S1PR2 blockade on the morphology and function of mitochondria in human renal glomerular endothelial cells (H...... hiện toàn bộ
Cost-effectiveness of home telemonitoring in chronic kidney disease patients at different stages by a pragmatic randomized controlled trial (eNephro): rationale and study design
BMC Nephrology - Tập 18 Số 1 - 2017
Nathalie Thilly, Jacques Chanliau, Luc Frimat, Christian Combe, Pierre Merville, P. Chauveau, Pierre Bataille, Raymond Azar, David Laplaud, Christian Noël, Michèle Kessler
Kidney function and nephrotoxic drug use among older home-dwelling persons with or without diabetes in Finland
BMC Nephrology - - 2020
Marjo Heinjoki, Matti Karjalainen, Juha Saltevo, Miia Tiihonen, Maija Haanpää, Hannu Kautiainen, Pekka Mäntyselkä
AbstractBackgroundDue to these changes in kidney function, aging kidneys are more prone to drug-induced impairments in renal properties. Diabetes has been associated with the declined kidney function and an elevated risk of renal failure. The aim of this study is to compare kidney function and potentially nephrotoxic drug use amon...... hiện toàn bộ
Bệnh thận C3 liên quan đến gammopathy đơn dòng có ý nghĩa thận: báo cáo ca bệnh Dịch bởi AI
BMC Nephrology - Tập 19 - Trang 1-5 - 2018
Juana Alonso-Titos, Lara Perea-Ortega, Eugenia Sola, Alvaro Torres-Rueda, Myriam León, Remedios Toledo, Ana D. Duarte, Teresa Vazquez, Maria Dolores Martinez-Esteban, Alicia Bailen, Pedro Ruiz-Esteban, Domingo Hernandez
Tỷ lệ mắc bệnh liên quan đến gammopathy đơn dòng có ý nghĩa thận cao do những tổn thương thận nghiêm trọng và những thay đổi hệ thống liên quan. Do đó, chẩn đoán sớm là rất quan trọng, đồng thời ngăn chặn sự sản xuất clone của immunoglobulin thông qua hóa trị liệu đặc hiệu. Một bệnh nhân nam 75 tuổi có bệnh thận mạn tính không rõ nguyên nhân từ năm 2010 đã trải qua sự suy giảm nhanh chóng chức năn...... hiện toàn bộ
#gammopathy đơn dòng #bệnh thận C3 #viêm cầu thận màng tăng sinh #bổ thể #sinh thiết thận
Characteristics of South African patients presenting with kidney disease in rural KwaZulu-Natal: a cross sectional study
BMC Nephrology - Tập 15 - Trang 1-9 - 2014
Nomandla D Madala, Gertrude P Thusi, Alain G H Assounga, Saraladevi Naicker
Diabetes mellitus is the leading cause of end-stage renal disease (ESRD) globally. Diabetes and human immunodeficiency virus (HIV), both prevalent in South Africa, have not been reported as significant causes of ESRD. We evaluated chronic kidney disease (CKD) and cardiovascular disease risk factors in a cross-sectional study of 302 patients (165 females/ 137 males) at a CKD clinic in rural norther...... hiện toàn bộ
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