BMC Medical Research Methodology
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Scanning for satisfaction or digging for dismay? Comparing findings from a postal survey with those from a focus group-study
BMC Medical Research Methodology - Tập 12 - Trang 1-8 - 2012
Despite growing support for mixed methods approaches we still have little systematic knowledge about the consequences of combining surveys and focus groups. While the methodological aspects of questionnaire surveys have been researched extensively, the characteristics of focus group methodology are understudied. We suggest and discuss whether the focus group setting, as compared to questionnaire s...... hiện toàn bộ
Doubly robust estimator of risk in the presence of censoring dependent on time-varying covariates: application to a primary prevention trial for coronary events with pravastatin
BMC Medical Research Methodology - Tập 20 - Trang 1-11 - 2020
In the presence of dependent censoring even after stratification of baseline covariates, the Kaplan–Meier estimator provides an inconsistent estimate of risk. To account for dependent censoring, time-varying covariates can be used along with two statistical methods: the inverse probability of censoring weighted (IPCW) Kaplan–Meier estimator and the parametric g-formula estimator. The consistency o...... hiện toàn bộ
“Best fit” framework synthesis: refining the method
BMC Medical Research Methodology - Tập 13 - Trang 1-16 - 2013
Following publication of the first worked example of the “best fit” method of evidence synthesis for the systematic review of qualitative evidence in this journal, the originators of the method identified a need to specify more fully some aspects of this particular derivative of framework synthesis. We therefore present a second such worked example in which all techniques are defined and explained...... hiện toàn bộ
Optimal designs for phase II/III drug development programs including methods for discounting of phase II resultsAbstract
Background
Go/no-go decisions after phase II and sample size chosen for phase III are usually based on phase II results (e.g., the treatment effect estimate of phase II). Due to the decision rule (only promising phase II results lead to phase III), treatment effect estimates from phase II that initiate a phase III trial c... ... hiện toàn bộ
BMC Medical Research Methodology - - 2020
Developing model biobanking consent language: what matters to prospective participants?
BMC Medical Research Methodology - Tập 20 - Trang 1-14 - 2020
Efforts to improve informed consent have led to calls for providing information a reasonable person would want to have, in a way that facilitates understanding of the reasons why one might or might not want to participate. At the same time, advances in large-scale genomic research have expanded both the opportunities and the risks for participants, families, and communities. To advance the use of ...... hiện toàn bộ
What is the value of social values? The uselessness of assessing health-related quality of life through preference measures
BMC Medical Research Methodology - Tập 4 - Trang 1-9 - 2004
The use of preference-based measures in the evaluation of health outcomes has extended considerably over the last decade. Their alleged advantage over other types of general instruments in the evaluation of health related quality of life (HRQOL), supposedly lies in the fact that preference measures incorporate values or utilities that reflects the value of social preferences through health states....... hiện toàn bộ
Who does not participate in a follow-up postal study? a survey of infertile couples treated by in vitro fertilization
BMC Medical Research Methodology - Tập 12 - Trang 1-8 - 2012
A good response rate has been considered as a proof of a study’s quality. Decreasing participation and its potential impact on the internal validity of the study are of growing interest. Our objective was to assess factors associated with contact and response to a postal survey in a epidemiological study of the long-term outcome of IVF couples. The DAIFI study is a retrospective cohort including 6...... hiện toàn bộ
Evaluating sensitivity to classification uncertainty in latent subgroup effect analyses
BMC Medical Research Methodology - Tập 22 - Trang 1-18 - 2022
Increasing attention is being given to assessing treatment effect heterogeneity among individuals belonging to qualitatively different latent subgroups. Inference routinely proceeds by first partitioning the individuals into subgroups, then estimating the subgroup-specific average treatment effects. However, because the subgroups are only latently associated with the observed variables, the actual...... hiện toàn bộ
Self-reported data in environmental health studies: mail vs. web-based surveys
BMC Medical Research Methodology - Tập 19 - Trang 1-13 - 2019
Internet has been broadly employed as a facilitator for epidemiological surveys, as a way to provide a more economical and practical alternative to traditional survey modes. A current trend in survey research is to combine Web-based surveys with other survey modes by offering the participant the possibility of choosing his/her preferred response method (i.e. mixed-mode approach). However, studies ...... hiện toàn bộ
Bayesian regularization to predict neuropsychiatric adverse events in smoking cessation with pharmacotherapy
BMC Medical Research Methodology - Tập 23 - Trang 1-11 - 2023
Research on risk factors for neuropsychiatric adverse events (NAEs) in smoking cessation with pharmacotherapy is scarce. We aimed to identify predictors and develop a prediction model for risk of NAEs in smoking cessation with medications using Bayesian regularization. Bayesian regularization was implemented by applying two shrinkage priors, Horseshoe and Laplace, to generalized linear mixed model...... hiện toàn bộ
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