Abdalrahim F. A. Aisha, Khalid M. Abu‐Salah, Zhari Ismail, Amin Malik Shah Abdul Majid
Abstract Background Xanthones are a group of oxygen-containing heterocyclic
compounds with remarkable pharmacological effects such as anti-cancer,
antioxidant, anti-inflammatory, and antimicrobial activities. Methods A
xanthones extract (81% α-mangostin and 16% γ-mangostin), was prepared by
crystallization of a toluene extract of G. mangostana fruit rinds and was
analyzed by LC-MS. Anti-colon canc... hiện toàn bộ
Xiu Fang Ding, Yue Hua Li, Jiaxu Chen, Long Ji Sun, Haiyan Jiao, Xin Xin Wang, Yan Zhou
Abstract Background Xiao Yao San (XYS) is an herbal prescription which is used
in the treatment of depression for thousands of years from Song dynasty in China
(960–1127 A.D.), and is the bestselling and most popular herb formula for
treating major depression. This study aimed to assess the chronic antidepressant
effects of XYS and fluoxetine in depressed mice induced by chronic unpredictable
mild... hiện toàn bộ
Xiaoxiao Zhang, Chang-le Shao, Songyi Cheng, Yinsu Zhu, Bo Liang, Ning Gu
Abstract Background Acute myocardial infarction (AMI) is the most serious and
lethal manifestation of coronary heart disease worldwide, presenting extremely
high disability and mortality. Our previous studies have shown that Guanxin
V (GXV) could significantly improve the cardiac function and the blood flow
dynamics, and reduce serum levels of inflammatory factors in AMI rats, thus
triggering vent... hiện toàn bộ
Tosin A. Olasehinde, Ademola O. Olaniran, Anthony I. Okoh
Abstract Background Sulfated polysaccharides from marine algae are known to
possess antioxidative activities, however, their therapeutic role in
metal-induced neurodegeneration has not been explored. In this study, the
neuroprotective potentials of sulfated polysaccharides isolated from Ecklonia
maxima (PKPM), Gelidium pristoides (PMNP), Ulva lactuca (PULV), Ulva rigida
(PURL) and Gracilaria graci... hiện toàn bộ
Mihret Ayalew, Azmeraw Bekele, Mestayet Geta Mengistie, Seyfe Asrade Atnafie
The use of traditional medicinal plants in the management of diarrhea has long
been practiced in Ethiopia. B. abyssinica fresen is one of the plants
traditionally used to treat diarrhea whereas an in vivo study had not yet been
conducted. Thus, this study aimed to evaluate the antidiarrheal activity of
crude extract and solvent fractions of the leaf of B. abyssinica in mice. Cold
maceration within... hiện toàn bộ
Adrian L. Lopresti, Stephen J. Smith, Alethea Rea, Shavon Michel
AbstractBackgroundThere is preliminary evidence to suggest curcumin can
alleviate digestive symptoms in adults with self-reported digestive complaints
and irritable bowel syndrome. However, in all these trials, curcumin was used as
a component of a multi-herbal combination and there were consistent concerns
associated with risk of bias in most studies. The goal of this study was to
investigate the... hiện toàn bộ
Siti Suraya Ruslee, Siti Sarah Mohamad Zaid, Ikmal Hisyam Bakrin, Yong Meng Goh, M. M. Noordin
AbstractBackgroundTo investigate the protective effects of Tualang honey against
the toxicity effects induced by cadmium (Cd) on the ovary.MethodsA total of 32
female Sprague Dawley rats were taken and randomly divided into four groups
(n = 8). Throughout the experimental period of 6 weeks, negative control-NC
(vehicle deionized water), positive control-CD (Cd at 5 mg/kg), Tualang honey
followed b... hiện toàn bộ
Abstract Background Coronavirus disease 2019 (COVID-19) is a novel infectious
disease caused by severe acute respiratory syndrome coronavirus 2, and
responsible for a global pandemic. Despite there being no known vaccines or
medicines that prevent or cure COVID-19, many traditional, integrative,
complementary and alternative medicines (TICAMs) have been touted as the
solution, as well as researche... hiện toàn bộ
Abstract Background The hand, foot and mouth disease (HFMD) is a febrile and
exanthematous childhood disease mainly caused by Enterovirus 71 (EV-A71). In
severe HFMD, virulent EV-A71 strains can cause acute flaccid paralysis and
cardiopulmonary edema leading to death. Currently, no FDA approved antiviral
treatment or vaccine is available for EV-A71. Flavonoids such as silymarin and
baicalein are k... hiện toàn bộ
Jiashun Li, Jie Xiang, Xiaoli Liang, Ziyu Chen, Peifang Xie, Xiping Pan, Beixian Zhou, Jing Li
Abstract Background Human respiratory system infected with influenza A virus
(IAV) elicited a robust pro-inflammatory response that resulted in severe
illness and even death. Currently, limited immunomodulator is available to
counteract IAV-associated pneumonia in the clinic. Sinensetin, a
polymethoxylated flavone with five methoxy groups, has been found to possess
anti-agiogenesis, anti-inflammat... hiện toàn bộ