BMC Cancer
SCIE-ISI SCOPUS (2001-2025)
1471-2407
Cơ quản chủ quản: BMC , BioMed Central Ltd.
Lĩnh vực:
OncologyCancer ResearchGenetics
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Noninvasive detection of lung cancer by analysis of exhaled breath
Tập 9 Số 1 - 2009
Abstract Background Lung cancer is one of the leading causes of death in Europe
and the western world. At present, diagnosis of lung cancer very often happens
late in the course of the disease since inexpensive, non-invasive and
sufficiently sensitive and specific screening methods are not available. Even
though the CT diagnostic methods are good, it must be assured that "screening
benefit outweig...
The claudin gene family: expression in normal and neoplastic tissues
Tập 6 Số 1 - 2006
AbstractBackgroundThe claudin (CLDN) genes encode a family of proteins important
in tight junction formation and function. Recently, it has become apparent
thatCLDNgene expression is frequently altered in several human cancers. However,
the exact patterns ofCLDNexpression in various cancers is unknown, as only a
limited number ofCLDNgenes have been investigated in a few tumors.MethodsWe
identified...
Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression
Tập 13 Số 1 - 2013
Abstract Background Long non-coding RNAs play an important role in
tumorigenesis, hence, identification of cancer-associated lncRNAs and
investigation of their biological functions and molecular mechanisms are
important for understanding the development and progression of cancer. Recently,
the downregulation of lncRNA MEG3 has been observed in various human cancers.
However, its role in non-small ...
MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN
- 2010
Abstract Background MicroRNAs (miRNAs) can function as either oncogenes or tumor
suppressor genes via regulation of cell proliferation and/or apoptosis. MiR-221
and miR-222 were discovered to induce cell growth and cell cycle progression via
direct targeting of p27 and p57 in various human malignancies. However, the
roles of miR-221 and miR-222 have not been reported in human gastric cancer. In
th...
Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition
Tập 14 Số 1 - 2014
High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer
Tập 6 Số 1 - 2006
Abstract Background The development of targeted therapies has created a pressing
clinical need for the rapid and robust molecular characterisation of cancers. We
describe here the application of high-resolution melting analysis (HRM) to
screen for KRAS mutations in clinical cancer samples. In non-small cell lung
cancer, KRAS mutations have been shown to identify a group of patients that do
not res...
Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment
- 2011
Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities
- 2008
Abstract Background Subclassification of ovarian carcinomas can be used to guide
treatment and determine prognosis. Germline and somatic mutations, loss of
heterozygosity (LOH), and epigenetic events such as promoter hypermethylation
can lead to decreased expression of BRCA1/2 in ovarian cancers. The mechanism of
BRCA1/2 loss is a potential method of subclassifying high grade serous
carcinomas. Me...