Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition
Tóm tắt
Từ khóa
Tài liệu tham khảo
Bissell MJ, Hines WC: Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med. 2011, 17 (3): 320-329. 10.1038/nm.2328.
Lu P, Weaver VM, Werb Z: The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012, 196 (4): 395-406. 10.1083/jcb.201102147.
Muschler J, Streuli CH: Cell-matrix interactions in mammary gland development and breast cancer. Cold Spring Harbor Perspect Biol. 2010, 2 (10): a003202-
Lochter A, Bissell MJ: Involvement of extracellular matrix constituents in breast cancer. Semin Cancer Biol. 1995, 6 (3): 165-173. 10.1006/scbi.1995.0017.
Provenzano PP, Eliceiri KW, Campbell JM, Inman DR, White JG, Keely PJ: Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med. 2006, 4 (1): 38-10.1186/1741-7015-4-38.
Canty EG, Kadler KE: Procollagen trafficking, processing and fibrillogenesis. J Cell Sci. 2005, 118 (Pt 7): 1341-1353.
Pozzi A, Wary KK, Giancotti FG, Gardner HA: Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol. 1998, 142 (2): 587-594. 10.1083/jcb.142.2.587.
Yeh YC, Lin HH, Tang MJ: A tale of two collagen receptors, integrin beta1 and discoidin domain receptor 1, in epithelial cell differentiation. Am J Physiol Cell Physiol. 2012, 303 (12): C1207-C1217. 10.1152/ajpcell.00253.2012.
Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD: The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol. 2013, 15 (6): 677-687. 10.1038/ncb2743.
Provenzano PP, Inman DR, Eliceiri KW, Knittel JG, Yan L, Rueden CT, White JG, Keely PJ: Collagen density promotes mammary tumor initiation and progression. BMC Med. 2008, 6: 11-10.1186/1741-7015-6-11.
Shields MA, Dangi-Garimella S, Krantz SB, Bentrem DJ, Munshi HG: Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion. J Biol Chem. 2011, 286 (12): 10495-10504. 10.1074/jbc.M110.195628.
Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J, et al: Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest. 2005, 115 (5): 1163-1176.
Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, et al: Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009, 139 (5): 891-906. 10.1016/j.cell.2009.10.027.
Van ‘t Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, et al: Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002, 415 (6871): 530-536. 10.1038/415530a.
Condeelis J, Segall JE: Intravital imaging of cell movement in tumours. Nat Rev Cancer. 2003, 3 (12): 921-930. 10.1038/nrc1231.
Myllyharju J: Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol. 2003, 22 (1): 15-24. 10.1016/S0945-053X(03)00006-4.
Gorres KL, Raines RT: Prolyl 4-hydroxylase. Crit Rev Biochem Mol Biol. 2010, 45 (2): 106-124. 10.3109/10409231003627991.
Kukkola L, Hieta R, Kivirikko KI, Myllyharju J: Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. J Biol Chem. 2003, 278 (48): 47685-47693. 10.1074/jbc.M306806200.
Pajunen L, Jones TA, Helaakoski T, Pihlajaniemi T, Solomon E, Sheer D, Kivirikko KI: Assignment of the gene coding for the alpha-subunit of prolyl 4-hydroxylase to human chromosome region 10q21.3-23.1. Am J Hum Genet. 1989, 45 (6): 829-834.
Annunen P, Helaakoski T, Myllyharju J, Veijola J, Pihlajaniemi T, Kivirikko KI: Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer: the alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer. J Biol Chem. 1997, 272 (28): 17342-17348. 10.1074/jbc.272.28.17342.
Sundberg C, Ivarsson M, Gerdin B, Rubin K: Pericytes as collagen-producing cells in excessive dermal scarring. Lab Invest. 1996, 74 (2): 452-466.
Stephens EH, Grande-Allen KJ: Age-related changes in collagen synthesis and turnover in porcine heart valves. J Heart Valve Dis. 2007, 16 (6): 672-682.
Bulleid NJ, John DC, Kadler KE: Recombinant expression systems for the production of collagen. Biochem Soc Trans. 2000, 28 (4): 350-353. 10.1042/0300-5127:0280350.
Nokelainen M, Nissi R, Kukkola L, Helaakoski T, Myllyharju J: Characterization of the human and mouse genes for the alpha subunit of type II prolyl 4-hydroxylase: identification of a previously unknown alternatively spliced exon and its expression in various tissues. Eur J Biochem. 2001, 268 (20): 5300-5309. 10.1046/j.0014-2956.2001.02464.x.
Grimmer C, Balbus N, Lang U, Aigner T, Cramer T, Muller L, Swoboda B, Pfander D: Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. Am J Pathol. 2006, 169 (2): 491-502. 10.2353/ajpath.2006.050738.
Myllyharju J, Schipani E: Extracellular matrix genes as hypoxia-inducible targets. Cell Tissue Res. 2010, 339 (1): 19-29. 10.1007/s00441-009-0841-7.
Chang KP, Yu JS, Chien KY, Lee CW, Liang Y, Liao CT, Yen TC, Lee LY, Huang LL, Liu SC, et al: Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology. J Proteome Res. 2011, 10 (11): 4935-4947. 10.1021/pr200311p.
Jarzab B, Wiench M, Fujarewicz K, Simek K, Jarzab M, Oczko-Wojciechowska M, Wloch J, Czarniecka A, Chmielik E, Lange D, et al: Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications. Cancer Res. 2005, 65 (4): 1587-1597. 10.1158/0008-5472.CAN-04-3078.
Mackay A, Jones C, Dexter T, Silva RL, Bulmer K, Jones A, Simpson P, Harris RA, Jat PS, Neville AM, et al: cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells. Oncogene. 2003, 22 (17): 2680-2688. 10.1038/sj.onc.1206349.
Pan PW, Zhang Q, Bai F, Hou J, Bai G: Profiling and comparative analysis of glycoproteins in Hs578BST and Hs578T and investigation of prolyl 4-hydroxylase alpha polypeptide II expression and influence in breast cancer cells. Biochemistry (Mosc). 2012, 77 (5): 539-545. 10.1134/S000629791205015X.
Petersen OW, Ronnov-Jessen L, Howlett AR, Bissell MJ: Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci USA. 1992, 89 (19): 9064-9068. 10.1073/pnas.89.19.9064.
Xu R, Nelson CM, Muschler JL, Veiseh M, Vonderhaar BK, Bissell MJ: Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J Cell Biol. 2009, 184 (1): 57-66. 10.1083/jcb.200807021.
Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL: Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 2013, 73 (11): 3285-3296. 10.1158/0008-5472.CAN-12-3963.
Gyorffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q, Szallasi Z: An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat. 2010, 123 (3): 725-731. 10.1007/s10549-009-0674-9.
Xu R, Mao JH: Gene transcriptional networks integrate microenvironmental signals in human breast cancer. Integr Biol: Quant Biosci Nano macro. 2011, 3 (4): 368-374.
Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, Lapuk A, Neve RM, Qian Z, Ryder T, et al: Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell. 2006, 10 (6): 529-541. 10.1016/j.ccr.2006.10.009.
Helleman J, Jansen MP, Ruigrok-Ritstier K, van Staveren IL, Look MP, Meijer-van Gelder ME, Sieuwerts AM, Klijn JG, Sleijfer S, Foekens JA, et al: Association of an extracellular matrix gene cluster with breast cancer prognosis and endocrine therapy response. Clin Cancer Res. 2008, 14 (17): 5555-5564. 10.1158/1078-0432.CCR-08-0555.
Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, Yang F, Talantov D, Timmermans M, Meijer-van Gelder ME, Yu J, et al: Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet. 2005, 365 (9460): 671-679.
Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, et al: The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol. 2007, 1 (1): 84-96. 10.1016/j.molonc.2007.02.004.
Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ: Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci USA. 1998, 95 (25): 14821-14826. 10.1073/pnas.95.25.14821.
Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ: Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol. 1997, 137 (1): 231-245. 10.1083/jcb.137.1.231.
Salic A, Mitchison TJ: A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci USA. 2008, 105 (7): 2415-2420. 10.1073/pnas.0712168105.
Xiong G, Wang C, Evers BM, Zhou BP, Xu R: RORalpha suppresses breast tumor invasion by inducing SEMA3F expression. Cancer Res. 2012, 72 (7): 1728-1739. 10.1158/0008-5472.CAN-11-2762.
Franklin TJ, Morris WP, Edwards PN, Large MS, Stephenson R: Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones. Biochem J. 2001, 353 (Pt 2): 333-338.
Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, et al: Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFkappaB activation in the tumor stromal microenvironment. Cell Cycle. 2010, 9 (17): 3515-3533. 10.4161/cc.9.17.12928.
Sondo E, Tomati V, Caci E, Esposito AI, Pfeffer U, Pedemonte N, Galietta LJ: Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling. Am J Physiol Cell Physiol. 2011, 301 (4): C872-C885. 10.1152/ajpcell.00507.2010.
Li Q, Chow AB, Mattingly RR: Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors. J Pharmacol Exper Ther. 2010, 332 (3): 821-828. 10.1124/jpet.109.160390.
Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS: Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012, 21 (2): 227-239. 10.1016/j.ccr.2011.12.024.
Pickl M, Ries CH: Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab. Oncogene. 2009, 28 (3): 461-468. 10.1038/onc.2008.394.
Spencer VA, Xu R, Bissell MJ: Extracellular matrix, nuclear and chromatin structure, and gene expression in normal tissues and malignant tumors: a work in progress. Adv Cancer Res. 2007, 97: 275-294.
Calvo F, Ege N, Grande-Garcia A, Hooper S, Jenkins RP, Chaudhry SI, Harrington K, Williamson P, Moeendarbary E, Charras G, et al: Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol. 2013, 15 (6): 637-646. 10.1038/ncb2756.
Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E, Massague J: Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med. 2011, 17 (7): 867-874. 10.1038/nm.2379.
El-Haibi CP, Bell GW, Zhang J, Collmann AY, Wood D, Scherber CM, Csizmadia E, Mariani O, Zhu C, Campagne A, et al: Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proc Natl Acad Sci USA. 2012, 109 (43): 17460-17465. 10.1073/pnas.1206653109.
Brownfield DG, Venugopalan G, Lo A, Mori H, Tanner K, Fletcher DA, Bissell MJ: Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules. Curr Biol. 2013, 23 (8): 703-709. 10.1016/j.cub.2013.03.032.