BMC Cancer

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Combining tissue and circulating tumor DNA increases the detection rate of a CTNNB1 mutation in hepatocellular carcinoma
BMC Cancer - Tập 21 Số 1 - 2021
Stine Karlsen, Michelle Simone Clement, Britta Weber, Henning Grønbæk, Stephen Hamilton-Dutoit, Boe Sandahl Sørensen, Jens Kelsen
Abstract Background and aims Studies suggest that mutations in the CTNNB1 gene are predictive of response to immunotherapy, an emerging therapy for advanced hepatocellular carcinoma (HCC). Analysis of circulating tumor DNA (ctDNA) offers the possibility of serial non-invas...... hiện toàn bộ
Metabolic mapping by use of high-resolution magic angle spinning 1H MR spectroscopy for assessment of apoptosis in cervical carcinomas
BMC Cancer - Tập 7 - Trang 1-12 - 2007
Heidi Lyng, Beathe Sitter, Tone F Bathen, Line R Jensen, Kolbein Sundfør, Gunnar B Kristensen, Ingrid S Gribbestad
High-resolution magic angle proton magnetic resonance spectroscopy (HR 1H MAS MRS) provides a broad metabolic mapping of intact tumor samples and allows for microscopy investigations of the samples after spectra acquisition. Experimental studies have suggested that the method can be used for detection of apoptosis, but this has not been investigated in a clinical setting so far. We have explored t...... hiện toàn bộ
A phase II trial proposal of total neoadjuvant treatment with primary chemotherapy, stereotactic body radiation therapy, and intraoperative radiation therapy in borderline resectable pancreatic adenocarcinoma
BMC Cancer - Tập 21 - Trang 1-8 - 2021
Salvatore Paiella, Giuseppe Malleo, Nicola Simoni, Renato Micera, Stefania Guariglia, Carlo Cavedon, Giovanni Marchegiani, Alessandro Esposito, Luca Landoni, Luca Casetti, Massimiliano Tuveri, Michele Milella, Erica Secchettin, Gessica Manzini, Chiara Bovo, Matteo De Pastena, Martina Fontana, Roberto Salvia, Renzo Mazzarotto, Claudio Bassi
The current management guidelines recommend that patients with borderline resectable pancreatic adenocarcinoma (BRPC) should initially receive neoadjuvant chemotherapy. The addition of advanced radiation therapy modalities, including stereotactic body radiation therapy (SBRT) and intraoperative radiation therapy (IORT), could result in a more effective neoadjuvant strategy, with higher rates of ma...... hiện toàn bộ
Antisense oligonucleotides and all-trans retinoic acid have a synergistic anti-tumor effect on oral squamous cell carcinoma
BMC Cancer - Tập 8 - Trang 1-9 - 2008
Qin Xu, Zhiyuan Zhang, Ping Zhang, Wantao Chen
Antisense oligonucleotides against hTR (As-ODN-hTR) have shown promising results as treatment strategies for various human malignancies. All-trans retinoic acid (ATRA) is a signalling molecule with important roles in differentiation and apoptosis. Biological responses to ATRA are currently used therapeutically in various human cancers. The aim of this study was to evaluate the anti-tumor effects o...... hiện toàn bộ
CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis
BMC Cancer - Tập 17 - Trang 1-13 - 2017
Darrin Gao, Lisa H. Cazares, Eleanor N. Fish
In earlier studies we have shown that CCL5 activation of CCR5 induces the proliferation and survival of breast cancer cells in a mechanistic target of rapamycin (mTOR)-dependent manner and that this is in part due to CCR5-mediated increases in glycolytic metabolism. Using the MDA-MB-231 triple negative human breast cancer cell line and mouse mammary tumor virus – polyomavirus middle T-antigen (MMT...... hiện toàn bộ
Genomic pathways modulated by Twist in breast cancer
BMC Cancer - Tập 17 - Trang 1-12 - 2017
Farhad Vesuna, Yehudit Bergman, Venu Raman
The basic helix-loop-helix transcription factor TWIST1 (Twist) is involved in embryonic cell lineage determination and mesodermal differentiation. There is evidence to indicate that Twist expression plays a role in breast tumor formation and metastasis, but the role of Twist in dysregulating pathways that drive the metastatic cascade is unclear. Moreover, many of the genes and pathways dysregulate...... hiện toàn bộ
Upregulation of Mrps18a in breast cancer identified by selecting phage antibody libraries on breast tissue sections
BMC Cancer - - 2017
Karen Marie Juul Sørensen, Theresa Meldgaard, Connie Jenning Melchjorsen, Agla J. Fridriksdottir, Henrik Pedersen, Ole William Petersen, Peter Kristensen
One of the hallmarks of cancer is an altered energy metabolism, and here, mitochondria play a central role. Previous studies have indicated that some mitochondrial ribosomal proteins change their expression patterns upon transformation. In this study, we have used the selection of recombinant antibody libraries displayed on the surface of filamentous bacteriophage as a proteomics discovery tool fo...... hiện toàn bộ
Protocol for MInimizing the Risk of Metachronous Adenomas of the CoLorectum with Green Tea Extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population
BMC Cancer - Tập 11 - Trang 1-9 - 2011
Julia C Stingl, Thomas Ettrich, Rainer Muche, Martina Wiedom, Jürgen Brockmöller, Angela Seeringer, Thomas Seufferlein
Prevention of colorectal cancer is a major health care issue. People who have undergone colonoscopy screening and had colorectal polyps removed have a higher risk of being diagnosed with polyps again compared to the normal population. Therefore, it would be ideal to find appropriate means that effectively help to prevent the reoccurrence of polyps after polypectomy. So far, pharmaceutical chemopre...... hiện toàn bộ
Serum irisin levels are lower in patients with breast cancer: association with disease diagnosis and tumor characteristics
BMC Cancer - Tập 15 - Trang 1-9 - 2015
Xeni Provatopoulou, Georgia P. Georgiou, Eleni Kalogera, Vasileios Kalles, Maira A. Matiatou, Ioannis Papapanagiotou, Alexandros Sagkriotis, George C. Zografos, Antonia Gounaris
Irisin is a recently discovered myokine, involved in the browning of white adipose tissue. To date, its function has been mainly associated with energy homeostasis and metabolism, and it has been proposed as a promising therapeutic target for obesity and metabolic diseases. This is the first study investigating the role of irisin in human breast cancer. Participants included one hundred and one (1...... hiện toàn bộ
Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer
BMC Cancer - Tập 18 Số 1 - 2018
Masaru Hagiwara, Nobuyuki Tanaka, Takeo Kosaka, Shuji Mikami, Hideyuki Saya, Mototsugu Oya
Tổng số: 11,110   
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