BMC Cancer
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Long-term mortality among women with epithelial ovarian cancer: a population-based study in British Columbia, Canada
BMC Cancer - Tập 18 - Trang 1-9 - 2018
Among women with epithelial ovarian cancer (EOC), histotype is one of the major
prognostic factors. However, few data are available on histotype- specific
survival and mortality estimates among these patients. We therefore examined
survival and causes of death among women with EOC by histotype. A population-
based cohort including all ovarian cancer patients diagnosed in British Columbia
(BC) betw...
Combining tissue and circulating tumor DNA increases the detection rate of a CTNNB1 mutation in hepatocellular carcinoma
BMC Cancer - Tập 21 Số 1 - 2021
Abstract Background and aims Studies suggest that mutations in the CTNNB1 gene
are predictive of response to immunotherapy, an emerging therapy for advanced
hepatocellular carcinoma (HCC). Analysis of circulating tumor DNA (ctDNA) offers
the possibility of serial non-invasive mutational profiling of tumors. Combining
tumor tissue and ctDNA analysis may increase the detection rate of mutations.
Thi...
Metabolic mapping by use of high-resolution magic angle spinning 1H MR spectroscopy for assessment of apoptosis in cervical carcinomas
BMC Cancer - Tập 7 - Trang 1-12 - 2007
High-resolution magic angle proton magnetic resonance spectroscopy (HR 1H MAS
MRS) provides a broad metabolic mapping of intact tumor samples and allows for
microscopy investigations of the samples after spectra acquisition. Experimental
studies have suggested that the method can be used for detection of apoptosis,
but this has not been investigated in a clinical setting so far. We have
explored t...
Incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer
BMC Cancer - Tập 18 - Trang 1-10 - 2018
Subsyndromal delirium, a condition in which patients exhibit some, but not all,
of the symptoms of delirium, can negatively affect the outcomes of patients with
cancer. However, the incidence of subsyndromal delirium in patients with gastric
cancer is unknown. Here, we investigated the incidence and risk factors of
subsyndromal delirium after curative resection of gastric cancer. We recruited
cons...
Phase II trial of selective internal radiation therapy and systemic chemotherapy for liver-predominant metastases from pancreatic adenocarcinoma
BMC Cancer - Tập 15 - Trang 1-12 - 2015
This prospective, open-label phase II study assessed the impact of
liver-directed therapy with selective internal radiation therapy (SIRT) and
systemic chemotherapy on progression-free survival (PFS) in liver-dominant
metastatic pancreatic adenocarcinoma. Patients received yttrium-90-labelled
(90Y) resin microspheres (SIR-Spheres; Sirtex Medical Limited, Sydney,
Australia) as a single procedure on...
Intraepithelial lymphocytes are indicators of better prognosis in surgically resected endometrioid-type endometrial carcinomas at early and advanced stages
BMC Cancer - Tập 22 - Trang 1-15 - 2022
Tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs)
may be useful prognostic indicators in endometrial cancer. However, standardized
assessment methods and the prognostic roles of these cells in different stage
groups are unclear. Formalin-fixed paraffin-embedded tissue samples of 107
endometrioid-type endometrial carcinomas (EECs) comprising 60 stage IB and 47
stage IIIC...
Concomitant Temozolomide plus radiotherapy for high-grade and recurrent meningioma: a retrospective chart review
BMC Cancer - Tập 22 - Trang 1-6 - 2022
High-grade and recurrent meningiomas are often treatment resistant and pose a
therapeutic challenge after surgical and radiation therapy (RT) failure.
Temozolomide (TMZ) is a DNA alkylating agent that appears to have a
radiosensitizing effect when used in combination with RT and may be worthwhile
in meningioma treatment. Thus, we investigated the potential efficacy of
concomitant RT plus TMZ compa...
Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy?
BMC Cancer - Tập 15 - Trang 1-9 - 2015
TP53 gene mutation is widely known as one of the determinants of impaired
chemosensitivity. p53 is a tumor-suppressor protein in humans encoded by the
TP53 gene. Some studies have shown that TP53 gene mutation and accumulation of
the p53 protein are closely related with serum anti-p53 antibody positivity.
This study aimed to evaluate the predictive significance of the serum p53
antibody status in ...
NPM1 as a potential therapeutic target for atypical teratoid/rhabdoid tumors
BMC Cancer - Tập 19 - Trang 1-12 - 2019
Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant brain tumors
with inactivation of the SMARCB1 gene, which play a critical role in genomic
transcriptional control. In this study, we analyzed the genomic and
transcriptomic profiles of human AT/RTs to discover new druggable targets.
Multiplanar sequencing analyses, including whole exome sequencing (WES), single
nucleotide polymorphism...
Could aspirin be a lifesaver for prostate cancer patients in prostate cancer-specific mortality?: an update systematic review and meta-analysis
BMC Cancer - Tập 19 - Trang 1-8 - 2019
Currently, clinical studies on the prognosis of prostate cancer (PC) taking
aspirin were developing, but the precise mechanism of aspirin on tumor cells was
still unclear. In addition, the conclusion that aspirin can improve the
prognosis of PC patients continues to be controversial. Therefore, we collected
comprehensive literatures and performed our study to explore the prognostic
effect of aspir...
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