Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice Tập 1 Số 3 - Trang 147-158 - 2008
Kathryn K. Chadman, Shiaoching Gong, María Luisa Scattoni, Sarah E. Boltuck, Shruti U. Gandhy, Nathaniel Heintz, Jacqueline N. Crawley
AbstractNeuroligin‐3 is a member of the class of cell adhesion proteins that
mediate synapse development and have been implicated in autism. Mice with the
human R451C mutation (NL3), identical to the point mutation found in two
brothers with autism spectrum disorders, were generated and phenotyped in
multiple behavioral assays with face validity to the diagnostic symptoms of
autism. No differences... hiện toàn bộ
Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6–35 Years Tập 8 Số 1 - Trang 82-93 - 2015
Nicholas de Lange, Brittany G. Travers, Erin D. Bigler, Molly B. D. Prigge, Alyson Froehlich, Jared A. Nielsen, Annahir N. Cariello, Brandon A. Zielinski, Jeffrey S. Anderson, P. Thomas Fletcher, Andrew Alexander, Janet E. Lainhart
Since the impairments associated with autism spectrum disorder (ASD) tend to
persist or worsen from childhood into adulthood, it is of critical importance to
examine how the brain develops over this growth epoch. We report initial
findings on whole and regional longitudinal brain development in 100 male
participants with ASD (226 high‐quality magnetic resonance imaging [MRI] scans;
mean inter‐scan... hiện toàn bộ
Measuring social attention and motivation in autism spectrum disorder using eye‐tracking: Stimulus type matters Tập 8 Số 5 - Trang 620-628 - 2015
Coralie Chevallier, Julia Parish‐Morris, Alana J. McVey, Keiran Rump, Noah J. Sasson, John D. Herrington
Autism Spectrum Disorder (ASD) is characterized by social impairments that have
been related to deficits in social attention, including diminished gaze to
faces. Eye‐tracking studies are commonly used to examine social attention and
social motivation in ASD, but they vary in sensitivity. In this study, we
hypothesized that the ecological nature of the social stimuli would affect
participants' soci... hiện toàn bộ
Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism Tập 2 Số 4 - Trang 205-219 - 2009
Adrian L. Oblak, Terrell T. Gibbs, Gene J. Blatt
AbstractThe anterior cingulate cortex (ACC; BA 24) via its extensive limbic and
high order association cortical connectivity to prefrontal cortex is a key part
of an important circuitry participating in executive function, affect, and
socio‐emotional behavior. Multiple lines of evidence, including genetic and
imaging studies, suggest that the ACC and gamma‐amino‐butyric acid (GABA) system
may be a... hiện toàn bộ
Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder Tập 1 Số 3 - Trang 159-168 - 2008
Jerry L. Campbell, Chun Li, James S. Sutcliffe, Antonio M. Persico, Pat Levitt
AbstractA functional promoter variant of the gene encoding the MET receptor
tyrosine kinase alters SP1 and SUB1 transcription factor binding, and is
associated with autism spectrum disorder (ASD). Recent analyses of postmortem
cerebral cortex from ASD patients revealed altered expression of MET protein and
three transcripts encoding proteins that regulate MET signaling, hepatocyte
growth factor (H... hiện toàn bộ
Atypical diffusion tensor hemispheric asymmetry in autism Tập 3 Số 6 - Trang 350-358 - 2010
Nicholas de Lange, Molly B. DuBray, Jee Eun Lee, Michael P. Froimowitz, Alyson Froehlich, Nagesh Adluru, Bryon E. Wright, Caitlin Ravichandran, P. Thomas Fletcher, Erin D. Bigler, Andrew L. Alexander, Janet E. Lainhart
AbstractBackground: Biological measurements that distinguish individuals with
autism from typically developing individuals and those with other developmental
and neuropsychiatric disorders must demonstrate very high performance to have
clinical value as potential imaging biomarkers. We hypothesized that further
study of white matter microstructure (WMM) in the superior temporal gyrus (STG)
and tem... hiện toàn bộ
Self–other relations in social development and autism: multiple roles for mirror neurons and other brain bases Tập 1 Số 2 - Trang 73-90 - 2008
Justin H. G. Williams
AbstractMirror neuron system dysfunction may underlie a self–other matching
impairment, which has previously been suggested to account for autism. Embodied
Cognition Theory, which proposes that action provides a foundation for cognition
has lent further credence to these ideas. The hypotheses of a self–other
matching deficit and impaired mirror neuron function in autism have now been
well supporte... hiện toàn bộ
Rumination and Perceived Impairment Associated With Depressive Symptoms in a Verbal Adolescent–Adult ASD Sample Tập 7 Số 3 - Trang 381-391 - 2014
Katherine Gotham, Somer Bishop, Steven M. Brunwasser, Catherine Lord
The aim of this study was to examine the association between depressive symptoms
and several psychosocial constructs (insight into autism symptoms, rumination,
desire for social interaction, and satisfaction with social support) that may
play a role in the development or maintenance of depression in verbally fluent
adolescents and adults with ASD. Participants included 50 individuals with ASD
and ... hiện toàn bộ