Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice Tập 1 Số 3 - Trang 147-158 - 2008
Kathryn K. Chadman, Shiaoching Gong, María Luisa Scattoni, Sarah E. Boltuck, Shruti U. Gandhy, Nathaniel Heintz, Jacqueline N. Crawley
AbstractNeuroligin‐3 is a member of the class of cell adhesion proteins that mediate synapse development and have been implicated in autism. Mice with the human R451C mutation (NL3), identical to the point mutation found in two brothers with autism spectrum disorders, were generated and phenotyped in multiple behavioral assays with face validity to the diagnostic s...... hiện toàn bộ Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6–35 Years Tập 8 Số 1 - Trang 82-93 - 2015
Nicholas de Lange, Brittany G. Travers, Erin D. Bigler, Molly B. D. Prigge, Alyson Froehlich, Jared A. Nielsen, Annahir N. Cariello, Brandon A. Zielinski, Jeffrey S. Anderson, P. Thomas Fletcher, Andrew Alexander, Janet E. Lainhart
Since the impairments associated with autism spectrum disorder (ASD) tend to persist or worsen from childhood into adulthood, it is of critical importance to examine how the brain develops over this growth epoch. We report initial findings on whole and regional longitudinal brain development in 100 male participants with ... hiện toàn bộ Measuring social attention and motivation in autism spectrum disorder using eye‐tracking: Stimulus type matters Tập 8 Số 5 - Trang 620-628 - 2015
Coralie Chevallier, Julia Parish‐Morris, Alana J. McVey, Keiran Rump, Noah J. Sasson, John D. Herrington
Autism Spectrum Disorder (ASD) is characterized by social impairments that have been related to deficits in social attention, including diminished gaze to faces. Eye‐tracking studies are commonly used to examine social attention and social motivation in ASD, but they vary in sensitivity. In this study, we hypothesized that the ecological nature of the social stimuli would affect participan...... hiện toàn bộ Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism Tập 2 Số 4 - Trang 205-219 - 2009
Adrian L. Oblak, Terrell T. Gibbs, Gene J. Blatt
AbstractThe anterior cingulate cortex (ACC; BA 24) via its extensive limbic and high order association cortical connectivity to prefrontal cortex is a key part of an important circuitry participating in executive function, affect, and socio‐emotional behavior. Multiple lines of evidence, including genetic and imaging studies, suggest that the ACC and gamma‐amino‐bu...... hiện toàn bộ Atypical diffusion tensor hemispheric asymmetry in autism Tập 3 Số 6 - Trang 350-358 - 2010
Nicholas de Lange, Molly B. DuBray, Jee Eun Lee, Michael P. Froimowitz, Alyson Froehlich, Nagesh Adluru, Bryon E. Wright, Caitlin Ravichandran, P. Thomas Fletcher, Erin D. Bigler, Andrew L. Alexander, Janet E. Lainhart
AbstractBackground: Biological measurements that distinguish individuals with autism from typically developing individuals and those with other developmental and neuropsychiatric disorders must demonstrate very high performance to have clinical value as potential imaging biomarkers. We hypothesized that further study of white matter micro...... hiện toàn bộ