Assessment of an Extracorporeal Liver Assist Device in Anhepatic DogsArtificial Organs - Tập 16 Số 4 - Trang 418-422 - 1992
James H. Kelly, Tarek Koussayer, Da-Er He, Maria G. Chong, Thomas A. Shang, Hartwell H. Whisennand, Norman Sussman
Abstract: We have used an anhepatic dog model to demonstrate the efficacy of a bioartificial liver assist device. Six dogs underwent total hepatectomy. Three received only medical care (controls) while the remainder were connected to an extracorporeal liver assist device (ELAD). The control dogs failed to regain consciousness after anesthesia although all lived 4–5 ...... hiện toàn bộ
The Hepatix Extracorporeal Liver Assist Device: Initial Clinical ExperienceArtificial Organs - Tập 18 Số 5 - Trang 390-396 - 1994
Norman Sussman, Gardar T. Gislason, Carol Conlin, James H. Kelly
Abstract: Eleven patients were treated with the Hepatix extracorporeal liver assist device (ELAD) between June 1991 and August 1993. The first 2 patients were treated according to Food and Drug Administration guidelines (“Emergency Use of Unapproved Medical Devices,” October 22, 1985), and the remaining 9 were treated according to an Investigational Device Exemption...... hiện toàn bộ
Higher Renal Replacement Therapy Dose Delivery Influences on Drug TherapyArtificial Organs - Tập 27 Số 9 - Trang 808-814 - 2003
Bruce A. Mueller, Deborah A. Pasko, Kevin M. Sowinski
Abstract: Higher doses of renal replacement therapy have profound effects on pharmacotherapy, yet little research has been conducted in this area. High‐volume renal replacement therapies influence both the pharmacokinetic and the pharmacodynamic profiles of all drugs administered to these critically ill patients. Intermittent high‐dose “hybrid” hemodialysis therapies...... hiện toàn bộ
Comparison of Sustained Hemodiafiltration With Continuous Venovenous Hemodiafiltration for the Treatment of Critically Ill Patients With Acute Kidney InjuryArtificial Organs - Tập 34 Số 4 - Trang 331-338 - 2010
Masanori Abe, Kazuyoshi Okada, Midori Suzuki, Chinami Nagura, Yuko Ishihara, Yuki Fujii, Kazuya Ikeda, Kazo Kaizu, Koichi Matsumoto
AbstractDespite improvements in medical care, the mortality of critically ill patients with acute kidney injury (AKI) who require renal replacement therapy (RRT) remains high. We describe a new approach, sustained hemodiafiltration, to treat patients who suffered from acute kidney injury and were admitted to intensive care units (ICUs). In our study, 60 critically ...... hiện toàn bộ
Hemodiafiltration: A New Alternative To Hemofiltration And Conventional Hemodialysis*Artificial Organs - Tập 2 Số 2 - Trang 150-153 - 1978
H. W. Leber, V. Wizemann, G Goubeaud, P Rawer, G Schütterle
ABSTRACTA new dialysis method, termed hemodiafiltration, is proposed. The procedure consists of the combination of hemofiltration and conventional hemodialysis using high flux membranes with a transmembrane pressure (TMP) of 300–500 mmHg and a dialysate flow of 900 ml/min. Due to the combination of convective mass transfer and diffusion, the clearance values of bot...... hiện toàn bộ
New Method to Calculate Creatinine Generation Rate Using Pre‐ and Postdialysis Creatinine Concentra tionsArtificial Organs - Tập 21 Số 8 - Trang 864-872 - 1997
Toru Shinzato, Shigeru Nakai, Masamiki Miwa, Norihisa Iwayama, Ichiro Takai, Yoshihiro Matsumoto, Hiroyuki Morita, Kenji Maeda
Abstract: The creatinine (Cr) generation rate reflects the muscle mass, a possible indicator of protein nutritional status. Thus, in this study, we developed equations for calculating the Cr generation rate. Depner and Daugirdas recently developed a method for determining the protein catabolic rate (PCR) from the pre‐ and postdialysis blood urea nitrogen concentrati...... hiện toàn bộ
Bisphenol A in Chronic Kidney DiseaseArtificial Organs - Tập 37 Số 3 - Trang 283-290 - 2013
Detlef H. Krieter, Bernard Canaud, Horst‐Dieter Lemke, A. Rodríguez, A. Morgenroth, K. von Appen, G. P. Dragoun, Christoph Wanner
AbstractThe estrogenic endocrine‐disrupting substance bisphenol A (BPA) is extensively used as a starting material for a variety of consumer plastic products including dialyzer materials. The present study was performed to explore plasma ... hiện toàn bộ
Principles and Practice of Hemofiltration and HemodiafiltrationArtificial Organs - Tập 22 Số 1 - Trang 20-25 - 1998
Ingrid Ledebo
There is growing interest in the convective dialysis therapies, hemofiltration (HF) and hemodiafiltration (HDF). Both require dialysis membranes which are highly permeable to solutes as well as fluid, and in both cases large volumes of ultrafiltration are the condition for convective transport. In HDF the convection is combined with diffusion, and as a consequence, maximum clearance over t...... hiện toàn bộ
Structure and Dosimetric Analysis of Biodegradable Glasses for Prostate Cancer TreatmentArtificial Organs - Tập 27 Số 5 - Trang 432-436 - 2003
Wanderley dos Santos Roberto, Marivalda M. Pereira, Tarcísio Passos Ribeiro de Campos
Abstract: This work analyzes SiO2 and SiO2‐CaO glasses incorporated with samarium atoms produced by sol‐gel synthesis. The goal is to provide biocompatible and biodegradable radioactive seeds as an alternative to be used in brachytherapy for the treatment of prostate cancer. The chemical and physical characteristics of the ob...... hiện toàn bộ