Assessment of an Extracorporeal Liver Assist Device in Anhepatic DogsArtificial Organs - Tập 16 Số 4 - Trang 418-422 - 1992
James H. Kelly, Tarek Koussayer, Da-Er He, Maria G. Chong, Thomas A. Shang, Hartwell H. Whisennand, Norman Sussman
Abstract: We have used an anhepatic dog model to demonstrate the efficacy of a
bioartificial liver assist device. Six dogs underwent total hepatectomy. Three
received only medical care (controls) while the remainder were connected to an
extracorporeal liver assist device (ELAD). The control dogs failed to regain
consciousness after anesthesia although all lived 4–5 h postoperativlely. Plasma
ammon... hiện toàn bộ
The Hepatix Extracorporeal Liver Assist Device: Initial Clinical ExperienceArtificial Organs - Tập 18 Số 5 - Trang 390-396 - 1994
Norman Sussman, Gardar T. Gislason, Carol Conlin, James H. Kelly
Abstract: Eleven patients were treated with the Hepatix extracorporeal liver
assist device (ELAD) between June 1991 and August 1993. The first 2 patients
were treated according to Food and Drug Administration guidelines (“Emergency
Use of Unapproved Medical Devices,” October 22, 1985), and the remaining 9 were
treated according to an Investigational Device Exemption (IDE). The goal of the
study wa... hiện toàn bộ
Higher Renal Replacement Therapy Dose Delivery Influences on Drug TherapyArtificial Organs - Tập 27 Số 9 - Trang 808-814 - 2003
Bruce A. Mueller, Deborah A. Pasko, Kevin M. Sowinski
Abstract: Higher doses of renal replacement therapy have profound effects on
pharmacotherapy, yet little research has been conducted in this area.
High‐volume renal replacement therapies influence both the pharmacokinetic and
the pharmacodynamic profiles of all drugs administered to these critically ill
patients. Intermittent high‐dose “hybrid” hemodialysis therapies remove drugs to
a much differe... hiện toàn bộ
Comparison of Sustained Hemodiafiltration With Continuous Venovenous Hemodiafiltration for the Treatment of Critically Ill Patients With Acute Kidney InjuryArtificial Organs - Tập 34 Số 4 - Trang 331-338 - 2010
Masanori Abe, Kazuyoshi Okada, Midori Suzuki, Chinami Nagura, Yuko Ishihara, Yuki Fujii, Kazuya Ikeda, Kazo Kaizu, Koichi Matsumoto
AbstractDespite improvements in medical care, the mortality of critically ill
patients with acute kidney injury (AKI) who require renal replacement therapy
(RRT) remains high. We describe a new approach, sustained hemodiafiltration, to
treat patients who suffered from acute kidney injury and were admitted to
intensive care units (ICUs). In our study, 60 critically ill patients with AKI
who require... hiện toàn bộ
Hemodiafiltration: A New Alternative To Hemofiltration And Conventional Hemodialysis*Artificial Organs - Tập 2 Số 2 - Trang 150-153 - 1978
H. W. Leber, V. Wizemann, G Goubeaud, P Rawer, G Schütterle
ABSTRACTA new dialysis method, termed hemodiafiltration, is proposed. The
procedure consists of the combination of hemofiltration and conventional
hemodialysis using high flux membranes with a transmembrane pressure (TMP) of
300–500 mmHg and a dialysate flow of 900 ml/min. Due to the combination of
convective mass transfer and diffusion, the clearance values of both small and
larger molecules are ... hiện toàn bộ
New Method to Calculate Creatinine Generation Rate Using Pre‐ and Postdialysis Creatinine Concentra tionsArtificial Organs - Tập 21 Số 8 - Trang 864-872 - 1997
Toru Shinzato, Shigeru Nakai, Masamiki Miwa, Norihisa Iwayama, Ichiro Takai, Yoshihiro Matsumoto, Hiroyuki Morita, Kenji Maeda
Abstract: The creatinine (Cr) generation rate reflects the muscle mass, a
possible indicator of protein nutritional status. Thus, in this study, we
developed equations for calculating the Cr generation rate. Depner and Daugirdas
recently developed a method for determining the protein catabolic rate (PCR)
from the pre‐ and postdialysis blood urea nitrogen concentrations. We modified
their method to... hiện toàn bộ
Bisphenol A in Chronic Kidney DiseaseArtificial Organs - Tập 37 Số 3 - Trang 283-290 - 2013
Detlef H. Krieter, Bernard Canaud, Horst‐Dieter Lemke, A. Rodríguez, A. Morgenroth, K. von Appen, G. P. Dragoun, Christoph Wanner
AbstractThe estrogenic endocrine‐disrupting substance bisphenol A (BPA) is
extensively used as a starting material for a variety of consumer plastic
products including dialyzer materials. The present study was performed to
explore plasma BPA levels in patients with impaired renal function and to
investigate if dialyzers differing in elutable BPA influence plasma levels in
patients on maintenance h... hiện toàn bộ
Structure and Dosimetric Analysis of Biodegradable Glasses for Prostate Cancer TreatmentArtificial Organs - Tập 27 Số 5 - Trang 432-436 - 2003
Wanderley dos Santos Roberto, Marivalda M. Pereira, Tarcísio Passos Ribeiro de Campos
Abstract: This work analyzes SiO2 and SiO2‐CaO glasses incorporated with
samarium atoms produced by sol‐gel synthesis. The goal is to provide
biocompatible and biodegradable radioactive seeds as an alternative to be used
in brachytherapy for the treatment of prostate cancer. The chemical and physical
characteristics of the obtained glasses were analyzed by energy dispersive x‐ray
spectroscopy, x‐r... hiện toàn bộ
Civilian Uses of Hemoglobin‐based Oxygen CarriersArtificial Organs - Tập 28 Số 9 - Trang 795-799 - 2004
A. Gerson Greenburg, Hae Won Kim
Abstract: This article briefly discusses a few key issues related to
transfusion, the concept of hemoglobin‐based red blood cell substitutes (HBOCs),
and some parameters useful in evaluating the current properties of solutions.
Potential uses of HBOCs in civilian applications are identified and listed. Use
of HBOCs as a hemodiluent for intraoperative autologous blood donation (IAD) is
a particula... hiện toàn bộ