Assessment of an Extracorporeal Liver Assist Device in Anhepatic Dogs

Artificial Organs - Tập 16 Số 4 - Trang 418-422 - 1992
James H. Kelly1, Tarek Koussayer2, Da-Er He2, Maria G. Chong2, Thomas A. Shang2, Hartwell H. Whisennand2, Norman Sussman2
1Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
2Departments of Pathology, Medicine, and Surgery, Baylor College of Medicine, Houston, Texas, U.S.A

Tóm tắt

Abstract: We have used an anhepatic dog model to demonstrate the efficacy of a bioartificial liver assist device. Six dogs underwent total hepatectomy. Three received only medical care (controls) while the remainder were connected to an extracorporeal liver assist device (ELAD). The control dogs failed to regain consciousness after anesthesia although all lived 4–5 h postoperativlely. Plasma ammonia concentration increased by an average of 2–50 μmol/L between the end of surgery and the demise of the animals. The treated dogs lived 3–12.5 h, and 2 of them required repeated doses of thiamylal sodium to maintain sedation. Plasma ammonia concentration was unchanged after connection to the ELAD except in the longest survivor, whose ammonia began to rise after 8 h on the ELAD. The short survival in the other 2 treated dogs was the result of uncontrolled intraabdominal bleeding. This device is capable of replacing the metabolic function of the liver, and might provide hepatic support in patients awaiting transplantation or in fulrninant hepatic failure.

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Artificial Organs

Tập 16 Số 4

418-422

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