Molecular Adsorbent Recycling System (MARS): Clinical Results of a New Membrane‐Based Blood Purification System for Bioartificial Liver Support Tập 23 Số 4 - Trang 319-330 - 1999
Stange, Mitzner, Risler, Erley, Lauchart, Goehl, Sebastian Klammt, Peszynski, Freytag, Hickstein, Matthias Löhr, Liebe, Schareck, Hopt, Schmidt
The use of xenogenic or genetically engineered cell types in bioartificial liver
support systems requires separation methods between the patients' blood and the
liver support bioreactors that guarantee the sufficient transfer of
pathophysiologically relevant substances but prevent complications. The present
paper describes a new membrane separation system that is nearly impermeable to
proteins but... hiện toàn bộ
The Hepatix Extracorporeal Liver Assist Device: Initial Clinical Experience Tập 18 Số 5 - Trang 390-396 - 1994
Norman Sussman, Gardar T. Gislason, Carol Conlin, James H. Kelly
Abstract: Eleven patients were treated with the Hepatix extracorporeal liver
assist device (ELAD) between June 1991 and August 1993. The first 2 patients
were treated according to Food and Drug Administration guidelines (“Emergency
Use of Unapproved Medical Devices,” October 22, 1985), and the remaining 9 were
treated according to an Investigational Device Exemption (IDE). The goal of the
study wa... hiện toàn bộ
Detergent Decellularization of Heart Valves for Tissue Engineering: Toxicological Effects of Residual Detergents on Human Endothelial Cells Tập 34 Số 3 - Trang 206-210 - 2010
Serghei Cebotari, I. Tudorache, Thomas Jaekel, Andres Hilfiker, Suzanne E. Dorfman, Waldemar Ternes, Axel Haverich, Artur Lichtenberg
AbstractDetergents are powerful agents for tissue decellularization. Despite
this, the high toxicity of detergent residua can be a major limitation. This
study evaluated the efficacy of detergent removal from decellularized pulmonary
valves (PVs) and the consequences of repopulation with human endothelial cells
(HECs). Porcine PVs were treated with 1% sodium deoxycholate (SDC), group A; 1%
sodium ... hiện toàn bộ
Study on Biocompatibility of Complexes of Collagen–Chitosan–Sodium Hyaluronate and Cornea Tập 29 Số 2 - Trang 104-113 - 2005
Jiansu Chen, Qinghua Li, Jintang Xu, Yao‐Xiong Huang, Yong Ding, Hongwei Deng, Songbin Zhao, Rui Chen
Abstract: In this study we investigated the biocompatibility of
collagen–chitosan–sodium hyaluronate (Col–Chi–NaHA) complexes and cornea tissue,
and the feasibility of Col–Chi–NaHA complexes as substrates for cultivating
rabbit corneal cells. Different components of Col–Chi–NaHA complexes were
prepared and tested. A circular complex film with a diameter of 6 mm was
inserted into rabbit stomal poc... hiện toàn bộ
Development of a Bioartificial Liver Using Isolated Hepatocytes Tập 18 Số 5 - Trang 371-384 - 1994
Vivek Dixit
Abstract: Severe liver disease is very often life‐threatening and dramatically
diminishes quality of life. Liver support systems based on detoxification alone
have been proved ineffective because they cannot correct biochemical disorders.
An effective artificial liver support system should be capable of carrying out
the liver's essential processes, such as synthetic and metabolic functions,
detoxi... hiện toàn bộ
Effects of a Chitosan Scaffold Containing TGF‐β1 Encapsulated Chitosan Microspheres on In Vitro Chondrocyte Culture Tập 28 Số 9 - Trang 829-839 - 2004
Jong Eun Lee, Seoung Eun Kim, Ick Chan Kwon, Hyun Jeong Ahn, Cho Hyun-Chul, Sang‐Hoon Lee, Hee Joong Kim, Sang Cheol Seong, Myung Chul Lee
Abstract: The objectives of this study were (1) to develop a three‐dimensional
chitosan scaffold in combination with transforming growth factor‐beta1
(TGF‐β1)‐loaded chitosan microspheres and (2) to evaluate the effect of
the TGF‐β1 release on the chondrogenic potential of rabbit chondrocytes in the
scaffolds. TGF‐β1 was loaded into chitosan microspheres using an
emulsion‐crosslinking met... hiện toàn bộ
New Method to Calculate Creatinine Generation Rate Using Pre‐ and Postdialysis Creatinine Concentra tions Tập 21 Số 8 - Trang 864-872 - 1997
Toru Shinzato, Shigeru Nakai, Masamiki Miwa, Norihisa Iwayama, Ichiro Takai, Yoshihiro Matsumoto, Hiroyuki Morita, Kenji Maeda
Abstract: The creatinine (Cr) generation rate reflects the muscle mass, a
possible indicator of protein nutritional status. Thus, in this study, we
developed equations for calculating the Cr generation rate. Depner and Daugirdas
recently developed a method for determining the protein catabolic rate (PCR)
from the pre‐ and postdialysis blood urea nitrogen concentrations. We modified
their method to... hiện toàn bộ