Molecular Adsorbent Recycling System (MARS): Clinical Results of a New Membrane‐Based Blood Purification System for Bioartificial Liver Support

Artificial Organs - Tập 23 Số 4 - Trang 319-330 - 1999
Stange1, Mitzner1, Risler2, Erley2, Lauchart3, Goehl4, Sebastian Klammt1, Peszynski1, Freytag1, Hickstein1, Matthias Löhr1, Liebe1, Schareck5, Hopt5, Schmidt1
1Department of Internal Medicine, Rostock, Germany,
2Department of Internal Medicine, Tübingen, Germany
3Department of Surgery, Eberhard‐Karls‐University Tübingen, Tübingen, Germany,
4Gambro Dialysatoren Hechingen, Hechingen, Germany,
5Department of Surgery, University of Rostock, Rostock, Germany

Tóm tắt

The use of xenogenic or genetically engineered cell types in bioartificial liver support systems requires separation methods between the patients' blood and the liver support bioreactors that guarantee the sufficient transfer of pathophysiologically relevant substances but prevent complications. The present paper describes a new membrane separation system that is nearly impermeable to proteins but enables the exchange of water soluble and protein bound toxins by a special membrane and a recycled protein containing dialysate. Because the full range of toxins in hepatic failure has still not been identified, the value of this membrane separation method was evaluated clinically. Thirteen patients suffering from life threatening hepatic failure who had not responded to state of the art therapy were treated with this device, the molecular adsorbent recycling system (MARS). The overall survival rate was 69%. All patients showed positive response to the therapy, indicating that the presented membrane separator combines therapeutic effectivity with the highest safety criteria for the patient by cutting the exchange of substances below the level of proteins.

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Artificial Organs

Tập 23 Số 4

319-330

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