The proliferative human monocyte subpopulation contains osteoclast precursorsArthritis Research & Therapy - Tập 11 - Trang 1-6 - 2009
Roya Lari, Peter D Kitchener, John A Hamilton
Immediate precursors of bone-resorbing osteoclasts are cells of the monocyte/macrophage lineage. Particularly during clinical conditions showing bone loss, it would appear that osteoclast precursors are mobilized from bone marrow into the circulation prior to entering tissues undergoing such loss. The observed heterogeneity of peripheral blood monocytes has led to the notion that different monocyt...... hiện toàn bộ
High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystalsArthritis Research & Therapy - Tập 12 - Trang 1-10 - 2010
Anna Scanu, Francesca Oliviero, Lyssia Gruaz, Paolo Sfriso, Assunta Pozzuoli, Federica Frezzato, Carlo Agostini, Danielle Burger, Leonardo Punzi
To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Human FLS isolated from synovial tissue explants were stimulated with MSU crystals (0.01 to 0.5 mg/ml) or interleukin (IL)-1β (10 pg/ml) in the pr...... hiện toàn bộ