Arthritis Research & Therapy
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Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population
Arthritis Research & Therapy - - 2011
Marked expression of IL-1 receptors in cell nuclei and muscle fiber membrane in muscle tissue of patients with idiopathic inflammatory myopathies
Arthritis Research & Therapy - Tập 7 - Trang 1-1 - 2005
Pathogenic protease expression in murine OA is critically dependent upon mechanical joint loading
Arthritis Research & Therapy - Tập 14 - Trang 1-54 - 2012
Association of functional variants of PTPN22 and tp53in psoriatic arthritis: a case-control study
Arthritis Research & Therapy - Tập 8 - Trang 1-3 - 2006
Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding p......
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies
Arthritis Research & Therapy - Tập 8 - Trang 1-14 - 2006
Leukocyte infiltration during acute and chronic inflammation is regulated by exogenous and endogenous factors, including cytokines, chemokines and proteases. Stimulation of fibroblasts and human microvascular endothelial cells with the inflammatory cytokines interleukin-1β (IL-1β) or tumour necrosis factor alpha (TNF-α) combined with either interferon-α (IFN-α), IFN-β or IFN-γ resulted in a synerg......
The renal metallothionein expression profile is altered in human lupus nephritis
Arthritis Research & Therapy - Tập 10 - Trang 1-9 - 2008
Metallothionein (MT) isoforms I + II are polypeptides with potent antioxidative and anti-inflammatory properties. In healthy kidneys, MT-I+II have been described as intracellular proteins of proximal tubular cells. The aim of the present study was to investigate whether the renal MT-I+II expression profile is altered during lupus nephritis. Immunohistochemistry was performed on renal biopsies from......
Glucosamine prevents in vitro collagen degradation in chondrocytes by inhibiting advanced lipoxidation reactions and protein oxidation
Arthritis Research & Therapy - Tập 9 - Trang 1-10 - 2007
Osteoarthritis (OA) affects a large segment of the aging population and is a major cause of pain and disability. At present, there is no specific treatment available to prevent or retard the cartilage destruction that occurs in OA. Recently, glucosamine sulfate has received attention as a putative agent that may retard cartilage degradation in OA. The precise mechanism of action of glucosamine is ......
The proliferative human monocyte subpopulation contains osteoclast precursors
Arthritis Research & Therapy - Tập 11 - Trang 1-6 - 2009
Immediate precursors of bone-resorbing osteoclasts are cells of the monocyte/macrophage lineage. Particularly during clinical conditions showing bone loss, it would appear that osteoclast precursors are mobilized from bone marrow into the circulation prior to entering tissues undergoing such loss. The observed heterogeneity of peripheral blood monocytes has led to the notion that different monocyt......
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