Arthritis Research & Therapy
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Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis
Arthritis Research & Therapy - Tập 13 - Trang 1-10 - 2011
We and others have previously shown that antibodies against cyclic citrullinated proteins (anti-CCP) precede the development of rheumatoid arthritis (RA) and in a more recent study we reported that individuals who subsequently developed RA had increased concentrations of several cytokines and chemokines years before the onset of symptoms of joint disease. Here we aimed to evaluate the prevalence a...... hiện toàn bộ
Protein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease
Arthritis Research & Therapy - Tập 18 - Trang 1-11 - 2016
There is currently no blood-based test for detection of early-stage osteoarthritis (OA) and the anti-cyclic citrullinated peptide (CCP) antibody test for rheumatoid arthritis (RA) has relatively low sensitivity for early-stage disease. Morbidity in arthritis could be markedly decreased if early-stage arthritis could be routinely detected and classified by clinical chemistry test. We hypothesised t...... hiện toàn bộ
Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation
Arthritis Research & Therapy - Tập 24 - Trang 1-9 - 2022
Neutrophil extracellular traps (NETs) are critically involved in microscopic polyangiitis (MPA) pathogenesis, and some patients with MPA possess anti-NET antibody (ANETA). Anti-myosin light chain 6 (MYL6) antibody is an ANETA that affects NETs. This study aimed to determine the significance of anti-MYL6 antibody in MPA. The influence of anti-MYL6 antibody on NET formation and actin rearrangement n...... hiện toàn bộ
Interaction between hsp73 and rheumatoid-arthritis-associated HLA-DR alleles
Arthritis Research & Therapy - Tập 5 - Trang 1-1 - 2003
Analyses of chondrogenic induction of adipose mesenchymal stem cells by combined co-stimulation mediated by adenoviral gene transfer
Arthritis Research & Therapy - Tập 15 - Trang 1-13 - 2013
Adipose-derived stem cells (ASCs) have the potential to differentiate into cartilage under stimulation with some reported growth and transcriptional factors, which may constitute an alternative for cartilage replacement approaches. In this study, we analyzed the in vitro chondrogenesis of ASCs transduced with adenoviral vectors encoding insulin-like growth factor-1 (IGF-1), transforming growth fac...... hiện toàn bộ
Resistin in idiopathic inflammatory myopathies
Arthritis Research & Therapy - Tập 14 - Trang 1-9 - 2012
The purpose of this study was to evaluate and compare the serum levels and local expression of resistin in patients with idiopathic inflammatory myopathies to controls, and to determine the relationship between resistin levels, inflammation and disease activity. Serum resistin levels were determined in 42 patients with inflammatory myopathies and 27 healthy controls. The association among resistin...... hiện toàn bộ
Higher susceptibility to Fas ligand induced apoptosis and altered modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis
Arthritis Research & Therapy - Tập 5 - Trang 1-9 - 2003
The aim of the present study was to investigate the expression of Fas in periarticular tenocytes of patients with osteoarthritis (OA) and to study their susceptibility to Fas ligand-mediated apoptosis. Tendon samples were obtained from the quadriceps femoris muscle of patients with knee OA and used for histological evaluation, for immunohistochemical detection of Fas, and to establish tenocyte cul...... hiện toàn bộ
Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats
Arthritis Research & Therapy - Tập 7 - Trang 1-9 - 2005
Tetrathiomolybdate (TM), a drug developed for Wilson's disease, produces an anti-angiogenic and anti-inflammatory effect by reducing systemic copper levels. TM therapy has proved effective in inhibiting the growth of tumors in animal tumor models and in cancer patients. We have hypothesized that TM may be used for the therapy of rheumatoid arthritis and have examined the efficacy of TM on adjuvant...... hiện toàn bộ
Clinical response to the anti-tumor necrosis factor alpha antibody infliximab in patients with ankylosing spondylitis over 3 years
Arthritis Research & Therapy - Tập 7 - Trang 1-1 - 2005
MicroRNAs in innate immune responses and autoimmune diseases
Arthritis Research & Therapy - Tập 14 - Trang 1-28 - 2012
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