Association of functional variants of PTPN22 and tp53in psoriatic arthritis: a case-control studyArthritis Research & Therapy - Tập 8 - Trang 1-3 - 2006
Christopher Butt, Lynette Peddle, Celia Greenwood, Sean Hamilton, Dafna Gladman, Proton Rahman
Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding p...... hiện toàn bộ
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathiesArthritis Research & Therapy - Tập 8 - Trang 1-14 - 2006
Paul Proost, Sofie Struyf, Tamara Loos, Mieke Gouwy, Evemie Schutyser, René Conings, Isabelle Ronsse, Marc Parmentier, Bernard Grillet, Ghislain Opdenakker, Jan Balzarini, Jo Van Damme
Leukocyte infiltration during acute and chronic inflammation is regulated by exogenous and endogenous factors, including cytokines, chemokines and proteases. Stimulation of fibroblasts and human microvascular endothelial cells with the inflammatory cytokines interleukin-1β (IL-1β) or tumour necrosis factor alpha (TNF-α) combined with either interferon-α (IFN-α), IFN-β or IFN-γ resulted in a synerg...... hiện toàn bộ
The renal metallothionein expression profile is altered in human lupus nephritisArthritis Research & Therapy - Tập 10 - Trang 1-9 - 2008
Mikkel Faurschou, Milena Penkowa, Claus Bøgelund Andersen, Henrik Starklint, Søren Jacobsen
Metallothionein (MT) isoforms I + II are polypeptides with potent antioxidative and anti-inflammatory properties. In healthy kidneys, MT-I+II have been described as intracellular proteins of proximal tubular cells. The aim of the present study was to investigate whether the renal MT-I+II expression profile is altered during lupus nephritis. Immunohistochemistry was performed on renal biopsies from...... hiện toàn bộ
The proliferative human monocyte subpopulation contains osteoclast precursorsArthritis Research & Therapy - Tập 11 - Trang 1-6 - 2009
Roya Lari, Peter D Kitchener, John A Hamilton
Immediate precursors of bone-resorbing osteoclasts are cells of the monocyte/macrophage lineage. Particularly during clinical conditions showing bone loss, it would appear that osteoclast precursors are mobilized from bone marrow into the circulation prior to entering tissues undergoing such loss. The observed heterogeneity of peripheral blood monocytes has led to the notion that different monocyt...... hiện toàn bộ